gabapentin has been researched along with Reflex Sympathetic Dystrophy in 23 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Reflex Sympathetic Dystrophy: A syndrome characterized by severe burning pain in an extremity accompanied by sudomotor, vasomotor, and trophic changes in bone without an associated specific nerve injury. This condition is most often precipitated by trauma to soft tissue or nerve complexes. The skin over the affected region is usually erythematous and demonstrates hypersensitivity to tactile stimuli and erythema. (Adams et al., Principles of Neurology, 6th ed, p1360; Pain 1995 Oct;63(1):127-33)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this paper is to investigate the effect of gabapentin in the earlier stage of reflex sympathetic dystrophy syndrome (RSD)." | 9.12 | The effect of gabapentin in earlier stage of reflex sympathetic dystrophy. ( Duman, I; Hazneci, B; Kalyon, TA; Tan, AK; Taşkaynatan, MA, 2007) |
| "Patients reported significant pain relief in favor of gabapentin in the first period." | 9.11 | Randomised controlled trial of gabapentin in Complex Regional Pain Syndrome type 1 [ISRCTN84121379]. ( Kessels, AH; Stomp-van den Berg, SG; van de Vusse, AC; Weber, WE, 2004) |
| "Gabapentin, which has been approved for add-on therapy of focal seizures, is increasingly used for treatment of neuropathic pain." | 8.81 | [Gabapentin therapy for pain]. ( Block, F, 2001) |
| "The use of the recently released anticonvulsant, gabapentin (Neurontin), in the treatment of severe and refractory reflex sympathetic dystrophy (RSD) pain in six patients ranging in age from 42 to 68 years is reported." | 7.69 | Reflex sympathetic dystrophy treated with gabapentin. ( Mellick, GA; Mellick, LB, 1997) |
| "The objective of this paper is to investigate the effect of gabapentin in the earlier stage of reflex sympathetic dystrophy syndrome (RSD)." | 5.12 | The effect of gabapentin in earlier stage of reflex sympathetic dystrophy. ( Duman, I; Hazneci, B; Kalyon, TA; Tan, AK; Taşkaynatan, MA, 2007) |
| "Patients reported significant pain relief in favor of gabapentin in the first period." | 5.11 | Randomised controlled trial of gabapentin in Complex Regional Pain Syndrome type 1 [ISRCTN84121379]. ( Kessels, AH; Stomp-van den Berg, SG; van de Vusse, AC; Weber, WE, 2004) |
| "Gabapentin, which has been approved for add-on therapy of focal seizures, is increasingly used for treatment of neuropathic pain." | 4.81 | [Gabapentin therapy for pain]. ( Block, F, 2001) |
| "The use of the recently released anticonvulsant, gabapentin (Neurontin), in the treatment of severe and refractory reflex sympathetic dystrophy (RSD) pain in six patients ranging in age from 42 to 68 years is reported." | 3.69 | Reflex sympathetic dystrophy treated with gabapentin. ( Mellick, GA; Mellick, LB, 1997) |
| "Treatment of neuropathic pain in children is challenging, and requires a multimodal approach of pharmacologic, physical, and psychological therapies; however there is little evidence to guide practice." | 2.82 | A randomized controlled trial of amitriptyline versus gabapentin for complex regional pain syndrome type I and neuropathic pain in children. ( Amaria, K; Brown, S; Campbell, F; Johnston, B; McGrath, P; Pehora, C; Watkins, J, 2016) |
| "Mice were tested for tactile mechanical hyperalgesia at 1, 2, and 3 weeks following procedures." | 1.42 | Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor. ( Batisti, AP; Daruge-Neto, E; Emer, AA; Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Prado, MR; Santos, AR, 2015) |
| "Gabapentin was effective in the last two attacks." | 1.33 | A case of recurrent and migratory complex regional pain syndrome type I: Prevention by gabapentin. ( Akkus, S; Yener, M; Yorgancigil, H, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 13 (56.52) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, S | 1 |
| Johnston, B | 1 |
| Amaria, K | 1 |
| Watkins, J | 1 |
| Campbell, F | 1 |
| Pehora, C | 1 |
| McGrath, P | 1 |
| Wertli, MM | 1 |
| Kessels, AG | 1 |
| Perez, RS | 1 |
| Bachmann, LM | 1 |
| Brunner, F | 1 |
| Martins, DF | 1 |
| Prado, MR | 1 |
| Daruge-Neto, E | 1 |
| Batisti, AP | 1 |
| Emer, AA | 1 |
| Mazzardo-Martins, L | 1 |
| Santos, AR | 1 |
| Piovezan, AP | 1 |
| Hey, M | 1 |
| Wilson, I | 1 |
| Johnson, MI | 1 |
| Lee, SK | 1 |
| Yang, DS | 1 |
| Lee, JW | 1 |
| Choy, WS | 1 |
| Haitzer, G | 1 |
| von Orelli, F | 1 |
| Almahrezi, A | 1 |
| Fitzcharles, MA | 1 |
| van de Vusse, AC | 1 |
| Stomp-van den Berg, SG | 1 |
| Kessels, AH | 1 |
| Weber, WE | 1 |
| Braune, S | 1 |
| Lalwani, K | 1 |
| Shoham, A | 1 |
| Koh, JL | 1 |
| McGraw, T | 1 |
| Akkus, S | 1 |
| Yorgancigil, H | 1 |
| Yener, M | 1 |
| Tan, AK | 1 |
| Duman, I | 1 |
| Taşkaynatan, MA | 1 |
| Hazneci, B | 1 |
| Kalyon, TA | 1 |
| Ackerman, WE | 1 |
| Ahmad, M | 1 |
| Mellick, GA | 3 |
| Mellicy, LB | 1 |
| Mellick, LB | 3 |
| McCaffery, M | 1 |
| Rovetta, G | 2 |
| Baratto, L | 2 |
| Monteforte, P | 2 |
| Wheeler, DS | 1 |
| Vaux, KK | 1 |
| Tam, DA | 1 |
| Maneksha, FR | 1 |
| Mirza, H | 1 |
| Poppers, PJ | 1 |
| Block, F | 1 |
| Farinelli, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Complex Regional Pain Syndrome With Once Daily Gastric-Retentive Gabapentin (Gralise)[NCT01623271] | 5 participants (Actual) | Interventional | 2013-05-31 | Terminated (stopped due to Due to limited population of research participants.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Subjects rated their pain using the VAS at visit 3, which was the last day of their maintenance phase. After this visit, subjects begin to taper the gralise. The VAS is subject reported on a scale of 0-10 with 0 being no pain and 10 being the worst pain they can imagine. Results reported are an average of the 3 subjects who completed visit 3. (NCT01623271)
Timeframe: At visit 3
| Intervention | units on the VAS (Mean) |
|---|---|
| CRPS I Pain Subjects | 3.67 |
4 reviews available for gabapentin and Reflex Sympathetic Dystrophy
| Article | Year |
|---|---|
Rational pain management in complex regional pain syndrome 1 (CRPS 1)--a network meta-analysis.
