gabexate has been researched along with Hemorrhage in 12 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Hemorrhage: Bleeding or escape of blood from a vessel.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of the cholecystokinin (CCK)-receptor antagonist proglumide, the protease inhibitor gabexate, and the hormones secretin and cholecystokinin-octapeptide (CCK-8) were studied in a model of acute hemorrhagic pancreatitis induced by feeding mice a choline-deficient, ethionine-supplemented (CDE) diet." | 7.67 | Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. ( Ferrell, LD; Grendell, JH; Liddle, RA; Niederau, C, 1986) |
| "The effects of gabexate mesilate (GM) on hemodynamics and phospholipase A2 activities (PLA2) during acute hemorrhagic pancreatitis (AHP) were studied in 17 piglets which were randomly divided into three groups: The control group (CG) received only the fluid replacement, whereas the pretreatment group (PG) was given an infusion of GM (20 mg/kg/5h), which was started 30 min before and in the treatment group (TG) 30 min after the induction of AHP." | 7.67 | The effect of gabexate mesilate on the outcome of acute hemorrhagic pancreatitis in pigs. ( Gröhn, P; Kiviniemi, H; Mahlberg, K; Mokka, RE; Rämö, OJ; Ristkari, SK, 1989) |
| "The efficacy of gabexate mesilate (FOY), a synthetic serine proteinase inhibitor, was compared with that of heparin in preventing the acceleration of bleeding after hemodialysis." | 7.67 | Hemodialysis using gabexate mesilate (FOY) in patients with a high bleeding risk. ( Okada, T; Shimada, Y; Tachimori, Y; Taenaka, N; Takahashi, H; Takezawa, J; Terada, N; Yoshiya, I, 1986) |
| "The effects of the cholecystokinin (CCK)-receptor antagonist proglumide, the protease inhibitor gabexate, and the hormones secretin and cholecystokinin-octapeptide (CCK-8) were studied in a model of acute hemorrhagic pancreatitis induced by feeding mice a choline-deficient, ethionine-supplemented (CDE) diet." | 3.67 | Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. ( Ferrell, LD; Grendell, JH; Liddle, RA; Niederau, C, 1986) |
| "The effects of gabexate mesilate (GM) on hemodynamics and phospholipase A2 activities (PLA2) during acute hemorrhagic pancreatitis (AHP) were studied in 17 piglets which were randomly divided into three groups: The control group (CG) received only the fluid replacement, whereas the pretreatment group (PG) was given an infusion of GM (20 mg/kg/5h), which was started 30 min before and in the treatment group (TG) 30 min after the induction of AHP." | 3.67 | The effect of gabexate mesilate on the outcome of acute hemorrhagic pancreatitis in pigs. ( Gröhn, P; Kiviniemi, H; Mahlberg, K; Mokka, RE; Rämö, OJ; Ristkari, SK, 1989) |
| "The efficacy of gabexate mesilate (FOY), a synthetic serine proteinase inhibitor, was compared with that of heparin in preventing the acceleration of bleeding after hemodialysis." | 3.67 | Hemodialysis using gabexate mesilate (FOY) in patients with a high bleeding risk. ( Okada, T; Shimada, Y; Tachimori, Y; Taenaka, N; Takahashi, H; Takezawa, J; Terada, N; Yoshiya, I, 1986) |
| "In mongrel dogs with induced pancreatitis we studied the effects of the nonspecific phospholipase A2-inhibitors chlorpromazine, gabexate mesilate and CaNa2EDTA on the course of pancreatogenic shock and the intrapancreatic lysolecithin production." | 3.67 | [Phospholipase A2 inhibitors in hemorrhagic-necrotizing pancreatitis. Animal experiment evaluation of a new treatment concept]. ( Alles, JU; Kahle, M; Klein, U; König, W; Martin, U, 1985) |
| "Gabexate mesilate (FOY), a synthetic serine proteinase inhibitor, prevented and controlled bleeding during hemodialysis of 3 patients with active bleeding sites and/or hemorrhagic tendencies." | 3.66 | New approach to regional anticoagulation in hemodialysis using gabexate mesilate (FOY). ( Hirata, T; Nishijima, M; Shimada, Y; Taenaka, N; Yoshiya, I, 1982) |
| "Acute pancreatitis was induced in 19 anesthetized dogs by retrograde injection of bile mixed with trypsin into the pancreatic duct." | 1.28 | Synthetic antiproteases in acute pancreatitis: an experimental study. ( Babicki, A; Basiński, A; Dobosz, M; Juszkiewicz, P; Sledziński, Z; Wajda, Z, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (50.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Steinmetzer, T | 1 |
