gabapentin has been researched along with Nausea in 18 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain." | 9.69 | Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023) |
| "Gabapentin and intravenous patient-controlled analgesia (PCA) can reduce postoperative pain scores, postoperative opioid use, and time to completing physical therapy compared to PCA alone after posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS)." | 9.41 | Gabapentin and intrathecal morphine combination therapy results in decreased oral narcotic use and more consistent pain scores after posterior spinal fusion for adolescent idiopathic scoliosis. ( Caird, MS; Hong, RA; Leis, A; Li, Y; Robbins, C; Swallow, J, 2021) |
| "In an anecdotal report, complete resolution of chemotherapy-induced nausea was seen in a patient with breast cancer, after she was placed on the anticonvulsant gabapentin." | 9.10 | Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer. ( Griggs, J; Guttuso, T; Roscoe, J, 2003) |
| "To provide a qualitative, systematic update and review of the pharmacology, pharmacokinetics, efficacy in mood disorders, adverse effects, and costs of lamotrigine." | 8.81 | Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002) |
| "Gabapentin/placebo was started the day of chemotherapy and continued through day 5 for the first chemotherapy cycle, whereas dex was titrated down on days 2-4." | 6.79 | Phase III double-blind, placebo-controlled study of gabapentin for the prevention of delayed chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy, NCCTG N08C3 (Alliance). ( Barton, DL; Blair, SC; Diekmann, B; Fuloria, J; Jaslowski, AJ; Kottschade, LA; Loprinzi, CL; Lyss, AP; Mazurczak, MA; Sloan, JA; Terstriep, S; Thanarajasingam, G, 2014) |
| "Gabapentin is a low-cost strategy to improve complete control of CINV, specially delayed CINV control." | 6.77 | Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study. ( Carrasco, MM; Cruz, FM; da Costa Miranda, M; da Cunha Vieira, M; de Afonseca, SO; de Iracema Gomes Cubero, D; de Souza Fêde, AB; del Giglio, A; Lera, AT; Lerner, T; Pinczowski, H; Schindler, F; Taranto, P, 2012) |
| "The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain." | 5.69 | Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023) |
| "Gabapentin and intravenous patient-controlled analgesia (PCA) can reduce postoperative pain scores, postoperative opioid use, and time to completing physical therapy compared to PCA alone after posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS)." | 5.41 | Gabapentin and intrathecal morphine combination therapy results in decreased oral narcotic use and more consistent pain scores after posterior spinal fusion for adolescent idiopathic scoliosis. ( Caird, MS; Hong, RA; Leis, A; Li, Y; Robbins, C; Swallow, J, 2021) |
| " Other outcomes were overall pain during well-defined mobilizations and at rest and sedation during the first 48 hours and from days 2-6, morphine use, anxiety, depression, sleep quality, and nausea, vomiting, dizziness, concentration difficulty, headache, visual disturbances, and adverse reactions." | 5.20 | Analgesic and sedative effects of perioperative gabapentin in total knee arthroplasty: a randomized, double-blind, placebo-controlled dose-finding study. ( Hansen, LT; Husted, H; Kehlet, H; Laursen, MB; Lunn, TH, 2015) |
| "In an anecdotal report, complete resolution of chemotherapy-induced nausea was seen in a patient with breast cancer, after she was placed on the anticonvulsant gabapentin." | 5.10 | Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer. ( Griggs, J; Guttuso, T; Roscoe, J, 2003) |
| " On the other hand, patients with divalproex exhibited significantly higher risk of nausea compared to those with placebo, topiramate, propranolol, gabapentin and amitriptyline." | 4.95 | Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis. ( He, A; Li, C; Song, D; Zhang, L, 2017) |
