gabapentin has been researched along with Peripheral Nerve Injuries in 26 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Peripheral Nerve Injuries: Injuries to the PERIPHERAL NERVES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of genistein were compared with those of gabapentin, which is widely used in clinical practice for peripheral nerve injury." | 7.85 | Neuroprotective Effect of Genistein in Peripheral Nerve Injury. ( Arslantas, A; Aydin, HE; Baycu, C; Bektur, E; Kocman, AE; Kose, A; Ozbek, Z; Ozkara, E; Sahin, E; Vural, M, 2017) |
| "These results suggest that peripheral nerve injury induces plasticity of GABAergic neurons differently in the LC and spinal dorsal horn and that gabapentin reduces presynaptic GABA release in the LC but not in the spinal dorsal horn." | 7.78 | Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. ( Eisenach, JC; Hayashida, K; Parker, RA; Yoshizumi, M, 2012) |
| "Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration." | 7.74 | Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007) |
| "Systemic gabapentin, commonly used to treat chronic pain, impaired the novel object recognition task in normal but not SNL animals." | 5.40 | Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. ( Eisenach, JC; Hayashida, K; Suto, T, 2014) |
| "A double-blind, randomized, placebo-controlled cross-over multi-center study was conducted to evaluate the efficacy and safety of gabapentin in the treatment of neuropathic pain caused by traumatic or postsurgical peripheral nerve injury, using doses up to 2400 mg/day." | 5.13 | Gabapentin in traumatic nerve injury pain: a randomized, double-blind, placebo-controlled, cross-over, multi-center study. ( Arnèr, S; Biber, B; Boivie, J; Gordh, TE; Jensen, TS; Kalliomäki, J; Kalso, E; Mannheimer, C; Stubhaug, A, 2008) |
| "Gabapentin promotes neurological recovery histopathologically in peripheral nerve injury due to its neuroprotective properties." | 3.88 | Effect of gabapentin on primary surgical treatment of experimental sciatic nerve injury in rats. ( Bulduk, EB; Çivi, S; Durdağ, E; Kardeş, Ö; Selçuk, FK; Süner, Hİ; Tufan, K, 2018) |
| " The effects of genistein were compared with those of gabapentin, which is widely used in clinical practice for peripheral nerve injury." | 3.85 | Neuroprotective Effect of Genistein in Peripheral Nerve Injury. ( Arslantas, A; Aydin, HE; Baycu, C; Bektur, E; Kocman, AE; Kose, A; Ozbek, Z; Ozkara, E; Sahin, E; Vural, M, 2017) |
| "These results suggest that peripheral nerve injury induces plasticity of GABAergic neurons differently in the LC and spinal dorsal horn and that gabapentin reduces presynaptic GABA release in the LC but not in the spinal dorsal horn." | 3.78 | Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. ( Eisenach, JC; Hayashida, K; Parker, RA; Yoshizumi, M, 2012) |
| "Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration." | 3.74 | Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007) |
| " In the current study, we evaluated the behavioral effects of two standard drugs used clinically for neuropathic pain, the anticonvulsant gabapentin and antidepressant imipramine, in rats at different times after peripheral nerve injury." | 3.73 | The effect of antinociceptive drugs tested at different times after nerve injury in rats. ( Borsook, D; Hama, AT, 2005) |
| "Processes involved in the onset of neuropathic pain differ from those involved in its long-term maintenance." | 2.58 | Etiology and Pharmacology of Neuropathic Pain. ( Alles, SRA; Smith, PA, 2018) |
| "Chronic pain affects quality of life and adversely affects functional outcomes." | 2.49 | Management of chronic pain following nerve injuries/CRPS type II. ( Carroll, I; Curtin, CM, 2013) |
