gabexate has been researched along with Blood Pressure, High in 5 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with camostat mesilate or FOY-251 decreased equivalent current (Ieq) in M-1 cells in a dose-dependent manner and inhibited the protease activity of prostasin in vitro." | 5.35 | Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. ( Adachi, M; Kakizoe, Y; Kitamura, K; Ko, T; Maekawa, A; Miyoshi, T; Shiraishi, N; Tomita, K; Wakida, N, 2009) |
| "To determine the role of the kallikrein-kinin (KK) system in patients with diabetes mellitus in relation to nephropathy and/or hypertension, the single-dose effects of captopril (25 mg, p." | 3.67 | The hypotensive effect of single-dose captopril in diabetics. ( Chimori, K; Kosaka, J; Miura, K; Miyazaki, S; Sakanaka, A; Yasuda, K, 1986) |
| "Treatment with camostat mesilate or FOY-251 decreased equivalent current (Ieq) in M-1 cells in a dose-dependent manner and inhibited the protease activity of prostasin in vitro." | 1.35 | Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. ( Adachi, M; Kakizoe, Y; Kitamura, K; Ko, T; Maekawa, A; Miyoshi, T; Shiraishi, N; Tomita, K; Wakida, N, 2009) |
| "These changes included acute disseminated intravascular coagulation, severe elevations of liver enzymes, severe renal dysfunction, and hemolytic anemia." | 1.27 | A case of postpartum hemolytic uremic syndrome with severe elevations of liver enzymes. ( Fujii, S; Kanzaki, H; Kariya, M; Matsuura, S; Mori, T; Sagawa, N, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maekawa, A | 1 |
| Kakizoe, Y | 1 |
| Miyoshi, T | 1 |
| Wakida, N | 1 |
| Ko, T | 1 |
| Shiraishi, N | 1 |
| Adachi, M | 1 |
| Tomita, K | 2 |
| Kitamura, K | 2 |
| Ura, N | 1 |
| Shimamoto, K | 1 |
| Nakao, T | 1 |
| Ogasawara, A | 1 |
| Tanaka, S | 1 |
| Mita, T | 1 |
| Nishimiya, T | 1 |
| Iimura, O | 1 |
| Chimori, K | 1 |
| Miyazaki, S | 1 |
| Kosaka, J | 1 |
| Sakanaka, A | 1 |
| Yasuda, K | 1 |
| Miura, K | 1 |
| Sagawa, N | 1 |
| Kariya, M | 1 |
| Kanzaki, H | 1 |
| Fujii, S | 1 |
| Matsuura, S | 1 |
| Mori, T | 1 |
1 review available for gabexate and Blood Pressure, High
| Article | Year |
|---|---|
Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension.
Topics: Animals; Epithelial Sodium Channels; Esters; Furin; Gabexate; Guanidines; Humans; Hypertension; Rats | 2012 |
4 other studies available for gabexate and Blood Pressure, High
| Article | Year |
|---|---|
Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension.
Topics: Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Cells, Cultured; Esters; Gabexate; Gu | 2009 |
The excretion of human urinary kallikrein quantity and activity in normal and low renin subgroups of essential hypertension.
Topics: Adult; Aged; Aprotinin; Clinical Enzyme Tests; Female; Gabexate; Guanidines; Humans; Hypertension; K | 1983 |
The hypotensive effect of single-dose captopril in diabetics.
Topics: Blood Pressure; Captopril; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Drug E | 1986 |
A case of postpartum hemolytic uremic syndrome with severe elevations of liver enzymes.
Topics: Adult; Alkaline Phosphatase; Disseminated Intravascular Coagulation; Female; Furosemide; Gabexate; G | 1985 |