Page last updated: 2024-10-27

gabexate and Pancreatitis

gabexate has been researched along with Pancreatitis in 139 studies

Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.

Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.

Research Excerpts

ExcerptRelevanceReference
"No significant difference in the occurrence of pancreatitis, hyperamylasemia, or abdominal pain was observed among placebo-, gabexate-, and somatostatin-treated patients."10.20Gabexate or somatostatin administration before ERCP in patients at high risk for post-ERCP pancreatitis: a multicenter, placebo-controlled, randomized clinical trial. ( Andriulli, A; Clemente, R; De Maio, G; Leandro, G; Leo, P; Perri, F; Sigillito, A; Solmi, L; Suriani, R; Terruzzi, V, 2002)
"The objective of this study is to evaluate the efficacy of somatostatin, ulinastatin and gabexate for the treatment of severe acute pancreatitis."9.22Effect of Somatostatin, Ulinastatin and Gabexate on the Treatment of Severe Acute Pancreatitis. ( Liu, Y; Qiu, P; Wang, G; Wen, J; Wen, P; Xiao, X; Xu, L; Zhou, SF, 2016)
"The evidence provided by syntheses of the preventative effects of gabexate mesilate against pancreatitis among patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) is limited and highly heterogeneous."9.12Efficacy of gabexate mesilate in preventing post endoscopic retrograde cholangiopancreatography pancreatitis: A meta-analysis of randomized clinical trials. ( Chang, CC; Chao, CC; Chen, SC; Chiu, YJ; Hou, SK; Kang, YN, 2021)
"The objective of the present study was to determine the efficacy of prophylactic administration of gabexate for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, hyperamylasemia and pancreatic pain."9.12Clinical trial of gabexate in the prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis. ( Ge, ZZ; Wu, SM; Xiong, GS; Zhang, XW, 2006)
"It has been reported that the administration of ulinastatin, gabexate mesylate, or somatostatin may be effective in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis."9.12Comparison between ulinastatin and gabexate mesylate for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a prospective, randomized trial. ( Fujimura, N; Kawamoto, K; Matsui, T; Otani, K; Sakaguchi, S; Shimizu, A; Ueki, T, 2007)
"Gabexate mesylate reduces the incidence of post-ERCP pancreatitis."9.12Efficacy of postprocedure administration of gabexate mesylate in the prevention of post-ERCP pancreatitis: a randomized, controlled, multicenter study. ( Ardizzone, S; Lombardi, G; Manes, G; Pieramico, O; Porro, GB; Uomo, G, 2007)
"It still is debated whether post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis can be prevented by administering either somatostatin or gabexate mesylate."9.11Prophylaxis of ERCP-related pancreatitis: a randomized, controlled trial of somatostatin and gabexate mesylate. ( Andriulli, A; Belmonte, A; Ciliberto, E; Festa, V; Forte, G; Leo, P; Loperfido, S; Magnolia, MR; Marenco, G; Monica, F; Perri, F; Sabatino, A; Silla, M; Solmi, L; Spirito, F; Terruzzi, V, 2004)
"A continuous 13-h infusion of gabexate starting 30-90 min before endoscopic cholangiopancreatography (ERCP) can reduce postprocedural pancreatitis, the onset of which is generally observed within the first 6 h after ERCP."9.10Comparison of two dosing regimens of gabexate in the prophylaxis of post-ERCP pancreatitis. ( Cavallini, G; Costamagna, G; Curioni, S; Dragonetti, C; Frulloni, L; Innocenti, P; Macarri, G; Mariani, A; Masci, E; Testoni, PA; Tittobello, A; Uomo, G; Zambelli, S, 2003)
"The authors report the results of a randomized, double-blind multicenter clinical trial on the use of gabexate mesilate vs aprotinin in the therapy of acute pancreatitis."9.07Gabexate mesilate vs aprotinin in human acute pancreatitis (GA.ME.P.A.). A prospective, randomized, double-blind multicenter study. ( Bassi, C; Cavallini, G; Falconi, M; Pederzoli, P, 1993)
"A multicenter controlled study was performed to evaluate the effect of high doses of the low molecular weight protease inhibitor gabexate mesilate on mortality and complications associated with moderate and severe acute pancreatitis."9.07Gabexate mesilate in human acute pancreatitis. German Pancreatitis Study Group. ( Adler, G; Beger, HG; Büchler, M; Gaus, W; Malfertheiner, P; Rolle, K; Schölmerich, J; Stöckmann, F; Uhl, W, 1993)
"A multicenter, randomized, double-blind trial was carried out to evaluate the efficacy of gabexate mesylate (FOY) in acute pancreatitis."9.07Multicenter double-blind trial of gabexate mesylate (FOY) in unselected patients with acute pancreatitis. ( Adrián, MJ; Estruch, J; Navarro, S; Pérez-Mateo, M; Sanjosé, L; Valderrama, R; Vázquez, N, 1992)
"We investigated the effect of a new synthetic protease- and phospholipase A2-inhibitor gabexate mesilate (FOY) in a multicenter (6 hospitals in Hannover and vicinity) double-blind study on the clinical course of acute pancreatitis."9.06[Gabexate mesilate in the treatment of acute pancreatitis. Results of a Hannover multicenter double-blind study with 50 patients]. ( Freise, J; Horbach, L; Melzer, P; Schmidt, FW, 1986)
"We employed the method recommended by the Cochrane Collaboration to perform a meta-analysis of randomized controlled trials (RCTs) of gabexate in the prevention of post-ERCP pancreatitis (PEP) including three RCTs conducted in Italy and one in China."8.84Gabexate in the prophylaxis of post-ERCP pancreatitis: a meta-analysis of randomized controlled trials. ( Chen, Y; Li, J; Yang, X; Zeng, Q; Zhang, Y; Zheng, M, 2007)
"Our purpose was to update the meta-analysis on somatostatin (SS, 16 studies) or gabexate mesylate (GM, 9 studies) prophylaxis of post-ERCP pancreatitis and to run sensitivity analyses by subgrouping trials according to schedules of drug administration."8.84Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis. ( Andriulli, A; Annese, V; Federici, T; Forlano, R; Iacobellis, A; Ippolito, A; Leandro, G, 2007)
"Prior studies have suggested the efficacy of somatostatin and gabexate in post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis prevention."8.84Somatostatin and gabexate for post-endoscopic retrograde cholangiopancreatography pancreatitis prevention: meta-analysis of randomized placebo-controlled trials. ( Kiss, A; Rudin, D; Sottile, VM; Wetz, RV, 2007)
"Since the effectiveness of gabexate mesilate in patients with acute pancreatitis is controversial, a metaanalysis of the published literature was conducted to address this problem."8.79Effectiveness of gabexate mesilate in acute pancreatitis. A metaanalysis. ( Bassi, C; Falconi, M; Martini, N; Messori, A; Olivato, R; Pederzoli, P; Rampazzo, R; Scroccaro, G, 1995)
"We have previously shown that gabexate mesylate-poloxamer 407 conjugate (GMTI) alleviates traumatic pancreatitis in rats."8.31Gabexate Mesylate-Poloxamer 407 Conjugate Alleviates Sodium Taurocholate-Induced Severe Acute Pancreatitis in an Optimized Rat Model. ( Gao, H; Gao, Y; Jiao, Z; Luo, Y; Song, Q; Wu, W; Yang, J, 2023)
" The prophylaxis for acute pancreatitis (AP) post-endoscopic retrograde cholangiopancreatography (ERCP) consists of rectal indomethacin, but some studies are not concordant."7.85Rectal indomethacin or intravenous gabexate mesylate as prophylaxis for acute pancreatitis post-endoscopic retrograde cholangiopancreatography. ( Giorgio, P; Guerra, V; Guglielmi, V; Tutino, M, 2017)
"Gabexate mesilate (GM) is a trypsin inhibitor, and mainly used for treatment of various acute pancreatitis, including traumatic pancreatitis (TP), edematous pancreatitis, and acute necrotizing pancreatitis."7.81A novel thermosensitive in-situ gel of gabexate mesilate for treatment of traumatic pancreatitis: An experimental study. ( Gao, HJ; Luo, YK; Lv, FQ; Mei, XG; Song, Q; Tang, J; Wang, S; Wang, YR, 2015)
"Ciprofloxacin is considered to be a safe and effective treatment for acute infectious colitis."7.80Acute pancreatitis secondary to ciprofloxacin therapy in patients with infectious colitis. ( Cheung, DY; Cho, HJ; Cho, SH; Kim, JI; Kim, JK; Kim, SS; Lee, HJ; Sung, HY, 2014)
"The present study showed that gabexate infusion has some clinical benefits for acute pancreatitis in children."7.79Clinical efficacy of gabexate mesilate for acute pancreatitis in children. ( Kim, SC; Yang, HR, 2013)
"Despite a lack of evidence, gabexate mesylate (GM) is routinely used for the treatment of acute pancreatitis (AP) in some countries."7.79Effect and cost of treatment for acute pancreatitis with or without gabexate mesylate: a propensity score analysis using a nationwide administrative database. ( Fushimi, K; Hashimoto, H; Horiguchi, H; Matsuda, S; Yasunaga, H, 2013)
"To evaluate the efficacy of continuous regional arterial infusion therapy (CRAI) with gabexate mesilate and antibiotics for severe acute pancreatitis (SAP)."7.74Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis. ( Akashi, T; Arita, Y; Furukawa, M; Igarashi, H; Ino, Y; Ito, T; Kawabe, K; Kimura, T; Miyahara, T; Ogoshi, K; Oono, T; Ouchi, J; Takayanagi, R, 2008)
"Camostat mesilate (CM), an oral protease inhibitor, has been used clinically for the treatment of chronic pancreatitis in Japan."7.73Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity. ( Arita, Y; Fujimori, N; Gibo, J; Hisano, T; Inoue, M; Ito, T; Kawabe, K; Nawata, H; Oono, T, 2005)
"Gabexate mesylate is a drug marketed only in Italy and Japan and it is considered an essential drug in the treatment of acute pancreatitis."7.73Gabexate mesilate and acute pancreatitis: an experience of evidence based drug information for improving rational drug use. ( Aiazzi, M; Banfi, R; Borselli, G; Cappelletti, S; Mari, L; Taddei, V, 2005)
"Routine gabexate prophylaxis was associated with a significant reduction of post-ERCP pancreatitis rate, severe hyperamylasaemia and hospitalisation-related costs only in high-risk patients."7.73Frequency of post-ERCP pancreatitis in a single tertiary referral centre without and with routine prophylaxis with gabexate: a 6-year survey and cost-effectiveness analysis. ( Curioni, S; Mariani, A; Masci, E; Testoni, PA, 2006)
"An oral protease inhibitor, camostat mesilate (CM) has been used clinically for chronic pancreatitis (CP) in Japan, but it lacks enough scientific evidence of its effectiveness."7.71Effect of camostat mesilate on the expression of pancreatitis-associated protein (PAP), p8, and cytokines in rat spontaneous chronic pancreatitis. ( Iovanna, JL; Motoo, Y; Sawabu, N; Su, SB; Xie, MJ, 2001)
" In this report, the effects of loxiglumide and gabexate mesilate were studied on three experimental acute pancreatitis models induced by caerulein, sodium taurocholate + caerulein and closed duodenal loop."7.70Effects of loxiglumide on experimental acute pancreatitis in comparison with gabexate mesilate. ( Fujii, M; Kasai, H; Kimura, K; Saito, T; Tominaga, K, 1998)
"An experimental model of chronic pancreatitis was induced by a retrograde injection of a viscous solution consisting of zein-oleic acid-linoleic acid (0."7.70Pathophysiologic studies of experimental chronic pancreatitis in rats induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct. ( Kashima, K; Kataoka, K; Sakagami, J; Sasaki, T; Yorizumi, H, 1998)
