gabexate has been researched along with Invasiveness, Neoplasm in 4 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Transforming growth factor beta1 (TGF-beta1) is a multifunctional poly-peptide that regulates cell growth and differentiation, ECM deposition, cellular adhesion properties, angiogenesis, and also immune functions." | 1.32 | Inhibition and mechanism of action of a protease inhibitor in human pancreatic cancer cells. ( Hirakawa, K; Maeda, K; Nishihara, T; Ohira, M; Sawada, T; Uchima, Y, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brandi, G | 1 |
| Tavolari, S | 1 |
| De Rosa, F | 1 |
| Di Girolamo, S | 1 |
| Agostini, V | 1 |
| Barbera, MA | 1 |
| Frega, G | 1 |
| Biasco, G | 1 |
| Yoon, WH | 1 |
| Jung, YJ | 1 |
| Kim, TD | 1 |
| Li, G | 1 |
| Park, BJ | 1 |
| Kim, JY | 1 |
| Lee, YC | 1 |
| Kim, JM | 1 |
| Park, JI | 1 |
| Park, HD | 1 |
| No, ZS | 1 |
| Lim, K | 1 |
| Hwang, BD | 1 |
| Kim, YS | 1 |
| Uchima, Y | 2 |
| Sawada, T | 2 |
| Nishihara, T | 1 |
| Maeda, K | 1 |
| Ohira, M | 1 |
| Hirakawa, K | 2 |
4 other studies available for gabexate and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Antitumoral efficacy of the protease inhibitor gabexate mesilate in colon cancer cells harbouring KRAS, BRAF and PIK3CA mutations.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Com | 2012 |
Gabexate mesilate inhibits colon cancer growth, invasion, and metastasis by reducing matrix metalloproteinases and angiogenesis.
Topics: Animals; Capillaries; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells, Culture | 2004 |
Inhibition and mechanism of action of a protease inhibitor in human pancreatic cancer cells.
Topics: Adenocarcinoma; Animals; Cell Division; Cell Line, Tumor; Collagen; Drug Combinations; Enzyme Induct | 2004 |
Action of antiproteases on pancreatic cancer cells.
Topics: Adenocarcinoma; Cell Line, Tumor; Cell Proliferation; Extracellular Matrix; Gabexate; Humans; Neopla | 2007 |