Page last updated: 2024-10-27

gabapentin and Nociceptive Pain

gabapentin has been researched along with Nociceptive Pain in 12 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Nociceptive Pain: Dull or sharp aching pain caused by stimulated NOCICEPTORS due to tissue injury, inflammation or diseases. It can be divided into somatic or tissue pain and VISCERAL PAIN.

Research Excerpts

ExcerptRelevanceReference
" The current study evaluated the pharmacological activity of gabapentin (GBP) and its salicylaldehyde derivative (gabapentsal; [2-(1-(((2-hydroxybenzylidene) amino) methyl) cyclohexyl) acetic acid]; GPS) in well-established mouse models of nociceptive pain, inflammatory edema, and pyrexia at doses of 25-100 mg/kg."8.02Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia. ( Ahmad, N; Akbar, S; Amin, MU; Islam, NU; Khurram, M; Sewell, RDE; Shahid, M; Subhan, F; Ullah, I; Ullah, N; Ullah, R, 2021)
" The current study evaluated the pharmacological activity of gabapentin (GBP) and its salicylaldehyde derivative (gabapentsal; [2-(1-(((2-hydroxybenzylidene) amino) methyl) cyclohexyl) acetic acid]; GPS) in well-established mouse models of nociceptive pain, inflammatory edema, and pyrexia at doses of 25-100 mg/kg."4.02Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia. ( Ahmad, N; Akbar, S; Amin, MU; Islam, NU; Khurram, M; Sewell, RDE; Shahid, M; Subhan, F; Ullah, I; Ullah, N; Ullah, R, 2021)
"Managing cancer-related pain in patients who are also pregnant compounds the challenge for adequate pain management, as studies have largely excluded this population."3.01Pharmacologic Management of Cancer-Related Pain in Pregnant Patients. ( McGinn, R; Smith, MA; Zerfas, I, 2023)
"Multiple causes of neuropathic pain have been described and its incidence is likely to increase owing to the ageing global population, increased incidence of diabetes mellitus and improved survival from cancer after chemotherapy."2.55Neuropathic pain. ( Attal, N; Baron, R; Bennett, DL; Bouhassira, D; Colloca, L; Dickenson, AH; Dworkin, RH; Eccleston, C; Finnerup, NB; Freeman, R; Kalso, E; Ludman, T; Raja, SN; Truini, A; Yarnitsky, D, 2017)
" Time-course data for the dose-response effects were analyzed using two-way analysis of variance and the posthoc Tukey-Kramer multiple-comparison test."1.40Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. ( Hashimoto, R; Hosokawa, K; Mashimo, T; Nakae, A; Nakai, K, 2014)
"Neuropathic pain is currently an insufficiently treated clinical condition."1.40Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. ( Hammock, BD; Inceoglu, B; Wagner, K; Yang, J, 2014)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (66.67)24.3611
2020's4 (33.33)2.80