| " The complications of vomiting, nausea, dizziness and pruritus were also compiled to assess the safety of gabapentin and pregabalin." | 4.93 | The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis. ( Ding, W; Mao, Y; Wu, L, 2016) |
| "To provide a qualitative, systematic update and review of the pharmacology, pharmacokinetics, efficacy in mood disorders, adverse effects, and costs of lamotrigine." | 4.81 | Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002) |
| " Pharmacodynamic measures were limited to subject assessment of somnolence, dizziness, and nausea conducted by using a visual analog scale (VAS)." | 2.80 | Gabapentin enacarbil and morphine administered in combination versus alone: a double-blind, randomized, pharmacokinetic, and tolerability comparison. ( Arumugham, T; Chen, C; Davy, M; Stier, B; Upward, J, 2015) |
| "Gabapentin/placebo was started the day of chemotherapy and continued through day 5 for the first chemotherapy cycle, whereas dex was titrated down on days 2-4." | 2.79 | Phase III double-blind, placebo-controlled study of gabapentin for the prevention of delayed chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy, NCCTG N08C3 (Alliance). ( Barton, DL; Blair, SC; Diekmann, B; Fuloria, J; Jaslowski, AJ; Kottschade, LA; Loprinzi, CL; Lyss, AP; Mazurczak, MA; Sloan, JA; Terstriep, S; Thanarajasingam, G, 2014) |
| "Gabapentin is a low-cost strategy to improve complete control of CINV, specially delayed CINV control." | 2.77 | Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study. ( Carrasco, MM; Cruz, FM; da Costa Miranda, M; da Cunha Vieira, M; de Afonseca, SO; de Iracema Gomes Cubero, D; de Souza Fêde, AB; del Giglio, A; Lera, AT; Lerner, T; Pinczowski, H; Schindler, F; Taranto, P, 2012) |
| "Pain was rated on a scale from 0 (no pain) to 10 (maximum pain)." | 2.52 | Pharmacological treatment for pain in Guillain-Barré syndrome. ( Liu, J; McNicol, ED; Wang, LN, 2015) |
| "Pain was rated on a scale from 0 (no pain) to 10 (maximum pain)." | 2.49 | Pharmacological treatment for pain in Guillain-Barré syndrome. ( Liu, J; McNicol, ED; Wang, LN, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 5 (27.78) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Swallow, J | 1 |
| Robbins, C | 1 |
| Caird, MS | 1 |
| Leis, A | 1 |
| Hong, RA | 1 |
| Hung, KC | 1 |
| Wu, SC | 1 |
| Chiang, MH | 1 |
| Hsu, CW | 1 |
| Chen, JY | 1 |
| Huang, PW | 1 |
| Sun, CK | 1 |
| Brant, AR | 1 |
| Reeves, MF | 1 |
| Ye, PP | 1 |
| Scott, RK | 1 |
| Floyd, S | 1 |
| Tefera, E | 1 |
| Lotke, PS | 1 |
| Jouybar, R | 1 |
| Kazemifar, S | 1 |
| Asmarian, N | 1 |
| Karami, A | 1 |
| Khademi, S | 1 |
| Chaghazardi, S | 1 |
| Hedari, M | 1 |
| Bazargan-Hejazi, S | 1 |
| Mohammadi, R | 1 |
| Ahmadi, A | 1 |
| Liu, J | 2 |
| Wang, LN | 2 |
| McNicol, ED | 2 |
| Guttuso, T | 2 |
| Barton, DL | 1 |
| Thanarajasingam, G | 1 |
| Sloan, JA | 1 |
| Diekmann, B | 1 |
| Fuloria, J | 1 |
| Kottschade, LA | 1 |
| Lyss, AP | 1 |
| Jaslowski, AJ | 1 |
| Mazurczak, MA | 1 |
| Blair, SC | 1 |
| Terstriep, S | 1 |
| Loprinzi, CL | 1 |
| Chen, C | 1 |
| Upward, J | 1 |
| Arumugham, T | 1 |
| Stier, B | 1 |
| Davy, M | 1 |
| Lunn, TH | 1 |
| Husted, H | 1 |
| Laursen, MB | 1 |
| Hansen, LT | 1 |
| Kehlet, H | 1 |
| Kottschade, L | 1 |
| Novotny, P | 1 |
| Lyss, A | 1 |
| Mazurczak, M | 1 |
| Loprinzi, C | 1 |
| Barton, D | 1 |
| Mao, Y | 1 |
| Wu, L | 1 |
| Ding, W | 1 |
| He, A | 1 |
| Song, D | 1 |
| Zhang, L | 1 |
| Li, C | 1 |
| Cruz, FM | 1 |
| de Iracema Gomes Cubero, D | 1 |
| Taranto, P | 1 |
| Lerner, T | 1 |
| Lera, AT | 1 |
| da Costa Miranda, M | 1 |
| da Cunha Vieira, M | 1 |
| de Souza Fêde, AB | 1 |
| Schindler, F | 1 |
| Carrasco, MM | 1 |
| de Afonseca, SO | 1 |
| Pinczowski, H | 1 |
