gaboxadol has been researched along with Huntington Disease in 3 studies
gaboxadol: GABA agonist; inhibitor of GABA uptake systems; structure
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wójtowicz, AM | 1 |
| Dvorzhak, A | 1 |
| Semtner, M | 1 |
| Grantyn, R | 1 |
| Foster, NL | 1 |
| Chase, TN | 1 |
| Denaro, A | 1 |
| Hare, TA | 1 |
| Tamminga, CA | 1 |
| Waddington, JL | 1 |
| Cross, AJ | 1 |
1 trial available for gaboxadol and Huntington Disease
| Article | Year |
|---|---|
THIP treatment of Huntington's disease.
Topics: Adult; Clinical Trials as Topic; Disability Evaluation; Double-Blind Method; Female; Homovanillic Ac | 1983 |
2 other studies available for gaboxadol and Huntington Disease
| Article | Year |
|---|---|
Reduced tonic inhibition in striatal output neurons from Huntington mice due to loss of astrocytic GABA release through GAT-3.
Topics: Animals; Anisoles; Astrocytes; Corpus Striatum; GABA Agonists; GABA Plasma Membrane Transport Protei | 2013 |
Therapeutic failure of GABA agonist treatment in Huntington's disease.
Topics: gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoxazoles; Oxazoles | 1984 |