Page last updated: 2024-10-27

gabapentin and Peripheral Nerve Injuries

gabapentin has been researched along with Peripheral Nerve Injuries in 26 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Peripheral Nerve Injuries: Injuries to the PERIPHERAL NERVES.

Research Excerpts

ExcerptRelevanceReference
" The effects of genistein were compared with those of gabapentin, which is widely used in clinical practice for peripheral nerve injury."7.85Neuroprotective Effect of Genistein in Peripheral Nerve Injury. ( Arslantas, A; Aydin, HE; Baycu, C; Bektur, E; Kocman, AE; Kose, A; Ozbek, Z; Ozkara, E; Sahin, E; Vural, M, 2017)
"These results suggest that peripheral nerve injury induces plasticity of GABAergic neurons differently in the LC and spinal dorsal horn and that gabapentin reduces presynaptic GABA release in the LC but not in the spinal dorsal horn."7.78Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. ( Eisenach, JC; Hayashida, K; Parker, RA; Yoshizumi, M, 2012)
"Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration."7.74Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007)
"Systemic gabapentin, commonly used to treat chronic pain, impaired the novel object recognition task in normal but not SNL animals."5.40Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. ( Eisenach, JC; Hayashida, K; Suto, T, 2014)
"A double-blind, randomized, placebo-controlled cross-over multi-center study was conducted to evaluate the efficacy and safety of gabapentin in the treatment of neuropathic pain caused by traumatic or postsurgical peripheral nerve injury, using doses up to 2400 mg/day."5.13Gabapentin in traumatic nerve injury pain: a randomized, double-blind, placebo-controlled, cross-over, multi-center study. ( Arnèr, S; Biber, B; Boivie, J; Gordh, TE; Jensen, TS; Kalliomäki, J; Kalso, E; Mannheimer, C; Stubhaug, A, 2008)
"Gabapentin promotes neurological recovery histopathologically in peripheral nerve injury due to its neuroprotective properties."3.88Effect of gabapentin on primary surgical treatment of experimental sciatic nerve injury in rats. ( Bulduk, EB; Çivi, S; Durdağ, E; Kardeş, Ö; Selçuk, FK; Süner, Hİ; Tufan, K, 2018)
" The effects of genistein were compared with those of gabapentin, which is widely used in clinical practice for peripheral nerve injury."3.85Neuroprotective Effect of Genistein in Peripheral Nerve Injury. ( Arslantas, A; Aydin, HE; Baycu, C; Bektur, E; Kocman, AE; Kose, A; Ozbek, Z; Ozkara, E; Sahin, E; Vural, M, 2017)
"These results suggest that peripheral nerve injury induces plasticity of GABAergic neurons differently in the LC and spinal dorsal horn and that gabapentin reduces presynaptic GABA release in the LC but not in the spinal dorsal horn."3.78Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. ( Eisenach, JC; Hayashida, K; Parker, RA; Yoshizumi, M, 2012)
"Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration."3.74Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007)
" In the current study, we evaluated the behavioral effects of two standard drugs used clinically for neuropathic pain, the anticonvulsant gabapentin and antidepressant imipramine, in rats at different times after peripheral nerve injury."3.73The effect of antinociceptive drugs tested at different times after nerve injury in rats. ( Borsook, D; Hama, AT, 2005)
"Processes involved in the onset of neuropathic pain differ from those involved in its long-term maintenance."2.58Etiology and Pharmacology of Neuropathic Pain. ( Alles, SRA; Smith, PA, 2018)
"Chronic pain affects quality of life and adversely affects functional outcomes."2.49Management of chronic pain following nerve injuries/CRPS type II. ( Carroll, I; Curtin, CM, 2013)
"Sinomenine can enhance the efficacy of gabapentin or ligustrazine hydrochloride in rodent models of peripheral or central neuropathic pain, without introducing tolerance or other notable side effects."1.51Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain. ( Gao, T; Jiang, JD; Li, T; Shi, T; Wiesenfeld-Hallin, Z; Xu, XJ, 2019)
"In addition, PLSN-induced mechanical and thermal hyperalgesia was prevented by systemic (i."1.40The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice. ( Calixto, JB; Costa, R; Manjavachi, MN; Quintão, NL, 2014)
"Systemic gabapentin, commonly used to treat chronic pain, impaired the novel object recognition task in normal but not SNL animals."1.40Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. ( Eisenach, JC; Hayashida, K; Suto, T, 2014)
"Animal models of neuropathic pain have enabled the identification of key pathophysiological changes occurring within nociceptive pathways as a result of injury, and serve an invaluable role for preclinical screening of novel analgesic candidates."1.34The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Jensen, DG; Rode, F; Thomsen, M, 2007)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.85)18.2507
2000's8 (30.77)29.6817
2010's15 (57.69)24.3611
2020's2 (7.69)2.80

