gabapentin has been researched along with Lesion of Sciatic Nerve in 30 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of genistein were compared with those of gabapentin, which is widely used in clinical practice for peripheral nerve injury." | 7.85 | Neuroprotective Effect of Genistein in Peripheral Nerve Injury. ( Arslantas, A; Aydin, HE; Baycu, C; Bektur, E; Kocman, AE; Kose, A; Ozbek, Z; Ozkara, E; Sahin, E; Vural, M, 2017) |
| "Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated CCI-induced static- (days 10-30) and dynamic-allodynia (days 15-30), suppressed cold-allodynia (days 10-30), heat- (days 15-30) and mechano-hyperalgesia (days 5-30) indicating a local action." | 7.85 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Ambroxol's effects were compared with those of gabapentin." | 5.33 | Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. ( Arndt, K; Gaida, W; Klinder, K; Weiser, T, 2005) |
| "The degree of allodynia was most marked following 10 min of irradiation." | 5.32 | Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003) |
| " The effects of genistein were compared with those of gabapentin, which is widely used in clinical practice for peripheral nerve injury." | 3.85 | Neuroprotective Effect of Genistein in Peripheral Nerve Injury. ( Arslantas, A; Aydin, HE; Baycu, C; Bektur, E; Kocman, AE; Kose, A; Ozbek, Z; Ozkara, E; Sahin, E; Vural, M, 2017) |
| "Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated CCI-induced static- (days 10-30) and dynamic-allodynia (days 15-30), suppressed cold-allodynia (days 10-30), heat- (days 15-30) and mechano-hyperalgesia (days 5-30) indicating a local action." | 3.85 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| " Two distinct FAAH inhibitory compounds, URB597 and PF-3845 were tested, and contrasted with standard antinociceptive gabapentin or vehicle treatment, for attenuation of tactile allodynia, cold allodynia, and mechanical hyperalgesia." | 3.81 | Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy. ( Jergova, S; Nasirinezhad, F; Pearson, JP; Sagen, J, 2015) |
| "To evaluate the antinociceptive and hypnotic effects of pregabalin, we established a neuropathic pain-like model in mice using partial sciatic nerve ligation (PSNL), and examined thermal hyperalgesia, mechanical allodynia, electroencephalogram, rota-rod testing, and c-Fos expression in the anterior cingulate cortex." | 3.81 | Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice. ( Guo, W; Han, WJ; Hong, ZY; Huang, ZL; Li, YD; Liu, YY; Qu, WM; Wang, TX; Yin, D, 2015) |
| " To further establish the neurochemical basis for its supraspinally mediated analgesic action, concentrations of spinal noradrenaline, 4-hydroxy-3-methoxyphenylglycol (MHPG), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and dopamine were measured using high-performance liquid chromatography in a murine neuropathic pain model that was prepared by partial ligation of the sciatic nerve (the Seltzer model)." | 3.74 | Neurochemical evidence that supraspinally administered gabapentin activates the descending noradrenergic system after peripheral nerve injury. ( Honda, M; Ono, H; Takasu, K; Takeuchi, Y; Tanabe, M, 2007) |
| "We have previously demonstrated that gabapentin supraspinally activates the descending noradrenergic system to ameliorate pain hypersensitivity in mice with partial nerve ligation." | 3.74 | Gabapentin produces PKA-dependent pre-synaptic inhibition of GABAergic synaptic transmission in LC neurons following partial nerve injury in mice. ( Ono, H; Takasu, K; Tanabe, M, 2008) |
| " The effects of diacerhein were compared with those of gabapentin, a drug used clinically for the management of neuropathic pain." | 3.73 | The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice. ( Calixto, JB; Campos, MM; Medeiros, R; Quintão, NLM; Santos, ARS, 2005) |
