Page last updated: 2024-10-27

gabapentin and Reflex Sympathetic Dystrophy

gabapentin has been researched along with Reflex Sympathetic Dystrophy in 23 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Reflex Sympathetic Dystrophy: A syndrome characterized by severe burning pain in an extremity accompanied by sudomotor, vasomotor, and trophic changes in bone without an associated specific nerve injury. This condition is most often precipitated by trauma to soft tissue or nerve complexes. The skin over the affected region is usually erythematous and demonstrates hypersensitivity to tactile stimuli and erythema. (Adams et al., Principles of Neurology, 6th ed, p1360; Pain 1995 Oct;63(1):127-33)

Research Excerpts

ExcerptRelevanceReference
"The objective of this paper is to investigate the effect of gabapentin in the earlier stage of reflex sympathetic dystrophy syndrome (RSD)."9.12The effect of gabapentin in earlier stage of reflex sympathetic dystrophy. ( Duman, I; Hazneci, B; Kalyon, TA; Tan, AK; Taşkaynatan, MA, 2007)
"Patients reported significant pain relief in favor of gabapentin in the first period."9.11Randomised controlled trial of gabapentin in Complex Regional Pain Syndrome type 1 [ISRCTN84121379]. ( Kessels, AH; Stomp-van den Berg, SG; van de Vusse, AC; Weber, WE, 2004)
"Gabapentin, which has been approved for add-on therapy of focal seizures, is increasingly used for treatment of neuropathic pain."8.81[Gabapentin therapy for pain]. ( Block, F, 2001)
"The use of the recently released anticonvulsant, gabapentin (Neurontin), in the treatment of severe and refractory reflex sympathetic dystrophy (RSD) pain in six patients ranging in age from 42 to 68 years is reported."7.69Reflex sympathetic dystrophy treated with gabapentin. ( Mellick, GA; Mellick, LB, 1997)
"The objective of this paper is to investigate the effect of gabapentin in the earlier stage of reflex sympathetic dystrophy syndrome (RSD)."5.12The effect of gabapentin in earlier stage of reflex sympathetic dystrophy. ( Duman, I; Hazneci, B; Kalyon, TA; Tan, AK; Taşkaynatan, MA, 2007)
"Patients reported significant pain relief in favor of gabapentin in the first period."5.11Randomised controlled trial of gabapentin in Complex Regional Pain Syndrome type 1 [ISRCTN84121379]. ( Kessels, AH; Stomp-van den Berg, SG; van de Vusse, AC; Weber, WE, 2004)
"Gabapentin, which has been approved for add-on therapy of focal seizures, is increasingly used for treatment of neuropathic pain."4.81[Gabapentin therapy for pain]. ( Block, F, 2001)
"The use of the recently released anticonvulsant, gabapentin (Neurontin), in the treatment of severe and refractory reflex sympathetic dystrophy (RSD) pain in six patients ranging in age from 42 to 68 years is reported."3.69Reflex sympathetic dystrophy treated with gabapentin. ( Mellick, GA; Mellick, LB, 1997)
"Treatment of neuropathic pain in children is challenging, and requires a multimodal approach of pharmacologic, physical, and psychological therapies; however there is little evidence to guide practice."2.82A randomized controlled trial of amitriptyline versus gabapentin for complex regional pain syndrome type I and neuropathic pain in children. ( Amaria, K; Brown, S; Campbell, F; Johnston, B; McGrath, P; Pehora, C; Watkins, J, 2016)
"Mice were tested for tactile mechanical hyperalgesia at 1, 2, and 3 weeks following procedures."1.42Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor. ( Batisti, AP; Daruge-Neto, E; Emer, AA; Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Prado, MR; Santos, AR, 2015)
"Gabapentin was effective in the last two attacks."1.33A case of recurrent and migratory complex regional pain syndrome type I: Prevention by gabapentin. ( Akkus, S; Yener, M; Yorgancigil, H, 2006)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (21.74)18.2507
2000's13 (56.52)29.6817
2010's5 (21.74)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brown, S1
Johnston, B1
Amaria, K1
Watkins, J1
Campbell, F1
Pehora, C1
McGrath, P1
Wertli, MM1
Kessels, AG1
Perez, RS1
Bachmann, LM1
Brunner, F1
Martins, DF1
Prado, MR1
Daruge-Neto, E1
Batisti, AP1
Emer, AA1
Mazzardo-Martins, L1
Santos, AR1
Piovezan, AP1
Hey, M1
Wilson, I1
Johnson, MI1
Lee, SK1
Yang, DS1
Lee, JW1
Choy, WS1
Haitzer, G1
von Orelli, F1
Almahrezi, A1
Fitzcharles, MA1
van de Vusse, AC1
Stomp-van den Berg, SG1
Kessels, AH1
Weber, WE1
Braune, S1
Lalwani, K1
Shoham, A1
Koh, JL1
McGraw, T1
Akkus, S1
Yorgancigil, H1
Yener, M1
Tan, AK1
Duman, I1
Taşkaynatan, MA1
Hazneci, B1
Kalyon, TA1
Ackerman, WE1
Ahmad, M1
Mellick, GA3
Mellicy, LB1
Mellick, LB3
McCaffery, M1
Rovetta, G2
Baratto, L2
Monteforte, P2
Wheeler, DS1
Vaux, KK1
Tam, DA1
Maneksha, FR1
Mirza, H1
Poppers, PJ1
Block, F1
Farinelli, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Treatment of Complex Regional Pain Syndrome With Once Daily Gastric-Retentive Gabapentin (Gralise)[NCT01623271]5 participants (Actual)Interventional2013-05-31Terminated (stopped due to Due to limited population of research participants.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Visual Analog Scale (VAS) at Visit 3

