gaboxadol has been researched along with Disease Models, Animal in 26 studies
gaboxadol: GABA agonist; inhibitor of GABA uptake systems; structure
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling." | 7.77 | The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. ( Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J, 2011) |
| "Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling." | 3.77 | The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. ( Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J, 2011) |
| "The psychotomimetic NMDA receptor antagonist phencyclidine (PCP) is frequently employed to model schizophrenia in animal disease models." | 3.77 | Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia. ( Damgaard, T; Hansen, SL; Neill, JC; Plath, N, 2011) |
| "The anticonvulsant efficacy of the GABAmimetic drugs cetyl GABA, progabide and THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-ol) was studied against minor (myoclonic) and major (generalized tonic-clonic) seizures in gerbils as well as against maximal electroshock and s." | 3.67 | Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states. ( Löscher, W, 1985) |
| "Seven GABAmimetic drugs, namely cetyl gamma-aminobutyric acid (cetyl GABA), 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol, progabide, aminooxyacetic acid, alpha-acetylenic GABA, (-)-nipecotic acid ethyl ester and (+/-)-cis-4-hydroxynipecotic acid methyl ester, were tested for their potency to block "major" (generalized clonic-tonic) seizures in gerbils, induced by blowing at the animals with compressed air." | 3.66 | High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "Autism spectrum disorder is a neurodevelopmental syndrome diagnosed primarily by persistent deficits in social interactions and communication, unusual sensory reactivity, motor stereotypies, repetitive behaviors, and restricted interests." | 1.51 | Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism. ( Crawley, JN; Kazdoba, TM; Parrott, JM; Rhine, MA; Schultz, MN, 2019) |
| "Alterations in the Duchenne muscular dystrophy (DMD) gene have been associated with enhanced stress reactivity in vertebrate species, suggesting a role for brain dystrophin in fear-related behavioral and cognitive processes." | 1.46 | Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice. ( Chaussenot, R; Vaillend, C, 2017) |
| "Angelman syndrome is a neurodevelopmental disorder caused by loss of function of the UBE3A gene encoding a ubiquitin E3 ligase." | 1.38 | Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome. ( Egawa, K; Fukuda, A; Inoue, K; Kishino, T; Kitagawa, K; Kitagawa, M; Saitoh, S; Takayama, C; Takayama, M, 2012) |
| "Animal models of neuropathic pain have enabled the identification of key pathophysiological changes occurring within nociceptive pathways as a result of injury, and serve an invaluable role for preclinical screening of novel analgesic candidates." | 1.34 | The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Jensen, DG; Rode, F; Thomsen, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (15.38) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 3 (11.54) | 29.6817 |
| 2010's | 17 (65.38) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Rhine, MA | 1 |
| Parrott, JM | 1 |
| Schultz, MN | 1 |
| Kazdoba, TM | 1 |
| Crawley, JN | 1 |
| Wan, L | 1 |
| Liu, X | 1 |
| Wu, Z | 1 |
| Ren, W | 1 |
| Kong, S | 1 |
| Dargham, RA | 1 |
| Cheng, L | 1 |
| Wang, Y | 1 |
| González, MI | 1 |
| Grabenstatter, HL | 1 |
| Cea-Del Rio, CA | 1 |
| Cruz Del Angel, Y | 1 |
| Carlsen, J | 1 |
| Laoprasert, RP | 1 |
| White, AM | 1 |
| Huntsman, MM | 2 |
| Brooks-Kayal, A | 1 |
| Dissel, S | 1 |
| Angadi, V | 1 |
| Kirszenblat, L | 1 |
| Suzuki, Y | 1 |
| Donlea, J | 1 |
| Klose, M | 1 |
| Koch, Z | 1 |
| English, D | 1 |
| Winsky-Sommerer, R | 1 |
| van Swinderen, B | 1 |
| Shaw, PJ | 1 |
| Boychuk, JA | 2 |
| Butler, CR | 2 |
| Halmos, KC | 1 |
| Smith, BN | 2 |
| Zhong, W | 1 |
| Johnson, CM | 1 |
| Cui, N | 1 |
| Xing, H | 1 |
| Wu, Y | 1 |
| Jiang, C | 1 |
| Vaillend, C | 1 |
| Chaussenot, R | 1 |
| Holm, MM | 1 |
| Nieto-Gonzalez, JL | 1 |
| Vardya, I | 1 |
| Henningsen, K | 1 |
| Jayatissa, MN | 1 |
| Wiborg, O | 2 |
| Jensen, K | 1 |
| Olmos-Serrano, JL | 2 |
| Paluszkiewicz, SM | 1 |
| Martin, BS | 1 |
| Kaufmann, WE | 1 |
| Corbin, JG | 2 |
| Gonzalez-Sulser, A | 1 |
| Wang, J | 1 |
| Motamedi, GK | 1 |
| Avoli, M | 1 |
| Vicini, S | 1 |
| Dzakpasu, R | 1 |
| Damgaard, T | 1 |
| Plath, N | 1 |
| Neill, JC | 1 |
| Hansen, SL | 1 |
