gabexate has been researched along with Diabetic Nephropathies in 4 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the role of the kallikrein-kinin (KK) system in patients with diabetes mellitus in relation to nephropathy and/or hypertension, the single-dose effects of captopril (25 mg, p." | 3.67 | The hypotensive effect of single-dose captopril in diabetics. ( Chimori, K; Kosaka, J; Miura, K; Miyazaki, S; Sakanaka, A; Yasuda, K, 1986) |
| "Camostat mesilate is a developed derivative of gabexate mesilate for oral administration and is known to be one of the most potent protease inhibitors." | 1.28 | Effect of camostat mesilate for the treatment of advanced diabetic nephropathy. ( Hotta, O; Ishizaki, M; Kurosawa, K; Matsubara, M; Suzuki, K; Taguma, Y, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikeda, T | 1 |
| Hoshino, T | 1 |
| Matsubara, M | 2 |
| Taguma, Y | 2 |
| Saito, T | 1 |
| Yoshinaga, K | 1 |
| Kurosawa, K | 1 |
| Hotta, O | 1 |
| Suzuki, K | 1 |
| Ishizaki, M | 1 |
| Chimori, K | 1 |
| Miyazaki, S | 1 |
| Kosaka, J | 1 |
| Sakanaka, A | 1 |
| Yasuda, K | 1 |
| Miura, K | 1 |
1 trial available for gabexate and Diabetic Nephropathies
| Article | Year |
|---|---|
Anti-proteinuric and anti-coagulatory effects of camostat mesilate in azotemic diabetics.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Blood Coagulation; Captopril; | 1992 |
3 other studies available for gabexate and Diabetic Nephropathies
| Article | Year |
|---|---|
An inhibition of urinary albumin excretion by protease inhibitor in streptozotocin-diabetic rats.
Topics: Albuminuria; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephr | 1996 |
Effect of camostat mesilate for the treatment of advanced diabetic nephropathy.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Diabetic Nephropathies; Drug Therapy, Combina | 1990 |
The hypotensive effect of single-dose captopril in diabetics.
Topics: Blood Pressure; Captopril; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Drug E | 1986 |