"This study was undertaken to determine whether synthetic proteinase inhibitors--nafamostat mesilate (FUT-175) and gabexate mesilate (FOY) have any influence on multiorgan oxidant-antioxidant balance in acute haemorrhagic pancreatitis induced in Wistar rats using a retrograde intraductal injection of 5% Na-taurocholate."7.69The effect of nafamostat mesilate (FUT-175) and gabexate mesilate (FOY) on multiorgan oxidant-antioxidant balance in acute experimental pancreatitis. ( Dabrowski, A; Gabryelewicz, A, 1994)
"The present study investigates the effect of oral pretreatment with the protease inhibitor camostate on the outcome of pancreatitis in three experimental models."7.68Effect of camostate administration for two weeks on experimental pancreatitis in mice and rats. ( Creutzfeldt, W; Leonhardt, U; Seidensticker, F; Stöckmann, F, 1993)
"Systemic prostacyclin and thromboxane A2 production in rat experimental acute pancreatitis has been evaluated by measuring the urinary excretion of the 2,3-dinor 6-keto prostaglandin F1 alpha and 2,3-dinor thromboxane B2, respectively."7.68Changes of systemic prostacyclin and thromboxane A2 in sodium taurocholate- and cerulein-induced acute pancreatitis in rats. ( Bulbena, O; Closa, D; Fernandez-Cruz, L; Gelpi, E; Hotter, G; Martrat, A; Rosello-Catafau, J, 1993)
"In vivo microscopy was performed to assess the effect of dextran 40, gabexate mesilate and somatostatin on the microcirculation in sodium taurocholate-induced pancreatitis in rats."7.68The effect of somatostatin, gabexate mesilate and dextran 40 on the microcirculation in sodium taurocholate-induced pancreatitis. ( Enghofer, M; Kusterer, K; Poschmann, T; Usadel, KH, 1992)
"The therapeutic effect and the mechanism of action of the synthetic trypsin inhibitor camostate were studied in a rat model of acute interstitial pancreatitis induced by four subcutaneous injections of 20 micrograms/kg body weight of cerulein at hourly intervals."7.68Beneficial effects of the synthetic trypsin inhibitor camostate in cerulein-induced acute pancreatitis in rats. ( Fuji, M; Fujisawa, T; Itoh, H; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S, 1990)
"Due to its biochemical properties, the newly developed low-molecular protease inhibitor gabexate mesilate is assumed to be efficient in the treatment of complicated acute pancreatitis."7.68[The protease inhibitor gabexate mesilate in experimentally-induced acute pancreatitis with early gram-negative infection in the Göttingen minipig: therapeutic efficacy and effects on blood coagulation and fibrinolysis]. ( Emde, C; Heitz, J; Jansen, U; Schäfer, JH; Semsch, B, 1990)
"The effect of peritoneal lavage with the addition of camostate to the lavage fluid on the outcome of taurocholate pancreatitis in rats was studied."7.68Camostate (FOY-305) improves the therapeutic effect of peritoneal lavage on taurocholate induced pancreatitis. ( Creutzfeldt, W; Fussek, M; Leonhardt, U; Seidensticker, F; Stöckmann, F, 1990)
"The effects of the cholecystokinin (CCK)-receptor antagonist proglumide, the protease inhibitor gabexate, and the hormones secretin and cholecystokinin-octapeptide (CCK-8) were studied in a model of acute hemorrhagic pancreatitis induced by feeding mice a choline-deficient, ethionine-supplemented (CDE) diet."7.67Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. ( Ferrell, LD; Grendell, JH; Liddle, RA; Niederau, C, 1986)
"The effects of gabexate mesilate (GM) on hemodynamics and phospholipase A2 activities (PLA2) during acute hemorrhagic pancreatitis (AHP) were studied in 17 piglets which were randomly divided into three groups: The control group (CG) received only the fluid replacement, whereas the pretreatment group (PG) was given an infusion of GM (20 mg/kg/5h), which was started 30 min before and in the treatment group (TG) 30 min after the induction of AHP."7.67The effect of gabexate mesilate on the outcome of acute hemorrhagic pancreatitis in pigs. ( Gröhn, P; Kiviniemi, H; Mahlberg, K; Mokka, RE; Rämö, OJ; Ristkari, SK, 1989)
"Two models of severe acute pancreatitis were chosen and pancreatitis induced by sodium taurocholate and by a choline-deficient ethionine-supplemented diet, to evaluate the effectiveness of FOY-305 (camostate), a new synthetic trypsin inhibitor."7.67Effect of FOY-305 (camostate) on severe acute pancreatitis in two experimental animal models. ( Göke, B; Gröne, HJ; Lankisch, PG; Otto, J; Pohl, U; Rahlf, G; Wereszczynska-Siemiatkowska, U, 1989)
"In order to evaluate the efficacy and safety of gabexate mesilate (FOY = [ethyl-4-(6-guanidinohexanoyloxy) benzoate methane sulfonate]), a synthetic inhibitor of various proteases as well as phospholipase A 2, 17 patients with acute pancreatitis were treated with FOY in doses of 3 X 150 mg/day per i."7.66[Therapy of acute pancreatitis with a synthetic protease and phospholipase A2 inhibitor gabexate mesilate]. ( Freise, J, 1983)
"No significant difference in the occurrence of pancreatitis, hyperamylasemia, or abdominal pain was observed among placebo-, gabexate-, and somatostatin-treated patients."6.20Gabexate or somatostatin administration before ERCP in patients at high risk for post-ERCP pancreatitis: a multicenter, placebo-controlled, randomized clinical trial. ( Andriulli, A; Clemente, R; De Maio, G; Leandro, G; Leo, P; Perri, F; Sigillito, A; Solmi, L; Suriani, R; Terruzzi, V, 2002)
"Gabexate mesilate was infused intravenously 6 hours after the initiation of induction of acute pancreatitis at doses of 0."5.30Gabexate mesilate improves pancreatic microcirculation and reduces lung edema in a rat model of acute pancreatitis. ( Chen, HM; Chen, MF; Shyr, MH, 1997)
"Antiprotease has long been used for the treatment of acute pancreatitis, although its effects and mechanism have not been fully elucidated."5.29The effect of gabexate mesilate on pancreatic and hepatic microcirculation in acute experimental pancreatitis in rats. ( Chen, HM; Chen, MF; Hwang, TL, 1996)
"Acute pancreatitis was induced in ten anesthetized dogs by retrograde injection for bile mixed with trypsin into the pancreatic duct."5.28Effect on hemodynamics of therapeutic infusion of gabexate mesilate (FOY) in experimental acute pancreatitis. ( Babicki, A; Basiński, A; Dobosz, M; Sledziński, Z; Stanek, A; Wajda, Z, 1989)
"Comparing the two groups of acute pancreatitis patients after 6 days of treatment with gabexate mesilate, we observed a statistically significantly lower alpha-amylase activity in the serum of treated patients compared with the placebo group."5.27Gabexate mesilate and camostate: new inhibitors of phospholipase A2 and their influence on the alpha-amylase activity in serum of patients with acute pancreatitis. ( Freise, J; Magerstedt, P; Schmid, K; Schmidt, FW, 1985)
"The objective of this study is to evaluate the efficacy of somatostatin, ulinastatin and gabexate for the treatment of severe acute pancreatitis."5.22Effect of Somatostatin, Ulinastatin and Gabexate on the Treatment of Severe Acute Pancreatitis. ( Liu, Y; Qiu, P; Wang, G; Wen, J; Wen, P; Xiao, X; Xu, L; Zhou, SF, 2016)
"The evidence provided by syntheses of the preventative effects of gabexate mesilate against pancreatitis among patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) is limited and highly heterogeneous."5.12Efficacy of gabexate mesilate in preventing post endoscopic retrograde cholangiopancreatography pancreatitis: A meta-analysis of randomized clinical trials. ( Chang, CC; Chao, CC; Chen, SC; Chiu, YJ; Hou, SK; Kang, YN, 2021)
"The objective of the present study was to determine the efficacy of prophylactic administration of gabexate for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, hyperamylasemia and pancreatic pain."5.12Clinical trial of gabexate in the prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis. ( Ge, ZZ; Wu, SM; Xiong, GS; Zhang, XW, 2006)
"It has been reported that the administration of ulinastatin, gabexate mesylate, or somatostatin may be effective in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis."5.12Comparison between ulinastatin and gabexate mesylate for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a prospective, randomized trial. ( Fujimura, N; Kawamoto, K; Matsui, T; Otani, K; Sakaguchi, S; Shimizu, A; Ueki, T, 2007)
"Gabexate mesylate reduces the incidence of post-ERCP pancreatitis."5.12Efficacy of postprocedure administration of gabexate mesylate in the prevention of post-ERCP pancreatitis: a randomized, controlled, multicenter study. ( Ardizzone, S; Lombardi, G; Manes, G; Pieramico, O; Porro, GB; Uomo, G, 2007)
"It still is debated whether post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis can be prevented by administering either somatostatin or gabexate mesylate."5.11Prophylaxis of ERCP-related pancreatitis: a randomized, controlled trial of somatostatin and gabexate mesylate. ( Andriulli, A; Belmonte, A; Ciliberto, E; Festa, V; Forte, G; Leo, P; Loperfido, S; Magnolia, MR; Marenco, G; Monica, F; Perri, F; Sabatino, A; Silla, M; Solmi, L; Spirito, F; Terruzzi, V, 2004)
"A continuous 13-h infusion of gabexate starting 30-90 min before endoscopic cholangiopancreatography (ERCP) can reduce postprocedural pancreatitis, the onset of which is generally observed within the first 6 h after ERCP."5.10Comparison of two dosing regimens of gabexate in the prophylaxis of post-ERCP pancreatitis. ( Cavallini, G; Costamagna, G; Curioni, S; Dragonetti, C; Frulloni, L; Innocenti, P; Macarri, G; Mariani, A; Masci, E; Testoni, PA; Tittobello, A; Uomo, G; Zambelli, S, 2003)
"Prophylactic treatment with gabexate reduced pancreatic damage related to ERCP, as reflected by reductions in the extent but not the frequency of elevated enzyme levels and in the frequency of pancreatic pain and acute pancreatitis."5.08Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy--Italian Group. ( Cavallini, G; Di Francesco, V; Frulloni, L; Mariana, A; Masci, E; Tittobello, A, 1996)
"The authors report the results of a randomized, double-blind multicenter clinical trial on the use of gabexate mesilate vs aprotinin in the therapy of acute pancreatitis."5.07Gabexate mesilate vs aprotinin in human acute pancreatitis (GA.ME.P.A.). A prospective, randomized, double-blind multicenter study. ( Bassi, C; Cavallini, G; Falconi, M; Pederzoli, P, 1993)
"A multicenter controlled study was performed to evaluate the effect of high doses of the low molecular weight protease inhibitor gabexate mesilate on mortality and complications associated with moderate and severe acute pancreatitis."5.07Gabexate mesilate in human acute pancreatitis. German Pancreatitis Study Group. ( Adler, G; Beger, HG; Büchler, M; Gaus, W; Malfertheiner, P; Rolle, K; Schölmerich, J; Stöckmann, F; Uhl, W, 1993)
"A multicenter, randomized, double-blind trial was carried out to evaluate the efficacy of gabexate mesylate (FOY) in acute pancreatitis."5.07Multicenter double-blind trial of gabexate mesylate (FOY) in unselected patients with acute pancreatitis. ( Adrián, MJ; Estruch, J; Navarro, S; Pérez-Mateo, M; Sanjosé, L; Valderrama, R; Vázquez, N, 1992)
"We investigated the effect of a new synthetic protease- and phospholipase A2-inhibitor gabexate mesilate (FOY) in a multicenter (6 hospitals in Hannover and vicinity) double-blind study on the clinical course of acute pancreatitis."5.06[Gabexate mesilate in the treatment of acute pancreatitis. Results of a Hannover multicenter double-blind study with 50 patients]. ( Freise, J; Horbach, L; Melzer, P; Schmidt, FW, 1986)
