Page last updated: 2024-10-27

gabapentin and Long Sleeper Syndrome

gabapentin has been researched along with Long Sleeper Syndrome in 31 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Research Excerpts

ExcerptRelevanceReference
" Our goal was to compare the effects of gabapentin and pregabalin on improving sleep quality and depression among hemodialysis patients with PPN."9.17Gabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: a randomized prospective crossover trial. ( Atalay, H; Biyik, Z; Gaipov, A; Guney, F; Solak, Y; Turk, S, 2013)
"We assessed the efficacy and safety of extended-release gabapentin in a 15-week, open-label, single-arm, single-center study in patients with fibromyalgia (FM)."7.83The Effect of a Novel form of Extended-Release Gabapentin on Pain and Sleep in Fibromyalgia Subjects: An Open-Label Pilot Study. ( Hong, KS; North, JM; Rauck, RL, 2016)
" Our goal was to compare the effects of gabapentin and pregabalin on improving sleep quality and depression among hemodialysis patients with PPN."5.17Gabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: a randomized prospective crossover trial. ( Atalay, H; Biyik, Z; Gaipov, A; Guney, F; Solak, Y; Turk, S, 2013)
") and restless legs syndrome treated with ropinirole and gabapentin, will be discussed."4.89Recent advances in sleep research. ( Anderer, P; Saletu, B; Saletu-Zyhlarz, GM, 2013)
"Gabapentin (GBP) is a antiepileptic drug (AED) indicated as adjunct therapy for treatment of partial seizures, with and without secondary generalization, in patients 12 and older with epilepsy."4.80Gabapentin. ( Morris, GL, 1999)
"We assessed the efficacy and safety of extended-release gabapentin in a 15-week, open-label, single-arm, single-center study in patients with fibromyalgia (FM)."3.83The Effect of a Novel form of Extended-Release Gabapentin on Pain and Sleep in Fibromyalgia Subjects: An Open-Label Pilot Study. ( Hong, KS; North, JM; Rauck, RL, 2016)
"To evaluate the antinociceptive and hypnotic effects of pregabalin, we established a neuropathic pain-like model in mice using partial sciatic nerve ligation (PSNL), and examined thermal hyperalgesia, mechanical allodynia, electroencephalogram, rota-rod testing, and c-Fos expression in the anterior cingulate cortex."3.81Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice. ( Guo, W; Han, WJ; Hong, ZY; Huang, ZL; Li, YD; Liu, YY; Qu, WM; Wang, TX; Yin, D, 2015)
" XP13512 immediate-release (up to 2800 mg single dose and 2100 mg twice daily) was well absorbed (>68%, based on urinary recovery of gabapentin), converted rapidly to gabapentin, and provided dose-proportional exposure, whereas absorption of oral gabapentin declined with increasing doses to <27% at 1200 mg."2.73Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin. ( Canafax, DM; Cundy, KC; Luo, W; Moors, TL; Sastry, S; Zou, J, 2008)
"The gabapentin was often first prescribed to facilitate sleep."2.70Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy. ( Brodrick, PS; Hamner, MB; Labbate, LA, 2001)
"Treatment with gabapentinoids (GBs) has been shown to reduce pain, but its effects on sleep health have not been systematically evaluated."2.66Evaluating the impact of gabapentinoids on sleep health in patients with chronic neuropathic pain: a systematic review and meta-analysis. ( Bhatia, A; Brull, R; Davidson, A; Kapustin, D; McParland, A; Singh, M; Trivedi, A, 2020)
"Sleep quality, chronotype, daytime sleepiness, neuropathic pain severity and interference were assessed based on questionnaires."1.51Actigraphy-based evaluation of sleep quality and physical activity in individuals with spinal cord injury. ( Albu, S; Forner-Cordero, A; Umemura, G, 2019)
"In a model of neuropathic pain, sciatic nerve ligation caused a marked decrease in the latency of paw withdrawal in response to a thermal stimulus only on the ipsilateral side."1.37Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis. ( Furuya, M; Hatakeyama, N; Horiuchi, H; Imai, S; Kinoshita, H; Kuzumaki, N; Matoba, M; Narita, M; Niikura, K; Senba, E; Suzuki, T; Takemura, Y; Tsukiyama, Y; Yamashita, A; Yamazaki, M; Yanase, M, 2011)
"A total of 578 women with breast cancer were managed at the Menopausal Symptoms After Cancer Clinic between January 2003 and December 2008."1.36The multidisciplinary management of menopausal symptoms after breast cancer: a unique model of care. ( Doherty, DA; Emery, LI; Gregson, J; Hickey, M; Saunders, CM, 2010)
"Anxiety and depression are often also present."1.35Fibromyalgia: poorly understood; treatments are disappointing. ( , 2009)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (6.45)18.2507
2000's10 (32.26)29.6817
2010's17 (54.84)24.3611
2020's2 (6.45)2.80

