Page last updated: 2024-10-27

gabapentin and Pelvic Pain

gabapentin has been researched along with Pelvic Pain in 22 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Pelvic Pain: Pain in the pelvic region of genital and non-genital origin.

Research Excerpts

ExcerptRelevanceReference
"This study was adequately powered, but treatment with gabapentin did not result in significantly lower pain scores in women with chronic pelvic pain, and was associated with higher rates of side-effects than placebo."9.34Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial. ( Daniels, JP; Doust, AM; Hewitt, CA; Horne, AW; Koscielniak, M; Middleton, LJ; Szubert, W; Vincent, K, 2020)
"Chronic pelvic pain in women may be treated sufficiently with Gabapentin."9.30Gabapentin for the management of chronic pelvic pain in women. ( AbdelHafeez, MA; El-Zeneiny, H; Elnaggar, A; Mokhles, JM; Reda, A, 2019)
"To inform feasibility and design of a future randomised controlled trial (RCT) using brain functional MRI (fMRI) to determine the mechanism of action of gabapentin in managing chronic pelvic pain (CPP) in women."9.30The use of brain functional magnetic resonance imaging to determine the mechanism of action of gabapentin in managing chronic pelvic pain in women: a pilot study. ( Horne, AW; Murnane, J; Murray, SR; Pernet, C; Seretny, M; Whalley, H; Whitaker, L, 2019)
" Gabapentin (a GABA analogue) is efficacious and often well tolerated in other chronic pain conditions."9.27GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women: study protocol. ( Baranowski, A; Bhattacharya, S; Birch, J; Cheong, Y; Cregg, R; Daniels, J; Hewitt, CA; Horne, AW; Macfarlane, GJ; Middleton, L; Szubert, W; Tracey, I; Vincent, K; Williams, ACC, 2018)
" Based on the efficacy of gabapentin in the treatment of chronic pain, we conducted this study to evaluate the efficacy and safety of gabapentin in reducing pain in women with CPP."9.22Is gabapentin effective and safe in the treatment of chronic pelvic pain in women: a systematic review and meta-analysis. ( He, Y; Ma, W; Zhuang, X, 2022)
"The aim of this study was to compare the efficacy and side effects of gabapentin, amitriptyline, and their combination in women with chronic pelvic pain."9.11Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study. ( Ellend, A; Frickey, N; Gleiss, A; Kozek-Langenecker, SA; Kress, HG; Sator-Katzenschlager, SM; Scharbert, G, 2005)
"This study was adequately powered, but treatment with gabapentin did not result in significantly lower pain scores in women with chronic pelvic pain, and was associated with higher rates of side-effects than placebo."5.34Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial. ( Daniels, JP; Doust, AM; Hewitt, CA; Horne, AW; Koscielniak, M; Middleton, LJ; Szubert, W; Vincent, K, 2020)
"Chronic pelvic pain in women may be treated sufficiently with Gabapentin."5.30Gabapentin for the management of chronic pelvic pain in women. ( AbdelHafeez, MA; El-Zeneiny, H; Elnaggar, A; Mokhles, JM; Reda, A, 2019)
"To inform feasibility and design of a future randomised controlled trial (RCT) using brain functional MRI (fMRI) to determine the mechanism of action of gabapentin in managing chronic pelvic pain (CPP) in women."5.30The use of brain functional magnetic resonance imaging to determine the mechanism of action of gabapentin in managing chronic pelvic pain in women: a pilot study. ( Horne, AW; Murnane, J; Murray, SR; Pernet, C; Seretny, M; Whalley, H; Whitaker, L, 2019)
" Gabapentin (a GABA analogue) is efficacious and often well tolerated in other chronic pain conditions."5.27GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women: study protocol. ( Baranowski, A; Bhattacharya, S; Birch, J; Cheong, Y; Cregg, R; Daniels, J; Hewitt, CA; Horne, AW; Macfarlane, GJ; Middleton, L; Szubert, W; Tracey, I; Vincent, K; Williams, ACC, 2018)
" Based on the efficacy of gabapentin in the treatment of chronic pain, we conducted this study to evaluate the efficacy and safety of gabapentin in reducing pain in women with CPP."5.22Is gabapentin effective and safe in the treatment of chronic pelvic pain in women: a systematic review and meta-analysis. ( He, Y; Ma, W; Zhuang, X, 2022)
"The aim of this study was to compare the efficacy and side effects of gabapentin, amitriptyline, and their combination in women with chronic pelvic pain."5.11Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study. ( Ellend, A; Frickey, N; Gleiss, A; Kozek-Langenecker, SA; Kress, HG; Sator-Katzenschlager, SM; Scharbert, G, 2005)
"Chronic pelvic pain is a common and debilitating condition; its aetiology is multifactorial, involving social, psychological and biological factors."2.50Non-surgical interventions for the management of chronic pelvic pain. ( Cheong, YC; Smotra, G; Williams, AC, 2014)
"Recent awareness that chronic pain may occur after childbirth has prompted clinicians and researchers to investigate this topic."2.49Chronic pain after childbirth. ( Bollag, L; Landau, R; Ortner, C, 2013)
"The analysis of the case of vulvodynia coexisting with depression."1.46Vulvodynia and depression - a case study. ( Derewianka-Polak, M; Dziwota, EA; Gerhant, A; Olajossy, M; Perzyńska-Starkiewicz, A, 2017)
"Pelvic pain was detected 5 days after antigen instillation and was sustained beyond 30 days, indicating the development of chronic pain."1.35Experimental autoimmune prostatitis induces chronic pelvic pain. ( Rudick, CN; Schaeffer, AJ; Thumbikat, P, 2008)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (9.09)18.2507
2000's4 (18.18)29.6817
2010's12 (54.55)24.3611
2020's4 (18.18)2.80