"We employed the method recommended by the Cochrane Collaboration to perform a meta-analysis of randomized controlled trials (RCTs) of gabexate in the prevention of post-ERCP pancreatitis (PEP) including three RCTs conducted in Italy and one in China."4.84Gabexate in the prophylaxis of post-ERCP pancreatitis: a meta-analysis of randomized controlled trials. ( Chen, Y; Li, J; Yang, X; Zeng, Q; Zhang, Y; Zheng, M, 2007)
"Our purpose was to update the meta-analysis on somatostatin (SS, 16 studies) or gabexate mesylate (GM, 9 studies) prophylaxis of post-ERCP pancreatitis and to run sensitivity analyses by subgrouping trials according to schedules of drug administration."4.84Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis. ( Andriulli, A; Annese, V; Federici, T; Forlano, R; Iacobellis, A; Ippolito, A; Leandro, G, 2007)
"Prior studies have suggested the efficacy of somatostatin and gabexate in post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis prevention."4.84Somatostatin and gabexate for post-endoscopic retrograde cholangiopancreatography pancreatitis prevention: meta-analysis of randomized placebo-controlled trials. ( Kiss, A; Rudin, D; Sottile, VM; Wetz, RV, 2007)
"The study described the pattern of use of gabexate mesylate in Italian hospitals and provided information on the outcome of the subgroup treated for acute pancreatitis."4.82Use of gabexate mesylate in Italian hospitals: a multicentre observational study. ( Cecchi, M; Messori, A; Pelagotti, F, 2003)
"Since the effectiveness of gabexate mesilate in patients with acute pancreatitis is controversial, a metaanalysis of the published literature was conducted to address this problem."4.79Effectiveness of gabexate mesilate in acute pancreatitis. A metaanalysis. ( Bassi, C; Falconi, M; Martini, N; Messori, A; Olivato, R; Pederzoli, P; Rampazzo, R; Scroccaro, G, 1995)
"We have previously shown that gabexate mesylate-poloxamer 407 conjugate (GMTI) alleviates traumatic pancreatitis in rats."4.31Gabexate Mesylate-Poloxamer 407 Conjugate Alleviates Sodium Taurocholate-Induced Severe Acute Pancreatitis in an Optimized Rat Model. ( Gao, H; Gao, Y; Jiao, Z; Luo, Y; Song, Q; Wu, W; Yang, J, 2023)
" The prophylaxis for acute pancreatitis (AP) post-endoscopic retrograde cholangiopancreatography (ERCP) consists of rectal indomethacin, but some studies are not concordant."3.85Rectal indomethacin or intravenous gabexate mesylate as prophylaxis for acute pancreatitis post-endoscopic retrograde cholangiopancreatography. ( Giorgio, P; Guerra, V; Guglielmi, V; Tutino, M, 2017)
"Gabexate mesilate (GM) is a trypsin inhibitor, and mainly used for treatment of various acute pancreatitis, including traumatic pancreatitis (TP), edematous pancreatitis, and acute necrotizing pancreatitis."3.81A novel thermosensitive in-situ gel of gabexate mesilate for treatment of traumatic pancreatitis: An experimental study. ( Gao, HJ; Luo, YK; Lv, FQ; Mei, XG; Song, Q; Tang, J; Wang, S; Wang, YR, 2015)
"Ciprofloxacin is considered to be a safe and effective treatment for acute infectious colitis."3.80Acute pancreatitis secondary to ciprofloxacin therapy in patients with infectious colitis. ( Cheung, DY; Cho, HJ; Cho, SH; Kim, JI; Kim, JK; Kim, SS; Lee, HJ; Sung, HY, 2014)
"The present study showed that gabexate infusion has some clinical benefits for acute pancreatitis in children."3.79Clinical efficacy of gabexate mesilate for acute pancreatitis in children. ( Kim, SC; Yang, HR, 2013)
"Despite a lack of evidence, gabexate mesylate (GM) is routinely used for the treatment of acute pancreatitis (AP) in some countries."3.79Effect and cost of treatment for acute pancreatitis with or without gabexate mesylate: a propensity score analysis using a nationwide administrative database. ( Fushimi, K; Hashimoto, H; Horiguchi, H; Matsuda, S; Yasunaga, H, 2013)
"To evaluate the efficacy of continuous regional arterial infusion therapy (CRAI) with gabexate mesilate and antibiotics for severe acute pancreatitis (SAP)."3.74Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis. ( Akashi, T; Arita, Y; Furukawa, M; Igarashi, H; Ino, Y; Ito, T; Kawabe, K; Kimura, T; Miyahara, T; Ogoshi, K; Oono, T; Ouchi, J; Takayanagi, R, 2008)
"Camostat mesilate, an orally available proteinase inhibitor, is clinically used for treatment of pancreatitis."3.74The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. ( Ishiki, T; Ishikura, H; Kamanaka, Y; Kawabata, A; Matsunami, M; Nakatani, T; Naruse, M; Nishimura, S; Sekiguchi, F; Tsujiuchi, T, 2007)
"Camostat mesilate (CM), an oral protease inhibitor, has been used clinically for the treatment of chronic pancreatitis in Japan."3.73Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity. ( Arita, Y; Fujimori, N; Gibo, J; Hisano, T; Inoue, M; Ito, T; Kawabe, K; Nawata, H; Oono, T, 2005)
"Gabexate mesylate is a drug marketed only in Italy and Japan and it is considered an essential drug in the treatment of acute pancreatitis."3.73Gabexate mesilate and acute pancreatitis: an experience of evidence based drug information for improving rational drug use. ( Aiazzi, M; Banfi, R; Borselli, G; Cappelletti, S; Mari, L; Taddei, V, 2005)
"Routine gabexate prophylaxis was associated with a significant reduction of post-ERCP pancreatitis rate, severe hyperamylasaemia and hospitalisation-related costs only in high-risk patients."3.73Frequency of post-ERCP pancreatitis in a single tertiary referral centre without and with routine prophylaxis with gabexate: a 6-year survey and cost-effectiveness analysis. ( Curioni, S; Mariani, A; Masci, E; Testoni, PA, 2006)
"An oral protease inhibitor, camostat mesilate (CM) has been used clinically for chronic pancreatitis (CP) in Japan, but it lacks enough scientific evidence of its effectiveness."3.71Effect of camostat mesilate on the expression of pancreatitis-associated protein (PAP), p8, and cytokines in rat spontaneous chronic pancreatitis. ( Iovanna, JL; Motoo, Y; Sawabu, N; Su, SB; Xie, MJ, 2001)
"Gabexate mesilate is an antiprotease drug, which reduced the severity of pancreatitis and frequency of post-ERCP pancreatitis."3.71Effects of gabexate mesilate, a protease inhibitor, on human sphincter of Oddi motility. ( Angelini, G; Cavallini, G; Di Francesco, V; Frulloni, L; Mariani, A; Masci, E; Passaretti, S; Talamini, G; Testoni, P, 2002)
" In this report, the effects of loxiglumide and gabexate mesilate were studied on three experimental acute pancreatitis models induced by caerulein, sodium taurocholate + caerulein and closed duodenal loop."3.70Effects of loxiglumide on experimental acute pancreatitis in comparison with gabexate mesilate. ( Fujii, M; Kasai, H; Kimura, K; Saito, T; Tominaga, K, 1998)
"An experimental model of chronic pancreatitis was induced by a retrograde injection of a viscous solution consisting of zein-oleic acid-linoleic acid (0."3.70Pathophysiologic studies of experimental chronic pancreatitis in rats induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct. ( Kashima, K; Kataoka, K; Sakagami, J; Sasaki, T; Yorizumi, H, 1998)
"The effect of methylcarbonylmethyl 2(S)-14-(4-guanidino-benzoyloxy) phenyl] propionate methanesulfonate (TT-S24) on experimental pancreatitis in rats was examined in comparison with that of camostat."3.70Effect of methylcarbonylmethyl 2(S)-[4-(4-guanidino-benzoyloxy)phenyl] propionate methanesulfonate (TT-S24) on experimental pancreatitis in rats. ( Abe, S; Kamei, C; Tagami, H; Tanaka, I; Yoshida, Y, 1998)
"This study was undertaken to determine whether synthetic proteinase inhibitors--nafamostat mesilate (FUT-175) and gabexate mesilate (FOY) have any influence on multiorgan oxidant-antioxidant balance in acute haemorrhagic pancreatitis induced in Wistar rats using a retrograde intraductal injection of 5% Na-taurocholate."3.69The effect of nafamostat mesilate (FUT-175) and gabexate mesilate (FOY) on multiorgan oxidant-antioxidant balance in acute experimental pancreatitis. ( Dabrowski, A; Gabryelewicz, A, 1994)
"The effect of oral administration of protease inhibitor (camostat) on pancreatic morphology and exocrine function (conscious rat model) was investigated using WBN/Kob rats with spontaneous chronic pancreatitis."3.69Effect of oral administration of protease inhibitor on pancreatic exocrine function in WBN/Kob rats with chronic pancreatitis. ( Atomi, Y; Kobori, O; Kuroda, A; Muto, T; Sugiyama, M; Wada, N, 1996)
"We evaluated the protective effect of the CCK receptor antagonist L-364,718 (devazepide) and of the trypsin inhibitor camostat, on taurocholate-induced pancreatitis in rats."3.69The cholecystokinin receptor antagonist L-364,718 reduces taurocholate-induced pancreatitis in rats. ( Kim, DG; Kim, KH; Lee, MG, 1996)
"Effects of a new cholecystokinin (CCK)A-receptor antagonist, T-0632 [sodium (S)-1-(2-fluorophenyl)-2, 3-dihydro-3-[(3-isoquinolinylcarbonyl) amino]-6-methoxy-2-oxo-1H-indole-3-propanoate], on caerulein-induced and pancreatic duct ligation-induced pancreatitis models were studied and compared with the CCKA-receptor antagonist loxiglumide and the orally active protease inhibitor camostate, respectively."3.69Effect of T-0632, a cholecystokininA receptor antagonist, on experimental acute pancreatitis. ( Endo, T; Kume, E; Nagasaki, M; Shikano, T; Taniguchi, H; Yomota, E, 1997)
"A 59-year-old Japanese man developed septal panniculitis with eosinophilic infiltration in both forearms and the dorsum of the left hand after a gabexate mesilate intravenous drip infusion for acute pancreatitis through catheters implanted in these sites."3.69Panniculitis with eosinophilic infiltration due to gabexate mesilate (FOY): possibility of allergic reaction. ( Nakayama, F, 1997)
"The present study investigates the effect of oral pretreatment with the protease inhibitor camostate on the outcome of pancreatitis in three experimental models."3.68Effect of camostate administration for two weeks on experimental pancreatitis in mice and rats. ( Creutzfeldt, W; Leonhardt, U; Seidensticker, F; Stöckmann, F, 1993)
"Systemic prostacyclin and thromboxane A2 production in rat experimental acute pancreatitis has been evaluated by measuring the urinary excretion of the 2,3-dinor 6-keto prostaglandin F1 alpha and 2,3-dinor thromboxane B2, respectively."3.68Changes of systemic prostacyclin and thromboxane A2 in sodium taurocholate- and cerulein-induced acute pancreatitis in rats. ( Bulbena, O; Closa, D; Fernandez-Cruz, L; Gelpi, E; Hotter, G; Martrat, A; Rosello-Catafau, J, 1993)
"In vivo microscopy was performed to assess the effect of dextran 40, gabexate mesilate and somatostatin on the microcirculation in sodium taurocholate-induced pancreatitis in rats."3.68The effect of somatostatin, gabexate mesilate and dextran 40 on the microcirculation in sodium taurocholate-induced pancreatitis. ( Enghofer, M; Kusterer, K; Poschmann, T; Usadel, KH, 1992)
"The present study investigated the protective effects of the new potent synthetic protease inhibitors, ONO3307 (4-sulfamoyl phenyl-4-guanidinobenzoate methanesulfonate) and FOY007 (gabexate misilate), on the exocrine pancreas in rat caerulein-induced acute pancreatitis in both in vitro and in vivo experiments."3.68Protection by a new synthetic protease inhibitor, ONO3307, of the rat exocrine pancreas during acute edematous pancreatitis induced by a supramaximal dose of caerulein in comparison with FOY007. ( Hirano, T; Manabe, T; Tobe, T, 1992)