| Pilgram, O | 1 |
| Wenzel, BM | 1 |
| Wiedemeyer, SJA | 1 |
| Hashimoto, D | 1 |
| Okawa, T | 1 |
| Maruyama, R | 1 |
| Matsumura, F | 1 |
| Shibata, Y | 1 |
| Kohrogi, H | 1 |
| Oh, MJ | 1 |
| Kim, TN | 1 |
| Saito, T | 1 |
| Tsuchiya, M | 1 |
| Shikata, C | 1 |
| Yamaguchi, H | 1 |
| Miyata, S | 1 |
| Matsuo, S | 1 |
| Ishizawa, S | 1 |
| Yoshimura, K | 1 |
| Taenaka, N | 2 |
| Shimada, Y | 2 |
| Hirata, T | 1 |
| Nishijima, M | 1 |
| Yoshiya, I | 2 |
| Kinugasa, E | 1 |
| Makita, T | 1 |
| Akizawa, T | 1 |
| Koshikawa, S | 1 |
| Dobosz, M | 1 |
| Sledziński, Z | 1 |
| Babicki, A | 1 |
| Juszkiewicz, P | 1 |
| Basiński, A | 1 |
| Wajda, Z | 1 |
| Niederau, C | 1 |
| Liddle, RA | 1 |
| Ferrell, LD | 1 |
| Grendell, JH | 1 |
| Ristkari, SK | 1 |
| Rämö, OJ | 1 |
| Kiviniemi, H | 1 |
| Gröhn, P | 1 |
| Mahlberg, K | 1 |
| Mokka, RE | 1 |
| Masuda, M | 1 |
| Fukamachi, K | 1 |
| Matsuzaki, K | 1 |
| Asou, T | 1 |
| Toshima, Y | 1 |
| Kinoshita, K | 1 |
| Mayumi, H | 1 |
| Tominaga, R | 1 |
| Miyamoto, K | 1 |
| Komori, M | 1 |
| Terada, N | 1 |
| Takahashi, H | 1 |
| Tachimori, Y | 1 |
| Okada, T | 1 |
| Takezawa, J | 1 |
| Kahle, M | 1 |
| Klein, U | 1 |
| König, W | 1 |
| Martin, U | 1 |
| Alles, JU | 1 |
1 review available for gabexate and Hemorrhage
| Article | Year |
|---|---|
Anticoagulant Therapy for Disseminated Intravascular Coagulation After Gastrointestinal Surgery.
Topics: Anticoagulants; Digestive System Surgical Procedures; Disseminated Intravascular Coagulation; Gabexa | 2019 |
1 trial available for gabexate and Hemorrhage
| Article | Year |
|---|---|
Prospective comparative study of endoscopic papillary large balloon dilation and endoscopic sphincterotomy for removal of large bile duct stones in patients above 45 years of age.
Topics: Aged; Aged, 80 and over; Ampulla of Vater; Anticoagulants; Catheterization; Chi-Square Distribution; | 2012 |
10 other studies available for gabexate and Hemorrhage
| Article | Year |
|---|---|
Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding.
Topics: Animals; Antifibrinolytic Agents; Catalytic Domain; Crystallography, X-Ray; Fibrinolysin; Fibrinolys | 2020 |
Microscopic polyangiitis associated with marked systemic bleeding tendency caused by disseminated intravascular coagulation.
Topics: Antibodies, Antineutrophil Cytoplasmic; Anticoagulants; Disseminated Intravascular Coagulation; Fata | 2003 |
New approach to regional anticoagulation in hemodialysis using gabexate mesilate (FOY).
Topics: Aged; Anticoagulants; Female; Gabexate; Guanidines; Hemorrhage; Humans; Male; Middle Aged; Renal Dia | 1982 |
[Treatment of uremic patients at high bleeding risk].
Topics: Benzamidines; Blood Transfusion; Deamino Arginine Vasopressin; Gabexate; Guanidines; Hemorrhage; Hep | 1992 |
Synthetic antiproteases in acute pancreatitis: an experimental study.
Topics: Acute Disease; Animals; Benzamidines; Dogs; Gabexate; Guanidines; Hemodynamics; Hemorrhage; Pancreat | 1992 |
Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Cholecystokinin; Choline Deficiency; Disease Models, Animal; Ethio | 1986 |
The effect of gabexate mesilate on the outcome of acute hemorrhagic pancreatitis in pigs.
Topics: Acute Disease; Animals; Gabexate; Guanidines; Hemodynamics; Hemorrhage; Pancreatitis; Phospholipases | 1989 |
[Clinical assessment of anticoagulation therapy during left ventricular assist with artificial heart: induction with protease inhibitor].
Topics: Aged; Assisted Circulation; Benzamidines; Drug Evaluation; Drug Therapy, Combination; Gabexate; Guan | 1989 |
Hemodialysis using gabexate mesilate (FOY) in patients with a high bleeding risk.
Topics: Acute Kidney Injury; Adult; Aged; Anticoagulants; Blood Transfusion; Blood Volume; Drug Evaluation; | 1986 |
[Phospholipase A2 inhibitors in hemorrhagic-necrotizing pancreatitis. Animal experiment evaluation of a new treatment concept].
Topics: Acute Disease; Animals; Chlorpromazine; Dogs; Edetic Acid; Female; Gabexate; Guanidines; Hemodynamic | 1985 |