| del Giglio, A | 1 |
| Roscoe, J | 1 |
| Griggs, J | 1 |
| Hurley, SC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gabapentin as an Adjunct for Pain Management During Dilation and Evacuation: A Double-blind Randomized Controlled Trial[NCT03635905] | Phase 4 | 130 participants (Actual) | Interventional | 2017-05-26 | Completed | ||
| Comparison of Gabapentin and Metoclopramide for Treating Hyperemesis Gravidarum[NCT02163434] | Phase 2 | 31 participants (Actual) | Interventional | 2014-06-30 | Completed | ||
| A Double-Blind, 3-Part Crossover Study to Assess the Pharmacokinetics and Tolerability of Single Doses of Gabapentin Enacarbil and Morphine Administered Alone and in Combination in Healthy Subjects[NCT01476124] | Phase 1 | 18 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Randomized Prospective Study Comparing Variable Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy[NCT05172570] | Phase 3 | 120 participants (Anticipated) | Interventional | 2021-04-06 | Recruiting | ||
| PUCE Study: Prevention of Unmitigated Chemotherapy-induced Emesis[NCT03996863] | 0 participants (Actual) | Interventional | 2019-08-01 | Withdrawn (stopped due to Drexel Oncology was shut down a few days before first patient in.) | |||
| "Preoperative Gabapentin and Its Effects on Postoperative Analgesia in Patients Undergoing Cosmetic Breast Surgery"[NCT05997355] | 100 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Efficacy of Olanzapine, Netupitant and Palonosetron in Controlling Nausea and Vomiting Associated With Highly Emetogenic Chemotherapy in Patients With Breast Cancer[NCT04669132] | Phase 2 | 50 participants (Actual) | Interventional | 2020-12-17 | Completed | ||
| Clinical Trial of Gabapentin in the Prevention of Nausea Ond Vomiting Induced by Chemotherapy, a Randomized, Double-blind, Placebo Controled Study[NCT01052844] | Phase 3 | 80 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Score range: 6-30 with higher score indicating a worse outcome. (NCT02163434)
Timeframe: 1 week
| Intervention | units on a scale (Mean) |
|---|---|
| Gabapentin | 6.35 |
| Metoclopramide | 13.22 |
Score range: 2-10 with higher score indicating a worse outcome. (NCT02163434)
Timeframe: 1 week
| Intervention | units on a scale (Mean) |
|---|---|
| Gabapentin | 2.01 |
| Metoclopramide | 3.69 |
Score range: 0-15 with higher score indicating a better outcome. (NCT02163434)
Timeframe: 1 week
| Intervention | units on a scale (Mean) |
|---|---|
| Gabapentin | 7.86 |
| Metoclopramide | 4.01 |
Scores: 0=no, 1=yes. Thus, a higher score indicates a better outcome. (NCT02163434)
Timeframe: 1 week
| Intervention | units on a scale (Mean) |
|---|---|
| Gabapentin | 0.67 |
| Metoclopramide | 0.14 |
Score range: 0-4 with higher score indicating a better outcome. (NCT02163434)
Timeframe: 1 week
| Intervention | units on a scale (Mean) |
|---|---|
| Gabapentin | 2.22 |
| Metoclopramide | 0.63 |
(NCT02163434)
Timeframe: 1 week
| Intervention | Participants (Count of Participants) |
|---|---|
| Gabapentin | 5 |
| Metoclopramide | 5 |
The CR was defined as no emetic episodes and no nausea episodes from day 1 to day 5 (0-120h) (NCT01052844)
Timeframe: 5 days
| Intervention | participants (Number) |
|---|---|
| Control Group | 17 |
| Gabapentin | 26 |
Complete response during delayed-onset phase was defined as the absence of any episode of nausea or vomiting and no use of rescue medication when occurring during the period from days 2 through 5 after chemotherapy (NCT01052844)
Timeframe: 6 days
| Intervention | participants (Number) |
|---|---|
| Control Group | 21 |
| Gabapentin | 29 |
7 reviews available for gabapentin and Nausea
| Article | Year |
|---|---|
Analgesic Efficacy of Gabapentin and Pregabalin in Patients Undergoing Laparoscopic Bariatric Surgeries: a Systematic Review and Meta-analysis.
