gabexate has been researched along with Liver Failure in 2 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study examined the effects of GM on hepatic encephalopathy in rats with acute and chronic liver failure." | 5.36 | Lack of therapeutic effects of gabexate mesilate on the hepatic encephalopathy in rats with acute and chronic hepatic failure. ( Chan, CY; Chang, CC; Hsu, CY; Huang, HC; Huo, TI; Lee, FY; Lee, SD; Lin, HC; Teng, TH; Wang, SS, 2010) |
| "This study examined the effects of GM on hepatic encephalopathy in rats with acute and chronic liver failure." | 1.36 | Lack of therapeutic effects of gabexate mesilate on the hepatic encephalopathy in rats with acute and chronic hepatic failure. ( Chan, CY; Chang, CC; Hsu, CY; Huang, HC; Huo, TI; Lee, FY; Lee, SD; Lin, HC; Teng, TH; Wang, SS, 2010) |
| "The roles of TNFalpha and IL-6 in liver reperfusion injury were not clear, though TNFalpha might have had an effect during the early phase." | 1.30 | Effect of protease inhibitor on ischemia-reperfusion injury to rat liver. ( Choe, KJ; Ha, J; Jung, SE; Kim, SJ; Lee, JE; Noh, DY; Oh, SK; Youn, YK; Yun, IJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hsu, CY | 1 |
| Lee, FY | 1 |
| Huo, TI | 1 |
| Chan, CY | 1 |
| Huang, HC | 1 |
| Lin, HC | 1 |
| Chang, CC | 1 |
| Teng, TH | 1 |
| Wang, SS | 1 |
| Lee, SD | 1 |
| Jung, SE | 1 |
| Yun, IJ | 1 |
| Youn, YK | 1 |
| Lee, JE | 1 |
| Ha, J | 1 |
| Noh, DY | 1 |
| Kim, SJ | 1 |
| Oh, SK | 1 |
| Choe, KJ | 1 |
2 other studies available for gabexate and Liver Failure
| Article | Year |
|---|---|
Lack of therapeutic effects of gabexate mesilate on the hepatic encephalopathy in rats with acute and chronic hepatic failure.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Blood Pressure; Chronic Disease; Common Bile Duct; Di | 2010 |
Effect of protease inhibitor on ischemia-reperfusion injury to rat liver.
Topics: Animals; Catalase; Disease Models, Animal; Female; Gabexate; Interleukin-6; Lipid Peroxidation; Live | 1999 |