gabexate has been researched along with Cancer of Pancreas in 16 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In about 1% acute pancreatitis or recurrency of chronic pancreatitis occurs." | 2.65 | [Effect of secretin and gabexate-mesilate (synthetic protease inhibitor) on serum amylase level after ERCP]. ( Rösch, W; Tympner, F, 1982) |
| "Transforming growth factor beta1 (TGF-beta1) is a multifunctional poly-peptide that regulates cell growth and differentiation, ECM deposition, cellular adhesion properties, angiogenesis, and also immune functions." | 1.32 | Inhibition and mechanism of action of a protease inhibitor in human pancreatic cancer cells. ( Hirakawa, K; Maeda, K; Nishihara, T; Ohira, M; Sawada, T; Uchima, Y, 2004) |
| "Cholecystokinin is thought to be an important factor regulating the growth of human pancreatic cancers." | 1.29 | Loxiglumide (CR1505), a cholecystokinin antagonist, specifically inhibits the growth of human pancreatic cancer lines xenografted into nude mice. ( Fukumoto, M; Hayashi, H; Imamura, M; Kawabata, K; Manabe, T; Masai, Y; Morimoto, H; Nio, Y; Tsubono, M, 1993) |
| "Camostate caused an increase in growth of the pancreas and a decrease in the number of (pre)neoplastic ductular pancreatic lesions." | 1.28 | Effects of the synthetic trypsin inhibitor camostate on the development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic lesions in hamsters. ( Jansen, JB; Lamers, CB; Meijers, M; Rovati, LC; van Garderen-Hoetmer, A; Woutersen, RA, 1991) |
| "Camostate has been shown to induce pancreatic enlargement in rats by the same mechanism." | 1.27 | Stimulation of the growth of azaserine-induced nodules in the rat pancreas by dietary camostate (FOY-305). ( Lhoste, EF; Longnecker, DS; Roebuck, BD, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 8 (50.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brandi, G | 1 |
| Tavolari, S | 1 |
| Guarnieri, T | 1 |
| Di Marco, M | 1 |
| Paterini, P | 1 |
| Macchini, M | 1 |
| Di Girolamo, S | 1 |
| Papi, A | 1 |
| De Rosa, F | 1 |
| Biasco, G | 1 |
| Daniluk, J | 1 |
| Liu, Y | 1 |
| Deng, D | 1 |
| Chu, J | 1 |
| Huang, H | 1 |
| Gaiser, S | 1 |
| Cruz-Monserrate, Z | 1 |
| Wang, H | 1 |
| Ji, B | 1 |
| Logsdon, CD | 1 |
| Uchima, Y | 2 |
| Sawada, T | 2 |
| Nishihara, T | 1 |
| Maeda, K | 1 |
| Ohira, M | 1 |
| Hirakawa, K | 2 |
| Takahashi, H | 1 |
| Funahashi, H | 1 |
| Sawai, H | 1 |
| Matsuo, Y | 1 |
| Yamamoto, M | 1 |
| Okada, Y | 1 |
| Takeyama, H | 1 |
| Manabe, T | 4 |
| Tympner, F | 1 |
| Rösch, W | 1 |
| Furukawa, F | 1 |
| Nishikawa, A | 1 |
| Imazawa, T | 1 |
| Yoshimura, H | 1 |
| Sato, M | 1 |
| Aze, Y | 1 |
| Takahashi, M | 1 |
| Asano, N | 2 |
| Yoshimura, T | 2 |
| Suwa, H | 1 |
| Imamura, T | 1 |
| Ohshio, G | 1 |
| Nio, Y | 1 |
| Tsubono, M | 1 |
| Morimoto, H | 1 |
| Kawabata, K | 1 |
| Masai, Y | 1 |
| Hayashi, H | 1 |
| Imamura, M | 1 |
| Fukumoto, M | 1 |
| Watanapa, P | 1 |
| Williamson, RC | 1 |
| Ohta, T | 1 |
| Futagami, F | 1 |
| Arakawa, H | 1 |
| Tsukioka, Y | 1 |
| Kitagawa, H | 1 |
| Kayahara, M | 1 |
| Nagakawa, T | 1 |
| Miyazaki, I | 1 |
| Meijers, M | 1 |
| van Garderen-Hoetmer, A | 1 |
| Lamers, CB | 2 |
| Rovati, LC | 2 |
| Jansen, JB | 2 |
| Woutersen, RA | 2 |
| Imanishi, K | 1 |
| Tobe, T | 1 |
| Silverman, JA | 1 |
| Kuhlmann, ET | 1 |
| Zurlo, J | 1 |
| Yager, JD | 1 |
| Longnecker, DS | 2 |
| Douglas, BR | 1 |
| de Jong, AJ | 1 |
| Lhoste, EF | 1 |
| Roebuck, BD | 1 |
2 reviews available for gabexate and Cancer of Pancreas
| Article | Year |
|---|---|
Experimental pancreatic hyperplasia and neoplasia: effects of dietary and surgical manipulation.
