gabapentin has been researched along with Long Sleeper Syndrome in 31 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our goal was to compare the effects of gabapentin and pregabalin on improving sleep quality and depression among hemodialysis patients with PPN." | 9.17 | Gabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: a randomized prospective crossover trial. ( Atalay, H; Biyik, Z; Gaipov, A; Guney, F; Solak, Y; Turk, S, 2013) |
| "We assessed the efficacy and safety of extended-release gabapentin in a 15-week, open-label, single-arm, single-center study in patients with fibromyalgia (FM)." | 7.83 | The Effect of a Novel form of Extended-Release Gabapentin on Pain and Sleep in Fibromyalgia Subjects: An Open-Label Pilot Study. ( Hong, KS; North, JM; Rauck, RL, 2016) |
| " Our goal was to compare the effects of gabapentin and pregabalin on improving sleep quality and depression among hemodialysis patients with PPN." | 5.17 | Gabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: a randomized prospective crossover trial. ( Atalay, H; Biyik, Z; Gaipov, A; Guney, F; Solak, Y; Turk, S, 2013) |
| ") and restless legs syndrome treated with ropinirole and gabapentin, will be discussed." | 4.89 | Recent advances in sleep research. ( Anderer, P; Saletu, B; Saletu-Zyhlarz, GM, 2013) |
| "Gabapentin (GBP) is a antiepileptic drug (AED) indicated as adjunct therapy for treatment of partial seizures, with and without secondary generalization, in patients 12 and older with epilepsy." | 4.80 | Gabapentin. ( Morris, GL, 1999) |
| "We assessed the efficacy and safety of extended-release gabapentin in a 15-week, open-label, single-arm, single-center study in patients with fibromyalgia (FM)." | 3.83 | The Effect of a Novel form of Extended-Release Gabapentin on Pain and Sleep in Fibromyalgia Subjects: An Open-Label Pilot Study. ( Hong, KS; North, JM; Rauck, RL, 2016) |
| "To evaluate the antinociceptive and hypnotic effects of pregabalin, we established a neuropathic pain-like model in mice using partial sciatic nerve ligation (PSNL), and examined thermal hyperalgesia, mechanical allodynia, electroencephalogram, rota-rod testing, and c-Fos expression in the anterior cingulate cortex." | 3.81 | Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice. ( Guo, W; Han, WJ; Hong, ZY; Huang, ZL; Li, YD; Liu, YY; Qu, WM; Wang, TX; Yin, D, 2015) |
| " XP13512 immediate-release (up to 2800 mg single dose and 2100 mg twice daily) was well absorbed (>68%, based on urinary recovery of gabapentin), converted rapidly to gabapentin, and provided dose-proportional exposure, whereas absorption of oral gabapentin declined with increasing doses to <27% at 1200 mg." | 2.73 | Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin. ( Canafax, DM; Cundy, KC; Luo, W; Moors, TL; Sastry, S; Zou, J, 2008) |
| "The gabapentin was often first prescribed to facilitate sleep." | 2.70 | Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy. ( Brodrick, PS; Hamner, MB; Labbate, LA, 2001) |
| "Treatment with gabapentinoids (GBs) has been shown to reduce pain, but its effects on sleep health have not been systematically evaluated." | 2.66 | Evaluating the impact of gabapentinoids on sleep health in patients with chronic neuropathic pain: a systematic review and meta-analysis. ( Bhatia, A; Brull, R; Davidson, A; Kapustin, D; McParland, A; Singh, M; Trivedi, A, 2020) |
| "Sleep quality, chronotype, daytime sleepiness, neuropathic pain severity and interference were assessed based on questionnaires." | 1.51 | Actigraphy-based evaluation of sleep quality and physical activity in individuals with spinal cord injury. ( Albu, S; Forner-Cordero, A; Umemura, G, 2019) |