"The therapeutic effect and the mechanism of action of the synthetic trypsin inhibitor camostate were studied in a rat model of acute interstitial pancreatitis induced by four subcutaneous injections of 20 micrograms/kg body weight of cerulein at hourly intervals."3.68Beneficial effects of the synthetic trypsin inhibitor camostate in cerulein-induced acute pancreatitis in rats. ( Fuji, M; Fujisawa, T; Itoh, H; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S, 1990)
" Caerulein-induced pancreatitis or treatment with the synthetic protease inhibitor camostate had no significant effects on permeability."3.68Pancreatic microvascular permeability in caerulein-induced acute pancreatitis. ( Mann, GE; Sweiry, JH, 1991)
"Due to its biochemical properties, the newly developed low-molecular protease inhibitor gabexate mesilate is assumed to be efficient in the treatment of complicated acute pancreatitis."3.68[The protease inhibitor gabexate mesilate in experimentally-induced acute pancreatitis with early gram-negative infection in the Göttingen minipig: therapeutic efficacy and effects on blood coagulation and fibrinolysis]. ( Emde, C; Heitz, J; Jansen, U; Schäfer, JH; Semsch, B, 1990)
"The effect of peritoneal lavage with the addition of camostate to the lavage fluid on the outcome of taurocholate pancreatitis in rats was studied."3.68Camostate (FOY-305) improves the therapeutic effect of peritoneal lavage on taurocholate induced pancreatitis. ( Creutzfeldt, W; Fussek, M; Leonhardt, U; Seidensticker, F; Stöckmann, F, 1990)
"The effects of the cholecystokinin (CCK)-receptor antagonist proglumide, the protease inhibitor gabexate, and the hormones secretin and cholecystokinin-octapeptide (CCK-8) were studied in a model of acute hemorrhagic pancreatitis induced by feeding mice a choline-deficient, ethionine-supplemented (CDE) diet."3.67Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. ( Ferrell, LD; Grendell, JH; Liddle, RA; Niederau, C, 1986)
"The effect of a synthetic protease inhibitor, gabexate mesilate (GM), which was administered directly into the pancreatic duct, on acute pancreatitis induced by sodium taurocholate in dogs was investigated."3.67Prevention of the spread of experimental acute pancreatitis by intraductal administration of a synthetic protease inhibitor in dogs. ( Idezuki, Y; Itoh, T; Shibayama, K; Wakayama, T, 1989)
"The effects of gabexate mesilate (GM) on hemodynamics and phospholipase A2 activities (PLA2) during acute hemorrhagic pancreatitis (AHP) were studied in 17 piglets which were randomly divided into three groups: The control group (CG) received only the fluid replacement, whereas the pretreatment group (PG) was given an infusion of GM (20 mg/kg/5h), which was started 30 min before and in the treatment group (TG) 30 min after the induction of AHP."3.67The effect of gabexate mesilate on the outcome of acute hemorrhagic pancreatitis in pigs. ( Gröhn, P; Kiviniemi, H; Mahlberg, K; Mokka, RE; Rämö, OJ; Ristkari, SK, 1989)
"Two models of severe acute pancreatitis were chosen and pancreatitis induced by sodium taurocholate and by a choline-deficient ethionine-supplemented diet, to evaluate the effectiveness of FOY-305 (camostate), a new synthetic trypsin inhibitor."3.67Effect of FOY-305 (camostate) on severe acute pancreatitis in two experimental animal models. ( Göke, B; Gröne, HJ; Lankisch, PG; Otto, J; Pohl, U; Rahlf, G; Wereszczynska-Siemiatkowska, U, 1989)
"In this study we evaluated the effects of hydration, oxygenation, peritoneal lavage, and the protease inhibitor gabexate mesilate in acute hemorrhagic pancreatitis induced by feeding mice a choline-deficient, ethionine-supplemented diet."3.67Therapeutic regimens in acute experimental hemorrhagic pancreatitis. Effects of hydration, oxygenation, peritoneal lavage, and a potent protease inhibitor. ( Crass, RA; Ferrell, LD; Grendell, JH; Niederau, C; Silver, G, 1988)
"In mongrel dogs with induced pancreatitis we studied the effects of the nonspecific phospholipase A2-inhibitors chlorpromazine, gabexate mesilate and CaNa2EDTA on the course of pancreatogenic shock and the intrapancreatic lysolecithin production."3.67[Phospholipase A2 inhibitors in hemorrhagic-necrotizing pancreatitis. Animal experiment evaluation of a new treatment concept]. ( Alles, JU; Kahle, M; Klein, U; König, W; Martin, U, 1985)
"In order to evaluate the efficacy and safety of gabexate mesilate (FOY = [ethyl-4-(6-guanidinohexanoyloxy) benzoate methane sulfonate]), a synthetic inhibitor of various proteases as well as phospholipase A 2, 17 patients with acute pancreatitis were treated with FOY in doses of 3 X 150 mg/day per i."3.66[Therapy of acute pancreatitis with a synthetic protease and phospholipase A2 inhibitor gabexate mesilate]. ( Freise, J, 1983)
" These results may justify further, larger scale studies or evaluation of alternate dosage or route of administration."2.66Controlled trial of protease inhibitor gabexelate mesilate (FOY) in the treatment of acute pancreatitis. ( Chang-Chien, CS; Liaw, YF; Yang, CY, 1987)
"In about 1% acute pancreatitis or recurrency of chronic pancreatitis occurs."2.65[Effect of secretin and gabexate-mesilate (synthetic protease inhibitor) on serum amylase level after ERCP]. ( Rösch, W; Tympner, F, 1982)
"Acute pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP)."2.44Early successes and late failures in the prevention of post endoscopic retrograde cholangiopancreatography. ( Draganov, PV; Lieb, JG, 2007)
"Nitroglycerin (NGL) is a nitrogen oxide (NO) donor, which relaxes the sphincter of Oddi."2.44Pharmacological approach to acute pancreatitis. ( Bang, UC; Bendtsen, F; Nojgaard, C; Semb, S, 2008)
" Initial studies using ulinastatin are promising but additional dose-response studies are needed."2.43Pharmacological management of pancreatitis. ( Hoogerwerf, WA, 2005)
"The management of acute pancreatitis (AP) is still based on speculative and unproven paradigms in many centers."2.43Evidence-based treatment of acute pancreatitis: a look at established paradigms. ( Clavien, PA; Heinrich, S; Rousson, V; Schäfer, M, 2006)
"Acute pancreatitis is a disease with a wide variety of pathophysiologies, ranging from mild to severe condition."2.42[Essential therapeutic strategies for acute pancreatitis--guidelines for initial treatment and their significance]. ( Hirata, K, 2004)
"Protease inhibitors are used to treat acute pancreatitis, but their effectiveness remains unclear."2.42Treatment of acute pancreatitis with protease inhibitors: a meta-analysis. ( Fukui, T; Noguchi, Y; Seta, T; Shikata, S; Shimada, T, 2004)
"57], p = 0."2.41Pharmacologic treatment can prevent pancreatic injury after ERCP: a meta-analysis. ( Andriulli, A; Conoscitore, P; De Maio, G; Facciorusso, D; Festa, V; Gambassi, G; Leandro, G; Mangia, A; Niro, G; Spirito, F; Villani, MR, 2000)
"Pancreatitis is rightly the most feared complication of endoscopic retrograde cholangiopancreatography (ERCP)."2.41Predicting and preventing post-ERCP pancreatitis. ( Baillie, J, 2002)
"Today, the mortality in severe acute pancreatitis is determined by septic complications due to infected pancreatic necroses in the late phase 2-3 weeks after the onset of the disease."2.39Protease-antiprotease interactions and the rationale for therapeutic protease inhibitors. ( Büchler, MW; Schmid, S; Uhl, W, 1996)
" During the follow-up CT and dosage amylase and lipase in blood were performed."1.40[Acute pancreatitis in pediatric age: our experience in 52 cases]. ( Cofini, M; Favoriti, P; Quadrozzi, F, 2014)
"The incidence of acute pancreatitis associated with diagnostic and therapeutic ERCP is 0."1.36Post-ERCP pancreatitis. ( Amano, H; Arata, S; Gabata, T; Hirata, K; Hirota, M; Ito, T; Kataoka, K; Kimura, Y; Kiriyama, S; Mayumi, T; Sekimoto, M; Takada, T; Takeda, K; Tanaka, M; Wada, K; Yokoe, M; Yoshida, M, 2010)
"However two cases had mild acute pancreatitis in the group B."1.34Evaluation of serum amylase and gabexate mesilate with endoscopic papillary balloon dilatation. ( Aoki, R; Ito, S; Muguruma, N; Nakamoto, J; Nakasono, M; Okamura, S; Sato, Y, 2007)
"Acute pancreatitis is a pancreatic inflammation that recognises Salmonella typhi among its aetiological agents."1.34[Typhoid fever and acute pancreatitis: two cases]. ( Bertuccio, SN; Rombolà, F, 2007)
"Thus, the main problem in acute pancreatitis, especially in the severe form of the disease, is the difficulty of planning clinical studies capable of giving hard statistically significant answers regarding the benefits of the various proposed therapeutic agents previously tested in experimental settings."1.33New approaches for the treatment of acute pancreatitis. ( Fantini, L; Morselli-Labate, AM; Pezzilli, R, 2006)
"This is the first case report of severe acute pancreatitis in the setting of overlap syndrome of SLE and SSc."1.33A case of severe acute pancreatitis, in overlap syndrome of systemic sclerosis and systemic lupus erythematosus, successfully treated with plasmapheresis. ( Hara, M; Kamatani, N; Koizumi, K; Okamoto, H; Suzuki, Y; Tateishi, M, 2006)
"We report a case of acute pancreatitis, which occurred after delivery in a woman who had an uneventful course of pregnancy and parturition."1.32Acute pancreatitis occurring in the early postpartum period: a case report. ( Chaen, H; Eguchi, F; Fukami, T; Imura, H; Sudou, K, 2003)
"Gabexate mesilate was infused intravenously 6 hours after the initiation of induction of acute pancreatitis at doses of 0."1.30Gabexate mesilate improves pancreatic microcirculation and reduces lung edema in a rat model of acute pancreatitis. ( Chen, HM; Chen, MF; Shyr, MH, 1997)
"Pancreatitis was induced in 6-week-old male SPF Sprague-Dawley rats by two intravenous (i."1.30Induction of apoptosis with an extract of Artemisia asiatica attenuates the severity of cerulein-induced pancreatitis in rats. ( Ahn, BO; Cho, SW; Hahm, KB; Kim, JH; Kim, WB; Kim, YS; Yim, H; You, BM, 1998)
"Antiprotease has long been used for the treatment of acute pancreatitis, although its effects and mechanism have not been fully elucidated."1.29The effect of gabexate mesilate on pancreatic and hepatic microcirculation in acute experimental pancreatitis in rats. ( Chen, HM; Chen, MF; Hwang, TL, 1996)
"Acute pancreatitis was induced in 19 anesthetized dogs by retrograde injection of bile mixed with trypsin into the pancreatic duct."1.28Synthetic antiproteases in acute pancreatitis: an experimental study. ( Babicki, A; Basiński, A; Dobosz, M; Juszkiewicz, P; Sledziński, Z; Wajda, Z, 1992)
"Acute pancreatitis was induced in ten anesthetized dogs by retrograde injection for bile mixed with trypsin into the pancreatic duct."1.28Effect on hemodynamics of therapeutic infusion of gabexate mesilate (FOY) in experimental acute pancreatitis. ( Babicki, A; Basiński, A; Dobosz, M; Sledziński, Z; Stanek, A; Wajda, Z, 1989)
"Comparing the two groups of acute pancreatitis patients after 6 days of treatment with gabexate mesilate, we observed a statistically significantly lower alpha-amylase activity in the serum of treated patients compared with the placebo group."1.27Gabexate mesilate and camostate: new inhibitors of phospholipase A2 and their influence on the alpha-amylase activity in serum of patients with acute pancreatitis. ( Freise, J; Magerstedt, P; Schmid, K; Schmidt, FW, 1985)

