gabexate has been researched along with Reperfusion Injury in 14 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether gabexate mesilate, a synthetic protease inhibitor with anticoagulant properties, prevents hepatic damage by inhibiting leukocyte activation, we examined its effect on ischemia/reperfusion injury of rat liver in which activated leukocytes play a critical role." | 7.70 | Gabexate mesilate, a synthetic protease inhibitor, reduces ischemia/reperfusion injury of rat liver by inhibiting leukocyte activation. ( Harada, N; Kushimoto, S; Okajima, K, 1999) |
| "To assess the effects of gabexate mesilate (FOY), a protease inhibitor, on a canine model of pulmonary ischemia-reperfusion injury." | 7.70 | Effects of gabexate mesilate (FOY) on ischemia-reperfusion-induced acute lung injury in dogs. ( Chen, JS; Kuo, SH; Lee, YC; Lin-Shiau, SY; Luh, SP; Shau, WY; Tsai, CC, 1999) |
| "To investigate whether gabexate mesilate, a synthetic protease inhibitor with anticoagulant properties, prevents hepatic damage by inhibiting leukocyte activation, we examined its effect on ischemia/reperfusion injury of rat liver in which activated leukocytes play a critical role." | 3.70 | Gabexate mesilate, a synthetic protease inhibitor, reduces ischemia/reperfusion injury of rat liver by inhibiting leukocyte activation. ( Harada, N; Kushimoto, S; Okajima, K, 1999) |
| "To assess the effects of gabexate mesilate (FOY), a protease inhibitor, on a canine model of pulmonary ischemia-reperfusion injury." | 3.70 | Effects of gabexate mesilate (FOY) on ischemia-reperfusion-induced acute lung injury in dogs. ( Chen, JS; Kuo, SH; Lee, YC; Lin-Shiau, SY; Luh, SP; Shau, WY; Tsai, CC, 1999) |
| " GM was administered intravenously at a dosage of 2." | 2.72 | Evaluation of a protease inhibitor in the prevention of ischemia and reperfusion injury in hepatectomy under intermittent Pringle maneuver. ( Chun, BY; Chung, HJ; Hwang, YJ; Kim, YI; Lee, JW; Lee, YJ; Song, KE, 2006) |
| "Gabexate mesilate pretreatment abrogated the positive correlation between postreperfusion hepatocyte injury and hepatic ischemia time." | 2.70 | Hepatocyte protection by a protease inhibitor against ischemia/reperfusion injury of human liver. ( Chun, BY; Hwang, YJ; Kim, YI; Lee, JW; Song, KE; Yun, YK, 2002) |
| "The roles of TNFalpha and IL-6 in liver reperfusion injury were not clear, though TNFalpha might have had an effect during the early phase." | 1.30 | Effect of protease inhibitor on ischemia-reperfusion injury to rat liver. ( Choe, KJ; Ha, J; Jung, SE; Kim, SJ; Lee, JE; Noh, DY; Oh, SK; Youn, YK; Yun, IJ, 1999) |
| "Reperfusion injury is a large problem in the early stage after lung transplantation." | 1.29 | The effect of protease inhibitor on reperfusion injury after unilateral pulmonary ischemia. ( Harada, Y; Horiguchi, T, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, YI | 2 |
| Hwang, YJ | 2 |
| Song, KE | 2 |
| Yun, YK | 1 |
| Lee, JW | 2 |
| Chun, BY | 2 |
| Fitzal, F | 1 |
| DeLano, FA | 1 |
| Young, C | 1 |
| Schmid-Schönbein, GW | 1 |
| Inoue, S | 1 |
| Sugitani, A | 1 |
| Yamamoto, H | 1 |
| Kitada, H | 1 |
| Motoyama, K | 1 |
| Okabe, Y | 1 |
| Ohta, M | 1 |
| Yoshida, J | 1 |
| Nishiyama, K | 1 |
| Tanaka, M | 1 |
| Chung, HJ | 1 |
| Lee, YJ | 1 |
| Gezici, A | 1 |
| Ozturk, H | 2 |
| Buyukbayram, H | 1 |
| Okur, H | 1 |
| Chen, CF | 1 |
| Wang, D | 1 |
| Lin, HI | 1 |
| Shen, CY | 1 |
| Yang, NP | 1 |
| Horiguchi, T | 1 |
| Harada, Y | 1 |
| Hossain, MA | 1 |
| Hamamoto, I | 1 |
| Okano, K | 1 |
| Okada, S | 1 |
| Wakabayashi, H | 1 |
| Maeba, T | 1 |
| Maeta, H | 1 |
| Harada, N | 1 |
| Okajima, K | 1 |
| Kushimoto, S | 1 |
| Zimmerman, JJ | 1 |
| Jung, SE | 1 |
| Yun, IJ | 1 |
| Youn, YK | 1 |
| Lee, JE | 1 |
| Ha, J | 1 |
| Noh, DY | 1 |
| Kim, SJ | 1 |
| Oh, SK | 1 |
| Choe, KJ | 1 |
| Luh, SP | 2 |
| Tsai, CC | 2 |
| Shau, WY | 2 |
| Chen, JS | 1 |
| Kuo, SH | 2 |
| Lin-Shiau, SY | 1 |
| Lee, YC | 1 |
| Shiau, SY | 1 |
| Jan, IS | 1 |
| Yang, PC | 1 |
| Sasaki, S | 1 |
2 trials available for gabexate and Reperfusion Injury
| Article | Year |
|---|---|
Hepatocyte protection by a protease inhibitor against ischemia/reperfusion injury of human liver.