| "Sinomenine can enhance the efficacy of gabapentin or ligustrazine hydrochloride in rodent models of peripheral or central neuropathic pain, without introducing tolerance or other notable side effects." | 1.51 | Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain. ( Gao, T; Jiang, JD; Li, T; Shi, T; Wiesenfeld-Hallin, Z; Xu, XJ, 2019) |
| "In addition, PLSN-induced mechanical and thermal hyperalgesia was prevented by systemic (i." | 1.40 | The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice. ( Calixto, JB; Costa, R; Manjavachi, MN; Quintão, NL, 2014) |
| "Systemic gabapentin, commonly used to treat chronic pain, impaired the novel object recognition task in normal but not SNL animals." | 1.40 | Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. ( Eisenach, JC; Hayashida, K; Suto, T, 2014) |
| "Animal models of neuropathic pain have enabled the identification of key pathophysiological changes occurring within nociceptive pathways as a result of injury, and serve an invaluable role for preclinical screening of novel analgesic candidates." | 1.34 | The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Jensen, DG; Rode, F; Thomsen, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 15 (57.69) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Yogeeswari, P | 1 |
| Ragavendran, JV | 1 |
| Sriram, D | 1 |
| Nageswari, Y | 1 |
| Kavya, R | 1 |
| Sreevatsan, N | 1 |
| Vanitha, K | 1 |
| Stables, J | 1 |
| Lee, N | 1 |
| Nho, B | 1 |
| Ko, KR | 1 |
| Kim, S | 1 |
| Lee, J | 1 |
| Cutts, S | 1 |
| Gangoo, S | 1 |
| Srinivasan, SH | 1 |
| Modi, N | 1 |
| Pasapula, C | 1 |
| Power, D | 1 |
| Alles, SRA | 1 |
| Smith, PA | 1 |
| Fernandez, L | 1 |
| Komatsu, DE | 1 |
| Gurevich, M | 1 |
| Hurst, LC | 1 |
| Kardeş, Ö | 1 |
| Çivi, S | 1 |
| Bulduk, EB | 1 |
| Selçuk, FK | 1 |
| Süner, Hİ | 1 |
| Durdağ, E | 1 |
| Tufan, K | 1 |
| Gao, T | 1 |
| Shi, T | 1 |
| Wiesenfeld-Hallin, Z | 2 |
| Li, T | 1 |
| Jiang, JD | 1 |
| Xu, XJ | 2 |
| Carroll, I | 1 |
| Curtin, CM | 1 |
| Manjavachi, MN | 1 |
| Costa, R | 1 |
| Quintão, NL | 1 |
| Calixto, JB | 1 |
| Lana, B | 1 |
| Schlick, B | 1 |
| Martin, S | 1 |
| Pratt, WS | 1 |
| Page, KM | 1 |
| Goncalves, L | 1 |
| Rahman, W | 1 |
| Dickenson, AH | 1 |
| Bauer, CS | 1 |
| Dolphin, AC | 1 |
| Suto, T | 1 |
| Eisenach, JC | 5 |
| Hayashida, K | 3 |
| Miranda, HF | 1 |
| Noriega, V | 1 |
| Zepeda, R | 1 |
| Zanetta, P | 1 |
| Prieto-Rayo, J | 1 |
| Prieto, JC | 1 |
| Sierralta, F | 1 |
| Griggs, RB | 1 |
| Bardo, MT | 1 |
| Taylor, BK | 1 |
| Kimura, M | 1 |
| Hayashida, KI | 1 |
| Ozbek, Z | 1 |
| Aydin, HE | 1 |
| Kocman, AE | 1 |
| Ozkara, E | 1 |
| Sahin, E | 1 |
| Bektur, E | 1 |
| Vural, M | 1 |
| Kose, A | 1 |
| Arslantas, A | 1 |
| Baycu, C | 1 |
| Tanabe, M | 1 |
| Takasu, K | 1 |
| Takeuchi, Y | 1 |
| Ono, H | 1 |
| Ewan, EE | 1 |
| Martin, TJ | 1 |
| Andrews, N | 1 |
| Legg, E | 1 |
| Lisak, D | 1 |
| Issop, Y | 1 |
| Richardson, D | 1 |
| Harper, S | 1 |
| Pheby, T | 1 |
| Huang, W | 1 |
| Burgess, G | 1 |
| Machin, I | 1 |
| Rice, AS | 1 |
| Yoshizumi, M | 1 |
| Parker, RA | 1 |
| Wu, WP | 1 |
| Hao, JX | 1 |
| Ongini, E | 1 |
| Impagnatiello, F | 1 |
| Presotto, C | 1 |
| Hama, AT | 2 |
| Borsook, D | 2 |
| Rode, F | 1 |
| Thomsen, M | 1 |
| Broløs, T | 1 |
| Jensen, DG | 1 |
| Blackburn-Munro, G | 1 |
| Bjerrum, OJ | 1 |
| Parker, R | 1 |
| Gordh, TE | 1 |
| Stubhaug, A | 1 |
| Jensen, TS | 1 |
| Arnèr, S | 1 |
| Biber, B | 1 |
| Boivie, J | 1 |
| Mannheimer, C | 1 |
| Kalliomäki, J | 1 |
| Kalso, E | 1 |
| Pan, HL | 1 |
| Chen, SR | 1 |
5 reviews available for gabapentin and Peripheral Nerve Injuries
| Article | Year |
|---|---|
Complex regional pain syndrome: an evolving perspective.