Authors

AuthorsStudies
Yogeeswari, P1
Ragavendran, JV1
Sriram, D1
Nageswari, Y1
Kavya, R1
Sreevatsan, N1
Vanitha, K1
Stables, J1
Lee, N1
Nho, B1
Ko, KR1
Kim, S1
Lee, J1
Cutts, S1
Gangoo, S1
Srinivasan, SH1
Modi, N1
Pasapula, C1
Power, D1
Alles, SRA1
Smith, PA1
Fernandez, L1
Komatsu, DE1
Gurevich, M1
Hurst, LC1
Kardeş, Ö1
Çivi, S1
Bulduk, EB1
Selçuk, FK1
Süner, Hİ1
Durdağ, E1
Tufan, K1
Gao, T1
Shi, T1
Wiesenfeld-Hallin, Z2
Li, T1
Jiang, JD1
Xu, XJ2
Carroll, I1
Curtin, CM1
Manjavachi, MN1
Costa, R1
Quintão, NL1
Calixto, JB1
Lana, B1
Schlick, B1
Martin, S1
Pratt, WS1
Page, KM1
Goncalves, L1
Rahman, W1
Dickenson, AH1
Bauer, CS1
Dolphin, AC1
Suto, T1
Eisenach, JC5
Hayashida, K3
Miranda, HF1
Noriega, V1
Zepeda, R1
Zanetta, P1
Prieto-Rayo, J1
Prieto, JC1
Sierralta, F1
Griggs, RB1
Bardo, MT1
Taylor, BK1
Kimura, M1
Hayashida, KI1
Ozbek, Z1
Aydin, HE1
Kocman, AE1
Ozkara, E1
Sahin, E1
Bektur, E1
Vural, M1
Kose, A1
Arslantas, A1
Baycu, C1
Tanabe, M1
Takasu, K1
Takeuchi, Y1
Ono, H1
Ewan, EE1
Martin, TJ1
Andrews, N1
Legg, E1
Lisak, D1
Issop, Y1
Richardson, D1
Harper, S1
Pheby, T1
Huang, W1
Burgess, G1
Machin, I1
Rice, AS1
Yoshizumi, M1
Parker, RA1
Wu, WP1
Hao, JX1
Ongini, E1
Impagnatiello, F1
Presotto, C1
Hama, AT2
Borsook, D2
Rode, F1
Thomsen, M1
Broløs, T1
Jensen, DG1
Blackburn-Munro, G1
Bjerrum, OJ1
Parker, R1
Gordh, TE1
Stubhaug, A1
Jensen, TS1
Arnèr, S1
Biber, B1
Boivie, J1
Mannheimer, C1
Kalliomäki, J1
Kalso, E1
Pan, HL1
Chen, SR1

Reviews

5 reviews available for gabapentin and Peripheral Nerve Injuries

ArticleYear
Complex regional pain syndrome: an evolving perspective.
    Postgraduate medical journal, 2021, Volume: 97, Issue:1146

    Topics: Amputation, Surgical; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Ascorbic Acid; Botuli

2021
Etiology and Pharmacology of Neuropathic Pain.
    Pharmacological reviews, 2018, Volume: 70, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Gabapentin; Humans; Ion Channels; Molecular Targeted Therap

2018
Emerging Strategies on Adjuvant Therapies for Nerve Recovery.
    The Journal of hand surgery, 2018, Volume: 43, Issue:4

    Topics: Absorbable Implants; Allografts; Autografts; Calcium Channel Blockers; Erythropoietin; Gabapentin; H

2018
Management of chronic pain following nerve injuries/CRPS type II.
    Hand clinics, 2013, Volume: 29, Issue:3

    Topics: Amines; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Capsaicin; Causalgia; Chronic Pa