Authors

AuthorsStudies
Choi, Y1
Raymer, BK1
Kapustin, D1
Bhatia, A1
McParland, A1
Trivedi, A1
Davidson, A1
Brull, R1
Singh, M1
Kim, J1
Lee, SH1
Kim, TH1
Eloy, JD1
Anthony, C1
Amin, S1
Caparó, M1
Reilly, MC1
Shulman, S1
Ehlers, CL1
Sanchez-Alavez, M1
Wills, D1
Potter, B1
Schrager, S1
Dalby, J1
Torell, E1
Hampton, A1
Albu, S1
Umemura, G1
Forner-Cordero, A1
Ayala-Guerrero, F1
Mexicano, G1
Gutiérrez-Chávez, CA1
Lazo, LA1
Mateos, EL1
Winkelman, JW1
Gagnon, A1
Clair, AG1
Amos, LB1
Grekowicz, ML1
Kuhn, EM1
Olstad, JD1
Collins, MM1
Norins, NA1
D'Andrea, LA1
Saletu, B1
Anderer, P1
Saletu-Zyhlarz, GM1
Wang, TX1
Yin, D1
Guo, W1
Liu, YY1
Li, YD1
Qu, WM1
Han, WJ1
Hong, ZY1
Huang, ZL1
North, JM1
Hong, KS1
Rauck, RL1
Mowla, A1
Ahmadzadeh, L1
Razeghian Jahromi, L1
Dastgheib, SA1
Garland, SN1
Xie, SX1
Li, Q1
Seluzicki, C1
Basal, C1
Mao, JJ1
Cundy, KC1
Sastry, S1
Luo, W1
Zou, J1
Moors, TL1
Canafax, DM1
Ho, TW1
Backonja, M1
Ma, J1
Leibensperger, H1
Froman, S1
Polydefkis, M1
Biselx, S1
Büla, C1
Ghika, J1
Hickey, M1
Emery, LI1
Gregson, J1
Doherty, DA1
Saunders, CM1
Takemura, Y1
Yamashita, A1
Horiuchi, H1
Furuya, M1
Yanase, M1
Niikura, K1
Imai, S1
Hatakeyama, N1
Kinoshita, H1
Tsukiyama, Y1
Senba, E1
Matoba, M1
Kuzumaki, N1
Yamazaki, M1
Suzuki, T1
Narita, M1
Lucey, BP1
Noetzel, MJ1
Duntley, SP1
Biyik, Z1
Solak, Y1
Atalay, H1
Gaipov, A1
Guney, F1
Turk, S1
Joffe, H1
Soares, CN1
Cohen, LS1
Rejas, J1
Ribera, MV1
Ruiz, M1
Masrramón, X1
Bazil, CW1
Battista, J1
Basner, RC1
Lanz, M1
Happe, S1
Hanna, M1
O'Brien, C1
Wilson, MC1
Williams, DC1
Morris, GL1
Hamner, MB1
Brodrick, PS1
Labbate, LA1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Gabapentin on Postoperative Pain: a Randomized, Double Blind, Placebo Controlled Trial[NCT01546857]Phase 434 participants (Actual)Interventional2012-03-31Terminated (stopped due to No longer able to recruit subjects due to unavailability of orthopedic surgeon.)
The Treatment of Sleep Bruxism With the Luco Hybrid OSA Appliance[NCT02882880]51 participants (Actual)Interventional2015-07-31Completed
Acupuncture and Gabapentin for Hot Flashes Among Breast Cancer Survivors[NCT01005108]Phase 2120 participants (Actual)Interventional2009-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Opioid Consumption

Patient Controlled Analgesia use over 48 hours reported in Morphine equivalent dosage. (NCT01546857)
Timeframe: 48 hours post operatively

Interventionmg (Mean)
Placebo11.88
Gabapentin11.02

Visual Analogue Scale for Pain

Severity of pain measure on a scale from zero to ten. Zero no pain to ten severe pain. (NCT01546857)
Timeframe: 48 hours post operatively

Interventionunits on a scale (Mean)
Placebo5.15
Gabapentin4.38

Quality of Sleep.

