Page last updated: 2024-10-27

gabapentin and Sciatica

gabapentin has been researched along with Sciatica in 16 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Sciatica: A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.

Research Excerpts

ExcerptRelevanceReference
"This SR aims to assess the effectiveness of pregabalin and gabapentin on pain and disability caused by acute sciatica and the adverse events associated with their clinical use."9.22A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain. ( Carbonell-Sanchís, R; Díaz-Cambronero, JI; Giménez-Campos, MS; López-Briz, E; Pimenta-Fermisson-Ramos, P; Ruíz-García, V, 2022)
"Whilst pregabalin (PGB) and gabapentin (GBP) are both used to treat neuropathic pain, their relative role in sciatica is unclear."8.93Pregabalin and gabapentin for the treatment of sciatica. ( Marshman, LA; Plummer, D; Robertson, K, 2016)
"We describe a 60-year-old woman who became comatose after a single dose of gabapentin for right-sided sciatalgia."7.73Gabapentin-induced coma in a patient with renal failure. ( Aygen, B; Bektas, S; Berilgen, MS; Dag, S; Dogukan, A; Gunal, AI, 2006)
" When evaluated in the model of neuropathic pain caused by partial ligation of sciatic nerve, the hexanic extract inhibited the mechanical allodynia (77 +/- 7%), with a similar efficacy to the gabapentin (71 +/- 10%)."7.72Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. ( Calixto, JB; Kassuya, CA; Rehder, VL; Silvestre, AA, 2003)
"Gabapentin was superior to PGB, with fewer and less severe adverse events."6.90Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial. ( Downs, E; Marshman, LAG; Plummer, D; Robertson, K, 2019)
" Patients will continue their current pain medication at study onset, conditional upon dosage consistency during the prior 30 days."6.87Pregabalin versus gabapentin in the treatment of sciatica: study protocol for a randomised, double-blind, cross-over trial (PAGPROS). ( Harriss, L; Hennessy, M; Marshman, LAG; Plummer, D; Robertson, K, 2018)
"Gabapentin has been approved in the United States for the treatment of epilepsy and postherpetic neuralgia."5.35Gabapentin as a potential option for treatment of sciatica. ( Grice, GR; Mertens, MK, 2008)
"This SR aims to assess the effectiveness of pregabalin and gabapentin on pain and disability caused by acute sciatica and the adverse events associated with their clinical use."5.22A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain. ( Carbonell-Sanchís, R; Díaz-Cambronero, JI; Giménez-Campos, MS; López-Briz, E; Pimenta-Fermisson-Ramos, P; Ruíz-García, V, 2022)
"The gabapentinoid drugs gabapentin and pregabalin were originally developed as antiseizure drugs but now are prescribed mainly for treatment of pain."5.01A Clinical Overview of Off-label Use of Gabapentinoid Drugs. ( Brett, AS; Goodman, CW, 2019)
"Whilst pregabalin (PGB) and gabapentin (GBP) are both used to treat neuropathic pain, their relative role in sciatica is unclear."4.93Pregabalin and gabapentin for the treatment of sciatica. ( Marshman, LA; Plummer, D; Robertson, K, 2016)
"We describe a 60-year-old woman who became comatose after a single dose of gabapentin for right-sided sciatalgia."3.73Gabapentin-induced coma in a patient with renal failure. ( Aygen, B; Bektas, S; Berilgen, MS; Dag, S; Dogukan, A; Gunal, AI, 2006)
" When evaluated in the model of neuropathic pain caused by partial ligation of sciatic nerve, the hexanic extract inhibited the mechanical allodynia (77 +/- 7%), with a similar efficacy to the gabapentin (71 +/- 10%)."3.72Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. ( Calixto, JB; Kassuya, CA; Rehder, VL; Silvestre, AA, 2003)
"Gabapentin was superior to PGB, with fewer and less severe adverse events."2.90Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial. ( Downs, E; Marshman, LAG; Plummer, D; Robertson, K, 2019)
" Patients will continue their current pain medication at study onset, conditional upon dosage consistency during the prior 30 days."2.87Pregabalin versus gabapentin in the treatment of sciatica: study protocol for a randomised, double-blind, cross-over trial (PAGPROS). ( Harriss, L; Hennessy, M; Marshman, LAG; Plummer, D; Robertson, K, 2018)
"Gabapentin has been approved in the United States for the treatment of epilepsy and postherpetic neuralgia."1.35Gabapentin as a potential option for treatment of sciatica. ( Grice, GR; Mertens, MK, 2008)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (31.25)29.6817
2010's9 (56.25)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Giménez-Campos, MS1
Pimenta-Fermisson-Ramos, P1
Díaz-Cambronero, JI1
Carbonell-Sanchís, R1
López-Briz, E1
Ruíz-García, V1
Déciga-Campos, M1
Villafán-Gutiérrez, R1
Espinosa-Juárez, JV1
Jaramillo-Morales, OA1
López-Muñoz, FJ1
Robertson, K4
Marshman, LAG3
Hennessy, M1
Harriss, L1
Plummer, D4
Downs, E1
Goodman, CW1
Brett, AS1
Leal Rato, M1
Duarte, GS1
Ferreira, JJ1
Gialanella, B1
Prometti, P1
Ferlucci, C1
Hirsch, S1
Dickenson, A1
Corradini, L1
Marshman, LA2
Robertson, KL1
Kara, M1
Ozçakar, L1
Eken, G1
Ozen, G1
Kiraz, S1
Kassuya, CA1
Silvestre, AA1
Rehder, VL1
Calixto, JB1
Dogukan, A1
Aygen, B1
Berilgen, MS1
Dag, S1
Bektas, S1
Gunal, AI1
Narita, M2
Nakajima, M1
Miyoshi, K1
Nagumo, Y1
Miyatake, M1
Yajima, Y1
Yanagida, K1
Yamazaki, M1
Suzuki, T1
Grice, GR1
Mertens, MK1