2013
Pain relief by gabapentin and pregabalin via supraspinal mechanisms after peripheral nerve injury.
    Journal of neuroscience research, 2008, Nov-15, Volume: 86, Issue:15

    Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid

2008

Trials

1 trial available for gabapentin and Peripheral Nerve Injuries

ArticleYear
Gabapentin in traumatic nerve injury pain: a randomized, double-blind, placebo-controlled, cross-over, multi-center study.
    Pain, 2008, Aug-31, Volume: 138, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Amines; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blin

2008

Other Studies

20 other studies available for gabapentin and Peripheral Nerve Injuries

ArticleYear
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
    Journal of medicinal chemistry, 2007, May-17, Volume: 50, Issue:10

    Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia;

2007
Gabapentin inhibits the analgesic effects and nerve regeneration process induced by hepatocyte growth factor (HGF) in a peripheral nerve injury model: Implication for the use of VM202 and gabapentinoids for peripheral neuropathy.
    Molecular and cellular neurosciences, 2022, Volume: 122

    Topics: Analgesics; Animals; Axons; Disease Models, Animal; DNA; Gabapentin; Genetic Therapy; Hepatocyte Gro

2022
Effect of gabapentin on primary surgical treatment of experimental sciatic nerve injury in rats.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2018, Volume: 24, Issue:5

    Topics: Animals; Gabapentin; Male; Peripheral Nerve Injuries; Protective Agents; Random Allocation; Rats; Ra

2018
Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain.
    European journal of pharmacology, 2019, Jul-05, Volume: 854

    Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; Gabapentin; Male; Mice; Mice, Inbred C5

2019
The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice.
    Neuropharmacology, 2014, Volume: 79

    Topics: Amines; Analgesics; Animals; Antibodies; Chemokines; Cyclohexanecarboxylic Acids; Cyclooxygenase Inh

2014
Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury.
    Pain, 2014, Volume: 155, Issue:3

    Topics: Amines; Animals; Calcium Channels; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids; Gabapentin

2014
Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain.
    Pain, 2014, Volume: 155, Issue:10

    Topics: Adrenergic Neurons; Amines; Analgesics; Animals; Attention; Behavior, Animal; Chronic Pain; Cyclohex

2014
Antinociceptive synergism of gabapentin and nortriptyline in mice with partial sciatic nerve ligation.
    Pharmacology, 2015, Volume: 95, Issue:1-2

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Drug Synergism; Drug Therapy, Combination;

2015
Gabapentin alleviates affective pain after traumatic nerve injury.
    Neuroreport, 2015, Jun-17, Volume: 26, Issue:9

    Topics: Affect; Amines; Analgesics; Animals; Conditioning, Psychological; Cyclohexanecarboxylic Acids; Gabap

2015
Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.
    Pain, 2016, Volume: 157, Issue:9

    Topics: Amines; Analgesics; Animals; Antihypertensive Agents; Atropine; Bronchodilator Agents; Clonidine; CR

2016
Neuroprotective Effect of Genistein in Peripheral Nerve Injury.
    Turkish neurosurgery, 2017, Volume: 27, Issue:5

    Topics: Amines; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyr

2017
Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adenosine; Amines; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Cyclohexanecarboxylic

2011
Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain.
    European journal of pain (London, England), 2012, Volume: 16, Issue:4

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclohexanec

2012
Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Extracellular Space

2012
A nitric oxide (NO)-releasing derivative of gabapentin, NCX 8001, alleviates neuropathic pain-like behavior after spinal cord and peripheral nerve injury.
    British journal of pharmacology, 2004, Volume: 141, Issue:1

    Topics: Acetates; Amines; Animals; Aorta, Thoracic; Behavior, Animal; Cyclic GMP; Cyclohexanecarboxylic Acid

2004
Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:1

    Topics: Amines; Analgesics; Animals; Cold Temperature; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminob

2005
The effect of antinociceptive drugs tested at different times after nerve injury in rats.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:1

    Topics: Amines; Analgesics; Animals; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Dose-Res

2005
The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain.
    European journal of pharmacology, 2007, Jun-14, Volume: 564, Issue:1-3

    Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal

2007
Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
    Anesthesiology, 2007, Volume: 106, Issue:6

    Topics: Administration, Oral; Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic

2007
Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:3

    Topics: Acetates; Afferent Pathways; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease

1999