A questionnaire was administered asking participants about the quality of their sleep on the night of surgery asked on postoperative day 1, and on the first postoperative night ( POD 2) . Scored on a scale of zero to 3. Zero meaning poor postoperative sleep and 3 indicating better postoperative sleep. (NCT01546857)
Timeframe: Night of surgery (POD 1) and Postoperative Day 2.(POD 2)

,
Interventionunits on a scale (Mean)
POD 1POD 2
Gabapentin1.2350.647
Placebo1.3331

Reviews

9 reviews available for gabapentin and Long Sleeper Syndrome

ArticleYear
Sleep modulating agents.
    Bioorganic & medicinal chemistry letters, 2019, 08-15, Volume: 29, Issue:16

    Topics: Animals; Humans; Sleep; Sleep Aids, Pharmaceutical; Sleep Wake Disorders; Wakefulness-Promoting Agen

2019
Evaluating the impact of gabapentinoids on sleep health in patients with chronic neuropathic pain: a systematic review and meta-analysis.
    Pain, 2020, Volume: 161, Issue:3

    Topics: Analgesics; Chronic Pain; Clinical Trials as Topic; Gabapentin; Humans; Neuralgia; Pain Measurement;

2020
Menopause.
    Primary care, 2018, Volume: 45, Issue:4

    Topics: Contraception; Endometrial Neoplasms; Estrogen Replacement Therapy; Female; Gabapentin; Hot Flashes;

2018
Sensory symptoms in restless legs syndrome: the enigma of pain.
    Sleep medicine, 2013, Volume: 14, Issue:10

    Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid;

2013
Recent advances in sleep research.
    Psychiatria Danubina, 2013, Volume: 25, Issue:4

    Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Amines; Antiparkinson Agents; Biomedical Research;

2013
Assessment and treatment of hot flushes and menopausal mood disturbance.
    The Psychiatric clinics of North America, 2003, Volume: 26, Issue:3

    Topics: Acetates; Aging; Amines; Anti-Anxiety Agents; Cognition Disorders; Cyclohexanecarboxylic Acids; Fema

2003
[When the legs have to keep moving at night--the restless legs syndrome].
    MMW Fortschritte der Medizin, 2007, May-21, Volume: 149 Suppl 2

    Topics: Adult; Amines; Analgesics, Opioid; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Dopamine Ago

2007
Periodic limb movements of sleep and the restless legs syndrome.
    Virginia medical quarterly : VMQ, 1996,Fall, Volume: 123, Issue:4

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Folic Acid; Gabapentin; gamma-Aminob

1996
Gabapentin.
    Epilepsia, 1999, Volume: 40 Suppl 5

    Topics: Acetates; Amines; Anticonvulsants; Controlled Clinical Trials as Topic; Cyclohexanecarboxylic Acids;

1999

Trials

10 trials available for gabapentin and Long Sleeper Syndrome

ArticleYear
Gabapentin Does Not Appear to Improve Postoperative Pain and Sleep Patterns in Patients Who Concomitantly Receive Regional Anesthesia for Lower Extremity Orthopedic Surgery: A Randomized Control Trial.
    Pain research & management, 2017, Volume: 2017

    Topics: Adolescent; Adult; Aged; Amines; Analgesics; Arthroplasty, Replacement; Celecoxib; Cyclohexanecarbox

2017
Comparing Gabapentin with Clonazepam for Residual Sleeping Problems following Antidepressant Therapy in Patients with Major Depressive Disorder: A Randomized Clinical Trial.
    Clinical drug investigation, 2015, Volume: 35, Issue:8

    Topics: Adult; Amines; Antidepressive Agents; Clonazepam; Cyclohexanecarboxylic Acids; Depressive Disorder,

2015
Comparative effectiveness of electro-acupuncture versus gabapentin for sleep disturbances in breast cancer survivors with hot flashes: a randomized trial.
    Menopause (New York, N.Y.), 2017, Volume: 24, Issue:5

    Topics: Acupuncture Therapy; Adult; Aged; Amines; Anti-Anxiety Agents; Breast Neoplasms; Cyclohexanecarboxyl

2017
Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin.
    Journal of clinical pharmacology, 2008, Volume: 48, Issue:12

    Topics: Adult; Aged; Amines; Area Under Curve; Biological Availability; Capsules; Carbamates; Cross-Over Stu

2008
Efficient assessment of neuropathic pain drugs in patients with small fiber sensory neuropathies.
    Pain, 2009, Volume: 141, Issue:1-2

    Topics: Adolescent; Adult; Amines; Analgesics; Cross-Over Studies; Cyclohexanecarboxylic Acids; Diphenhydram

2009
Gabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: a randomized prospective crossover trial.
    International urology and nephrology, 2013, Volume: 45, Issue:3