Reviews

3 reviews available for gabapentin and Sciatica

ArticleYear
A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain.
    Atencion primaria, 2022, Volume: 54, Issue:1

    Topics: Adolescent; Adult; Analgesics; Gabapentin; Humans; Low Back Pain; Pregabalin; Sciatica

2022
A Clinical Overview of Off-label Use of Gabapentinoid Drugs.
    JAMA internal medicine, 2019, 05-01, Volume: 179, Issue:5

    Topics: Analgesics; Diabetic Neuropathies; Drug Approval; Fibromyalgia; Gabapentin; Humans; Low Back Pain; M

2019
Pregabalin and gabapentin for the treatment of sciatica.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2016, Volume: 26

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Neural

2016

Trials

3 trials available for gabapentin and Sciatica

ArticleYear
Pregabalin versus gabapentin in the treatment of sciatica: study protocol for a randomised, double-blind, cross-over trial (PAGPROS).
    Trials, 2018, Jan-09, Volume: 19, Issue:1

    Topics: Cross-Over Studies; Data Collection; Double-Blind Method; Gabapentin; Humans; Pregabalin; Prospectiv

2018
Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial.
    JAMA neurology, 2019, 01-01, Volume: 76, Issue:1

    Topics: Adult; Aged; Analgesics; Chronic Pain; Cross-Over Studies; Double-Blind Method; Female; Gabapentin;

2019
Gabapentin Superadded to a Pre-Existent Regime Containing Amytriptyline for Chronic Sciatica.
    Pain medicine (Malden, Mass.), 2016, Volume: 17, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Amines; Amitriptyline; Analgesics; Chronic Disease; Cohort Studies;

2016

Other Studies

10 other studies available for gabapentin and Sciatica

ArticleYear
Synergistic interaction between haloperidol and gabapentin in a model of neuropathic nociception in rat.
    European journal of pharmacology, 2021, Jan-15, Volume: 891

    Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug

2021
Proper or Improper Use of the Crossover Design in Clinical Trials in Chronic Sciatica?
    JAMA neurology, 2019, 06-01, Volume: 76, Issue:6

    Topics: Adult; Cross-Over Studies; Gabapentin; Humans; Low Back Pain; Pregabalin; Sciatica

2019
Proper or Improper Use of the Crossover Design in Clinical Trials in Chronic Sciatica?-Reply.
    JAMA neurology, 2019, 06-01, Volume: 76, Issue:6

    Topics: Adult; Cross-Over Studies; Gabapentin; Humans; Low Back Pain; Pregabalin; Sciatica

2019
Low back pain radiating to the leg: an atypical cause.
    La Clinica terapeutica, 2013, Volume: 164, Issue:5

    Topics: Amines; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclohexanecarbox

2013
Anesthesia influences neuronal activity and drug effectiveness in neuropathic rats.
    Pain, 2014, Volume: 155, Issue:12

    Topics: Action Potentials; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal;

2014
Deep venous thrombosis and inferior vena cava agenesis causing double crush sciatic neuropathy in Behçet's disease.
    Joint bone spine, 2008, Volume: 75, Issue:6

    Topics: Adolescent; Amines; Behcet Syndrome; Colchicine; Cyclohexanecarboxylic Acids; Drug Therapy, Combinat

2008
Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain.
    European journal of pharmacology, 2003, Oct-08, Volume: 478, Issue:2-3

    Topics: Acetates; Amines; Analgesics; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Edema;

2003
Gabapentin-induced coma in a patient with renal failure.
    Hemodialysis international. International Symposium on Home Hemodialysis, 2006, Volume: 10, Issue:2

    Topics: Administration, Oral; Amines; Coma; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; F

2006
Role of spinal voltage-dependent calcium channel alpha 2 delta-1 subunit in the expression of a neuropathic pain-like state in mice.
    Life sciences, 2007, May-08, Volume: 80, Issue:22

    Topics: Amines; Analgesics; Animals; Calcium Channels; Cells, Cultured; Cyclohexanecarboxylic Acids; Disease

2007
Gabapentin as a potential option for treatment of sciatica.
    Pharmacotherapy, 2008, Volume: 28, Issue:3

    Topics: Adult; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric

2008