gabapentin and Nervous System Disorders studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Research Excerpts

Excerpt	Relevance	Reference
"To evaluate the analgesic effectiveness and adverse effects of gabapentin for pain management in clinical practice."	8.82	Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005)
"Although its exact mode of action is not known, gabapentin appears to have a unique effect on voltage-dependent calcium ion channels at the postsynaptic dorsal horns and may, therefore, interrupt the series of events that possibly leads to the experience of a neuropathic pain sensation."	8.81	Gabapentin: pharmacology and its use in pain management. ( Kam, PC; Rose, MA, 2002)
"Gabapentin is a gamma-aminobutyric acid analog used for numerous neurologic conditions, including neuropathic pain and epilepsy."	7.75	Gabapentin therapy for pain and irritability in a neurologically impaired infant. ( Cox, TH; Garner, SS; Haney, AL, 2009)
"The objective of this study was to assess the efficacy and safety of Gabapentin as the sole analgesic in patients with HIV-related painful neuropathy."	7.71	Gabapentin in painful HIV-related neuropathy: a report of 19 patients, preliminary observations. ( Bottura, P; La Spina, I; Maggiolo, F; Porazzi, D; Suter, F, 2001)
"A variety of treatments for the pain were ineffective."	5.30	Gabapentin for treatment of neuropathic pain in a 12-year-old girl. ( McGraw, T; Stacey, BR, 1998)
"To evaluate the analgesic effectiveness and adverse effects of gabapentin for pain management in clinical practice."	4.82	Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005)
"Although its exact mode of action is not known, gabapentin appears to have a unique effect on voltage-dependent calcium ion channels at the postsynaptic dorsal horns and may, therefore, interrupt the series of events that possibly leads to the experience of a neuropathic pain sensation."	4.81	Gabapentin: pharmacology and its use in pain management. ( Kam, PC; Rose, MA, 2002)
"Gabapentin is a gamma-aminobutyric acid analog used for numerous neurologic conditions, including neuropathic pain and epilepsy."	3.75	Gabapentin therapy for pain and irritability in a neurologically impaired infant. ( Cox, TH; Garner, SS; Haney, AL, 2009)
"Gabapentin is an antiepileptic drug approved for the treatment of postherpetic neuralgia and as adjunctive therapy for partial seizures."	3.73	Gabapentin-induced neurologic toxicities. ( Bookwalter, T; Gitlin, M, 2005)
"The objective of this study was to assess the efficacy and safety of Gabapentin as the sole analgesic in patients with HIV-related painful neuropathy."	3.71	Gabapentin in painful HIV-related neuropathy: a report of 19 patients, preliminary observations. ( Bottura, P; La Spina, I; Maggiolo, F; Porazzi, D; Suter, F, 2001)
"The anticonvulsant gabapentin is effective against neuropathic pain, but the primary site(s) and mechanism(s) of action are unknown."	3.70	Antinociceptive effect of systemic gabapentin in mononeuropathic rats, depends on stimulus characteristics and level of test integration. ( Christensen, D; Kayser, V, 2000)
"Of 200 consecutive breast cancer patients, 191 received the full package."	2.75	Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. ( Callesen, T; Gärtner, R; Kehlet, H; Kroman, N, 2010)
"Neuropathic cranial pain, i."	2.42	Neuropathic cranial pain. ( Annovazzi, PO; Colombo, B; Comi, G, 2003)
"Gabapentin has demonstrated efficacy, specifically in painful diabetic neuropathy and postherpetic neuralgia."	2.41	Use of anticonvulsants for treatment of neuropathic pain. ( Backonja, MM, 2002)
"A variety of treatments for the pain were ineffective."	1.30	Gabapentin for treatment of neuropathic pain in a 12-year-old girl. ( McGraw, T; Stacey, BR, 1998)

Research

Studies (15)

Authors

Clinical Trials (8)