| "In a model of neuropathic pain, sciatic nerve ligation caused a marked decrease in the latency of paw withdrawal in response to a thermal stimulus only on the ipsilateral side." | 1.37 | Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis. ( Furuya, M; Hatakeyama, N; Horiuchi, H; Imai, S; Kinoshita, H; Kuzumaki, N; Matoba, M; Narita, M; Niikura, K; Senba, E; Suzuki, T; Takemura, Y; Tsukiyama, Y; Yamashita, A; Yamazaki, M; Yanase, M, 2011) |
| "A total of 578 women with breast cancer were managed at the Menopausal Symptoms After Cancer Clinic between January 2003 and December 2008." | 1.36 | The multidisciplinary management of menopausal symptoms after breast cancer: a unique model of care. ( Doherty, DA; Emery, LI; Gregson, J; Hickey, M; Saunders, CM, 2010) |
| "Anxiety and depression are often also present." | 1.35 | Fibromyalgia: poorly understood; treatments are disappointing. ( , 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.45) | 18.2507 |
| 2000's | 10 (32.26) | 29.6817 |
| 2010's | 17 (54.84) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, Y | 1 |
| Raymer, BK | 1 |
| Kapustin, D | 1 |
| Bhatia, A | 1 |
| McParland, A | 1 |
| Trivedi, A | 1 |
| Davidson, A | 1 |
| Brull, R | 1 |
| Singh, M | 1 |
| Kim, J | 1 |
| Lee, SH | 1 |
| Kim, TH | 1 |
| Eloy, JD | 1 |
| Anthony, C | 1 |
| Amin, S | 1 |
| Caparó, M | 1 |
| Reilly, MC | 1 |
| Shulman, S | 1 |
| Ehlers, CL | 1 |
| Sanchez-Alavez, M | 1 |
| Wills, D | 1 |
| Potter, B | 1 |
| Schrager, S | 1 |
| Dalby, J | 1 |
| Torell, E | 1 |
| Hampton, A | 1 |
| Albu, S | 1 |
| Umemura, G | 1 |
| Forner-Cordero, A | 1 |
| Ayala-Guerrero, F | 1 |
| Mexicano, G | 1 |
| Gutiérrez-Chávez, CA | 1 |
| Lazo, LA | 1 |
| Mateos, EL | 1 |
| Winkelman, JW | 1 |
| Gagnon, A | 1 |
| Clair, AG | 1 |
| Amos, LB | 1 |
| Grekowicz, ML | 1 |
| Kuhn, EM | 1 |
| Olstad, JD | 1 |
| Collins, MM | 1 |
| Norins, NA | 1 |
| D'Andrea, LA | 1 |
| Saletu, B | 1 |
| Anderer, P | 1 |
| Saletu-Zyhlarz, GM | 1 |
| Wang, TX | 1 |
| Yin, D | 1 |
| Guo, W | 1 |
| Liu, YY | 1 |
| Li, YD | 1 |
| Qu, WM | 1 |
| Han, WJ | 1 |
| Hong, ZY | 1 |
| Huang, ZL | 1 |
| North, JM | 1 |
| Hong, KS | 1 |
| Rauck, RL | 1 |
| Mowla, A | 1 |
| Ahmadzadeh, L | 1 |
| Razeghian Jahromi, L | 1 |
| Dastgheib, SA | 1 |
| Garland, SN | 1 |
| Xie, SX | 1 |
| Li, Q | 1 |
| Seluzicki, C | 1 |
| Basal, C | 1 |
| Mao, JJ | 1 |
| Cundy, KC | 1 |
| Sastry, S | 1 |
| Luo, W | 1 |
| Zou, J | 1 |
| Moors, TL | 1 |
| Canafax, DM | 1 |
| Ho, TW | 1 |
| Backonja, M | 1 |
| Ma, J | 1 |
| Leibensperger, H | 1 |
| Froman, S | 1 |
| Polydefkis, M | 1 |
| Biselx, S | 1 |
| Büla, C | 1 |
| Ghika, J | 1 |
| Hickey, M | 1 |
| Emery, LI | 1 |
| Gregson, J | 1 |
| Doherty, DA | 1 |
| Saunders, CM | 1 |
| Takemura, Y | 1 |
| Yamashita, A | 1 |
| Horiuchi, H | 1 |
| Furuya, M | 1 |
| Yanase, M | 1 |
| Niikura, K | 1 |
| Imai, S | 1 |
| Hatakeyama, N | 1 |
| Kinoshita, H | 1 |
| Tsukiyama, Y | 1 |
| Senba, E | 1 |
| Matoba, M | 1 |
| Kuzumaki, N | 1 |
| Yamazaki, M | 1 |
| Suzuki, T | 1 |
| Narita, M | 1 |
| Lucey, BP | 1 |
| Noetzel, MJ | 1 |
| Duntley, SP | 1 |
| Biyik, Z | 1 |
| Solak, Y | 1 |
| Atalay, H | 1 |
| Gaipov, A | 1 |
| Guney, F | 1 |
| Turk, S | 1 |
| Joffe, H | 1 |
| Soares, CN | 1 |
| Cohen, LS | 1 |
| Rejas, J | 1 |
| Ribera, MV | 1 |
| Ruiz, M | 1 |
| Masrramón, X | 1 |
| Bazil, CW | 1 |
| Battista, J | 1 |
| Basner, RC | 1 |
| Lanz, M | 1 |
| Happe, S | 1 |
| Hanna, M | 1 |
| O'Brien, C | 1 |
| Wilson, MC | 1 |
| Williams, DC | 1 |
| Morris, GL | 1 |
| Hamner, MB | 1 |
| Brodrick, PS | 1 |
