gabapentin has been researched along with Sciatica in 16 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Sciatica: A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This SR aims to assess the effectiveness of pregabalin and gabapentin on pain and disability caused by acute sciatica and the adverse events associated with their clinical use." | 9.22 | A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain. ( Carbonell-Sanchís, R; Díaz-Cambronero, JI; Giménez-Campos, MS; López-Briz, E; Pimenta-Fermisson-Ramos, P; Ruíz-García, V, 2022) |
| "Whilst pregabalin (PGB) and gabapentin (GBP) are both used to treat neuropathic pain, their relative role in sciatica is unclear." | 8.93 | Pregabalin and gabapentin for the treatment of sciatica. ( Marshman, LA; Plummer, D; Robertson, K, 2016) |
| "We describe a 60-year-old woman who became comatose after a single dose of gabapentin for right-sided sciatalgia." | 7.73 | Gabapentin-induced coma in a patient with renal failure. ( Aygen, B; Bektas, S; Berilgen, MS; Dag, S; Dogukan, A; Gunal, AI, 2006) |
| " When evaluated in the model of neuropathic pain caused by partial ligation of sciatic nerve, the hexanic extract inhibited the mechanical allodynia (77 +/- 7%), with a similar efficacy to the gabapentin (71 +/- 10%)." | 7.72 | Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. ( Calixto, JB; Kassuya, CA; Rehder, VL; Silvestre, AA, 2003) |
| "Gabapentin was superior to PGB, with fewer and less severe adverse events." | 6.90 | Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial. ( Downs, E; Marshman, LAG; Plummer, D; Robertson, K, 2019) |
| " Patients will continue their current pain medication at study onset, conditional upon dosage consistency during the prior 30 days." | 6.87 | Pregabalin versus gabapentin in the treatment of sciatica: study protocol for a randomised, double-blind, cross-over trial (PAGPROS). ( Harriss, L; Hennessy, M; Marshman, LAG; Plummer, D; Robertson, K, 2018) |
| "Gabapentin has been approved in the United States for the treatment of epilepsy and postherpetic neuralgia." | 5.35 | Gabapentin as a potential option for treatment of sciatica. ( Grice, GR; Mertens, MK, 2008) |
| "This SR aims to assess the effectiveness of pregabalin and gabapentin on pain and disability caused by acute sciatica and the adverse events associated with their clinical use." | 5.22 | A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain. ( Carbonell-Sanchís, R; Díaz-Cambronero, JI; Giménez-Campos, MS; López-Briz, E; Pimenta-Fermisson-Ramos, P; Ruíz-García, V, 2022) |
| "The gabapentinoid drugs gabapentin and pregabalin were originally developed as antiseizure drugs but now are prescribed mainly for treatment of pain." | 5.01 | A Clinical Overview of Off-label Use of Gabapentinoid Drugs. ( Brett, AS; Goodman, CW, 2019) |
| "Whilst pregabalin (PGB) and gabapentin (GBP) are both used to treat neuropathic pain, their relative role in sciatica is unclear." | 4.93 | Pregabalin and gabapentin for the treatment of sciatica. ( Marshman, LA; Plummer, D; Robertson, K, 2016) |
| "We describe a 60-year-old woman who became comatose after a single dose of gabapentin for right-sided sciatalgia." | 3.73 | Gabapentin-induced coma in a patient with renal failure. ( Aygen, B; Bektas, S; Berilgen, MS; Dag, S; Dogukan, A; Gunal, AI, 2006) |
| " When evaluated in the model of neuropathic pain caused by partial ligation of sciatic nerve, the hexanic extract inhibited the mechanical allodynia (77 +/- 7%), with a similar efficacy to the gabapentin (71 +/- 10%)." | 3.72 | Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. ( Calixto, JB; Kassuya, CA; Rehder, VL; Silvestre, AA, 2003) |
| "Gabapentin was superior to PGB, with fewer and less severe adverse events." | 2.90 | Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial. ( Downs, E; Marshman, LAG; Plummer, D; Robertson, K, 2019) |
| " Patients will continue their current pain medication at study onset, conditional upon dosage consistency during the prior 30 days." | 2.87 | Pregabalin versus gabapentin in the treatment of sciatica: study protocol for a randomised, double-blind, cross-over trial (PAGPROS). ( Harriss, L; Hennessy, M; Marshman, LAG; Plummer, D; Robertson, K, 2018) |
| "Gabapentin has been approved in the United States for the treatment of epilepsy and postherpetic neuralgia." | 1.35 | Gabapentin as a potential option for treatment of sciatica. ( Grice, GR; Mertens, MK, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Giménez-Campos, MS | 1 |