Authors

AuthorsStudies
Zerfas, I1
McGinn, R1
Smith, MA1
Gonçalves Dos Santos, G1
Jimenéz-Andrade, JM1
Woller, SA1
Muñoz-Islas, E1
Ramírez-Rosas, MB1
Ohashi, N1
Ferreira Catroli, G1
Fujita, Y1
Yaksh, TL1
Corr, M1
Déciga-Campos, M2
Villafán-Gutiérrez, R1
Espinosa-Juárez, JV1
Jaramillo-Morales, OA1
López-Muñoz, FJ2
Ahmad, N1
Subhan, F1
Islam, NU1
Shahid, M1
Ullah, N1
Ullah, R1
Khurram, M1
Amin, MU1
Akbar, S1
Ullah, I1
Sewell, RDE1
Davison, SN1
García-Hernández, L1
Navarrete-Vázquez, G1
González-Trujano, ME1
Nakai, K1
Nakae, A1
Hashimoto, R1
Mashimo, T1
Hosokawa, K1
Wagner, K1
Yang, J1
Inceoglu, B1
Hammock, BD1
Nakama-Kitamura, M1
Adães, S1
Ferreira-Gomes, J1
Mendonça, M1
Almeida, L1
Castro-Lopes, JM1
Neto, FL1
Colloca, L1
Ludman, T1
Bouhassira, D1
Baron, R1
Dickenson, AH1
Yarnitsky, D1
Freeman, R1
Truini, A1
Attal, N1
Finnerup, NB1
Eccleston, C1
Kalso, E1
Bennett, DL1
Dworkin, RH1
Raja, SN1
Vedula, SS1
Goldman, PS1
Rona, IJ1
Greene, TM1
Dickersin, K1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
BotulInum Toxin Type A for Peripheral Neuropathic Pain in subjEcts With Carpal Tunnel Syndrome: a Multicenter, Randomized, Doubleblind, Placebo-controlled Study[NCT05411900]Phase 2164 participants (Anticipated)Interventional2022-05-25Recruiting
Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management: A Randomized Controlled Trial of Efficacy and Safety[NCT05427058]36 participants (Anticipated)Interventional2022-08-01Not yet recruiting
Neuropathic Foot and Ankle in Rheumatoid Arthritis : Ultrasound and Nerve Conduction Study[NCT04550884]80 participants (Anticipated)Observational2020-10-31Not yet recruiting
NanaBis™ an Oro-buccal Administered Equimolar d9-THC & CBD Formulation as Monotherapy for Management of Opioid Requiring Bone Pain Due to Metastatic Cancer: Phase 3 Multi Centre Blinded Randomized Withdrawal Active & Placebo Controlled Trial[NCT04808531]Phase 3360 participants (Anticipated)Interventional2023-11-30Not yet recruiting
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.[NCT06030297]301 participants (Anticipated)Interventional2022-11-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for gabapentin and Nociceptive Pain

ArticleYear
Pharmacologic Management of Cancer-Related Pain in Pregnant Patients.
    Drugs, 2023, Volume: 83, Issue:12

    Topics: Analgesics; Analgesics, Opioid; Cancer Pain; Duloxetine Hydrochloride; Female; Gabapentin; Humans; N

2023
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017

Other Studies

10 other studies available for gabapentin and Nociceptive Pain

ArticleYear
The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling.
    Scientific reports, 2020, 09-24, Volume: 10, Issue:1

    Topics: Analgesics; Animals; Arthritis, Experimental; Female; Gabapentin; Ganglia, Spinal; Hyperalgesia; Kne

2020
Synergistic interaction between haloperidol and gabapentin in a model of neuropathic nociception in rat.
    European journal of pharmacology, 2021, Jan-15, Volume: 891

    Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug

2021
Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:10

    Topics: Aldehydes; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Carrageenan; Disease Models,

2021
Clinical Pharmacology Considerations in Pain Management in Patients with Advanced Kidney Failure.
    Clinical journal of the American Society of Nephrology : CJASN, 2019, 06-07, Volume: 14, Issue:6

    Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Carbamazepine; Chronic Pain

2019
Antihyperalgesic activity of a novel synthesized analogue of lidocaine in diabetic rats.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:5

    Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Diabetes Complications;

2013
Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats.
    Journal of oral & facial pain and headache, 2014,Winter, Volume: 28, Issue:1

    Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Animals; Cranial Nerve Injuries; Cyclohexanecarbox

2014
Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy.
    The journal of pain, 2014, Volume: 15, Issue:9

    Topics: Amines; Analgesics; Animals; Benzoates; Chronic Pain; Conditioning, Psychological; Cyclohexanecarbox

2014
The distinctive significance of analgesic drugs and olfactory stimulants on learned pain in mice.
    Brain research, 2014, Nov-07, Volume: 1588

    Topics: Acetaminophen; Amines; Analgesics; Animals; Conditioning, Psychological; Cyclohexanecarboxylic Acids

2014
Injury of primary afferent neurons may contribute to osteoarthritis induced pain: an experimental study using the collagenase model in rats.
    Osteoarthritis and cartilage, 2015, Volume: 23, Issue:6

    Topics: Amines; Analgesics; Animals; Arthritis, Experimental; Calcium Channels; Calcium Channels, L-Type; Co

2015
Implementation of a publication strategy in the context of reporting biases. A case study based on new documents from Neurontin litigation.
    Trials, 2012, Aug-13, Volume: 13

    Topics: Access to Information; Amines; Analgesics; Antimanic Agents; Authorship; Bipolar Disorder; Clinical

2012