gabexate has been researched along with Muscular Dystrophy, Duchenne in 1 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Muscular Dystrophy, Duchenne: An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Duchenne muscular dystrophy is known to be caused by a defective gene of dystrophin, a 427-kDa cytoskeletal protein, but the effective therapeutic drug is presently unavailable." | 1.32 | Therapeutic effect of camostat mesilate on Duchenne muscular dystrophy in mdx mice. ( Ban, S; Kakefuda, R; Kikukawa, Y; Nagahiro, K; Sawada, H; Shiomi, T; Yokosawa, H, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sawada, H | 1 |
| Nagahiro, K | 1 |
| Kikukawa, Y | 1 |
| Ban, S | 1 |
| Kakefuda, R | 1 |
| Shiomi, T | 1 |
| Yokosawa, H | 1 |
1 other study available for gabexate and Muscular Dystrophy, Duchenne
| Article | Year |
|---|---|
Therapeutic effect of camostat mesilate on Duchenne muscular dystrophy in mdx mice.
Topics: Animals; Esters; Gabexate; Guanidines; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; | 2003 |