| "A series of mutual prodrugs derived from gabapentin, pregabalin, memantine, venlafaxine were synthesized and their pharmacological properties to treat neuropathic pain were investigated in a rat model of chronic sciatic nerve constriction injury (CCI)." | 3.72 | Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury. ( Bo-Hua, Z; He, L; Hong-Ju, Y; Jun-Wei, W; Nan, Z; Wei-Guo, S; Wei-Xiu, Y; Zhe-Hui, G; Zheng-Hua, G; Zhi-Pu, L; Zhong-Wei, J, 2004) |
| "Gabapentin (GBP) is an established drug that has been used in the management of symptoms of neuropathy but it is associated with unwanted side effects such as sedation and motor incoordination." | 1.62 | A novel gabapentin analogue assuages neuropathic pain response in chronic sciatic nerve constriction model in rats. ( Ahmad, N; Akbar, S; Amin, MU; Islam, NU; Khurram, M; Sewell, RDE; Shahid, M; Subhan, F; Ullah, I; Ullah, N; Ullah, R, 2021) |
| "Many patients with chronic pain conditions suffer from depression." | 1.62 | Dynamic Change of Endocannabinoid Signaling in the Medial Prefrontal Cortex Controls the Development of Depression After Neuropathic Pain. ( Chao, D; Feng, Y; Hillard, CJ; Hogan, QH; Mecca, CM; Pan, B; Pawela, CP; Rodriguez-Garcia, DM; Segel, I; Yu, G; Zhang, Z, 2021) |
| "CCI also evoked mechanical allodynia that was fully developed on a week post-operation, but showed no recovery for at least 8 weeks." | 1.35 | Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats. ( Kurebayashi, Y; Nakazato-Imasato, E, 2009) |
| "Failure to identify sciatic neuropathy after traumatic injury to the lower extremity may lead to the delayed institution of neuropathic pharmacotherapy, electrodiagnostic testing, physical therapy, and increased risk for the development of complex regional pain syndrome." | 1.34 | Sciatic neuropathy after lower-extremity trauma: successful treatment of an uncommon pain and disability syndrome in an adolescent. ( Gold, AP; Roye, D; Saroyan, JM; Schechter, WS; Winfree, CJ, 2007) |
| "Similar bilateral hyperalgesia was observed when axotomy was performed using silk thread instead of chromic gut." | 1.33 | Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy. ( Miki, S; Senba, E; Yasuda, T; Yoshinaga, N, 2005) |
| "Neuropathic pain is a clinical manifestation characterized by the presence of spontaneous pain, allodynia and hyperalgesia." | 1.33 | Development and expression of neuropathic pain in CB1 knockout mice. ( Castañé, A; Célérier, E; Ledent, C; Maldonado, R; Martín, M; Parmentier, M; Valverde, O, 2006) |
| "Ambroxol's effects were compared with those of gabapentin." | 1.33 | Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. ( Arndt, K; Gaida, W; Klinder, K; Weiser, T, 2005) |
| "The degree of allodynia was most marked following 10 min of irradiation." | 1.32 | Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 20 (66.67) | 29.6817 |
| 2010's | 8 (26.67) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Hong-Ju, Y | 1 |
| He, L | 1 |
| Wei-Guo, S | 1 |
| Nan, Z | 1 |
| Wei-Xiu, Y | 1 |
| Zhong-Wei, J | 1 |
| Jun-Wei, W | 1 |
| Zheng-Hua, G | 1 |
| Bo-Hua, Z | 1 |
| Zhi-Pu, L | 1 |
| Zhe-Hui, G | 1 |
| Ahmad, N | 2 |
| Subhan, F | 2 |
| Islam, NU | 1 |
| Shahid, M | 2 |
| Ullah, N | 1 |
| Ullah, R | 1 |
| Akbar, S | 2 |
| Amin, MU | 1 |
| Khurram, M | 1 |
| Ullah, I | 1 |
| Sewell, RDE | 1 |
| Mecca, CM | 1 |
| Chao, D | 1 |
| Yu, G | 1 |
| Feng, Y | 1 |
| Segel, I | 1 |
| Zhang, Z | 1 |
| Rodriguez-Garcia, DM | 1 |
| Pawela, CP | 1 |
| Hillard, CJ | 1 |
| Hogan, QH | 1 |
| Pan, B | 1 |
| Assadsangabi, R | 1 |
| Hajmomenian, M | 1 |
| Nabavizadeh, SA | 1 |
| Vossough, A | 1 |
| Nasirinezhad, F | 1 |
| Jergova, S | 1 |
| Pearson, JP | 1 |
| Sagen, J | 1 |
| Wang, TX | 1 |
| Yin, D | 1 |
| Guo, W | 1 |
| Liu, YY | 1 |
| Li, YD | 1 |
| Qu, WM | 1 |
| Han, WJ | 1 |
| Hong, ZY | 1 |
| Huang, ZL | 1 |
| Nakazato-Imasato, E | 1 |
| