gabexate has been researched along with Complication, Postoperative in 16 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gabexate mesylate reduces the incidence of post-ERCP pancreatitis." | 9.12 | Efficacy of postprocedure administration of gabexate mesylate in the prevention of post-ERCP pancreatitis: a randomized, controlled, multicenter study. ( Ardizzone, S; Lombardi, G; Manes, G; Pieramico, O; Porro, GB; Uomo, G, 2007) |
| "We employed the method recommended by the Cochrane Collaboration to perform a meta-analysis of randomized controlled trials (RCTs) of gabexate in the prevention of post-ERCP pancreatitis (PEP) including three RCTs conducted in Italy and one in China." | 8.84 | Gabexate in the prophylaxis of post-ERCP pancreatitis: a meta-analysis of randomized controlled trials. ( Chen, Y; Li, J; Yang, X; Zeng, Q; Zhang, Y; Zheng, M, 2007) |
| "Gabexate mesylate reduces the incidence of post-ERCP pancreatitis." | 5.12 | Efficacy of postprocedure administration of gabexate mesylate in the prevention of post-ERCP pancreatitis: a randomized, controlled, multicenter study. ( Ardizzone, S; Lombardi, G; Manes, G; Pieramico, O; Porro, GB; Uomo, G, 2007) |
| "Reduction of systemic inflammatory response syndrome duration after esophagectomy by the continuous administration of gabexate mesilate started before operation may be through the suppression of TNF-alpha production capacity and Mac-1 expression on monocytes immediately after operation, and to suppression of increase in serum IL-6 level." | 5.09 | Effects of a protease inhibitor on reduction of surgical stress in esophagectomy. ( Aosasa, S; Mochizuki, H; Ono, S, 1999) |
| "We employed the method recommended by the Cochrane Collaboration to perform a meta-analysis of randomized controlled trials (RCTs) of gabexate in the prevention of post-ERCP pancreatitis (PEP) including three RCTs conducted in Italy and one in China." | 4.84 | Gabexate in the prophylaxis of post-ERCP pancreatitis: a meta-analysis of randomized controlled trials. ( Chen, Y; Li, J; Yang, X; Zeng, Q; Zhang, Y; Zheng, M, 2007) |
| "The pathogenesis of reflux esophagitis is not well understood and remains controversial." | 2.71 | Oral trypsin inhibitor can improve reflux esophagitis after distal gastrectomy concomitant with decreased trypsin activity. ( Fujii, H; Kamiyasu, K; Kono, K; Sugai, H; Takahashi, A; Teramatsu, M; Umekawa, T; Yano, T, 2005) |
| "Acute pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP)." | 2.44 | Early successes and late failures in the prevention of post endoscopic retrograde cholangiopancreatography. ( Draganov, PV; Lieb, JG, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adachi, T | 1 |
| Ono, S | 2 |
| Matsushima, H | 1 |
| Soyama, A | 1 |
| Hidaka, M | 1 |
| Takatsuki, M | 1 |
| Eguchi, S | 1 |
| Akahoshi, T | 1 |
| Sugimori, H | 1 |
| Kaku, N | 1 |
| Tokuda, K | 1 |
| Nagata, T | 1 |
| Noda, E | 1 |
| Morita, M | 1 |
| Hashizume, M | 1 |
| Maehara, Y | 1 |
| Kono, K | 1 |
| Takahashi, A | 1 |
| Sugai, H | 1 |
| Umekawa, T | 1 |
| Yano, T | 1 |
| Kamiyasu, K | 2 |
| Teramatsu, M | 1 |
| Fujii, H | 1 |
| Zheng, M | 1 |
| Chen, Y | 1 |
| Yang, X | 1 |
| Li, J | 1 |
| Zhang, Y | 1 |
| Zeng, Q | 1 |
| Manes, G | 1 |
| Ardizzone, S | 1 |
| Lombardi, G | 1 |
| Uomo, G | 1 |
| Pieramico, O | 1 |
| Porro, GB | 1 |
| Lieb, JG | 1 |
| Draganov, PV | 1 |
| Tamakuma, S | 1 |
| Kambayashi, J | 1 |
| Ogawa, Y | 1 |
| Kosaki, G | 1 |
| Chihara, K | 1 |
| Akiyama, F | 1 |
| Shinozaki, T | 1 |
| Shimamoto, M | 1 |
| Takahashi, K | 1 |
| Imura, H | 1 |
| Yamazaki, F | 1 |
| Kawarazaki, S | 1 |
| Huibregtse, K | 1 |
| Okada, Y | 1 |
| Hino, H | 1 |
| Nagahama, H | 1 |
| Kinouchi, H | 1 |
| Sakamoto, M | 1 |
| Aoki, T | 1 |
| Aosasa, S | 1 |
| Mochizuki, H | 1 |
| Awata, H | 1 |
| Inoshiri, S | 1 |
| Doi, A | 1 |
| Omawari, N | 1 |
| Okegawa, T | 1 |
| Kawasaki, A | 1 |
| Shinomiya, K | 1 |
| Tanaka, M | 1 |
| Suzuki, Y | 1 |
| Tsuzuki, T | 1 |
| Toyama, K | 1 |
| Nakayasu, K | 1 |
| Iida, S | 1 |
| Ueda, M | 1 |
| Toizumi, A | 1 |
| Asanuma, Y | 1 |
| Sugai, K | 1 |
| Akutsu, Y | 1 |
| Mori, K | 1 |
| Koyama, K | 1 |
| Owada, Y | 1 |
| Sato, T | 1 |
| Kabuto, T | 1 |
| Furukawa, H | 1 |
| Imaoka, S | 1 |
| Iwanaga, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fistulotomy as the Primary Cannulation Technique for All Patients Undergoing ERCP: A Randomized, Controlled Trial[NCT04559867] | 538 participants (Anticipated) | Interventional | 2020-09-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for gabexate and Complication, Postoperative
| Article | Year |
|---|---|
Gabexate in the prophylaxis of post-ERCP pancreatitis: a meta-analysis of randomized controlled trials.