Research

Studies (139)

TimeframeStudies, this research(%)All Research%
pre-199022 (15.83)18.7374
1990's50 (35.97)18.2507
2000's50 (35.97)29.6817
2010's13 (9.35)24.3611
2020's4 (2.88)2.80

Authors

AuthorsStudies
Song, Q2
Gao, H1
Wu, W1
Gao, Y1
Yang, J1
Jiao, Z1
Luo, Y1
Chiu, YJ1
Chen, SC1
Kang, YN2
Hou, SK1
Chao, CC1
Chang, CC2
Xie, J1
Li, L1
Guglielmi, V1
Tutino, M1
Guerra, V1
Giorgio, P1
Kim, SC1
Yang, HR1
Sung, HY1
Kim, JI1
Lee, HJ1
Cho, HJ1
Cheung, DY1
Kim, SS1
Cho, SH1
Kim, JK1
Seta, T2
Noguchi, Y2
Shikata, S2
Nakayama, T1
Cofini, M1
Favoriti, P1
Quadrozzi, F1
Jia, D1
Yamamoto, M1
Otsuki, M2
Gao, HJ1
Lv, FQ1
Wang, S1
Wang, YR1
Luo, YK1
Mei, XG1
Tang, J1
Wang, G1
Liu, Y1
Zhou, SF1
Qiu, P1
Xu, L1
Wen, P1
Wen, J1
Xiao, X1
Ino, Y1
Arita, Y3
Akashi, T2
Kimura, T2
Igarashi, H1
Oono, T3
Furukawa, M2
Kawabe, K3
Ogoshi, K1
Ouchi, J1
Miyahara, T1
Takayanagi, R1
Ito, T5
Arata, S1
Takada, T1
Hirata, K2
Yoshida, M1
Mayumi, T1
Hirota, M2
Yokoe, M1
Kiriyama, S1
Sekimoto, M1
Amano, H1
Wada, K1
Kimura, Y1
Gabata, T1
Takeda, K3
Kataoka, K3
Tanaka, M1
Zhang, ZF1
Yang, N1
Zhao, G1
Zhu, L1
Zhu, Y1
Wang, LX1
Kwon, YH1
Kim, JY1
Lee, SJ1
Jang, SY1
Park, HW1
Yang, HM1
Jung, MK1
Jeon, SW1
Cho, CM1
Tak, WY1
Kweon, YO1
Kim, SK1
Oh, MJ1
Kim, TN1
Yasunaga, H1
Horiguchi, H1
Hashimoto, H1
Matsuda, S1
Fushimi, K1
Andriulli, A5
Clemente, R2
Solmi, L2
Terruzzi, V2
Suriani, R1
Sigillito, A1
Leandro, G4
Leo, P2
De Maio, G2
Perri, F3
Hama, Y1
Iwasaki, Y1
Kaji, T1
Hatsuse, K1
Kusano, S1
Woods, CM1
Mawe, GM1
Shaffer, EA1
Toouli, J1
T P Saccone, G1
Pelagotti, F1
Cecchi, M1
Messori, A2
Matsukawa, Y1
Nishinarita, S1
Sawada, S1
Horie, T1
Suto, S1
Okuaki, Y1
Matsuoka, M1
Enomoto, Y1
Tsuruta, Y1
Miyagawa, Y1
Saito, A1
Aizawa, Y1
Toda, G1
Fukami, T1
Chaen, H1
Imura, H1
Sudou, K1
Eguchi, F1
Masci, E5
Cavallini, G5
Mariani, A4
Frulloni, L3
Testoni, PA2
Curioni, S2
Tittobello, A2
Uomo, G2
Costamagna, G1
Zambelli, S1
Macarri, G1
Innocenti, P1
Dragonetti, C2
Kamisawa, T1
Jiang, PH1
Motoo, Y2
Iovanna, JL2
Pébusque, MJ1
Xie, MJ2
Okada, G1
Sawabu, N2
Loperfido, S1
Festa, V3
Belmonte, A1
Spirito, F2
Silla, M1
Forte, G1
Marenco, G1
Ciliberto, E1
Sabatino, A1
Monica, F1
Magnolia, MR1
Inoue, N1
Gibo, J2
Nawata, H3
Funakoshi, A1
Hisano, T1
Inoue, M1
Fujimori, N1
Kohsaki, T1
Nishimori, I1
Onishi, S1
Shimada, T1
Fukui, T1
Banfi, R1
Borselli, G1
Cappelletti, S1
Mari, L1
Aiazzi, M1
Taddei, V1
Hoogerwerf, WA1
Xiong, GS1
Wu, SM1
Zhang, XW1
Ge, ZZ1
Pezzilli, R1
Fantini, L1
Morselli-Labate, AM1
Heinrich, S1
Schäfer, M1
Rousson, V1
Clavien, PA1
Hellmig, S1
Fölsch, UR1
Suzuki, Y1
Okamoto, H1
Koizumi, K1
Tateishi, M1
Hara, M1
Kamatani, N1
Famularo, G1
Minisola, G1
De Simone, C1
Sakai, M1
Harada, K1
Matsumura, H1
Takahashi, T1
Koie, H1
Yamaya, Y1
Watari, T1
Shibuya, H1
Sato, T1
Tokuriki, M1
Hasegawa, A1
Piscaglia, F1
Righini, R1
Tewelde, AG1
Zheng, M1
Chen, Y1
Yang, X1
Li, J1
Zhang, Y1
Zeng, Q1
Ueki, T1
Otani, K1
Kawamoto, K1
Shimizu, A1
Fujimura, N1
Sakaguchi, S1
Matsui, T1
Sato, Y1
Okamura, S1
Nakasono, M1
Aoki, R1
Nakamoto, J1
Muguruma, N1
Ito, S1
Federici, T1
Ippolito, A1
Forlano, R1
Iacobellis, A1
Annese, V2
Lee, JK1
Park, JK1
Yoon, WJ1
Lee, SH1
Lee, KH1
Ryu, JK1
Kim, YT1
Yoon, YB1
Ishikura, H1
Nishimura, S1
Matsunami, M1
Tsujiuchi, T1
Ishiki, T1
Sekiguchi, F1
Naruse, M1
Nakatani, T1
Kamanaka, Y1
Kawabata, A1
Rombolà, F1
Bertuccio, SN1
Manes, G1
Ardizzone, S1
Lombardi, G1
Pieramico, O1
Porro, GB1
Rudin, D2
Kiss, A1
Wetz, RV1
Sottile, VM1
Tsujino, T1
Kawabe, T1
Omata, M1
Lieb, JG1
Draganov, PV1
Jo, YJ1
Choi, HS1
Jun, DW1
Lee, OY1
Kang, JS1
Park, IG1
Jung, KH1
Hahm, JS1
Bang, UC1
Semb, S1
Nojgaard, C1
Bendtsen, F1
Tympner, F1
Rösch, W1
Freise, J3
Hesse, B1
Lankisch, PG3
Kunze, H1
Pederzoli, P3
Falconi, M3
Bassi, C3
Yamaguchi, H1
Goto, M1
Nakano, I1
Okumura, Y1
Inoue, H1
Fujiyama, Y1
Bamba, T1
Leonhardt, U2
Seidensticker, F2
Stöckmann, F3
Creutzfeldt, W2
Closa, D1
Rosello-Catafau, J1
Martrat, A1
Hotter, G1
Bulbena, O1
Fernandez-Cruz, L1
Gelpi, E1
Rampazzo, R1
Scroccaro, G1
Olivato, R1
Martini, N1
Kisfalvi, K1
Papp, M1
Friess, H1
Büchler, M3
Gorácz, UG1
Dabrowski, A1
Gabryelewicz, A1
Yamagiwa, I1
Obata, K1
Hatanaka, Y1
Saito, H1
Washio, M1
Yoshida, T1
Yamamoto, Y1
Malfertheiner, P2
Uhl, W3
Schölmerich, J1
Adler, G1
Gaus, W1
Rolle, K1
Beger, HG2
Warshaw, AL1
Huibregtse, K1
Sugiyama, M2
Kobori, O1
Atomi, Y2
Wada, N2
Kuroda, A2
Muto, T2
Mariana, A1
Di Francesco, V2
Schmid, S1
Büchler, MW1
Kim, KH1
Lee, MG1
Kim, DG1
Chen, HM2
Hwang, TL1
Chen, MF2
Taniguchi, H1
Yomota, E1
Kume, E1
Shikano, T1
Endo, T1
Nagasaki, M1
Pasricha, P1
Nakayama, F1
Schneider, J1
Barkin, J1
Ziebert, JJ1
Bjorkman, DJ1
Shyr, MH1
Kimura, K1
Tominaga, K1
Fujii, M1
Saito, T1
Kasai, H1
Sasaki, T1
Yorizumi, H1
Sakagami, J1
Kashima, K2
Tagami, H1
Abe, S1
Yoshida, Y1
Tanaka, I1
Kamei, C1
Caruso, N1
Lezzi, G1
Lichino, E1
Bruno, F1
Hahm, KB1
Kim, JH1
You, BM1
Kim, YS1
Cho, SW1
Yim, H1
Ahn, BO1
Kim, WB1
Otani, T1
Yuasa, C1
Irimura, K1
Oda, M1
Fukui, K1
Oka, T1
Niro, G1
Mangia, A1
Gambassi, G1
Villani, MR1
Facciorusso, D1
Conoscitore, P1
Haber, GB1
Heyries, L1
Su, SB1
Baillie, J1
Angelini, G1
Talamini, G1
Passaretti, S1
Testoni, P1
Kusterer, K1
Enghofer, M1
Poschmann, T1
Usadel, KH1
Umehara, K1
Hirano, T3
Manabe, T4
Tobe, T3
Valderrama, R1
Pérez-Mateo, M1
Navarro, S1
Vázquez, N1
Sanjosé, L1
Adrián, MJ1
Estruch, J1
Murakawa, M1
Okamura, T1
Shibuya, T1
Harada, M1
Otsuka, T1
Niho, Y1
Tani, S1
Okabayashi, Y1
Fuji, M1
Nakamura, T1
Fujisawa, T1
Itoh, H1
Yoshida, K1
Toki, F1
Takeuchi, T1
Dobosz, M2
Sledziński, Z2
Babicki, A2
Juszkiewicz, P1
Basiński, A2
Wajda, Z2
Harada, H1
Miyake, H1
Ochi, K1
Tanaka, J1
Kimura, I1
Benetti, L1
Girelli, R1
Nifosí, F1
Coviello, G1
Vesentini, S1
Tamura, K1
Sweiry, JH1
Mann, GE1
Heitz, J1
Semsch, B1
Emde, C1
Jansen, U1
Schäfer, JH1
Fussek, M1
Schmidt, FW2
Magerstedt, P1
Schmid, K1
Niederau, C3
Liddle, RA1
Ferrell, LD3
Grendell, JH3
Wisner, JR1
Renner, IG1
Ohshio, G1
Saluja, AK1
Leli, U1
Sengupta, A1
Steer, ML1
Wakayama, T1
Itoh, T1
Shibayama, K1
Idezuki, Y1
Kahle, M2
König, H1
Filler, RD1
Ristkari, SK1
Rämö, OJ1
Kiviniemi, H1
Gröhn, P1
Mahlberg, K1
Mokka, RE1
Stanek, A1
Mikata, N1
Imao, S1
Tanaka, Y1
Horiuchi, D1
Matsumoto, G1
Hasegawa, K1
Redmond, HP1
Leahy, AL1
Keane, FB1
Tanner, WA1
Pohl, U2
Göke, B1
Otto, J2
Wereszczynska-Siemiatkowska, U1
Gröne, HJ1
Rahlf, G1
Melzer, P1
Horbach, L1
Yang, CY1
Chang-Chien, CS1
Liaw, YF1
Wolf, HR1
Schwab, G1
Crass, RA1
Silver, G1
Yamasaki, Y1
Kuroshima, T1
Tsuji, K1
Kawamoto, H1
Higashimoto, Y1
Klein, U1
König, W1
Martin, U1
Alles, JU1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Fistulotomy as the Primary Cannulation Technique for All Patients Undergoing ERCP: A Randomized, Controlled Trial[NCT04559867]538 participants (Anticipated)Interventional2020-09-10Recruiting
Prevention of Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) - Induced Pancreatitis Using Aggressive Lactated Ringer's Infusion and/or Rectal Indomethacin[NCT02641561]Phase 3192 participants (Actual)Interventional2014-10-31Completed
Tailored Hydration for the Prevention of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis[NCT03561441]350 participants (Actual)Interventional2019-01-01Completed
Feasibility Study of a Randomized Trial of Aggressive Fluid Hydration to Prevent Post ERCP Pancreatitis[NCT01758549]62 participants (Actual)Interventional2012-07-31Completed
A Phase II Study to Establish the Efficacy of Synthetic Human SecretiN in Human Acute Pancreatitis (SNAP) Study[NCT03686618]Phase 240 participants (Anticipated)Interventional2018-10-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

The Length of Stay (LOS) of Participants After ERCP if Medical Care is Sought as Assessed in Days

(NCT02641561)
Timeframe: 30 days after ERCP

Interventiondays (Mean)
A (NS+Placebo)2.3
B (NS+IND)2.2
C (LR+Placebo)1.9
D (LR+IND)4.3

The Number of Participants Who Undergo Surgery After ERCP, as Assessed by Surgical Operative Report

(NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)0
B (NS+IND)0
C (LR+Placebo)0
D (LR+IND)0

The Number of Participants Who Were Readmitted After ERCP as Assessed by Medical Record and Patients Self-reporting

(NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)6
B (NS+IND)2
C (LR+Placebo)2
D (LR+IND)1

The Number of Participants With Acute Pancreatitis After ERCP as Assessed by Worsening Abdominal Pain Plus Either Elevated Amylase or Lipase 3 x Upper Limit of Normal

amylase or lipase (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)10
B (NS+IND)6
C (LR+Placebo)9
D (LR+IND)3

The Number of Participants With Acute Pancreatitis After ERCP as Assessed by Worsening Abdominal Pain Plus Imaging Suggestive of Acute Pancreatitis

Imaging may include Computer Tomography (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)0
B (NS+IND)1
C (LR+Placebo)0
D (LR+IND)1

The Number of Participants With Acute Respiratory Distress Syndrome (ARDS) After ERCP as Assessed by ARDSnet Criterion (Below)

bilateral opacities on chest imaging not explained by other lung pathology, respiratory failure not explained by heart failure or volume, and overload and a pulmonary arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio under 300, PaO2/FiO2 ratio is the partial pressure arterial oxygen and fraction of inspired oxygen (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)1
B (NS+IND)0
C (LR+Placebo)0
D (LR+IND)0

The Number of Participants With Mortality After ERCP as Assessed by Medical Record Reporting

(NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)1
B (NS+IND)2
C (LR+Placebo)2
D (LR+IND)1

The Number of Participants With Multiple Organ Failure (MOF) After ERCP as Assessed by Elevated Creatinine Blood Test

creatinine > 1.5 milligrams/deciliter (mg/dL) (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)0
B (NS+IND)1
C (LR+Placebo)0
D (LR+IND)0

The Number of Participants With Multiple Organ Failure (MOF) After ERCP as Assessed by Elevated International Normalized Ratio (INR)

INR > 1.5 (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)0
B (NS+IND)0
C (LR+Placebo)0
D (LR+IND)0

The Number of Participants With Pancreatic Abscess After ERCP as Assessed by Abdominal Imaging Suggestive of Pancreatic Abscess

Imaging may include Computer Tomography (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)0
B (NS+IND)0
C (LR+Placebo)0
D (LR+IND)0

The Number of Participants With Pancreatic Pseudocyst After ERCP as Assessed by Abdominal Imaging Suggestive of Pseudocyst

Imaging may include Computer Tomography (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)0
B (NS+IND)0
C (LR+Placebo)0
D (LR+IND)1

The Number of Participants With Perforation After ERCP as Assessed by Abdominal Imaging Suggestive of Perforation

Imaging may include Computer Tomography (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)0
B (NS+IND)0
C (LR+Placebo)0
D (LR+IND)0

The Number of Participants With Post-procedural Medical Care (ED Visit, Urgent Care, Hospitalization) as Assessed by Medical Record and Patients Self-reporting

(NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)6
B (NS+IND)2
C (LR+Placebo)2
D (LR+IND)1

The Number of Participants With Sepsis After ERCP as Assessed by Infectious Source Defined by Positive Microbiology Culture

positive blood culture (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)0
B (NS+IND)0
C (LR+Placebo)0
D (LR+IND)0

The Number of Participants With Systemic Inflammatory Response Syndrome (SIRS) After ERCP as Assessed by the SIRS Criterion (Below)

> 10% immature neutrophils (band forms). (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)10
B (NS+IND)6
C (LR+Placebo)9
D (LR+IND)3

The Number of Participants With Systemic Inflammatory Response Syndrome (SIRS) After ERCP as Assessed by the SIRS Criterion (Below)

Heart rate > 90 beats per minutes (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)10
B (NS+IND)6
C (LR+Placebo)9
D (LR+IND)3

The Number of Participants With Systemic Inflammatory Response Syndrome (SIRS) After ERCP as Assessed by the SIRS Criterion (Below)

PaCO2 < 4.3 kilopascal (kPa) (32 mmHg) (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)0
B (NS+IND)0
C (LR+Placebo)0
D (LR+IND)0

The Number of Participants With Systemic Inflammatory Response Syndrome (SIRS) After ERCP as Assessed by the SIRS Criterion (Below)

Respiratory rate > 20 breaths per minute (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)10
B (NS+IND)6
C (LR+Placebo)9
D (LR+IND)3

The Number of Participants With Systemic Inflammatory Response Syndrome (SIRS) After ERCP as Assessed by the SIRS Criterion (Below)

Temperature < 36°C(96.8°F) or > 38°C(100.4°F) (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)10
B (NS+IND)6
C (LR+Placebo)9
D (LR+IND)3

The Number of Participants With Systemic Inflammatory Response Syndrome (SIRS) After ERCP as Assessed by the SIRS Criterion (Below)

white blood cell (WBC) count < 4000 cells/mm³ (4 x 109 cells/L) (NCT02641561)
Timeframe: 30 days after ERCP

InterventionParticipants (Count of Participants)
A (NS+Placebo)0
B (NS+IND)0
C (LR+Placebo)0
D (LR+IND)0

Reviews

29 reviews available for gabexate and Pancreatitis

ArticleYear
Efficacy of gabexate mesilate in preventing post endoscopic retrograde cholangiopancreatography pancreatitis: A meta-analysis of randomized clinical trials.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2021, Volume: 120, Issue:4

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Humans; Pancreatitis; Randomized Controll

2021
Treatment of acute pancreatitis with protease inhibitors administered through intravenous infusion: an updated systematic review and meta-analysis.
    BMC gastroenterology, 2014, May-30, Volume: 14

    Topics: Acute Disease; Aprotinin; Gabexate; Humans; Infusions, Intravenous; Pancreatitis; Protease Inhibitor

2014
Preventive effect of ulinastatin and gabexate mesylate on post-endoscopic retrograde cholangiopancreatography pancreatitis.
    Chinese medical journal, 2010, Volume: 123, Issue:18

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Glycoproteins; Humans; Pancreatitis

