gabexate has been researched along with Acute Necrotizing Pancreatitis in 9 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gabexate mesilate is a synthetic protease inhibitor." | 5.33 | Effects of gabexate mesilate on serum inflammatory cytokines in rats with acute necrotizing pancreatitis. ( Chang, FY; Chen, CC; Lee, FY; Lee, SD; Lu, RH; Tsay, SH; Wang, SS, 2006) |
| "The management of acute pancreatitis (AP) is still based on speculative and unproven paradigms in many centers." | 2.43 | Evidence-based treatment of acute pancreatitis: a look at established paradigms. ( Clavien, PA; Heinrich, S; Rousson, V; Schäfer, M, 2006) |
| "A case of acute necrotizing pancreatitis due to Mycoplasma pneumoniae infection was treated in an 8-year-old girl." | 1.35 | Continuous regional arterial infusion therapy for acute necrotizing pancreatitis due to Mycoplasma pneumoniae infection in a child. ( Hara, M; Nakagawa, M; Ogino, H; Shibamoto, Y; Shimohira, M, 2009) |
| "Thus, the main problem in acute pancreatitis, especially in the severe form of the disease, is the difficulty of planning clinical studies capable of giving hard statistically significant answers regarding the benefits of the various proposed therapeutic agents previously tested in experimental settings." | 1.33 | New approaches for the treatment of acute pancreatitis. ( Fantini, L; Morselli-Labate, AM; Pezzilli, R, 2006) |
| "Gabexate mesilate is a synthetic protease inhibitor." | 1.33 | Effects of gabexate mesilate on serum inflammatory cytokines in rats with acute necrotizing pancreatitis. ( Chang, FY; Chen, CC; Lee, FY; Lee, SD; Lu, RH; Tsay, SH; Wang, SS, 2006) |
| "Acute necrotizing pancreatitis was induced by an injection of 10% Na-taurocholate (1ml/kg) into the main pancreatic duct of mongrel dogs." | 1.32 | The effect of continuous arterial infusion of gabexate mesilate (FOY-007) on experimental acute pancreatitis. ( Harada, M; Imawaka, H; Machii, K; Satoh, H; Shiroya, T; Tashiro, S, 2004) |
| "Nafamostat has maximal effects on the pancreas and peritoneal capillary leakage when delivered by way of local intra-arterial infusion, and shows a greater reduction of lung leukocyte infiltration and capillary leakage by the intravenous route." | 1.31 | Regional effects of nafamostat, a novel potent protease and complement inhibitor, on severe necrotizing pancreatitis. ( Antoniu, BA; Balcom, JH; Fernández-del Castillo, CF; Keck, T; Lewandrowski, K; Warshaw, AL, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Endo, A | 1 |
| Shiraishi, A | 1 |
| Fushimi, K | 1 |
| Murata, K | 1 |
| Otomo, Y | 1 |
| Nakagawa, M | 1 |
| Ogino, H | 1 |
| Shimohira, M | 1 |
| Hara, M | 1 |
| Shibamoto, Y | 1 |
| Uomo, G | 1 |
| Satoh, H | 1 |
| Harada, M | 1 |
| Tashiro, S | 1 |
| Shiroya, T | 1 |
| Imawaka, H | 1 |
| Machii, K | 1 |
| Pezzilli, R | 1 |
| Fantini, L | 1 |
| Morselli-Labate, AM | 1 |
| Heinrich, S | 1 |
| Schäfer, M | 1 |
| Rousson, V | 1 |
| Clavien, PA | 1 |
| Chen, CC | 1 |
| Wang, SS | 1 |
| Tsay, SH | 1 |
| Lee, FY | 1 |
| Lu, RH | 1 |
| Chang, FY | 1 |
| Lee, SD | 1 |
| Takeda, K | 1 |
| Matsuno, S | 1 |
| Ogawa, M | 1 |
| Watanabe, S | 1 |
| Atomi, Y | 1 |
| Keck, T | 1 |
| Balcom, JH | 1 |
| Antoniu, BA | 1 |
| Lewandrowski, K | 1 |
| Warshaw, AL | 1 |
| Fernández-del Castillo, CF | 1 |
1 review available for gabexate and Acute Necrotizing Pancreatitis
| Article | Year |
|---|---|
Evidence-based treatment of acute pancreatitis: a look at established paradigms.
Topics: Acute Disease; Anti-Bacterial Agents; Antibiotic Prophylaxis; Aprotinin; Cholecystectomy; Enteral Nu | 2006 |
8 other studies available for gabexate and Acute Necrotizing Pancreatitis
| Article | Year |
|---|---|
Impact of continuous regional arterial infusion in the treatment of acute necrotizing pancreatitis: analysis of a national administrative database.
Topics: Adult; Aged; Anti-Bacterial Agents; Databases, Factual; Female; Gabexate; Hospital Mortality; Humans | 2018 |
Continuous regional arterial infusion therapy for acute necrotizing pancreatitis due to Mycoplasma pneumoniae infection in a child.
Topics: Anti-Bacterial Agents; Child; Contrast Media; Drug Therapy, Combination; Female; Gabexate; Humans; I | 2009 |
Lesson from acute experimental pancreatitis: multidrug strategies is effective than single-target therapy.
Topics: Acetylcysteine; Animals; Antibodies, Monoclonal; Arginine; Disease Models, Animal; Drug Therapy, Com | 2012 |
The effect of continuous arterial infusion of gabexate mesilate (FOY-007) on experimental acute pancreatitis.
Topics: Amylases; Animals; Dogs; Female; Gabexate; Hemodynamics; Infusions, Intra-Arterial; Lipase; Male; Pa | 2004 |
New approaches for the treatment of acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Antibodies, Monoclonal; Cholangiopancreatography, Endoscopic Retro | 2006 |
Effects of gabexate mesilate on serum inflammatory cytokines in rats with acute necrotizing pancreatitis.
Topics: Amylases; Animals; Cytokines; Gabexate; Interleukin-6; Lipase; Male; Pancreatitis, Acute Necrotizing | 2006 |
Continuous regional arterial infusion (CRAI) therapy reduces the mortality rate of acute necrotizing pancreatitis: results of a cooperative survey in Japan.
Topics: Adult; Aged; Aged, 80 and over; Angiography; Anti-Bacterial Agents; Data Collection; Drug Therapy, C | 2001 |
Regional effects of nafamostat, a novel potent protease and complement inhibitor, on severe necrotizing pancreatitis.
Topics: Animals; Benzamidines; Capillary Permeability; Complement Inactivator Proteins; Evans Blue; Gabexate | 2001 |