Subjects rated their pain using the VAS at visit 3, which was the last day of their maintenance phase. After this visit, subjects begin to taper the gralise. The VAS is subject reported on a scale of 0-10 with 0 being no pain and 10 being the worst pain they can imagine. Results reported are an average of the 3 subjects who completed visit 3. (NCT01623271)
Timeframe: At visit 3

Interventionunits on the VAS (Mean)
CRPS I Pain Subjects3.67

Reviews

4 reviews available for gabapentin and Reflex Sympathetic Dystrophy

ArticleYear
Rational pain management in complex regional pain syndrome 1 (CRPS 1)--a network meta-analysis.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:9

    Topics: Adrenal Cortex Hormones; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Diphosphonates; Drug

2014
[Nonorganic pain -- only psychogenic?].
    Praxis, 2003, Nov-26, Volume: 92, Issue:48

    Topics: Acetates; Adult; Amines; Analgesics; Analgesics, Opioid; Anesthetics, Local; Back Pain; Chronic Dise

2003
[Evidence-based pharmacotherapy of neuropathic pain syndromes].
    MMW Fortschritte der Medizin, 2004, Dec-09, Volume: 146, Issue:50

    Topics: Amines; Analgesics; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Antioxidants; Cyclohexanec

2004
[Gabapentin therapy for pain].
    Der Nervenarzt, 2001, Volume: 72, Issue:2

    Topics: Acetates; Amines; Analgesics; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Diabetic Neurop

2001

Trials

5 trials available for gabapentin and Reflex Sympathetic Dystrophy

ArticleYear
A randomized controlled trial of amitriptyline versus gabapentin for complex regional pain syndrome type I and neuropathic pain in children.
    Scandinavian journal of pain, 2016, Volume: 13

    Topics: Adolescent; Amines; Amitriptyline; Analgesics; Child; Cyclohexanecarboxylic Acids; Female; Gabapenti

2016
Four treatment strategies for complex regional pain syndrome type 1.
    Orthopedics, 2012, Volume: 35, Issue:6

    Topics: Administration, Oral; Adult; Aged; Amines; Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory A

2012
Randomised controlled trial of gabapentin in Complex Regional Pain Syndrome type 1 [ISRCTN84121379].
    BMC neurology, 2004, Sep-29, Volume: 4