2010
Gabexate or somatostatin administration before ERCP in patients at high risk for post-ERCP pancreatitis: a multicenter, placebo-controlled, randomized clinical trial.
    Gastrointestinal endoscopy, 2002, Volume: 56, Issue:4

    Topics: Acute Disease; Adult; Cholangiopancreatography, Endoscopic Retrograde; Clinical Competence; Double-B

2002
Effects of bioactive agents on biliary motor function.
    Current gastroenterology reports, 2003, Volume: 5, Issue:2

    Topics: Animals; Biliary Tract; Electroacupuncture; Gabexate; Gallbladder; Gallbladder Emptying; Histamine;

2003
Use of gabexate mesylate in Italian hospitals: a multicentre observational study.
    Journal of clinical pharmacy and therapeutics, 2003, Volume: 28, Issue:3

    Topics: Acute Disease; Aged; Drug Utilization Review; Female; Gabexate; Humans; Inpatients; Italy; Male; Mid

2003
[A case of groove pancreatitis pure type treated with conservative therapy].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2003, Volume: 100, Issue:7

    Topics: Chronic Disease; Drug Therapy, Combination; Esters; Gabexate; Guanidines; Humans; Magnetic Resonance

2003
[Evidence-based therapeutic guidelines for severe acute pancreatitis].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2004, Jan-10, Volume: 93, Issue:1

    Topics: Acute Disease; Anti-Bacterial Agents; Decontamination; Disinfection; Drug Therapy, Combination; Evid

2004
[Autoimmune pancreatitis].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2004, Jan-10, Volume: 93, Issue:1

    Topics: Autoimmune Diseases; Diagnostic Imaging; Diet, Fat-Restricted; Drainage; Esters; Fasting; Gabexate;

2004
[Essential therapeutic strategies for acute pancreatitis--guidelines for initial treatment and their significance].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62, Issue:11

    Topics: Acute Disease; Analgesics, Opioid; Antibiotic Prophylaxis; Biopsy, Fine-Needle; Buprenorphine; Criti

2004
[Treatment of acute pancreatitis with protease inhibitor, H2 receptor antagonist and somatostatin analogue].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62, Issue:11

    Topics: Acute Disease; Aprotinin; Benzamidines; Cimetidine; Drug Administration Schedule; Drug Therapy, Comb

2004
Treatment of acute pancreatitis with protease inhibitors: a meta-analysis.
    European journal of gastroenterology & hepatology, 2004, Volume: 16, Issue:12

    Topics: Abdominal Abscess; Acute Disease; Aprotinin; Gabexate; Humans; Pancreatic Pseudocyst; Pancreatitis;

2004
Pharmacological management of pancreatitis.
    Current opinion in pharmacology, 2005, Volume: 5, Issue:6

    Topics: Animals; Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Glycoproteins; Humans; Octreotid

2005
Evidence-based treatment of acute pancreatitis: a look at established paradigms.
    Annals of surgery, 2006, Volume: 243, Issue:2

    Topics: Acute Disease; Anti-Bacterial Agents; Antibiotic Prophylaxis; Aprotinin; Cholecystectomy; Enteral Nu

2006
Gabexate in the prophylaxis of post-ERCP pancreatitis: a meta-analysis of randomized controlled trials.
    BMC gastroenterology, 2007, Feb-12, Volume: 7

    Topics: Acute Disease; Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Humans; Linear Models; Odd

2007
Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis.
    Gastrointestinal endoscopy, 2007, Volume: 65, Issue:4

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Hormones; Humans; Hyperamylasemia; Pancre

2007
Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis.
    Gastrointestinal endoscopy, 2007, Volume: 65, Issue:4

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Hormones; Humans; Hyperamylasemia; Pancre

2007
Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis.
    Gastrointestinal endoscopy, 2007, Volume: 65, Issue:4

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Hormones; Humans; Hyperamylasemia; Pancre

2007
Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis.
    Gastrointestinal endoscopy, 2007, Volume: 65, Issue:4

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Hormones; Humans; Hyperamylasemia; Pancre

2007
Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis.
    Gastrointestinal endoscopy, 2007, Volume: 65, Issue:4

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Hormones; Humans; Hyperamylasemia; Pancre

2007
Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis.
    Gastrointestinal endoscopy, 2007, Volume: 65, Issue:4

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Hormones; Humans; Hyperamylasemia; Pancre

2007
Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis.
    Gastrointestinal endoscopy, 2007, Volume: 65, Issue:4

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Hormones; Humans; Hyperamylasemia; Pancre

2007
Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis.
    Gastrointestinal endoscopy, 2007, Volume: 65, Issue:4

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Hormones; Humans; Hyperamylasemia; Pancre

2007
Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis.
    Gastrointestinal endoscopy, 2007, Volume: 65, Issue:4

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Hormones; Humans; Hyperamylasemia; Pancre

2007
Somatostatin and gabexate for post-endoscopic retrograde cholangiopancreatography pancreatitis prevention: meta-analysis of randomized placebo-controlled trials.
    Journal of gastroenterology and hepatology, 2007, Volume: 22, Issue:7

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Humans; Pancreatitis; Randomized Controll

2007
Antiproteases in preventing post-ERCP acute pancreatitis.
    JOP : Journal of the pancreas, 2007, Jul-09, Volume: 8, Issue:4 Suppl

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Glycoproteins; Humans; Pancreatitis; Rand

2007
Early successes and late failures in the prevention of post endoscopic retrograde cholangiopancreatography.
    World journal of gastroenterology, 2007, Jul-14, Volume: 13, Issue:26

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Cholangiopancreatography, Endoscopic

2007
Pharmacological approach to acute pancreatitis.
    World journal of gastroenterology, 2008, May-21, Volume: 14, Issue:19

    Topics: Acute Disease; Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, No

2008
Effectiveness of gabexate mesilate in acute pancreatitis. A metaanalysis.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:4

    Topics: Acute Disease; Gabexate; Humans; Pancreatitis

1995
[Clinical study of chronic pancreatitis].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1993, Mar-10, Volume: 82, Issue:3

    Topics: Alcohol Drinking; Cholangiopancreatography, Endoscopic Retrograde; Chronic Disease; Esters; Fasting;

1993
Damage prevention versus damage control in acute pancreatitis.
    Gastroenterology, 1993, Volume: 104, Issue:4

    Topics: Acute Disease; Gabexate; Humans; Pancreatitis

1993
Protease-antiprotease interactions and the rationale for therapeutic protease inhibitors.
    Scandinavian journal of gastroenterology. Supplement, 1996, Volume: 219

    Topics: Acute Disease; alpha 1-Antitrypsin; alpha-Macroglobulins; Animals; Aprotinin; Clinical Trials as Top

1996
Meta-analysis of somatostatin, octreotide and gabexate mesilate in the therapy of acute pancreatitis.
    Alimentary pharmacology & therapeutics, 1998, Volume: 12, Issue:3

    Topics: Acute Disease; Anticoagulants; Clinical Trials as Topic; Gabexate; Hormone Antagonists; Hormones; Hu

1998
[Synthetic protease inhibitors for human acute pancreatitis].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1998, Volume: 95, Issue:11

    Topics: Acute Disease; Animals; Aprotinin; Cholangiopancreatography, Endoscopic Retrograde; Europe; Gabexate

1998
Pharmacologic treatment can prevent pancreatic injury after ERCP: a meta-analysis.
    Gastrointestinal endoscopy, 2000, Volume: 51, Issue:1

    Topics: Acute Disease; Amylases; Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Hormones; Humans

2000
[Can post-ERCP acute pancreatitis be predicted and prevented?].
    Gastroenterologie clinique et biologique, 2001, Volume: 25, Issue:1 Suppl

    Topics: Acute Disease; Adrenal Cortex Hormones; Cholangiopancreatography, Endoscopic Retrograde; Contrast Me

2001
Predicting and preventing post-ERCP pancreatitis.
    Current gastroenterology reports, 2002, Volume: 4, Issue:2

    Topics: Acute Disease; Acute-Phase Proteins; Amylases; Biomarkers; Calcitonin; Cholangiopancreatography, End

2002

Trials

18 trials available for gabexate and Pancreatitis

ArticleYear
Effect of Somatostatin, Ulinastatin and Gabexate on the Treatment of Severe Acute Pancreatitis.
    The American journal of the medical sciences, 2016, Volume: 351, Issue:5

    Topics: Acute Disease; Adult; Double-Blind Method; Drug Therapy, Combination; Female; Gabexate; Glycoprotein

2016
[Could nafamostat or gabexate prevent the post endoscopic retrograde cholangiopancreatography pancreatitis?].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2012, Volume: 59, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Benzamidines; Cholangiopancreatography, Endoscopic Retrograde; Femal

2012
Prospective comparative study of endoscopic papillary large balloon dilation and endoscopic sphincterotomy for removal of large bile duct stones in patients above 45 years of age.
    Scandinavian journal of gastroenterology, 2012, Volume: 47, Issue:8-9

    Topics: Aged; Aged, 80 and over; Ampulla of Vater; Anticoagulants; Catheterization; Chi-Square Distribution;

2012
Gabexate or somatostatin administration before ERCP in patients at high risk for post-ERCP pancreatitis: a multicenter, placebo-controlled, randomized clinical trial.
    Gastrointestinal endoscopy, 2002, Volume: 56, Issue:4

    Topics: Acute Disease; Adult; Cholangiopancreatography, Endoscopic Retrograde; Clinical Competence; Double-B

2002
Comparison of two dosing regimens of gabexate in the prophylaxis of post-ERCP pancreatitis.
    The American journal of gastroenterology, 2003, Volume: 98, Issue:10

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Biliary Tract Diseases; Cholangiopancreat

2003
Short-term prophylactic prevention of post-ERCP pancreatitis.
    Gastrointestinal endoscopy, 2003, Volume: 58, Issue:5

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Humans; Pancreatitis; Somatostatin

2003
Prophylaxis of ERCP-related pancreatitis: a randomized, controlled trial of somatostatin and gabexate mesylate.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2004, Volume: 2, Issue:8

    Topics: Aged; Aged, 80 and over; Chemoprevention; Cholangiopancreatography, Endoscopic Retrograde; Double-Bl

2004
Clinical trial of gabexate in the prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2006, Volume: 39, Issue:1

    Topics: Abdominal Pain; Acute Disease; Cholangiopancreatography, Endoscopic Retrograde; Double-Blind Method;

2006
Comparison between ulinastatin and gabexate mesylate for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a prospective, randomized trial.
    Journal of gastroenterology, 2007, Volume: 42, Issue:2

    Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Female; Gabexate; Glycoproteins; Humans; Male

2007
Efficacy of postprocedure administration of gabexate mesylate in the prevention of post-ERCP pancreatitis: a randomized, controlled, multicenter study.
    Gastrointestinal endoscopy, 2007, Volume: 65, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Cholangiopancreatography, Endoscopic Retrograde; Dose-Response Relat

2007
[Effect of secretin and gabexate-mesilate (synthetic protease inhibitor) on serum amylase level after ERCP].
    Zeitschrift fur Gastroenterologie, 1982, Volume: 20, Issue:11

    Topics: Alkaline Phosphatase; Amylases; Cholangiopancreatography, Endoscopic Retrograde; Chronic Disease; Do

1982
Gabexate mesilate vs aprotinin in human acute pancreatitis (GA.ME.P.A.). A prospective, randomized, double-blind multicenter study.
    International journal of pancreatology : official journal of the International Association of Pancreatology, 1993, Volume: 14, Issue:2

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Aprotinin; Double-Blind Method; Female; Gabexate; Hum

1993
Gabexate mesilate in human acute pancreatitis. German Pancreatitis Study Group.
    Gastroenterology, 1993, Volume: 104, Issue:4

    Topics: Acute Disease; Adult; Aged; Double-Blind Method; Female; Gabexate; Humans; Male; Middle Aged; Pancre

1993
Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy--Italian Group.
    The New England journal of medicine, 1996, Sep-26, Volume: 335, Issue:13

    Topics: Acute Disease; Adult; Aged; Amylases; Cholangiopancreatography, Endoscopic Retrograde; Double-Blind

1996
Multicenter double-blind trial of gabexate mesylate (FOY) in unselected patients with acute pancreatitis.
    Digestion, 1992, Volume: 51, Issue:2

    Topics: Acute Disease; Double-Blind Method; Female; Gabexate; Humans; Male; Middle Aged; Pancreatitis; Prosp

1992
Clinical trial with a protease inhibitor gabexate mesilate in acute pancreatitis.
    International journal of pancreatology : official journal of the International Association of Pancreatology, 1991,Summer, Volume: 9

    Topics: Acute Disease; Female; Gabexate; Humans; Male; Middle Aged; Pancreatitis; Protease Inhibitors; Survi

1991
[Gabexate mesilate in the treatment of acute pancreatitis. Results of a Hannover multicenter double-blind study with 50 patients].
    Zeitschrift fur Gastroenterologie, 1986, Volume: 24, Issue:4

    Topics: Acute Disease; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Gabexate; Germany, West

1986
Controlled trial of protease inhibitor gabexelate mesilate (FOY) in the treatment of acute pancreatitis.
    Pancreas, 1987, Volume: 2, Issue:6

    Topics: Acute Disease; Clinical Trials as Topic; Female; Gabexate; Guanidines; Humans; Male; Pancreatitis; P

1987

Other Studies

93 other studies available for gabexate and Pancreatitis

ArticleYear
Gabexate Mesylate-Poloxamer 407 Conjugate Alleviates Sodium Taurocholate-Induced Severe Acute Pancreatitis in an Optimized Rat Model.
    Digestive diseases and sciences, 2023, Volume: 68, Issue:1