Authors

AuthorsStudies
He, Y1
Zhuang, X1
Ma, W1
Ghaith, S1
Quillen, JK1
Mead-Harvey, C1
Buras, MR1
Wasson, MN1
AbdelHafeez, MA1
Reda, A1
Elnaggar, A1
El-Zeneiny, H1
Mokhles, JM1
Horne, AW5
Vincent, K4
Hewitt, CA2
Middleton, LJ1
Koscielniak, M1
Szubert, W2
Doust, AM1
Daniels, JP1
Cregg, R2
Daniels, J2
Duffy, JMN1
Gerhant, A1
Dziwota, EA1
Perzyńska-Starkiewicz, A1
Derewianka-Polak, M1
Olajossy, M1
Baranowski, A1
Bhattacharya, S2
Birch, J1
Cheong, Y1
Macfarlane, GJ1
Middleton, L1
Tracey, I1
Williams, ACC1
Biggs, WS1
Carey, ET1
McIntyre, JM1
Till, SR1
As-Sanie, S1
Schrepf, A1
Seretny, M1
Murray, SR1
Whitaker, L1
Murnane, J1
Whalley, H1
Pernet, C1
Landau, R1
Bollag, L1
Ortner, C1
Cheong, YC1
Smotra, G1
Williams, AC1
Lewis, SC1
Wu, O1
Jack, SA1
Critchley, HO1
Porter, MA1
Cranley, D1
Wilson, JA1
Levy, BS1
Apgar, BS1
Strauss, AC1
Dimitrakov, JD1
Sator-Katzenschlager, SM1
Scharbert, G1
Kress, HG1
Frickey, N1
Ellend, A1
Gleiss, A1
Kozek-Langenecker, SA1
Rudick, CN1
Schaeffer, AJ1
Thumbikat, P1
Solaro, C1
Uccelli, MM1
Mancardi, GL1
Ben-David, B1
Friedman, M1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Musculoskeletal and Pelvic Floor Health in Female Chronic Overlapping Pelvic Pain Conditions (The MSK-PELVIC Study)[NCT05750212]208 participants (Anticipated)Observational2023-01-24Recruiting
Oral Gabapentin in Management of Chronic Pelvic Pain in Females: A Randomised Placebo-controlled Study.[NCT02918760]Phase 364 participants (Anticipated)Interventional2016-03-31Recruiting
Effects of Muscle Energy Technique Versus Aerobic Exercises on Pain and Disability in Patients With Chronic Pelvic Pain[NCT05429957]40 participants (Actual)Interventional2022-01-20Completed
Diagnostic Challenges in IC (and Male CPPS)[NCT00672087]1,000 participants (Anticipated)Observational2003-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for gabapentin and Pelvic Pain

ArticleYear
Is gabapentin effective and safe in the treatment of chronic pelvic pain in women: a systematic review and meta-analysis.
    International urogynecology journal, 2022, Volume: 33, Issue:5

    Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyri

2022
Limited evidence guides empiric Tx of female chronic pelvic pain.
    The Journal of family practice, 2018, Volume: 67, Issue:3

    Topics: Adult; Amitriptyline; Analgesics; Chronic Pain; Contraceptive Agents, Female; Contraceptives, Oral,

2018
Psychology of Chronic Pelvic Pain: Prevalence, Neurobiological Vulnerabilities, and Treatment.
    Clinical obstetrics and gynecology, 2019, Volume: 62, Issue:1

    Topics: Antidepressive Agents, Tricyclic; Anxiety; Catastrophization; Chronic Pain; Cognitive Behavioral The

2019
Chronic pain after childbirth.
    International journal of obstetric anesthesia, 2013, Volume: 22, Issue:2

    Topics: Acute Pain; Adrenergic alpha-Agonists; Adult; Amines; Analgesics; Anesthetics, Dissociative; Cesarea

2013
Non-surgical interventions for the management of chronic pelvic pain.
    The Cochrane database of systematic reviews, 2014, Mar-05, Issue:3

    Topics: Amines; Amitriptyline; Analgesics; Chronic Pain; Clonidine; Contraceptive Agents, Female; Cyclohexan