| Labbate, LA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Gabapentin on Postoperative Pain: a Randomized, Double Blind, Placebo Controlled Trial[NCT01546857] | Phase 4 | 34 participants (Actual) | Interventional | 2012-03-31 | Terminated (stopped due to No longer able to recruit subjects due to unavailability of orthopedic surgeon.) | ||
| The Treatment of Sleep Bruxism With the Luco Hybrid OSA Appliance[NCT02882880] | 51 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Acupuncture and Gabapentin for Hot Flashes Among Breast Cancer Survivors[NCT01005108] | Phase 2 | 120 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Patient Controlled Analgesia use over 48 hours reported in Morphine equivalent dosage. (NCT01546857)
Timeframe: 48 hours post operatively
| Intervention | mg (Mean) |
|---|---|
| Placebo | 11.88 |
| Gabapentin | 11.02 |
Severity of pain measure on a scale from zero to ten. Zero no pain to ten severe pain. (NCT01546857)
Timeframe: 48 hours post operatively
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 5.15 |
| Gabapentin | 4.38 |
A questionnaire was administered asking participants about the quality of their sleep on the night of surgery asked on postoperative day 1, and on the first postoperative night ( POD 2) . Scored on a scale of zero to 3. Zero meaning poor postoperative sleep and 3 indicating better postoperative sleep. (NCT01546857)
Timeframe: Night of surgery (POD 1) and Postoperative Day 2.(POD 2)
| Intervention | units on a scale (Mean) | |
|---|---|---|
| POD 1 | POD 2 | |
| Gabapentin | 1.235 | 0.647 |
| Placebo | 1.333 | 1 |
9 reviews available for gabapentin and Long Sleeper Syndrome
| Article | Year |
|---|---|
Sleep modulating agents.
Topics: Animals; Humans; Sleep; Sleep Aids, Pharmaceutical; Sleep Wake Disorders; Wakefulness-Promoting Agen | 2019 |
Evaluating the impact of gabapentinoids on sleep health in patients with chronic neuropathic pain: a systematic review and meta-analysis.
Topics: Analgesics; Chronic Pain; Clinical Trials as Topic; Gabapentin; Humans; Neuralgia; Pain Measurement; | 2020 |
Menopause.
Topics: Contraception; Endometrial Neoplasms; Estrogen Replacement Therapy; Female; Gabapentin; Hot Flashes; | 2018 |
Sensory symptoms in restless legs syndrome: the enigma of pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Recent advances in sleep research.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Amines; Antiparkinson Agents; Biomedical Research; | 2013 |
Assessment and treatment of hot flushes and menopausal mood disturbance.
Topics: Acetates; Aging; Amines; Anti-Anxiety Agents; Cognition Disorders; Cyclohexanecarboxylic Acids; Fema | 2003 |
[When the legs have to keep moving at night--the restless legs syndrome].
Topics: Adult; Amines; Analgesics, Opioid; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Dopamine Ago | 2007 |
Periodic limb movements of sleep and the restless legs syndrome.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Folic Acid; Gabapentin; gamma-Aminob | 1996 |
Gabapentin.
Topics: Acetates; Amines; Anticonvulsants; Controlled Clinical Trials as Topic; Cyclohexanecarboxylic Acids; | 1999 |
10 trials available for gabapentin and Long Sleeper Syndrome
| Article | Year |
|---|---|
Gabapentin Does Not Appear to Improve Postoperative Pain and Sleep Patterns in Patients Who Concomitantly Receive Regional Anesthesia for Lower Extremity Orthopedic Surgery: A Randomized Control Trial.
Topics: Adolescent; Adult; Aged; Amines; Analgesics; Arthroplasty, Replacement; Celecoxib; Cyclohexanecarbox | 2017 |
Comparing Gabapentin with Clonazepam for Residual Sleeping Problems following Antidepressant Therapy in Patients with Major Depressive Disorder: A Randomized Clinical Trial.