    Topics: Adult; Aged; Amines; Analgesics; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind Metho

2004
The effect of gabapentin in earlier stage of reflex sympathetic dystrophy.
    Clinical rheumatology, 2007, Volume: 26, Issue:4

    Topics: Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Exercise T

2007
Low dose gabapentin for shoulder-hand syndrome induced by phenobarbital: a three-month study.
    Drugs under experimental and clinical research, 1999, Volume: 25, Issue:4

    Topics: Acetates; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Dr

1999

Other Studies

14 other studies available for gabapentin and Reflex Sympathetic Dystrophy

ArticleYear
Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor.
    Journal of the peripheral nervous system : JPNS, 2015, Volume: 20, Issue:4

    Topics: Amines; Analgesics; Animals; Caffeine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapent

2015
Stellate ganglion blockade (SGB) for refractory index finger pain - a case report.
    Annals of physical and rehabilitation medicine, 2011, Volume: 54, Issue:3

    Topics: Abdominal Pain; Accidental Falls; Acetaminophen; Adult; Amines; Autonomic Nerve Block; Chronic Disea

2011
[Diagnose Sudeck's disease in good time and save your patient from martyrdom].
    MMW Fortschritte der Medizin, 2003, Feb-27, Volume: 145, Issue:9

    Topics: Acetates; Adrenergic Agents; Amines; Analgesics; Analgesics, Opioid; Antipsychotic Agents; Cyclohexa

2003
Dose-dependent severe arthralgia induced by gabapentin.
    The Journal of rheumatology, 2004, Volume: 31, Issue:6

    Topics: Acetates; Adult; Amines; Anticonvulsants; Arthralgia; Cyclohexanecarboxylic Acids; Female; Gabapenti

2004
Use of oxcarbazepine to treat a pediatric patient with resistant complex regional pain syndrome.
    The journal of pain, 2005, Volume: 6, Issue:10

    Topics: Amines; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants;

2005
A case of recurrent and migratory complex regional pain syndrome type I: Prevention by gabapentin.
    Rheumatology international, 2006, Volume: 26, Issue:9

    Topics: Amines; Cyclohexanecarboxylic Acids; Edema; Foot Diseases; Gabapentin; gamma-Aminobutyric Acid; Huma

2006
Recurrent postoperative CRPS I in patients with abnormal preoperative sympathetic function.
    The Journal of hand surgery, 2008, Volume: 33, Issue:2

    Topics: Adult; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nerve Block; Carpal Tu

2008
Gabapentin in the management of reflex sympathetic dystrophy.
    Journal of pain and symptom management, 1995, Volume: 10, Issue:4

    Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gam

1995
Successful treatment of reflex sympathetic dystrophy with gabapentin.
    The American journal of emergency medicine, 1995, Volume: 13, Issue:1

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Ami

1995
Reflex sympathetic dystrophy treated with gabapentin.
    Archives of physical medicine and rehabilitation, 1997, Volume: 78, Issue:1

    Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gam

1997
Gabapentin for lancinating neuropathic pain.
    The American journal of nursing, 1998, Volume: 98, Issue:4

    Topics: Acetates; Acquired Immunodeficiency Syndrome; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabap

1998
Use of gabapentin in the treatment of childhood reflex sympathetic dystrophy.
    Pediatric neurology, 2000, Volume: 22, Issue:3

    Topics: Acetates; Amines; Child; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Excitatory A

2000
Complex regional pain syndrome (CRPS) with resistance to local anesthetic block: a case report.
    Journal of clinical anesthesia, 2000, Volume: 12, Issue:1

    Topics: Acetates; Amines; Amitriptyline; Analgesia, Epidural; Analgesics; Analgesics, Non-Narcotic; Analgesi

2000
Three-month follow-up of shoulder-hand syndrome induced by phenobarbital and treated with gabapentin.
    International journal of tissue reactions, 2001, Volume: 23, Issue:1

    Topics: Acetaminophen; Acetates; Amines; Analgesics; Anticonvulsants; Arthralgia; Cyclohexanecarboxylic Acid

2001