gabexate has been researched along with Hypertension in 5 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with camostat mesilate or FOY-251 decreased equivalent current (Ieq) in M-1 cells in a dose-dependent manner and inhibited the protease activity of prostasin in vitro." | 5.35 | Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. ( Adachi, M; Kakizoe, Y; Kitamura, K; Ko, T; Maekawa, A; Miyoshi, T; Shiraishi, N; Tomita, K; Wakida, N, 2009) |
| "To determine the role of the kallikrein-kinin (KK) system in patients with diabetes mellitus in relation to nephropathy and/or hypertension, the single-dose effects of captopril (25 mg, p." | 3.67 | The hypotensive effect of single-dose captopril in diabetics. ( Chimori, K; Kosaka, J; Miura, K; Miyazaki, S; Sakanaka, A; Yasuda, K, 1986) |
| "Treatment with camostat mesilate or FOY-251 decreased equivalent current (Ieq) in M-1 cells in a dose-dependent manner and inhibited the protease activity of prostasin in vitro." | 1.35 | Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. ( Adachi, M; Kakizoe, Y; Kitamura, K; Ko, T; Maekawa, A; Miyoshi, T; Shiraishi, N; Tomita, K; Wakida, N, 2009) |
| "These changes included acute disseminated intravascular coagulation, severe elevations of liver enzymes, severe renal dysfunction, and hemolytic anemia." | 1.27 | A case of postpartum hemolytic uremic syndrome with severe elevations of liver enzymes. ( Fujii, S; Kanzaki, H; Kariya, M; Matsuura, S; Mori, T; Sagawa, N, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maekawa, A | 1 |
| Kakizoe, Y | 1 |
| Miyoshi, T | 1 |
| Wakida, N | 1 |
| Ko, T | 1 |
| Shiraishi, N | 1 |
| Adachi, M | 1 |
| Tomita, K | 2 |
| Kitamura, K | 2 |
| Ura, N | 1 |
| Shimamoto, K | 1 |
| Nakao, T | 1 |
| Ogasawara, A | 1 |
| Tanaka, S | 1 |
| Mita, T | 1 |
| Nishimiya, T | 1 |
| Iimura, O | 1 |
| Chimori, K | 1 |
| Miyazaki, S | 1 |
| Kosaka, J | 1 |
| Sakanaka, A | 1 |
| Yasuda, K | 1 |
| Miura, K | 1 |
| Sagawa, N | 1 |
| Kariya, M | 1 |
| Kanzaki, H | 1 |
| Fujii, S | 1 |
| Matsuura, S | 1 |
| Mori, T | 1 |
1 review available for gabexate and Hypertension
| Article | Year |
|---|---|
Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension.
Topics: Animals; Epithelial Sodium Channels; Esters; Furin; Gabexate; Guanidines; Humans; Hypertension; Rats | 2012 |
4 other studies available for gabexate and Hypertension
| Article | Year |
|---|---|
Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension.
Topics: Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Cells, Cultured; Esters; Gabexate; Gu | 2009 |
The excretion of human urinary kallikrein quantity and activity in normal and low renin subgroups of essential hypertension.
Topics: Adult; Aged; Aprotinin; Clinical Enzyme Tests; Female; Gabexate; Guanidines; Humans; Hypertension; K | 1983 |
The hypotensive effect of single-dose captopril in diabetics.
Topics: Blood Pressure; Captopril; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Drug E | 1986 |
A case of postpartum hemolytic uremic syndrome with severe elevations of liver enzymes.
Topics: Adult; Alkaline Phosphatase; Disseminated Intravascular Coagulation; Female; Furosemide; Gabexate; G | 1985 |