Page last updated: 2024-10-27

gabapentin and Respiratory Insufficiency

gabapentin has been researched along with Respiratory Insufficiency in 18 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
" Given its faster onset, increased bioavailability and potency, and nonsaturable absorption, pregabalin's pharmacokinetics theoretically enhance its misuse liability versus gabapentin."2.72Gabapentinoid Pharmacology in the Context of Emerging Misuse Liability. ( Covvey, JR; Evoy, KE; Peckham, AM; Tidgewell, KJ, 2021)
" To inform their safe prescribing in older adults with chronic kidney disease (CKD), we examined the 30-day risk of serious adverse events according to the prescribed starting dose."1.72Higher-Dose Gabapentinoids and the Risk of Adverse Events in Older Adults With CKD: A Population-Based Cohort Study. ( Ahmadi, F; Blake, PG; Cowan, A; Fleet, JL; Garg, AX; Muanda, FT; Sontrop, JM; Weir, MA, 2022)
"Gabapentin was administered by a nasogastric tube that quickly resulted in a reversal of his symptoms."1.51Complex encephalopathy arising from the combination of opioids and gabapentin. ( Handa, R; Kak, V; Singh, H; Wasilewski, A, 2019)
"Gabapentin was administered by a nasogastric tube that quickly resulted in a reversal of his symptoms."1.51Complex encephalopathy arising from the combination of opioids and gabapentin. ( Handa, R; Kak, V; Singh, H; Wasilewski, A, 2019)
" In the dose-response analysis, moderate-dose (OR 2."1.46Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case-control study. ( Antoniou, T; Gomes, T; Juurlink, DN; Mamdani, MM; Paterson, JM; van den Brink, W, 2017)
"The incidence of respiratory depression was 153 (95% confidence interval [CI], 146-161) episodes per 1000 cases."1.46Multimodal Analgesic Therapy With Gabapentin and Its Association With Postoperative Respiratory Depression. ( Cavalcante, AN; Schroeder, DR; Sprung, J; Weingarten, TN, 2017)
"Postmorphine Paco2 was significantly higher in the amitriptyline and combination groups at all time points over the 240 min, and in the gabapentin group at 10 and 30 min after morphine injection (P<0."1.35The effect of amitriptyline, gabapentin, and carbamazepine on morphine-induced hypercarbia in rabbits. ( Garcia-Bournissen, F; Hoshino, N; Ito, S; Kapur, B; Koren, G; Kozer, E; Leombruno, J; Levichek, Z; Taguchi, N, 2008)
"Quetiapine overdose is associated with coma, QTc prolongation and hypotension."1.31Massive gabapentin and presumptive quetiapine overdose. ( Cutino, L; Dunaway, MD; Spiller, HA, 2002)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (16.67)29.6817
2010's8 (44.44)24.3611
2020's7 (38.89)2.80

Authors

AuthorsStudies
Muanda, FT1
Weir, MA1
Ahmadi, F1
Sontrop, JM1
Cowan, A1
Fleet, JL1
Blake, PG1
Garg, AX1
Ghaith, S1
Quillen, JK1
Mead-Harvey, C1
Buras, MR1
Wasson, MN1
Fernández-Liz, E1
Barceló-Colomer, ME1
Gómez-Ganda, L1
Varon-Galcera, C1
Lalueza-Broto, P1
Medel-Rebollo, FJ1
Hortelano-García, MA1
Martín-Gracia, E1
Tambon, M1
Montarnal, B1
Lepetit, M1
Lapeyre-Mestre, M1
Elleby, LM1
Sprung, J3
Weingarten, TN3
Shrestha, S2
Palaian, S2
Evoy, KE1
Peckham, AM1
Covvey, JR1
Tidgewell, KJ1
Gomes, T1
Juurlink, DN1
Antoniou, T1
Mamdani, MM1
Paterson, JM1
van den Brink, W1
Deljou, A1
Hedrick, SJ1
Portner, ER1
Schroeder, DR2
Hooten, WM1
Singh, H2
Handa, R2
Kak, V2
Wasilewski, A2
Ongley, D1
Hayward, AK1
Allan, C1
Cavalcante, AN1
Kozer, E1
Levichek, Z1
Hoshino, N1
Kapur, B1
Leombruno, J1
Taguchi, N1
Garcia-Bournissen, F1
Koren, G1
Ito, S1
Benjaminsen, E1
Skjeflo, GW1
Dybwik, K1
Salvesen, R1
Spiller, HA1
Dunaway, MD1
Cutino, L1
Batoon, SB1
Vela, AT1
Dave, D1
Wahid, Z1
Conetta, R1
Iakovou, C1
Banzuela, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pattern of Acute Antipsychotic Drug- Toxicity in Children at Assiut University Children Hospital[NCT06125275]50 participants (Anticipated)Observational2023-10-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for gabapentin and Respiratory Insufficiency

ArticleYear
Non-opioid antinociceptive drugs : risk of respiratory depression and death related to concomitant use of gabapentinoids in addition to opioids.
    Expert opinion on drug safety, 2023, Volume: 22, Issue:3

    Topics: Analgesics, Opioid; Cross-Sectional Studies; Gabapentin; Humans; Pregabalin; Respiratory Insufficien

2023
Gabapentinoid Pharmacology in the Context of Emerging Misuse Liability.
    Journal of clinical pharmacology, 2021, Volume: 61 Suppl 2

    Topics: Area Under Curve; Calcium Channel Blockers; Drug Overdose; Gabapentin; Half-Life; Humans; Metabolic