Topics: Amputation, Surgical; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Ascorbic Acid; Botuli | 2021 |
Etiology and Pharmacology of Neuropathic Pain.
Topics: Analgesics; Analgesics, Opioid; Animals; Gabapentin; Humans; Ion Channels; Molecular Targeted Therap | 2018 |
Emerging Strategies on Adjuvant Therapies for Nerve Recovery.
Topics: Absorbable Implants; Allografts; Autografts; Calcium Channel Blockers; Erythropoietin; Gabapentin; H | 2018 |
Management of chronic pain following nerve injuries/CRPS type II.
Topics: Amines; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Capsaicin; Causalgia; Chronic Pa | 2013 |
Pain relief by gabapentin and pregabalin via supraspinal mechanisms after peripheral nerve injury.
Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid | 2008 |
1 trial available for gabapentin and Peripheral Nerve Injuries
| Article | Year |
|---|---|
Gabapentin in traumatic nerve injury pain: a randomized, double-blind, placebo-controlled, cross-over, multi-center study.
Topics: Adult; Aged; Aged, 80 and over; Amines; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blin | 2008 |
20 other studies available for gabapentin and Peripheral Nerve Injuries
| Article | Year |
|---|---|
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
Gabapentin inhibits the analgesic effects and nerve regeneration process induced by hepatocyte growth factor (HGF) in a peripheral nerve injury model: Implication for the use of VM202 and gabapentinoids for peripheral neuropathy.
Topics: Analgesics; Animals; Axons; Disease Models, Animal; DNA; Gabapentin; Genetic Therapy; Hepatocyte Gro | 2022 |
Effect of gabapentin on primary surgical treatment of experimental sciatic nerve injury in rats.
Topics: Animals; Gabapentin; Male; Peripheral Nerve Injuries; Protective Agents; Random Allocation; Rats; Ra | 2018 |
Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; Gabapentin; Male; Mice; Mice, Inbred C5 | 2019 |
The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice.
Topics: Amines; Analgesics; Animals; Antibodies; Chemokines; Cyclohexanecarboxylic Acids; Cyclooxygenase Inh | 2014 |
Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury.
Topics: Amines; Animals; Calcium Channels; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids; Gabapentin | 2014 |
Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain.
Topics: Adrenergic Neurons; Amines; Analgesics; Animals; Attention; Behavior, Animal; Chronic Pain; Cyclohex | 2014 |
Antinociceptive synergism of gabapentin and nortriptyline in mice with partial sciatic nerve ligation.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Drug Synergism; Drug Therapy, Combination; | 2015 |
Gabapentin alleviates affective pain after traumatic nerve injury.
Topics: Affect; Amines; Analgesics; Animals; Conditioning, Psychological; Cyclohexanecarboxylic Acids; Gabap | 2015 |
Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.
Topics: Amines; Analgesics; Animals; Antihypertensive Agents; Atropine; Bronchodilator Agents; Clonidine; CR | 2016 |
Neuroprotective Effect of Genistein in Peripheral Nerve Injury.
Topics: Amines; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyr | 2017 |
Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids.
Topics: Adenosine; Amines; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Cyclohexanecarboxylic | 2011 |
Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclohexanec | 2012 |
Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Extracellular Space | 2012 |
A nitric oxide (NO)-releasing derivative of gabapentin, NCX 8001, alleviates neuropathic pain-like behavior after spinal cord and peripheral nerve injury.
Topics: Acetates; Amines; Animals; Aorta, Thoracic; Behavior, Animal; Cyclic GMP; Cyclohexanecarboxylic Acid | 2004 |
Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat.
Topics: Amines; Analgesics; Animals; Cold Temperature; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminob | 2005 |
The effect of antinociceptive drugs tested at different times after nerve injury in rats.
Topics: Amines; Analgesics; Animals; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Dose-Res | 2005 |
The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2007 |
Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
Topics: Administration, Oral; Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic | 2007 |
Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats.
Topics: Acetates; Afferent Pathways; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease | 1999 |