Topics: Animals; Cricetinae; Diet; Disease Models, Animal; Energy Intake; Esters; Flour; Gabexate; Glycine m | 1993 |
[Inhibitory effect of FOY-305 on liver metastasis of the pancreatic cancer].
Topics: Animals; Esters; Gabexate; Guanidines; Humans; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplan | 1996 |
1 trial available for gabexate and Cancer of Pancreas
| Article | Year |
|---|---|
[Effect of secretin and gabexate-mesilate (synthetic protease inhibitor) on serum amylase level after ERCP].
Topics: Alkaline Phosphatase; Amylases; Cholangiopancreatography, Endoscopic Retrograde; Chronic Disease; Do | 1982 |
13 other studies available for gabexate and Cancer of Pancreas
| Article | Year |
|---|---|
Antiprotease strategy in pancreatic cancer treatment: emergence from a preclinical study.
Topics: Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Proto | 2014 |
An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Transformation, Neoplastic; Ceruletide; Cyclooxygenase 2 | 2012 |
Inhibition and mechanism of action of a protease inhibitor in human pancreatic cancer cells.
Topics: Adenocarcinoma; Animals; Cell Division; Cell Line, Tumor; Collagen; Drug Combinations; Enzyme Induct | 2004 |
Synthetic serine protease inhibitor, gabexate mesilate, prevents nuclear factor-kappaB activation and increases TNF-alpha-mediated apoptosis in human pancreatic cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Gabexate; Humans; NF-kappa B; Pancreatic Neoplasms; | 2007 |
Action of antiproteases on pancreatic cancer cells.
Topics: Adenocarcinoma; Cell Line, Tumor; Cell Proliferation; Extracellular Matrix; Gabexate; Humans; Neopla | 2007 |
Blocking effects of synthetic trypsin inhibitor (camostat) on pancreatic carcinogenesis in hamsters initiated with N-nitrosobis(2-oxopropyl)amine.
Topics: Adenocarcinoma; Animals; Carcinogens; Cricetinae; Esters; Female; Gabexate; Guanidines; Mesocricetus | 1994 |
Effect of synthetic protease inhibitor on histologic changes and free radical activity in hamsters with pancreatic cancer.
Topics: Adenocarcinoma; Adenocarcinoma, Papillary; Animals; Carcinogens; Cricetinae; Esters; Free Radical Sc | 1993 |
Loxiglumide (CR1505), a cholecystokinin antagonist, specifically inhibits the growth of human pancreatic cancer lines xenografted into nude mice.
Topics: Animals; Cell Division; Chloroquine; Cholecystokinin; DNA; Esters; Gabexate; Guanidines; Humans; Mic | 1993 |
Effects of the synthetic trypsin inhibitor camostate on the development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic lesions in hamsters.
Topics: Animals; Carcinogens; Carcinoma; Carcinoma in Situ; Cholecystokinin; Cricetinae; Esters; Gabexate; G | 1991 |
[Effect of synthetic protease inhibitor on the oncogenesis of pancreatic cancer in hamsters: study on pancreatic endocrine cells and free radicals].
Topics: Animals; Cricetinae; Esters; Free Radical Scavengers; Free Radicals; Gabexate; Glutathione; Guanidin | 1991 |
Expression of c-myc, c-raf-1, and c-Ki-ras in azaserine-induced pancreatic carcinomas and growing pancreas in rats.
Topics: Adenoma; Animals; Azaserine; Blotting, Northern; Carcinoma; Cell Cycle; Esters; Gabexate; Gene Expre | 1990 |
Modulation by CR-1409 (lorglumide), a cholecystokinin receptor antagonist, of trypsin inhibitor-enhanced growth of azaserine-induced putative preneoplastic lesions in rat pancreas.
Topics: Animals; Azaserine; Cholecystokinin; Esters; Gabexate; Glutamine; Guanidines; Male; Pancreatic Neopl | 1989 |
Stimulation of the growth of azaserine-induced nodules in the rat pancreas by dietary camostate (FOY-305).
Topics: Animals; Azaserine; Carcinogens; Cell Division; Diet; Esters; Gabexate; Guanidines; Pancreas; Pancre | 1988 |