| Pimenta-Fermisson-Ramos, P | 1 |
| Díaz-Cambronero, JI | 1 |
| Carbonell-Sanchís, R | 1 |
| López-Briz, E | 1 |
| Ruíz-García, V | 1 |
| Déciga-Campos, M | 1 |
| Villafán-Gutiérrez, R | 1 |
| Espinosa-Juárez, JV | 1 |
| Jaramillo-Morales, OA | 1 |
| López-Muñoz, FJ | 1 |
| Robertson, K | 4 |
| Marshman, LAG | 3 |
| Hennessy, M | 1 |
| Harriss, L | 1 |
| Plummer, D | 4 |
| Downs, E | 1 |
| Goodman, CW | 1 |
| Brett, AS | 1 |
| Leal Rato, M | 1 |
| Duarte, GS | 1 |
| Ferreira, JJ | 1 |
| Gialanella, B | 1 |
| Prometti, P | 1 |
| Ferlucci, C | 1 |
| Hirsch, S | 1 |
| Dickenson, A | 1 |
| Corradini, L | 1 |
| Marshman, LA | 2 |
| Robertson, KL | 1 |
| Kara, M | 1 |
| Ozçakar, L | 1 |
| Eken, G | 1 |
| Ozen, G | 1 |
| Kiraz, S | 1 |
| Kassuya, CA | 1 |
| Silvestre, AA | 1 |
| Rehder, VL | 1 |
| Calixto, JB | 1 |
| Dogukan, A | 1 |
| Aygen, B | 1 |
| Berilgen, MS | 1 |
| Dag, S | 1 |
| Bektas, S | 1 |
| Gunal, AI | 1 |
| Narita, M | 2 |
| Nakajima, M | 1 |
| Miyoshi, K | 1 |
| Nagumo, Y | 1 |
| Miyatake, M | 1 |
| Yajima, Y | 1 |
| Yanagida, K | 1 |
| Yamazaki, M | 1 |
| Suzuki, T | 1 |
| Grice, GR | 1 |
| Mertens, MK | 1 |
3 reviews available for gabapentin and Sciatica
| Article | Year |
|---|---|
A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain.
Topics: Adolescent; Adult; Analgesics; Gabapentin; Humans; Low Back Pain; Pregabalin; Sciatica | 2022 |
A Clinical Overview of Off-label Use of Gabapentinoid Drugs.
Topics: Analgesics; Diabetic Neuropathies; Drug Approval; Fibromyalgia; Gabapentin; Humans; Low Back Pain; M | 2019 |
Pregabalin and gabapentin for the treatment of sciatica.
Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Neural | 2016 |
3 trials available for gabapentin and Sciatica
| Article | Year |
|---|---|
Pregabalin versus gabapentin in the treatment of sciatica: study protocol for a randomised, double-blind, cross-over trial (PAGPROS).
Topics: Cross-Over Studies; Data Collection; Double-Blind Method; Gabapentin; Humans; Pregabalin; Prospectiv | 2018 |
Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial.
Topics: Adult; Aged; Analgesics; Chronic Pain; Cross-Over Studies; Double-Blind Method; Female; Gabapentin; | 2019 |
Gabapentin Superadded to a Pre-Existent Regime Containing Amytriptyline for Chronic Sciatica.
Topics: Adult; Aged; Aged, 80 and over; Amines; Amitriptyline; Analgesics; Chronic Disease; Cohort Studies; | 2016 |
10 other studies available for gabapentin and Sciatica
| Article | Year |
|---|---|
Synergistic interaction between haloperidol and gabapentin in a model of neuropathic nociception in rat.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug | 2021 |
Proper or Improper Use of the Crossover Design in Clinical Trials in Chronic Sciatica?
Topics: Adult; Cross-Over Studies; Gabapentin; Humans; Low Back Pain; Pregabalin; Sciatica | 2019 |
Proper or Improper Use of the Crossover Design in Clinical Trials in Chronic Sciatica?-Reply.
Topics: Adult; Cross-Over Studies; Gabapentin; Humans; Low Back Pain; Pregabalin; Sciatica | 2019 |
Low back pain radiating to the leg: an atypical cause.
Topics: Amines; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclohexanecarbox | 2013 |
Anesthesia influences neuronal activity and drug effectiveness in neuropathic rats.
Topics: Action Potentials; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2014 |
Deep venous thrombosis and inferior vena cava agenesis causing double crush sciatic neuropathy in Behçet's disease.
Topics: Adolescent; Amines; Behcet Syndrome; Colchicine; Cyclohexanecarboxylic Acids; Drug Therapy, Combinat | 2008 |
Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain.
Topics: Acetates; Amines; Analgesics; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Edema; | 2003 |
Gabapentin-induced coma in a patient with renal failure.
Topics: Administration, Oral; Amines; Coma; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; F | 2006 |
Role of spinal voltage-dependent calcium channel alpha 2 delta-1 subunit in the expression of a neuropathic pain-like state in mice.
Topics: Amines; Analgesics; Animals; Calcium Channels; Cells, Cultured; Cyclohexanecarboxylic Acids; Disease | 2007 |
Gabapentin as a potential option for treatment of sciatica.
Topics: Adult; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric | 2008 |