Trial Overview

Trial Outcomes

Prefrontal GABA+ Concentrations

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (6.67)	18.2507
2000's	11 (73.33)	29.6817
2010's	3 (20.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Calandre, EP	1
Rico-Villademoros, F	1
Slim, M	1
Bannwarth, B	1
Nebbioso, M	1
D'Innocenzo, D	1
Rapone, S	1
Di Benedetto, G	1
Grenga, R	1
Haney, AL	1
Garner, SS	1
Cox, TH	1
Gärtner, R	1
Kroman, N	1
Callesen, T	1
Kehlet, H	1
Singh, H	1
Wang, MY	1
Backonja, MM	1
Colombo, B	1
Annovazzi, PO	1
Comi, G	1
Wiffen, PJ	1
McQuay, HJ	1
Edwards, JE	1
Moore, RA	1
Bookwalter, T	1
Gitlin, M	1
Hauer, JM	1
Wical, BS	1
Charnas, L	1
McGraw, T	1
Stacey, BR	1
Kayser, V	1
Christensen, D	1
La Spina, I	1
Porazzi, D	1
Maggiolo, F	1
Bottura, P	1
Suter, F	1
Rose, MA	1
Kam, PC	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Psychosocial and Psychophysical Factors Influencing the Effect of Preemptive Systemic Analgesia in Combination With Regional Anesthesia on Postoperative Pain Following Upper Limb Surgery[NCT05248152]		90 participants (Anticipated)	Interventional	2022-01-13	Recruiting
Combined General Anesthesia Plus Paravertebral Block Versus General Anesthesia Plus Opioid Analgesia for Breast Cancer Surgery: A Prospective Randomized Trial[NCT01904266]		60 participants (Actual)	Interventional	2013-05-31	Completed
Multimodal Pain Treatment for Breast Cancer Surgery - a Prospective Cohort Study[NCT04875559]		236 participants (Actual)	Observational [Patient Registry]	2021-04-19	Completed
A Phase II, Randomized, Placebo-controlled, Double Blind, Cross-over, Study of the Effects of Gabapentin on Chronic Irritability in Neurologically Impaired Children[NCT01675960]	Phase 2	2 participants (Actual)	Interventional	2012-04-30	Terminated (stopped due to unable to enroll)
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.[NCT06030297]		301 participants (Anticipated)	Interventional	2022-11-01	Recruiting
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776]	Phase 2	54 participants (Actual)	Interventional	2017-08-07	Completed
Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial[NCT03080493]	Phase 4	121 participants (Actual)	Interventional	2017-03-20	Completed
Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures[NCT02957097]	Phase 4	0 participants (Actual)	Interventional	2019-09-30	Withdrawn (stopped due to Original PI left institution and the PI who took over was not able to initiate the study so it was never started.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition

Prefrontal Glx Concentrations

Intervention	mmol/kg (Mean)
N-Acetylcysteine	3.90
Gabapentin	3.93
Placebo Oral Tablet	3.73

Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition

Mean Change From Baseline in NRS Pain Score at 2 Hours After Dilator Insertion

Intervention	mmol/kg (Mean)
N-Acetylcysteine	21.59
Gabapentin	21.69
Placebo Oral Tablet	22.25

Pain score based on numeric rating scale (NRS [0 lowest value to 10 highest value, in which 0 is the lowest amount of pain and 10 is the highest amount of pain]); Baseline obtained prior to study drug ingestion/dilator insertion. NRS pain score obtained via text message. (NCT03080493)
Timeframe: 2 hours after insertion of last osmotic dilator

Mean Change From Baseline in NRS Pain Score at 4 Hours After Dilator Insertion

Intervention	Numeric rating scale pain score change (Median)
Gabapentin	3.5
Placebo Oral Capsule	4

Mean Change From Baseline in NRS Pain Score at 5 Minutes After Last Dilator Insertion

Intervention	Numeric rating scale pain score change (Mean)
Gabapentin	3
Placebo Oral Capsule	3.5

Pain score based on numeric rating scale (NRS [0 lowest value to 10 highest value, in which 0 is the lowest amount of pain and 10 is the highest amount of pain]); Baseline obtained prior to study drug ingestion/dilator insertion. NRS pain score obtained in person before subject leaves clinic appointment. (NCT03080493)
Timeframe: 5 minutes after insertion of last osmotic dilator

Mean Change From Baseline in NRS Pain Score at 8 Hours After Dilator Insertion

Intervention	Numeric rating scale pain score change (Median)
Gabapentin	1
Placebo Oral Capsule	2

Mean Change From Baseline in NRS Pain Score at Time of Presentation for D&E Procedure (Day Following Dilator Insertion)

Intervention	Numeric rating scale pain score change (Median)
Gabapentin	2
Placebo Oral Capsule	2.5