    Topics: Acute Disease; Animals; Gabexate; Interleukin-6; Pancreas; Pancreatitis; Poloxamer; Rats; Rats, Spra

2023
Efficacy of gabexate mesilate in preventing post endoscopic retrograde cholangiopancreatography pancreatitis: A meta-analysis of randomized clinical trials.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2021, Volume: 120, Issue:9

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Humans; Pancreatitis; Randomized Controll

2021
Response to letter to the editor: Appropriate data synthesis provide reliable evidence regarding efficacy of FOY in preventing post endoscopic retrograde cholangiopancreatography pancreatitis.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2021, Volume: 120, Issue:9

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Humans; Pancreatitis; Stents

2021
Rectal indomethacin or intravenous gabexate mesylate as prophylaxis for acute pancreatitis post-endoscopic retrograde cholangiopancreatography.
    European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:22

    Topics: Acute Disease; Administration, Intravenous; Administration, Rectal; Aged; Aged, 80 and over; Anti-In

2017
Clinical efficacy of gabexate mesilate for acute pancreatitis in children.
    European journal of pediatrics, 2013, Volume: 172, Issue:11

    Topics: Acute Disease; Adolescent; Child; Child, Preschool; Drug Administration Schedule; Female; Gabexate;

2013
Acute pancreatitis secondary to ciprofloxacin therapy in patients with infectious colitis.
    Gut and liver, 2014, Volume: 8, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infectio

2014
[Acute pancreatitis in pediatric age: our experience in 52 cases].
    Minerva pediatrica, 2014, Volume: 66, Issue:4

    Topics: Acute Disease; Adolescent; Amylases; Biomarkers; Child; Child, Preschool; Cholangiopancreatography,

2014
Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats.
    World journal of gastroenterology, 2015, Jul-07, Volume: 21, Issue:25

    Topics: Administration, Oral; Animals; Biomarkers; Bombesin; Cell Proliferation; Cholecystokinin; Disease Mo

2015
A novel thermosensitive in-situ gel of gabexate mesilate for treatment of traumatic pancreatitis: An experimental study.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2015, Volume: 35, Issue:5

    Topics: Amylases; Animals; C-Reactive Protein; Delayed-Action Preparations; Gabexate; Gels; Male; Muscle, Sk

2015
Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis.
    World journal of gastroenterology, 2008, Nov-07, Volume: 14, Issue:41

    Topics: Abdominal Pain; Acute Disease; Adult; Aged; Anti-Bacterial Agents; C-Reactive Protein; Drug Therapy,

2008
Post-ERCP pancreatitis.
    Journal of hepato-biliary-pancreatic sciences, 2010, Volume: 17, Issue:1

    Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograd

2010
Effect and cost of treatment for acute pancreatitis with or without gabexate mesylate: a propensity score analysis using a nationwide administrative database.
    Pancreas, 2013, Volume: 42, Issue:2

    Topics: Acute Disease; Adult; Aged; Chi-Square Distribution; Cost-Benefit Analysis; Drug Costs; Female; Gabe

2013
Coil compaction after embolization of the superior mesenteric artery pseudoaneurysm.
    European radiology, 2002, Volume: 12 Suppl 3

    Topics: Acute Disease; Aneurysm, False; Embolization, Therapeutic; Gabexate; Hematemesis; Humans; Male; Mese

2002
Fatal cases of gabexate mesilate-induced anaphylaxis.
    International journal of clinical pharmacology research, 2002, Volume: 22, Issue:3-4

    Topics: Anaphylaxis; Fatal Outcome; Female; Gabexate; Humans; Male; Middle Aged; Pancreatitis; Serine Protei

2002
Acute pancreatitis occurring in the early postpartum period: a case report.
    Journal of perinatal medicine, 2003, Volume: 31, Issue:4

    Topics: Abdominal Pain; Acute Disease; Adolescent; Back Pain; Famotidine; Female; Gabexate; Histamine H2 Ant

2003
Tumor protein p53-induced nuclear protein 1 (TP53INP1) in spontaneous chronic pancreatitis in the WBN/Kob rat: drug effects on its expression in the pancreas.
    JOP : Journal of the pancreas, 2004, Volume: 5, Issue:4

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Arginine; Carrier Proteins; Cell Line; Chronic Di

2004
Acute pancreatitis in the early stages of pregnancy associated with a PSTI gene mutation.
    Pancreas, 2004, Volume: 29, Issue:3

    Topics: Abdominal Pain; Acute Disease; Adult; Amino Acid Substitution; Amylases; Carrier Proteins; Diet, Fat

2004
Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity.
    Laboratory investigation; a journal of technical methods and pathology, 2005, Volume: 85, Issue:1

    Topics: Animals; Cell Proliferation; Chemokine CCL2; Disease Models, Animal; Dose-Response Relationship, Dru

2005
Gabexate mesilate and acute pancreatitis: an experience of evidence based drug information for improving rational drug use.
    Pharmacy world & science : PWS, 2005, Volume: 27, Issue:2

    Topics: Acute Disease; Anticoagulants; Dose-Response Relationship, Drug; Drug Information Services; Drug Pre

2005
New approaches for the treatment of acute pancreatitis.
    JOP : Journal of the pancreas, 2006, Jan-11, Volume: 7, Issue:1

    Topics: Acute Disease; Amylases; Animals; Antibodies, Monoclonal; Cholangiopancreatography, Endoscopic Retro

2006
Frequency of post-ERCP pancreatitis in a single tertiary referral centre without and with routine prophylaxis with gabexate: a 6-year survey and cost-effectiveness analysis.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2006, Volume: 38, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amylases; Child; Child, Preschool; Cholangiopancreatogra

2006
Pharmacological prevention of post-ERCP pancreatitis--an everlasting dream?
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2006, Volume: 38, Issue:8

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Cost-Benefit Analysis; Gabexate; Humans; Hyperamyla

2006
A case of severe acute pancreatitis, in overlap syndrome of systemic sclerosis and systemic lupus erythematosus, successfully treated with plasmapheresis.
    Modern rheumatology, 2006, Volume: 16, Issue:3

    Topics: Adult; Anti-Inflammatory Agents; Female; Gabexate; Humans; Lupus Erythematosus, Systemic; Methylpred

2006
Acute pancreatitis.
    The New England journal of medicine, 2006, Aug-31, Volume: 355, Issue:9

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Cost-Benefit Analysis; Gabexate; Humans; Infusions,

2006
A case of feline pancreatitis.
    The Journal of veterinary medical science, 2006, Volume: 68, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Cat Diseases; Cats; Female; Gabexate; Pancreatitis; Prednisolone;

2006
Prophylaxis of post-ERCP pancreatic complications with gabexate.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2007, Volume: 39, Issue:3

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Clinical Protocols; Gabexate; Humans; Pancreatitis;

2007
Evaluation of serum amylase and gabexate mesilate with endoscopic papillary balloon dilatation.
    The journal of medical investigation : JMI, 2007, Volume: 54, Issue:1-2

    Topics: Acute Disease; Aged; Amylases; Catheterization; Endoscopy, Digestive System; Female; Gabexate; Galls

2007
Risk for post-ERCP pancreatitis after needle knife precut sphincterotomy following repeated cannulation attempts.
    Journal of clinical gastroenterology, 2007, Volume: 41, Issue:4

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Catheterization; Cholangiopancreatography, Endoscopic

2007
The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents.
    Life sciences, 2007, May-01, Volume: 80, Issue:21

    Topics: Abdominal Pain; Animals; Ceruletide; Dose-Response Relationship, Drug; Esters; Gabexate; Guanidines;

2007
[Typhoid fever and acute pancreatitis: two cases].
    Le infezioni in medicina, 2007, Volume: 15, Issue:1

    Topics: Abdominal Pain; Acute Disease; Adult; Anti-Bacterial Agents; Anti-Ulcer Agents; Ceftriaxone; Female;

2007
Somatostatin bolus injection for post-ERCP pancreatitis prevention: a need for further study.
    Gastrointestinal endoscopy, 2008, Volume: 67, Issue:1

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Humans; Injections; Pancreatitis; Serine

2008
The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats.
    International immunopharmacology, 2008, Volume: 8, Issue:7

    Topics: Amylases; Animals; Ceruletide; Cytokines; Gabexate; Glycoproteins; Invertebrate Hormones; Leukocyte

2008
[Therapy of acute pancreatitis with a synthetic protease and phospholipase A2 inhibitor gabexate mesilate].
    Fortschritte der Medizin, 1983, Aug-25, Volume: 101, Issue:31-32

    Topics: Acute Disease; Adult; Aged; Amylases; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Pancr

1983
Effects of the serine protease inhibitor gabexate mesilate on purified pancreatic phospholipase A2.
    Pharmacological research communications, 1984, Volume: 16, Issue:7

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Gabexate; Guanidines; Pancreas; Pancreatitis; Phosphol

1984
Protective effects of gabexate mesilate on acute pancreatitis induced by tacrolimus (FK-506) in rats in which the pancreas was stimulated by caerulein.
    Journal of gastroenterology, 1994, Volume: 29, Issue:3

    Topics: Amylases; Animals; Ceruletide; Gabexate; Male; Pancreas; Pancreatic Elastase; Pancreatitis; Rats; Ra

1994
Effects of serine protease inhibitors on accumulation of polymorphonuclear leukocytes in the lung induced by acute pancreatitis in rats.
    Journal of gastroenterology, 1995, Volume: 30, Issue:3

    Topics: Acute Disease; Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Disease Models, Animal; Endot

1995
Effect of camostate administration for two weeks on experimental pancreatitis in mice and rats.
    Pancreas, 1993, Volume: 8, Issue:1

    Topics: Administration, Oral; Amylases; Animals; Cholecystokinin; Esters; Female; Gabexate; Guanidines; Male

1993
Changes of systemic prostacyclin and thromboxane A2 in sodium taurocholate- and cerulein-induced acute pancreatitis in rats.
    Digestive diseases and sciences, 1993, Volume: 38, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Amylases; Animals; Ceruletide; Epoprostenol; Gabexate;

1993
Beneficial effects of preventive oral administration of camostate on cerulein-induced pancreatitis in rats.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:3

    Topics: Administration, Oral; Animals; Ceruletide; Esters; Gabexate; Guanidines; Pancreatitis; Rats; Rats, W

1995
The effect of nafamostat mesilate (FUT-175) and gabexate mesilate (FOY) on multiorgan oxidant-antioxidant balance in acute experimental pancreatitis.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1994, Volume: 45, Issue:3

    Topics: Acute Disease; Animals; Benzamidines; Gabexate; Guanidines; Lung; Male; Malondialdehyde; Oxidative S

1994
Ischemic colitis complicating severe acute pancreatitis in a child.
    Journal of pediatric gastroenterology and nutrition, 1993, Volume: 16, Issue:2

    Topics: Acute Disease; Child, Preschool; Colitis, Ischemic; Colon; Colonoscopy; Female; Gabexate; Humans; Pa

1993
Gabexate mesilate in human acute pancreatitis.
    Gastroenterology, 1993, Volume: 105, Issue:6

    Topics: Acute Disease; Gabexate; Humans; Pancreatitis

1993
Complications of endoscopic sphincterotomy and their prevention.
    The New England journal of medicine, 1996, Sep-26, Volume: 335, Issue:13

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Clinical Competence; Gabexate; Humans; Pancreatitis

1996
Effect of oral administration of protease inhibitor on pancreatic exocrine function in WBN/Kob rats with chronic pancreatitis.
    Pancreas, 1996, Volume: 13, Issue:1

    Topics: Administration, Oral; Animals; Cholecystokinin; Chronic Disease; Disease Models, Animal; Esters; Gab

1996
The cholecystokinin receptor antagonist L-364,718 reduces taurocholate-induced pancreatitis in rats.
    International journal of pancreatology : official journal of the International Association of Pancreatology, 1996, Volume: 20, Issue:3

    Topics: Amylases; Animals; Benzodiazepinones; Cholagogues and Choleretics; Devazepide; Esters; Gabexate; Gua

1996
The effect of gabexate mesilate on pancreatic and hepatic microcirculation in acute experimental pancreatitis in rats.
    The Journal of surgical research, 1996, Volume: 66, Issue:2

    Topics: Acute Disease; Animals; Ceruletide; Disease Models, Animal; Endothelium, Vascular; Gabexate; Leukocy

1996
Effect of T-0632, a cholecystokininA receptor antagonist, on experimental acute pancreatitis.
    Japanese journal of pharmacology, 1997, Volume: 73, Issue:2

    Topics: Acute Disease; Amylases; Animals; Ceruletide; Disease Models, Animal; Dogs; Esters; Female; Gabexate

1997
Prevention of ERCP-induced pancreatitis: success at last.
    Gastroenterology, 1997, Volume: 112, Issue:4

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Double-Blind Method; Gabexate; Humans; Pancreatitis

1997
Panniculitis with eosinophilic infiltration due to gabexate mesilate (FOY): possibility of allergic reaction.
    The Journal of dermatology, 1997, Volume: 24, Issue:4

    Topics: Acute Disease; Blood Proteins; Connective Tissue; Cytoplasmic Granules; Drug Eruptions; Eosinophil G

1997
Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography.
    Gastrointestinal endoscopy, 1997, Volume: 45, Issue:5

    Topics: Acute Disease; Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Humans; Pancreas; Pancreat

1997
Protease inhibitors for prevention of ERCP pancreatitis: can we afford the price of success?
    The American journal of gastroenterology, 1997, Volume: 92, Issue:6

