gabexate has been researched along with Multiple Organ Failure in 7 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Several studies have reported that gabexate mesilate, a synthetic inhibitor of trypsin-like serine protease, protects tissues/organs against injury in the models of endotoxemia." | 7.81 | Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia: a potential use of thrombelastography in endotoxin-induced sepsis. ( Ding, C; Ka, SM; Liao, MH; Liaw, WJ; Tsai, HJ; Tsao, CM; Wu, CC, 2015) |
| " Several studies have reported that gabexate mesilate, a synthetic inhibitor of trypsin-like serine protease, protects tissues/organs against injury in the models of endotoxemia." | 3.81 | Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia: a potential use of thrombelastography in endotoxin-induced sepsis. ( Ding, C; Ka, SM; Liao, MH; Liaw, WJ; Tsai, HJ; Tsao, CM; Wu, CC, 2015) |
| "Thyroid storm is a rare disorder with a sudden onset, rapid progression and high mortality." | 1.38 | Thyroid storm with multiple organ failure, disseminated intravascular coagulation, and stroke with a normal serum FT3 level. ( Akiyama, H; Handa, M; Harada, Y; Ryuzaki, M; Urao, Y; Yoshimoto, T, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsai, HJ | 1 |
| Ding, C | 1 |
| Tsao, CM | 1 |
| Liao, MH | 1 |
| Ka, SM | 1 |
| Liaw, WJ | 1 |
| Wu, CC | 1 |
| Harada, Y | 1 |
| Akiyama, H | 1 |
| Yoshimoto, T | 1 |
| Urao, Y | 1 |
| Ryuzaki, M | 1 |
| Handa, M | 1 |
| Tamakuma, S | 1 |
| Okumura, Y | 1 |
| Inoue, H | 1 |
| Fujiyama, Y | 1 |
| Bamba, T | 1 |
| Mitsuoka, H | 1 |
| Kistler, EB | 1 |
| Schmid-Schönbein, GW | 1 |
| Kashima, K | 1 |
| Kataoka, K | 1 |
| Umehara, K | 1 |
| Yoshida, K | 1 |
| Toki, F | 1 |
| Takeuchi, T | 1 |
7 other studies available for gabexate and Multiple Organ Failure
| Article | Year |
|---|---|
Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia: a potential use of thrombelastography in endotoxin-induced sepsis.
Topics: Animals; Anticoagulants; Blood Coagulation Disorders; Endotoxemia; Gabexate; Lipopolysaccharides; Ma | 2015 |
Thyroid storm with multiple organ failure, disseminated intravascular coagulation, and stroke with a normal serum FT3 level.
Topics: Anti-Inflammatory Agents; Anticoagulants; Antithyroid Agents; Brain Edema; Decompression, Surgical; | 2012 |
[Severe surgical infection and DIC].
Topics: Adult; Aged; Animals; Bacterial Infections; Blood Coagulation Factors; Disseminated Intravascular Co | 1983 |
Effects of serine protease inhibitors on accumulation of polymorphonuclear leukocytes in the lung induced by acute pancreatitis in rats.
Topics: Acute Disease; Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Disease Models, Animal; Endot | 1995 |
Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock.
Topics: Animals; Blood Pressure; Endopeptidases; Esters; Gabexate; Guanidines; Humans; In Vitro Techniques; | 2002 |
[Treatment of acute pancreatitis].
Topics: Acute Disease; Benzamidines; Disseminated Intravascular Coagulation; Drainage; Gabexate; Glycoprotei | 1992 |
[Antienzyme preparations in the treatment of acute pancreatitis].
Topics: Acute Disease; Adult; Aprotinin; Benzamidines; Cytidine Diphosphate Choline; Disseminated Intravascu | 1990 |