Pain score based on numeric rating scale (NRS [0 lowest value to 10 highest value, in which 0 is the lowest amount of pain and 10 is the highest amount of pain]); Baseline obtained prior to study drug ingestion/dilator insertion. NRS pain score obtained in person upon presentation for D&E procedure. (NCT03080493)
Timeframe: Time of presentation for D&E (day after dilator insertion)

Number of Participants Using Narcotic Pain Medication (Acetaminophen/Codeine)

Intervention	Numeric rating scale pain score change (Median)
Gabapentin	0.5
Placebo Oral Capsule	1

Subject account of how many used acetaminophen/codeine (standard medications given for supplement NSAID as needed after dilator insertion) (NCT03080493)
Timeframe: Collected between each subject contact (2 hours, 4 hours, 8 hours after dilator insertion and at time of presentation for D&E procedure)

Article	Year
Alpha Expert review of neurotherapeutics, 2016, Volume: 16, Issue:11 Topics: Amines; Bridged Bicyclo Compounds; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Gabapentin	2016
[Nystagmus in ophthalmology]. La Clinica terapeutica, 2009, Volume: 160, Issue:2 Topics: Amines; Baclofen; Cyclohexanecarboxylic Acids; Diagnostic Techniques, Ophthalmological; Eye Diseases	2009
Gabapentin reduces experimental secondary neurologic dysfunction in rats. Neurosurgery, 2011, Volume: 68, Issue:4 Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Nervous S	2011
Use of anticonvulsants for treatment of neuropathic pain. Neurology, 2002, Sep-10, Volume: 59, Issue:5 Suppl 2 Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid;	2002
Neuropathic cranial pain. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2003, Volume: 24 Suppl 2 Topics: Acetates; Amines; Analgesics; Analgesics, Non-Narcotic; Anticonvulsants; Antidepressive Agents, Tric	2003
Gabapentin for acute and chronic pain. The Cochrane database of systematic reviews, 2005, Jul-20, Issue:3 Topics: Acute Disease; Amines; Analgesics; Anticonvulsants; Chronic Disease; Cyclohexanecarboxylic Acids; Ga	2005
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002

Article	Year
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. Minerva anestesiologica, 2010, Volume: 76, Issue:10 Topics: Acetaminophen; Aged; Amines; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Intra	2010
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. Minerva anestesiologica, 2010, Volume: 76, Issue:10 Topics: Acetaminophen; Aged; Amines; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Intra	2010
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. Minerva anestesiologica, 2010, Volume: 76, Issue:10 Topics: Acetaminophen; Aged; Amines; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Intra	2010
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. Minerva anestesiologica, 2010, Volume: 76, Issue:10 Topics: Acetaminophen; Aged; Amines; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Intra	2010

Article	Year
Is there a role for anticonvulsants in the management of rheumatic pain? Joint bone spine, 2008, Volume: 75, Issue:6 Topics: Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Fibromyalgia; Gabapentin; gamma-Am	2008
Gabapentin therapy for pain and irritability in a neurologically impaired infant. Pharmacotherapy, 2009, Volume: 29, Issue:8 Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Infant	2009
Gabapentin-induced neurologic toxicities. Pharmacotherapy, 2005, Volume: 25, Issue:12 Topics: Acute Kidney Injury; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminob	2005
Gabapentin successfully manages chronic unexplained irritability in children with severe neurologic impairment. Pediatrics, 2007, Volume: 119, Issue:2 Topics: Adolescent; Adult; Amines; Analgesics; Child; Child, Preschool; Chronic Disease; Cyclohexanecarboxyl	2007
Gabapentin for treatment of neuropathic pain in a 12-year-old girl. The Clinical journal of pain, 1998, Volume: 14, Issue:4 Topics: Acetates; Amines; Child; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; H	1998
Antinociceptive effect of systemic gabapentin in mononeuropathic rats, depends on stimulus characteristics and level of test integration. Pain, 2000, Volume: 88, Issue:1 Topics: Acetates; Amines; Analgesics; Animals; Cold Temperature; Cyclohexanecarboxylic Acids; Gabapentin; ga	2000
Gabapentin in painful HIV-related neuropathy: a report of 19 patients, preliminary observations. European journal of neurology, 2001, Volume: 8, Issue:1 Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Ami	2001

gabapentin and Nervous System Disorders