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Costs and Cost Analysis; Drug Costs; Gabexate; Huma

1997
Effect of oral protease inhibitor administration on gallbladder motility in patients with mild chronic pancreatitis.
    Journal of gastroenterology, 1997, Volume: 32, Issue:3

    Topics: Administration, Oral; Adult; Aged; Cholecystokinin; Chronic Disease; Esters; Female; Gabexate; Gallb

1997
Gabexate mesilate improves pancreatic microcirculation and reduces lung edema in a rat model of acute pancreatitis.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 1997, Volume: 96, Issue:9

    Topics: Acute Disease; Animals; Gabexate; Male; Microcirculation; Pancreas; Pancreatitis; Pulmonary Edema; R

1997
Effects of loxiglumide on experimental acute pancreatitis in comparison with gabexate mesilate.
    Arzneimittel-Forschung, 1998, Volume: 48, Issue:1

    Topics: Acute Disease; Amylases; Animals; Ceruletide; Duodenum; Female; Gabexate; Hormone Antagonists; Injec

1998
Pathophysiologic studies of experimental chronic pancreatitis in rats induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct.
    Pancreas, 1998, Volume: 16, Issue:3

    Topics: Amylases; Animals; Blood Glucose; Body Weight; Chronic Disease; Disease Models, Animal; Esters; Gabe

1998
Effect of methylcarbonylmethyl 2(S)-[4-(4-guanidino-benzoyloxy)phenyl] propionate methanesulfonate (TT-S24) on experimental pancreatitis in rats.
    Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:3

    Topics: Amylases; Animals; Ceruletide; Disease Models, Animal; Esters; Gabexate; Guanidines; Male; Pancreati

1998
Induction of apoptosis with an extract of Artemisia asiatica attenuates the severity of cerulein-induced pancreatitis in rats.
    Pancreas, 1998, Volume: 17, Issue:2

    Topics: Acute Disease; Amylases; Animals; Apoptosis; Artemisia; Ceruletide; DNA Fragmentation; Gabexate; Lip

1998
Oral administration of sepimostat mesilate prevents acute alcohol pancreatic injury in rats.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:7

    Topics: Acute Disease; Administration, Oral; Amylases; Animals; Ceruletide; Esters; Ethanol; Gabexate; Guani

1999
Prevention of post-ERCP pancreatitis.
    Gastrointestinal endoscopy, 2000, Volume: 51, Issue:1

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Hormones; Humans; Octreotide; Pancreatiti

2000
Effect of camostat mesilate on the expression of pancreatitis-associated protein (PAP), p8, and cytokines in rat spontaneous chronic pancreatitis.
    Pancreas, 2001, Volume: 23, Issue:2

    Topics: Acute-Phase Proteins; Animals; Antigens, Neoplasm; Basic Helix-Loop-Helix Transcription Factors; Bio

2001
Effects of gabexate mesilate, a protease inhibitor, on human sphincter of Oddi motility.
    Digestive diseases and sciences, 2002, Volume: 47, Issue:4

    Topics: Acute Disease; Adult; Female; Gabexate; Humans; Male; Manometry; Middle Aged; Pancreatitis; Serine P

2002
The effect of somatostatin, gabexate mesilate and dextran 40 on the microcirculation in sodium taurocholate-induced pancreatitis.
    Acta physiologica Hungarica, 1992, Volume: 80, Issue:1-4

    Topics: Animals; Capillary Permeability; Dextrans; Female; Fluorescein-5-isothiocyanate; Gabexate; Microcirc

1992
[Treatment of acute pancreatitis].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1992, Dec-10, Volume: 81, Issue:12

    Topics: Acute Disease; Benzamidines; Disseminated Intravascular Coagulation; Drainage; Gabexate; Glycoprotei

1992
"Cocktail" therapy for acute pancreatitis: combined therapy of protease inhibitor, xanthine oxidase inhibitor and platelet activating factor antagonist in rat caerulein-induced pancreatis.
    Nihon geka hokan. Archiv fur japanische Chirurgie, 1992, Nov-01, Volume: 61, Issue:6

    Topics: Acute Disease; Allopurinol; Animals; Ceruletide; Drug Therapy, Combination; Gabexate; Male; Pancreat

1992
Protection by a new synthetic protease inhibitor, ONO3307, of the rat exocrine pancreas during acute edematous pancreatitis induced by a supramaximal dose of caerulein in comparison with FOY007.
    Pharmacology, 1992, Volume: 45, Issue:2

    Topics: Acute Disease; Amylases; Animals; Body Water; Cathepsin B; Ceruletide; Edema; Gabexate; Guanidines;

1992
Use of a synthetic protease inhibitor for the treatment of L-asparaginase-induced acute pancreatitis complicated by disseminated intravascular coagulation.
    Annals of hematology, 1992, Volume: 64, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Benz

1992
Beneficial effects of the synthetic trypsin inhibitor camostate in cerulein-induced acute pancreatitis in rats.
    Digestive diseases and sciences, 1990, Volume: 35, Issue:2

    Topics: Acute Disease; Amylases; Animals; Ceruletide; Esters; Gabexate; Guanidines; Male; Organ Size; Pancre

1990
[Antienzyme preparations in the treatment of acute pancreatitis].
    Nihon rinsho. Japanese journal of clinical medicine, 1990, Volume: 48, Issue:1

    Topics: Acute Disease; Adult; Aprotinin; Benzamidines; Cytidine Diphosphate Choline; Disseminated Intravascu

1990
Protective effects of gabexate mesilate (FOY) against impaired pancreatic energy metabolism in rat acute pancreatitis induced by caerulein.
    Life sciences, 1991, Volume: 49, Issue:22

    Topics: Acute Disease; Amylases; Animals; Ceruletide; Gabexate; Malate Dehydrogenase; Male; Mitochondria; Pa

1991
[Protease inhibitors in the treatment of pancreatitis].
    Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:9

    Topics: Acute Disease; Animals; Aprotinin; Chronic Disease; Esters; Gabexate; Glycoproteins; Guanidines; Hum

1991
Synthetic antiproteases in acute pancreatitis: an experimental study.
    The Mount Sinai journal of medicine, New York, 1992, Volume: 59, Issue:1

    Topics: Acute Disease; Animals; Benzamidines; Dogs; Gabexate; Guanidines; Hemodynamics; Hemorrhage; Pancreat

1992
Early graft injuries after pancreatic transplantation in syngeneic rats. Cytoprotective effects of gabexate-mesilate.
    International journal of pancreatology : official journal of the International Association of Pancreatology, 1991, Volume: 8, Issue:4

    Topics: Analysis of Variance; Animals; Edema; Gabexate; Graft Survival; Necrosis; Organ Preservation; Pancre

1991
[Effect of oxygen free radicals on the rat pancreas in vivo].
    Nihon geka hokan. Archiv fur japanische Chirurgie, 1991, Sep-01, Volume: 60, Issue:5

    Topics: Acute Disease; Animals; Catalase; Free Radical Scavengers; Free Radicals; Gabexate; Hydrogen Peroxid

1991
Pancreatic microvascular permeability in caerulein-induced acute pancreatitis.
    The American journal of physiology, 1991, Volume: 261, Issue:4 Pt 1

    Topics: Acute Disease; Animals; Capillary Permeability; Ceruletide; Edetic Acid; Endothelium, Vascular; Este

1991
[The protease inhibitor gabexate mesilate in experimentally-induced acute pancreatitis with early gram-negative infection in the Göttingen minipig: therapeutic efficacy and effects on blood coagulation and fibrinolysis].
    Zeitschrift fur Gastroenterologie, 1990, Volume: 28, Issue:4

    Topics: Acute Disease; Animals; Anticoagulants; Blood Coagulation; Blood Coagulation Tests; Escherichia coli

1990
Camostate (FOY-305) improves the therapeutic effect of peritoneal lavage on taurocholate induced pancreatitis.
    Gut, 1990, Volume: 31, Issue:8

    Topics: Acute Disease; Animals; Esters; Gabexate; Guanidines; Male; Pancreatitis; Peritoneal Lavage; Proteas

1990
Gabexate mesilate and camostate: new inhibitors of phospholipase A2 and their influence on the alpha-amylase activity in serum of patients with acute pancreatitis.
    Clinical biochemistry, 1985, Volume: 18, Issue:4

    Topics: Acute Disease; alpha-Amylases; Aprotinin; Esters; Gabexate; Guanidines; Humans; Infusions, Parentera

1985
Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis.
    The Journal of clinical investigation, 1986, Volume: 78, Issue:4

    Topics: Acute Disease; Amylases; Animals; Cholecystokinin; Choline Deficiency; Disease Models, Animal; Ethio

1986
Gabexate mesilate (FOY) protects against ceruletide-induced acute pancreatitis in the rat.
    Pancreas, 1987, Volume: 2, Issue:2

    Topics: Acute Disease; Amylases; Animals; Ceruletide; Disease Models, Animal; Gabexate; Guanidines; Infusion

1987
[The Pancreas Study Group: Inhibition of pancreas secretion and trypsin activity. Mechanisms and importance of therapy of acute and chronic pancreatitis].
    Zeitschrift fur Gastroenterologie. Verhandlungsband, 1987, Volume: 22

    Topics: Adult; Animals; Aprotinin; Bicarbonates; Cholecystokinin; Chronic Disease; Dogs; Female; Gabexate; G

1987
Esterase inhibitors prevent lysosomal enzyme redistribution in two noninvasive models of experimental pancreatitis.
    Gastroenterology, 1989, Volume: 96, Issue:3

    Topics: Amylases; Animals; Cathepsin B; Esters; Gabexate; Guanidines; Male; Pancreas; Pancreatitis; Protease

1989
Prevention of the spread of experimental acute pancreatitis by intraductal administration of a synthetic protease inhibitor in dogs.
    The American journal of gastroenterology, 1989, Volume: 84, Issue:3

    Topics: Amylases; Animals; Dogs; Female; Gabexate; Guanidines; Infusions, Intravenous; Kidney; Male; Pancrea

1989
Lysolecithin concentration in pancreatic tissue during therapy with phospholipase A2-inhibitors in acute necrotizing pancreatitis.
    Klinische Wochenschrift, 1989, Feb-01, Volume: 67, Issue:3

    Topics: Acute Disease; Animals; Chlorpromazine; Dogs; Dose-Response Relationship, Drug; Edetic Acid; Female;

1989
The effect of gabexate mesilate on the outcome of acute hemorrhagic pancreatitis in pigs.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1989, Volume: 189, Issue:1

    Topics: Acute Disease; Animals; Gabexate; Guanidines; Hemodynamics; Hemorrhage; Pancreatitis; Phospholipases

1989
Effect on hemodynamics of therapeutic infusion of gabexate mesilate (FOY) in experimental acute pancreatitis.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1989, Volume: 189, Issue:2

    Topics: Acute Disease; Animals; Dogs; Gabexate; Guanidines; Hemodynamics; Male; Pancreatitis; Prostaglandins

1989
[A case of renal cancer complicated with acute hypercalcemia and acute pancreatitis].
    Hinyokika kiyo. Acta urologica Japonica, 1989, Volume: 35, Issue:11

    Topics: Acute Disease; Calcitonin; Emergencies; Gabexate; Guanidines; Humans; Hypercalcemia; Kidney Neoplasm

1989
Effect of FOY-305 (Camostate) on severe acute pancreatitis in two experimental animal models.
    Gastroenterology, 1989, Volume: 97, Issue:6

    Topics: Acute Disease; Animals; Disease Models, Animal; Esters; Gabexate; Guanidines; Pancreatitis; Rats; Ra

1989
Effect of FOY-305 (camostate) on severe acute pancreatitis in two experimental animal models.
    Gastroenterology, 1989, Volume: 96, Issue:1

    Topics: Acute Disease; Animals; Choline Deficiency; Esters; Female; Gabexate; Guanidines; Male; Mice; Pancre

1989
[Gabexate mesilate in the therapy of acute pancreatitis. Multicenter study of tolerance of a high intravenous dose (4 g/day)].
    Medizinische Klinik (Munich, Germany : 1983), 1988, Apr-29, Volume: 83, Issue:10

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Drug Evaluation; Ga

1988
Therapeutic regimens in acute experimental hemorrhagic pancreatitis. Effects of hydration, oxygenation, peritoneal lavage, and a potent protease inhibitor.
    Gastroenterology, 1988, Volume: 95, Issue:6

    Topics: Acute Disease; Animals; Female; Fluid Therapy; Gabexate; Guanidines; Mice; Oxygen; Pancreas; Pancrea

1988
Synthetic versus natural protease inhibitors in acute experimental pancreatitis.
    Digestive diseases and sciences, 1988, Volume: 33, Issue:11

    Topics: Animals; Esters; Gabexate; Guanidines; Male; Pancreatitis; Plasma; Protease Inhibitors; Rats

1988
[Protective effect of camostat mesilate and allopurinol in acute edematous pancreatitis in the rat induced by excessive doses of caerulein].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1987, Volume: 84, Issue:7

    Topics: Acute Disease; Allopurinol; Animals; Ceruletide; Edema; Esters; Gabexate; Guanidines; Male; Pancreat

1987
[Phospholipase A2 inhibitors in hemorrhagic-necrotizing pancreatitis. Animal experiment evaluation of a new treatment concept].
    Zeitschrift fur Gastroenterologie, 1985, Volume: 23, Issue:12

    Topics: Acute Disease; Animals; Chlorpromazine; Dogs; Edetic Acid; Female; Gabexate; Guanidines; Hemodynamic

1985