2014
The complex nature of chronic pelvic pain.
    The Journal of family practice, 2007, Volume: 56, Issue:3 Suppl Di

    Topics: Adult; Amines; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents,

2007
New treatments for chronic prostatitis/chronic pelvic pain syndrome.
    Nature reviews. Urology, 2010, Volume: 7, Issue:3

    Topics: Amines; Chronic Disease; Cognitive Behavioral Therapy; Cyclohexanecarboxylic Acids; Gabapentin; gamm

2010

Trials

7 trials available for gabapentin and Pelvic Pain

ArticleYear
Gabapentin for the management of chronic pelvic pain in women.
    Archives of gynecology and obstetrics, 2019, Volume: 300, Issue:5

    Topics: Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; Gabapentin; Humans; Pelvic Pain

2019
Gabapentin for the management of chronic pelvic pain in women.
    Archives of gynecology and obstetrics, 2019, Volume: 300, Issue:5

    Topics: Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; Gabapentin; Humans; Pelvic Pain

2019
Gabapentin for the management of chronic pelvic pain in women.
    Archives of gynecology and obstetrics, 2019, Volume: 300, Issue:5

    Topics: Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; Gabapentin; Humans; Pelvic Pain

2019
Gabapentin for the management of chronic pelvic pain in women.
    Archives of gynecology and obstetrics, 2019, Volume: 300, Issue:5

    Topics: Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; Gabapentin; Humans; Pelvic Pain

2019
Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2020, 09-26, Volume: 396, Issue:10255

    Topics: Adolescent; Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; Gabapentin; Humans; Off-La

2020
Gabapentin not effective for chronic pelvic pain in women.
    Drug and therapeutics bulletin, 2021, Volume: 59, Issue:8

    Topics: Adolescent; Adult; Analgesics; Chronic Disease; Double-Blind Method; Female; Gabapentin; Humans; Mid

2021
GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women: study protocol.
    BMJ open, 2018, 01-31, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Amines; Analgesics; Chronic Disease; Chronic Pain; Cyclohexanecarboxylic Acids; D

2018
The use of brain functional magnetic resonance imaging to determine the mechanism of action of gabapentin in managing chronic pelvic pain in women: a pilot study.
    BMJ open, 2019, 06-27, Volume: 9, Issue:6

    Topics: Adolescent; Adult; Analgesics; Brain; Brain Mapping; Chronic Pain; Female; Gabapentin; Humans; Magne

2019
Gabapentin for the Management of Chronic Pelvic Pain in Women (GaPP1): A Pilot Randomised Controlled Trial.
    PloS one, 2016, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Amines; Analgesics; Chronic Pain; Cost-Benefit Analysis; Cyclohexanecarboxylic Ac

2016
Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study.
    Wiener klinische Wochenschrift, 2005, Volume: 117, Issue:21-22

    Topics: Adult; Amines; Amitriptyline; Austria; Chronic Disease; Cyclohexanecarboxylic Acids; Drug Combinatio

2005

Other Studies

8 other studies available for gabapentin and Pelvic Pain

ArticleYear
Impact of timing of preoperative gabapentin administration on postoperative somnolence.
    Journal of osteopathic medicine, 2022, 02-22, Volume: 122, Issue:6

    Topics: Adult; Analgesics, Opioid; Female; Gabapentin; Humans; Pelvic Pain; Respiratory Insufficiency; Retro

2022
Is gabapentin effective for women with unexplained chronic pelvic pain?
    BMJ (Clinical research ed.), 2017, 09-21, Volume: 358

    Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyri

2017
How should we manage women with unexplained chronic pelvic pain in light of uncertainty about the effectiveness of gabapentin?
    BMJ (Clinical research ed.), 2017, 09-21, Volume: 358

    Topics: Chronic Pain; Female; Gabapentin; Humans; Pelvic Pain; Uncertainty

2017
Vulvodynia and depression - a case study.
    Psychiatria polska, 2017, Oct-29, Volume: 51, Issue:5

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Depression; Female; Gabapentin; gamma-Aminobutyric

2017
Challenges of fragmented care in long-term management of pelvic pain.
    The Journal of family practice, 2007, Volume: 56, Issue:3 Suppl Di

    Topics: Acetaminophen; Adult; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Chr

2007
Experimental autoimmune prostatitis induces chronic pelvic pain.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:4

    Topics: Amines; Analgesics; Anesthetics, Local; Animals; Autoimmune Diseases; Chronic Disease; Cyclohexaneca

2008
A patient with multiple sclerosis and Down's syndrome with a rare paroxysmal symptom at onset.
    European journal of neurology, 1999, Volume: 6, Issue:4

    Topics: Acetates; Amines; Brain; Cyclohexanecarboxylic Acids; Down Syndrome; Excitatory Amino Acid Antagonis

1999
Gabapentin therapy for vulvodynia.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:6

    Topics: Acetates; Adult; Aged; Aged, 80 and over; Amines; Analgesics; Chronic Disease; Cyclohexanecarboxylic

1999