Topics: Adult; Aged; Case-Control Studies; Female; Gabexate; Hepatectomy; Humans; Interleukin-6; Liver; Male | 2002 |
Evaluation of a protease inhibitor in the prevention of ischemia and reperfusion injury in hepatectomy under intermittent Pringle maneuver.
Topics: Adult; Female; Gabexate; Hepatectomy; Humans; Ischemia; Liver; Liver Diseases; Male; Middle Aged; Pr | 2006 |
12 other studies available for gabexate and Reperfusion Injury
| Article | Year |
|---|---|
Early capillary no-reflow during low-flow reperfusion after hind limb ischemia in the rat.
Topics: Animals; Capillary Resistance; Endothelium, Vascular; Erythrocytes; Femoral Artery; Fluorescent Dyes | 2002 |
Effect of synthetic protease inhibitor gabexate mesilate on the attenuation of ischemia/reperfusion injury in canine kidney autotransplantation.
Topics: Animals; Blood Urea Nitrogen; Creatinine; Cytokines; Dogs; Gabexate; Gene Expression; Kidney; Kidney | 2005 |
Effects of gabexate mesilate on ischemia-reperfusion-induced testicular injury in rats.
Topics: Animals; Gabexate; Lipid Peroxidation; Male; Microcirculation; Radionuclide Imaging; Random Allocati | 2006 |
Translocation of pancreatic juice after ischemia and reperfusion of the intestines and the effects of gabexate mesilate (FOY) in rats.
Topics: Animals; Disease Models, Animal; Gabexate; Intestines; Male; Mesenteric Artery, Superior; Pancreatic | 2007 |
The effect of protease inhibitor on reperfusion injury after unilateral pulmonary ischemia.
Topics: Animals; Dogs; Free Radical Scavengers; Gabexate; Glycoproteins; Ischemia; Lung; Neutrophils; Radiog | 1993 |
Ameliorative effect of gabexate mesilate on the disturbed microcirculation following prolonged cold ischemia of the liver.
Topics: Adenosine; Allopurinol; Analysis of Variance; Animals; Anticoagulants; Bile; Cold Temperature; Gabex | 1996 |
Gabexate mesilate, a synthetic protease inhibitor, reduces ischemia/reperfusion injury of rat liver by inhibiting leukocyte activation.
Topics: Analysis of Variance; Animals; Gabexate; Interleukin-8; Leukocytes; Liver; Liver Circulation; Liver | 1999 |
What's the buzz (on protease inhibitors)...tell me what's (mechanistically) happening.
Topics: Animals; Gabexate; Humans; Interleukin-8; Liver Circulation; Neutrophils; Rats; Reperfusion Injury; | 1999 |
Effect of protease inhibitor on ischemia-reperfusion injury to rat liver.
Topics: Animals; Catalase; Disease Models, Animal; Female; Gabexate; Interleukin-6; Lipid Peroxidation; Live | 1999 |
Effects of gabexate mesilate (FOY) on ischemia-reperfusion-induced acute lung injury in dogs.
Topics: Animals; Bronchoalveolar Lavage Fluid; Dogs; Gabexate; Hemodynamics; Ischemia; Lung; Neutrophils; Pe | 1999 |
Protective effects of inhaled nitric oxide and gabexate mesilate in lung reperfusion injury after transplantation from non-heart-beat donors.
Topics: Administration, Inhalation; Animals; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Capillary Per | 2002 |
[Experimental study on renal protection against damage in kidneys subjected warm ischemia--protective effect of FOY, SOD, and PEG-SOD on ischemic acute renal failure].
Topics: Acute Kidney Injury; Animals; Gabexate; Guanidines; Ischemia; Kidney; Kidney Tubules; Necrosis; Poly | 1989 |