gabexate has been researched along with Blood Coagulation Disorders in 4 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Blood Coagulation Disorders: Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Several studies have reported that gabexate mesilate, a synthetic inhibitor of trypsin-like serine protease, protects tissues/organs against injury in the models of endotoxemia." | 7.81 | Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia: a potential use of thrombelastography in endotoxin-induced sepsis. ( Ding, C; Ka, SM; Liao, MH; Liaw, WJ; Tsai, HJ; Tsao, CM; Wu, CC, 2015) |
| " Several studies have reported that gabexate mesilate, a synthetic inhibitor of trypsin-like serine protease, protects tissues/organs against injury in the models of endotoxemia." | 3.81 | Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia: a potential use of thrombelastography in endotoxin-induced sepsis. ( Ding, C; Ka, SM; Liao, MH; Liaw, WJ; Tsai, HJ; Tsao, CM; Wu, CC, 2015) |
| "Protease inhibitors, such as ulinastatin and gabexate mesilate, are widely used for the patients in shock state." | 3.67 | [The effect of protease inhibitors in shock]. ( Endo, Y; Inoue, H; Miura, J; Motoki, R; Terashima, S; Usuba, A; Watanabe, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsai, HJ | 1 |
| Ding, C | 1 |
| Tsao, CM | 1 |
| Liao, MH | 1 |
| Ka, SM | 1 |
| Liaw, WJ | 1 |
| Wu, CC | 1 |
| Yamamoto, H | 1 |
| Kawaguchi, Y | 1 |
| Sakai, O | 1 |
| Inoue, H | 1 |
| Usuba, A | 1 |
| Endo, Y | 1 |
| Terashima, S | 1 |
| Watanabe, M | 1 |
| Miura, J | 1 |
| Motoki, R | 1 |
| Asanuma, Y | 1 |
| Sugai, K | 1 |
| Akutsu, Y | 1 |
| Mori, K | 1 |
| Koyama, K | 1 |
| Owada, Y | 1 |
| Sato, T | 1 |
4 other studies available for gabexate and Blood Coagulation Disorders
| Article | Year |
|---|---|
Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia: a potential use of thrombelastography in endotoxin-induced sepsis.
Topics: Animals; Anticoagulants; Blood Coagulation Disorders; Endotoxemia; Gabexate; Lipopolysaccharides; Ma | 2015 |
[Protease inhibitors as anticoagulant in hemodialysis].
Topics: Benzamidines; Blood Coagulation Disorders; Gabexate; Guanidines; Humans; Protease Inhibitors; Renal | 1991 |
[The effect of protease inhibitors in shock].
Topics: Animals; Blood Coagulation Disorders; Dogs; Gabexate; Glycoproteins; Guanidines; Humans; Kidney; Ser | 1989 |
[Coagulation studies in patients after abdominal surgery].
Topics: Abdomen; Anticoagulants; Blood Coagulation; Blood Coagulation Disorders; Gabexate; Guanidines; Human | 1986 |