Topics: Adult; Amines; Antidepressive Agents; Clonazepam; Cyclohexanecarboxylic Acids; Depressive Disorder, | 2015 |
Comparative effectiveness of electro-acupuncture versus gabapentin for sleep disturbances in breast cancer survivors with hot flashes: a randomized trial.
Topics: Acupuncture Therapy; Adult; Aged; Amines; Anti-Anxiety Agents; Breast Neoplasms; Cyclohexanecarboxyl | 2017 |
Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin.
Topics: Adult; Aged; Amines; Area Under Curve; Biological Availability; Capsules; Carbamates; Cross-Over Stu | 2008 |
Efficient assessment of neuropathic pain drugs in patients with small fiber sensory neuropathies.
Topics: Adolescent; Adult; Amines; Analgesics; Cross-Over Studies; Cyclohexanecarboxylic Acids; Diphenhydram | 2009 |
Gabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: a randomized prospective crossover trial.
Topics: Amines; Anti-Anxiety Agents; Calcium Channel Blockers; Cross-Over Studies; Cyclohexanecarboxylic Aci | 2013 |
Psychometric properties of the MOS (Medical Outcomes Study) Sleep Scale in patients with neuropathic pain.
Topics: Adult; Aged; Amines; Analgesics; Anxiety; Cyclohexanecarboxylic Acids; Depression; Disability Evalua | 2007 |
Gabapentin improves sleep in the presence of alcohol.
Topics: Adult; Alcoholic Intoxication; Amines; Anti-Anxiety Agents; Cross-Over Studies; Cyclohexanecarboxyli | 2005 |
Prolonged-release oxycodone enhances the effects of existing gabapentin therapy in painful diabetic neuropathy patients.
Topics: Aged; Amines; Analgesics, Opioid; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Delayed-Act | 2008 |
Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy.
Topics: Acetates; Adult; Aged; Amines; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Gabapentin; gamma-A | 2001 |
12 other studies available for gabapentin and Long Sleeper Syndrome
| Article | Year |
|---|---|
Improvement of sleep quality after treatment in patients with lumbar spinal stenosis: a prospective comparative study between conservative versus surgical treatment.
Topics: Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Conservative Treatment; Decompres | 2020 |
Effect of gabapentin on sleep and delta and theta EEG power in adult rats exposed to chronic intermittent ethanol vapor and protracted withdrawal during adolescence.
Topics: Administration, Inhalation; Age Factors; Alcohol Drinking; Animals; Delta Rhythm; Electroencephalogr | 2018 |
Actigraphy-based evaluation of sleep quality and physical activity in individuals with spinal cord injury.
Topics: Actigraphy; Adult; Analgesics; Benzodiazepines; Case-Control Studies; Exercise; Female; Gabapentin; | 2019 |
Effect of gabapentin on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electrooculography; Epilepsy; Gabapentin | 2019 |
Treatment of pediatric restless legs syndrome.
Topics: Adolescent; Amines; Analgesics; Anticonvulsants; Antioxidants; Benzothiazoles; Child; Child, Prescho | 2014 |
Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice.
Topics: Amines; Analgesics; Animals; Cerebral Cortex; Cyclohexanecarboxylic Acids; Electroencephalography; G | 2015 |
The Effect of a Novel form of Extended-Release Gabapentin on Pain and Sleep in Fibromyalgia Subjects: An Open-Label Pilot Study.
Topics: Adult; Aged; Aged, 80 and over; Amines; Analgesics; Cyclohexanecarboxylic Acids; Delayed-Action Prep | 2016 |
[Restless legs syndrome in the elderly: an unrecognized disorder].
Topics: Aged, 80 and over; Alzheimer Disease; Amines; Anticonvulsants; Benzodiazepines; Cyclohexanecarboxyli | 2008 |
Fibromyalgia: poorly understood; treatments are disappointing.
Topics: Acetaminophen; Acupuncture Therapy; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Ant | 2009 |
The multidisciplinary management of menopausal symptoms after breast cancer: a unique model of care.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care Facilities; Amines; Anti-Anxiety Agents; Breast Neop | 2010 |
Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis.
Topics: Amines; Analgesics; Animals; Axotomy; Brain; Brain Mapping; Brain Waves; Cyclohexanecarboxylic Acids | 2011 |
Paroxysmal arousals and myoclonic movements associated with interictal epileptiform discharges in NREM and REM sleep.
Topics: Adolescent; Amines; Antiparkinson Agents; Arousal; Chromosome Disorders; Chromosome Inversion; Chrom | 2011 |