Topics: Adrenal Cortex Hormones; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Diphosphonates; Drug | 2014 |
[Nonorganic pain -- only psychogenic?].
Topics: Acetates; Adult; Amines; Analgesics; Analgesics, Opioid; Anesthetics, Local; Back Pain; Chronic Dise | 2003 |
[Evidence-based pharmacotherapy of neuropathic pain syndromes].
Topics: Amines; Analgesics; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Antioxidants; Cyclohexanec | 2004 |
[Gabapentin therapy for pain].
Topics: Acetates; Amines; Analgesics; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Diabetic Neurop | 2001 |
5 trials available for gabapentin and Reflex Sympathetic Dystrophy
| Article | Year |
|---|---|
A randomized controlled trial of amitriptyline versus gabapentin for complex regional pain syndrome type I and neuropathic pain in children.
Topics: Adolescent; Amines; Amitriptyline; Analgesics; Child; Cyclohexanecarboxylic Acids; Female; Gabapenti | 2016 |
Four treatment strategies for complex regional pain syndrome type 1.
Topics: Administration, Oral; Adult; Aged; Amines; Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory A | 2012 |
Randomised controlled trial of gabapentin in Complex Regional Pain Syndrome type 1 [ISRCTN84121379].
Topics: Adult; Aged; Amines; Analgesics; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind Metho | 2004 |
The effect of gabapentin in earlier stage of reflex sympathetic dystrophy.
Topics: Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Exercise T | 2007 |
Low dose gabapentin for shoulder-hand syndrome induced by phenobarbital: a three-month study.
Topics: Acetates; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Dr | 1999 |
14 other studies available for gabapentin and Reflex Sympathetic Dystrophy
| Article | Year |
|---|---|
Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor.
Topics: Amines; Analgesics; Animals; Caffeine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapent | 2015 |
Stellate ganglion blockade (SGB) for refractory index finger pain - a case report.
Topics: Abdominal Pain; Accidental Falls; Acetaminophen; Adult; Amines; Autonomic Nerve Block; Chronic Disea | 2011 |
[Diagnose Sudeck's disease in good time and save your patient from martyrdom].
Topics: Acetates; Adrenergic Agents; Amines; Analgesics; Analgesics, Opioid; Antipsychotic Agents; Cyclohexa | 2003 |
Dose-dependent severe arthralgia induced by gabapentin.
Topics: Acetates; Adult; Amines; Anticonvulsants; Arthralgia; Cyclohexanecarboxylic Acids; Female; Gabapenti | 2004 |
Use of oxcarbazepine to treat a pediatric patient with resistant complex regional pain syndrome.
Topics: Amines; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; | 2005 |
A case of recurrent and migratory complex regional pain syndrome type I: Prevention by gabapentin.
Topics: Amines; Cyclohexanecarboxylic Acids; Edema; Foot Diseases; Gabapentin; gamma-Aminobutyric Acid; Huma | 2006 |
Recurrent postoperative CRPS I in patients with abnormal preoperative sympathetic function.
Topics: Adult; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nerve Block; Carpal Tu | 2008 |
Gabapentin in the management of reflex sympathetic dystrophy.
Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gam | 1995 |
Successful treatment of reflex sympathetic dystrophy with gabapentin.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Ami | 1995 |
Reflex sympathetic dystrophy treated with gabapentin.
Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gam | 1997 |
Gabapentin for lancinating neuropathic pain.
Topics: Acetates; Acquired Immunodeficiency Syndrome; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabap | 1998 |
Use of gabapentin in the treatment of childhood reflex sympathetic dystrophy.
Topics: Acetates; Amines; Child; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Excitatory A | 2000 |
Complex regional pain syndrome (CRPS) with resistance to local anesthetic block: a case report.
Topics: Acetates; Amines; Amitriptyline; Analgesia, Epidural; Analgesics; Analgesics, Non-Narcotic; Analgesi | 2000 |
Three-month follow-up of shoulder-hand syndrome induced by phenobarbital and treated with gabapentin.
Topics: Acetaminophen; Acetates; Amines; Analgesics; Anticonvulsants; Arthralgia; Cyclohexanecarboxylic Acid | 2001 |