    Topics: Amines; Anti-Anxiety Agents; Calcium Channel Blockers; Cross-Over Studies; Cyclohexanecarboxylic Aci

2013
Psychometric properties of the MOS (Medical Outcomes Study) Sleep Scale in patients with neuropathic pain.
    European journal of pain (London, England), 2007, Volume: 11, Issue:3

    Topics: Adult; Aged; Amines; Analgesics; Anxiety; Cyclohexanecarboxylic Acids; Depression; Disability Evalua

2007
Gabapentin improves sleep in the presence of alcohol.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2005, Jul-15, Volume: 1, Issue:3

    Topics: Adult; Alcoholic Intoxication; Amines; Anti-Anxiety Agents; Cross-Over Studies; Cyclohexanecarboxyli

2005
Prolonged-release oxycodone enhances the effects of existing gabapentin therapy in painful diabetic neuropathy patients.
    European journal of pain (London, England), 2008, Volume: 12, Issue:6

    Topics: Aged; Amines; Analgesics, Opioid; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Delayed-Act

2008
Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2001, Volume: 13, Issue:3

    Topics: Acetates; Adult; Aged; Amines; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Gabapentin; gamma-A

2001

Other Studies

12 other studies available for gabapentin and Long Sleeper Syndrome

ArticleYear
Improvement of sleep quality after treatment in patients with lumbar spinal stenosis: a prospective comparative study between conservative versus surgical treatment.
    Scientific reports, 2020, 08-24, Volume: 10, Issue:1

    Topics: Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Conservative Treatment; Decompres

2020
Effect of gabapentin on sleep and delta and theta EEG power in adult rats exposed to chronic intermittent ethanol vapor and protracted withdrawal during adolescence.
    Psychopharmacology, 2018, Volume: 235, Issue:6

    Topics: Administration, Inhalation; Age Factors; Alcohol Drinking; Animals; Delta Rhythm; Electroencephalogr

2018
Actigraphy-based evaluation of sleep quality and physical activity in individuals with spinal cord injury.
    Spinal cord series and cases, 2019, Volume: 5

    Topics: Actigraphy; Adult; Analgesics; Benzodiazepines; Case-Control Studies; Exercise; Female; Gabapentin;

2019
Effect of gabapentin on sleep patterns disturbed by epilepsy.
    Epilepsy & behavior : E&B, 2019, Volume: 92

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electrooculography; Epilepsy; Gabapentin

2019
Treatment of pediatric restless legs syndrome.
    Clinical pediatrics, 2014, Volume: 53, Issue:4

    Topics: Adolescent; Amines; Analgesics; Anticonvulsants; Antioxidants; Benzothiazoles; Child; Child, Prescho

2014
Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 135

    Topics: Amines; Analgesics; Animals; Cerebral Cortex; Cyclohexanecarboxylic Acids; Electroencephalography; G

2015
The Effect of a Novel form of Extended-Release Gabapentin on Pain and Sleep in Fibromyalgia Subjects: An Open-Label Pilot Study.
    Pain practice : the official journal of World Institute of Pain, 2016, Volume: 16, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Amines; Analgesics; Cyclohexanecarboxylic Acids; Delayed-Action Prep

2016
[Restless legs syndrome in the elderly: an unrecognized disorder].
    Revue medicale suisse, 2008, Nov-05, Volume: 4, Issue:178

    Topics: Aged, 80 and over; Alzheimer Disease; Amines; Anticonvulsants; Benzodiazepines; Cyclohexanecarboxyli

2008
Fibromyalgia: poorly understood; treatments are disappointing.
    Prescrire international, 2009, Volume: 18, Issue:102

    Topics: Acetaminophen; Acupuncture Therapy; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Ant

2009
The multidisciplinary management of menopausal symptoms after breast cancer: a unique model of care.
    Menopause (New York, N.Y.), 2010, Volume: 17, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care Facilities; Amines; Anti-Anxiety Agents; Breast Neop

2010
Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis.
    Synapse (New York, N.Y.), 2011, Volume: 65, Issue:7

    Topics: Amines; Analgesics; Animals; Axotomy; Brain; Brain Mapping; Brain Waves; Cyclohexanecarboxylic Acids

2011
Paroxysmal arousals and myoclonic movements associated with interictal epileptiform discharges in NREM and REM sleep.
    Clinical neurology and neurosurgery, 2011, Volume: 113, Issue:5

    Topics: Adolescent; Amines; Antiparkinson Agents; Arousal; Chromosome Disorders; Chromosome Inversion; Chrom

2011