2021

Other Studies

16 other studies available for gabapentin and Respiratory Insufficiency

ArticleYear
Higher-Dose Gabapentinoids and the Risk of Adverse Events in Older Adults With CKD: A Population-Based Cohort Study.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2022, Volume: 80, Issue:1

    Topics: Aged; Aged, 80 and over; Brain Diseases; Cohort Studies; Female; Gabapentin; Humans; Male; Ontario;

2022
Impact of timing of preoperative gabapentin administration on postoperative somnolence.
    Journal of osteopathic medicine, 2022, 02-22, Volume: 122, Issue:6

    Topics: Adult; Analgesics, Opioid; Female; Gabapentin; Humans; Pelvic Pain; Respiratory Insufficiency; Retro

2022
Prevalence of Gabapentinoids and Central Nervous System Depressant Drugs, and Their Association with Risk Factors for Respiratory Depression in Primary Care Patients.
    Clinical drug investigation, 2022, Volume: 42, Issue:5

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Anxiety Agents; Cross-Sectional Studies; Female; G

2022
Postoperative Respiratory Depression May Be Related to Undiagnosed Sleep-Disordered Breathing or Obstructive Sleep Apnea.
    Anesthesia and analgesia, 2019, Volume: 129, Issue:3

    Topics: Analgesics; Gabapentin; Humans; Respiratory Insufficiency; Sleep Apnea Syndromes; Sleep Apnea, Obstr

2019
In brief: Respiratory depression with gabapentinoids.
    The Medical letter on drugs and therapeutics, 2020, Jun-01, Volume: 62, Issue:1599

    Topics: Analgesics; Gabapentin; Humans; Pregabalin; Respiratory Insufficiency

2020
Respiratory concerns of gabapentin and pregabalin: What does it mean to the pharmacovigilance systems in developing countries?
    F1000Research, 2020, Volume: 9

    Topics: Analgesics; Developing Countries; Gabapentin; Humans; Pharmacovigilance; Pregabalin; Respiratory Ins

2020
Respiratory concerns of gabapentin and pregabalin: What does it mean to the pharmacovigilance systems in developing countries?
    F1000Research, 2020, Volume: 9

    Topics: Analgesics; Developing Countries; Gabapentin; Humans; Pharmacovigilance; Pregabalin; Respiratory Ins

2020
Respiratory concerns of gabapentin and pregabalin: What does it mean to the pharmacovigilance systems in developing countries?
    F1000Research, 2020, Volume: 9

    Topics: Analgesics; Developing Countries; Gabapentin; Humans; Pharmacovigilance; Pregabalin; Respiratory Ins

2020
Respiratory concerns of gabapentin and pregabalin: What does it mean to the pharmacovigilance systems in developing countries?
    F1000Research, 2020, Volume: 9

    Topics: Analgesics; Developing Countries; Gabapentin; Humans; Pharmacovigilance; Pregabalin; Respiratory Ins

2020
Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case-control study.
    PLoS medicine, 2017, Volume: 14, Issue:10

    Topics: Adult; Aged; Amines; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studi

2017
Pattern of perioperative gabapentinoid use and risk for postoperative naloxone administration.
    British journal of anaesthesia, 2018, Volume: 120, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Anesthesia Recovery Period; Case-Control Stu

2018
Complex encephalopathy arising from the combination of opioids and gabapentin.
    BMJ case reports, 2019, Apr-20, Volume: 12, Issue:4

    Topics: Analgesics, Opioid; Brain Diseases; Chronic Pain; Gabapentin; Humans; Male; Middle Aged; Morphine; R

2019
Complex encephalopathy arising from the combination of opioids and gabapentin.
    Drug and therapeutics bulletin, 2019, Volume: 57, Issue:8

    Topics: Analgesics; Analgesics, Opioid; Brain Diseases; Drug Interactions; Gabapentin; Humans; Male; Middle

2019
Severe respiratory depression associated with perioperative opioid-sparing gabapentin use.
    Anaesthesia and intensive care, 2014, Volume: 42, Issue:1

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Respir

2014
Multimodal Analgesic Therapy With Gabapentin and Its Association With Postoperative Respiratory Depression.
    Anesthesia and analgesia, 2017, Volume: 125, Issue:1

    Topics: Adult; Aged; Amines; Analgesia; Analgesics; Analgesics, Opioid; Combined Modality Therapy; Critical

2017
The effect of amitriptyline, gabapentin, and carbamazepine on morphine-induced hypercarbia in rabbits.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:4

    Topics: Amines; Amitriptyline; Analgesics, Opioid; Animals; Anticonvulsants; Antidepressive Agents, Tricycli

2008
A man in his seventies with prolonged myasthenic crisis.
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2012, Oct-16, Volume: 132, Issue:19

    Topics: Aged; Amines; Anti-Bacterial Agents; Antibodies, Monoclonal, Murine-Derived; Cyclohexanecarboxylic A

2012
Massive gabapentin and presumptive quetiapine overdose.
    Veterinary and human toxicology, 2002, Volume: 44, Issue:4

    Topics: Acetates; Amines; Anti-Anxiety Agents; Antipsychotic Agents; Coma; Cyclohexanecarboxylic Acids; Dibe

2002
Recurrent hypoventilation and respiratory failure during gabapentin therapy.
    Journal of the American Geriatrics Society, 2001, Volume: 49, Issue:4

    Topics: Acetates; Aged; Amines; Analgesics; Anti-Anxiety Agents; Anticonvulsants; Cyclohexanecarboxylic Acid

2001