Page last updated: 2024-10-27

gabapentin and Osteoarthritis, Knee

gabapentin has been researched along with Osteoarthritis, Knee in 6 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)

Research Excerpts

ExcerptRelevanceReference
" Both gabapentin and duloxetine groups had significantly more reduction in pain VAS and WOMAC and its subscales compared to acetaminophen group, with no significant difference between groups."9.30Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis. ( Azami, A; Enteshari-Moghaddam, A; Habibzadeh, A; Isazadehfar, K; Jahanpanah, P; Mohebbi, H, 2019)
" Both gabapentin and duloxetine groups had significantly more reduction in pain VAS and WOMAC and its subscales compared to acetaminophen group, with no significant difference between groups."5.30Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis. ( Azami, A; Enteshari-Moghaddam, A; Habibzadeh, A; Isazadehfar, K; Jahanpanah, P; Mohebbi, H, 2019)
"Gabapentin can treat neuropathic pain syndromes and has increasingly been prescribed to treat nociplastic pain."1.91Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis. ( Bensen, GP; Collins, JE; Edwards, RR; Hunter, DJ; Katz, JN; Kostic, AM; Leifer, VP; Losina, E; Neogi, T; Paltiel, AD; Rogers, AC, 2023)
"Outcome measures were postsurgical pain at rest and during walking, consumption of opioids for pain rescue, knee swelling and knee range of motion, and complications."1.46Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty. ( Hansen, TB; Munk, S; Rytter, S; Stilling, M, 2017)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Bensen, GP3
Rogers, AC3
Leifer, VP3
Edwards, RR3
Neogi, T3
Kostic, AM3
Paltiel, AD3
Collins, JE3
Hunter, DJ3
Katz, JN3
Losina, E3
Ter Heegde, F1
Luiz, AP1
Santana-Varela, S1
Chessell, IP1
Welsh, F1
Wood, JN1
Chenu, C1
Enteshari-Moghaddam, A1
Azami, A1
Isazadehfar, K1
Mohebbi, H1
Habibzadeh, A1
Jahanpanah, P1
Kardeş, S1
Rytter, S1
Stilling, M1
Munk, S1
Hansen, TB1
Bove, SE1
Laemont, KD1
Brooker, RM1
Osborn, MN1
Sanchez, BM1
Guzman, RE1
Hook, KE1
Juneau, PL1
Connor, JR1
Kilgore, KS1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Preoperative Steroids Injection on Pain and Oedema After Total Knee Arthroplasty . A Double -Blinded Randomized Controlled Study.[NCT04084912]Phase 386 participants (Anticipated)Interventional2020-01-01Not yet recruiting
Efficacy of Steroids on Functional Outcomes After Musculoskeletal Injuries of the Hand[NCT05003596]Phase 2/Phase 360 participants (Anticipated)Interventional2021-09-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for gabapentin and Osteoarthritis, Knee

ArticleYear
Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis.
    Clinical rheumatology, 2019, Volume: 38, Issue:10

    Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Dulox

2019

Other Studies

5 other studies available for gabapentin and Osteoarthritis, Knee

ArticleYear
Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis.
    Osteoarthritis and cartilage, 2023, Volume: 31, Issue:2

    Topics: Cost-Benefit Analysis; Cost-Effectiveness Analysis; Gabapentin; Humans; Neuralgia; Osteoarthritis, K

2023
Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis.
    Osteoarthritis and cartilage, 2023, Volume: 31, Issue:2

    Topics: Cost-Benefit Analysis; Cost-Effectiveness Analysis; Gabapentin; Humans; Neuralgia; Osteoarthritis, K

2023
Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis.
    Osteoarthritis and cartilage, 2023, Volume: 31, Issue:2

    Topics: Cost-Benefit Analysis; Cost-Effectiveness Analysis; Gabapentin; Humans; Neuralgia; Osteoarthritis, K

2023
Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis.
    Osteoarthritis and cartilage, 2023, Volume: 31, Issue:2

    Topics: Cost-Benefit Analysis; Cost-Effectiveness Analysis; Gabapentin; Humans; Neuralgia; Osteoarthritis, K

2023
Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis.
    Osteoarthritis and cartilage, 2023, Volume: 31, Issue:2

    Topics: Cost-Benefit Analysis; Cost-Effectiveness Analysis; Gabapentin; Humans; Neuralgia; Osteoarthritis, K

2023
Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis.
    Osteoarthritis and cartilage, 2023, Volume: 31, Issue:2

    Topics: Cost-Benefit Analysis; Cost-Effectiveness Analysis; Gabapentin; Humans; Neuralgia; Osteoarthritis, K

2023
Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis.
    Osteoarthritis and cartilage, 2023, Volume: 31, Issue:2

    Topics: Cost-Benefit Analysis; Cost-Effectiveness Analysis; Gabapentin; Humans; Neuralgia; Osteoarthritis, K

2023
Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis.
    Osteoarthritis and cartilage, 2023, Volume: 31, Issue:2

    Topics: Cost-Benefit Analysis; Cost-Effectiveness Analysis; Gabapentin; Humans; Neuralgia; Osteoarthritis, K

2023
Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis.
    Osteoarthritis and cartilage, 2023, Volume: 31, Issue:2

    Topics: Cost-Benefit Analysis; Cost-Effectiveness Analysis; Gabapentin; Humans; Neuralgia; Osteoarthritis, K

2023
Noninvasive Mechanical Joint Loading as an Alternative Model for Osteoarthritic Pain.
    Arthritis & rheumatology (Hoboken, N.J.), 2019, Volume: 71, Issue:7

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Behavior, Animal; Cartilag

2019
Comment on "Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis".
    Clinical rheumatology, 2019, Volume: 38, Issue:11

    Topics: Analgesics; Duloxetine Hydrochloride; Gabapentin; Humans; Osteoarthritis, Knee; Pain

2019
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty,

2017
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty,

2017
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty,

2017
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty,

2017
Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia.
    Osteoarthritis and cartilage, 2006, Volume: 14, Issue:10

    Topics: Amines; Analgesics; Animals; Arthralgia; Cyclohexanecarboxylic Acids; Cyclooxygenase 2 Inhibitors; D

2006