Topics: Analgesics; Bariatric Surgery; Gabapentin; Humans; Laparoscopy; Nausea; Obesity, Morbid; Pain, Posto | 2022 |
Pharmacological treatment for pain in Guillain-Barré syndrome.
Topics: Amines; Analgesics; Carbamazepine; Constipation; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Amin | 2013 |
Gabapentin's anti-nausea and anti-emetic effects: a review.
Topics: Amines; Animals; Antiemetics; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Gabapentin; gam | 2014 |
Pharmacological treatment for pain in Guillain-Barré syndrome.
Topics: Amines; Analgesics; Carbamazepine; Constipation; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Amin | 2015 |
The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis.
Topics: Amines; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarboxylic Acids; Dizziness; Gabapent | 2016 |
Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis.
Topics: Adult; Amines; Amitriptyline; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizziness; Female; Fruct | 2017 |
Lamotrigine update and its use in mood disorders.
Topics: Acetates; Aggression; Amines; Antidepressive Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids; | 2002 |
10 trials available for gabapentin and Nausea
| Article | Year |
|---|---|
Gabapentin and intrathecal morphine combination therapy results in decreased oral narcotic use and more consistent pain scores after posterior spinal fusion for adolescent idiopathic scoliosis.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics, Opioid; Gabapentin; Humans; Kyphosis; Morphin | 2021 |
Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial.
Topics: Dilatation; Double-Blind Method; Female; Fentanyl; Gabapentin; Humans; Midazolam; Nausea; Pain; Pain | 2023 |
Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trial.
Topics: Adult; Anti-Anxiety Agents; Dexmedetomidine; Double-Blind Method; Gabapentin; Humans; Iran; Laminect | 2022 |
Comparing the Effect of Gabapentin, Ketamine, Dexmedetomidine, and Entonox on Pain Control in Burn Wound Dressing.
Topics: Adult; Analgesics; Bandages; Blood Pressure; Burns; Debridement; Dexmedetomidine; Female; Gabapentin | 2020 |
Phase III double-blind, placebo-controlled study of gabapentin for the prevention of delayed chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy, NCCTG N08C3 (Alliance).
Topics: Adult; Aged; Amines; Antineoplastic Agents; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug A | 2014 |
Gabapentin enacarbil and morphine administered in combination versus alone: a double-blind, randomized, pharmacokinetic, and tolerability comparison.
Topics: Adult; Amines; Analgesics, Opioid; Carbamates; Cross-Over Studies; Cyclohexanecarboxylic Acids; Dizz | 2015 |
Analgesic and sedative effects of perioperative gabapentin in total knee arthroplasty: a randomized, double-blind, placebo-controlled dose-finding study.
Topics: Aged; Aged, 80 and over; Amines; Analgesics; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Cy | 2015 |
Chemotherapy-induced nausea and vomiting: incidence and characteristics of persistent symptoms and future directions NCCTG N08C3 (Alliance).
Topics: Adult; Aged; Amines; Antiemetics; Antineoplastic Agents; Cisplatin; Cyclohexanecarboxylic Acids; Dru | 2016 |
Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study.
Topics: Amines; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclohexanecarboxylic Acids; De | 2012 |
Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study.
Topics: Amines; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclohexanecarboxylic Acids; De | 2012 |
Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study.
Topics: Amines; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclohexanecarboxylic Acids; De | 2012 |
Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study.
Topics: Amines; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclohexanecarboxylic Acids; De | 2012 |
Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer.
Topics: Acetates; Administration, Oral; Amines; Antineoplastic Combined Chemotherapy Protocols; Breast Neopl | 2003 |
1 other study available for gabapentin and Nausea
| Article | Year |
|---|---|
Valproate and other anticonvulsants for psychiatric disorders.
Topics: Abnormalities, Drug-Induced; Acetates; Adult; Amines; Anti-Anxiety Agents; Anticonvulsants; Bipolar | 2000 |