gabexate has been researched along with Carcinoma, Squamous Cell in 8 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Reduction of systemic inflammatory response syndrome duration after esophagectomy by the continuous administration of gabexate mesilate started before operation may be through the suppression of TNF-alpha production capacity and Mac-1 expression on monocytes immediately after operation, and to suppression of increase in serum IL-6 level." | 5.09 | Effects of a protease inhibitor on reduction of surgical stress in esophagectomy. ( Aosasa, S; Mochizuki, H; Ono, S, 1999) |
| "Sixty-one patients operated for esophageal cancer from 1996 to 2000 were treated postoperatively with low dose dopamine (300 microg/kg/h), gabexate mesilate (80 mg/h), and ulinastatin (300 000 unit/day) as a study group." | 1.33 | Use of low dose dopamine, gabexate mesilate and ulinastatin reduces the water balance and pulmonary complication in thoracic esophagectomy patients. ( Fujii, Y; Ishiguro, H; Kimura, M; Kuwabara, Y; Sato, A; Shinoda, N, 2005) |
| " This drug at a dosage of 10 mg/kg or 20 mg/kg was administered by ip injection to 20 mice each harboring a solitary tumor twice daily for 10 weeks." | 1.26 | Inhibition of growth of 3-methylcholanthrene-induced mouse skin tumor by protease inhibitor [N,N-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)-phenylacetate] methanesulfate. ( Ohkoshi, M, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sato, A | 1 |
| Kuwabara, Y | 1 |
| Shinoda, N | 1 |
| Kimura, M | 1 |
| Ishiguro, H | 1 |
| Fujii, Y | 1 |
| Ohkoshi, M | 6 |
| Fujii, S | 3 |
| Oka, T | 1 |
| Ono, S | 1 |
| Aosasa, S | 1 |
| Mochizuki, H | 1 |
1 review available for gabexate and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
[Protease inhibitors as anticancer chemotherapy--experimental and clinical studies].
Topics: Adenocarcinoma; Animals; Carcinoma, Lewis Lung; Carcinoma, Squamous Cell; Cell Division; Colonic Neo | 1995 |
1 trial available for gabexate and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
Effects of a protease inhibitor on reduction of surgical stress in esophagectomy.
Topics: Aged; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administ | 1999 |
6 other studies available for gabexate and Carcinoma, Squamous Cell