| Kueh, SL | 1 |
| Dempster, J | 1 |
| Head, SI | 1 |
| Morley, JW | 1 |
| Burns, MP | 1 |
| Christensen, T | 1 |
| Bétry, C | 1 |
| Mnie-Filali, O | 1 |
| Etievant, A | 1 |
| Ebert, B | 1 |
| Haddjeri, N | 1 |
| Egawa, K | 1 |
| Kitagawa, K | 1 |
| Inoue, K | 1 |
| Takayama, M | 1 |
| Takayama, C | 1 |
| Saitoh, S | 1 |
| Kishino, T | 1 |
| Kitagawa, M | 1 |
| Fukuda, A | 1 |
| Rode, F | 2 |
| Jensen, DG | 2 |
| Blackburn-Munro, G | 2 |
| Bjerrum, OJ | 2 |
| Thomsen, M | 1 |
| Broløs, T | 1 |
| Löscher, W | 2 |
| Frey, HH | 1 |
| Reiche, R | 1 |
| Schultz, D | 1 |
| Golden, GT | 1 |
| Fariello, RG | 1 |
| Rudissaar, R | 1 |
| Pruus, K | 1 |
| Skrebuhhova-Malmros, T | 1 |
| Allikmets, L | 1 |
| Matto, V | 1 |
| Snead, OC | 1 |
| Chapman, AG | 1 |
2 reviews available for gaboxadol and Disease Models, Animal
| Article | Year |
|---|---|
Pharmacological models of generalized absence seizures in rodents.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; Isoxazoles; Penicillins; Pentylenetetrazole; Rod | 1992 |
Valproate and myoclonus.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; F | 1986 |
24 other studies available for gaboxadol and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Brain; Cognition; Disease Models, Animal; Groom | 2019 |
Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons.
Topics: Animals; Benzothiadiazines; CA1 Region, Hippocampal; Convulsants; Disease Models, Animal; GABA Agoni | 2014 |
Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.
Topics: Animals; Biotinylation; Disease Models, Animal; Excitatory Amino Acid Antagonists; GABA Agonists; Ge | 2015 |
Sleep restores behavioral plasticity to Drosophila mutants.
Topics: Adenylyl Cyclases; Alzheimer Disease; Animals; Animals, Genetically Modified; Behavior, Animal; Dise | 2015 |
Enduring changes in tonic GABAA receptor signaling in dentate granule cells after controlled cortical impact brain injury in mice.
Topics: Anesthetics; Animals; Brain Injuries; Cerebral Cortex; Dentate Gyrus; Desoxycorticosterone; Disease | 2016 |
Differential effects of rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice.
Topics: Anesthetics; Animals; Brain Injuries; Dentate Gyrus; Disease Models, Animal; Functional Laterality; | 2016 |
Effects of chronic exposure to low dose THIP on brainstem neuronal excitability in mouse models of Rett syndrome: Evidence from symptomatic females.
Topics: Animals; Brain Stem; Disease Models, Animal; Dose-Response Relationship, Drug; Double-Blind Method; | 2017 |
Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice.
Topics: Animals; Brain; Cognition; Disease Models, Animal; Dystrophin; Fear; GABAergic Neurons; Humans; Isox | 2017 |
Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression.
Topics: Action Potentials; Animals; Antidepressive Agents, Second-Generation; Citalopram; Dentate Gyrus; Dep | 2011 |
Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
Topics: Amygdala; Animals; Disease Models, Animal; Evoked Potentials; Fragile X Mental Retardation Protein; | 2010 |
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Ani | 2011 |
Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, | 2011 |
Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse.
Topics: Animals; Disease Models, Animal; Female; GABA Agonists; GABA Antagonists; Isoxazoles; Male; Mice; Mi | 2011 |
The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Fear; Fragile X Ment | 2011 |
Synergistic antidepressant-like action of gaboxadol and escitalopram.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Dentate Gyrus; Depression; Disease Mod | 2012 |
Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome.
Topics: Angelman Syndrome; Animals; Cerebellum; Disease Models, Animal; GABA Agonists; GABA Plasma Membrane | 2012 |
Centrally-mediated antinociceptive actions of GABA(A) receptor agonists in the rat spared nerve injury model of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Agonists; GABA-A | 2005 |
The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2007 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, An | 1983 |
Penicillin spikes in rats. Limitations of a simple model for the study of anticonvulsants.
Topics: Action Potentials; Animals; Anticonvulsants; Dimethyl Sulfoxide; Disease Models, Animal; Drug Evalua | 1984 |
Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats.
Topics: Aggression; Animals; Apomorphine; Baclofen; Behavior, Animal; Disease Models, Animal; GABA Agonists; | 2000 |
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Ger | 1985 |