Topics: Acute Disease; Cholangiopancreatography, Endoscopic Retrograde; Gabexate; Humans; Linear Models; Odd | 2007 |
Early successes and late failures in the prevention of post endoscopic retrograde cholangiopancreatography.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Cholangiopancreatography, Endoscopic | 2007 |
3 trials available for gabexate and Complication, Postoperative
| Article | Year |
|---|---|
Oral trypsin inhibitor can improve reflux esophagitis after distal gastrectomy concomitant with decreased trypsin activity.
Topics: Administration, Oral; Aged; Esophagitis, Peptic; Esters; Female; Gabexate; Gastrectomy; Gastroentero | 2005 |
Efficacy of postprocedure administration of gabexate mesylate in the prevention of post-ERCP pancreatitis: a randomized, controlled, multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Cholangiopancreatography, Endoscopic Retrograde; Dose-Response Relat | 2007 |
Effects of a protease inhibitor on reduction of surgical stress in esophagectomy.
Topics: Aged; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administ | 1999 |
11 other studies available for gabexate and Complication, Postoperative
| Article | Year |
|---|---|
Efficacy of Triple-Drug Therapy to Prevent Pancreatic Fistulas in Patients With High Drain Amylase Levels After Pancreaticoduodenectomy.
Topics: Adult; Aged; Aged, 80 and over; Amylases; Carbapenems; Drug Therapy, Combination; Gabexate; Humans; | 2019 |
Comparison of recombinant human thrombomodulin and gabexate mesylate for treatment of disseminated intravascular coagulation (DIC) with sepsis following emergent gastrointestinal surgery: a retrospective study.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Critical Care; Disseminated Intravascular Coagulatio | 2015 |
[Severe surgical infection and DIC].
Topics: Adult; Aged; Animals; Bacterial Infections; Blood Coagulation Factors; Disseminated Intravascular Co | 1983 |
[Fungal sepsis and DIC in surgical patients].
Topics: Adult; Aged; Amphotericin B; Disseminated Intravascular Coagulation; Female; Flucytosine; Gabexate; | 1983 |
[Disseminated intravascular coagulation (DIC) following open heart surgery and great vessel surgery. The result of early administration of gabexate mesilate (FOY)].
Topics: Adolescent; Adult; Aged; Blood Transfusion; Cardiac Surgical Procedures; Coronary Disease; Dissemina | 1984 |
Complications of endoscopic sphincterotomy and their prevention.
Topics: Cholangiopancreatography, Endoscopic Retrograde; Clinical Competence; Gabexate; Humans; Pancreatitis | 1996 |
[Anesthesia in two patients with essential thrombocythemia].
Topics: Aged; Aged, 80 and over; Anesthesia, Epidural; Anesthesia, Inhalation; Anesthesia, Intravenous; Anti | 1997 |
[Effects of FOY-305 on post-operative reflux esophagitis in rats (I). Effects of FOY-305 on reflux esophagitis after total gastrectomy in rats].
Topics: Alginates; Animals; Body Weight; Cimetidine; Disease Models, Animal; Esophagitis, Peptic; Esters; Ga | 1991 |
Disseminated intravascular coagulation after hepatic resection.
Topics: Anticoagulants; Bile Ducts; Carcinoma, Hepatocellular; Disseminated Intravascular Coagulation; Fibri | 1990 |
[Coagulation studies in patients after abdominal surgery].
Topics: Abdomen; Anticoagulants; Blood Coagulation; Blood Coagulation Disorders; Gabexate; Guanidines; Human | 1986 |
[Therapy of postoperative hypoxia following mediastinal lymph node excision of esophageal cancer].
Topics: Aged; Animals; Dogs; Esophageal Neoplasms; Gabexate; Guanidines; Humans; Hypoxia; Lymph Node Excisio | 1987 |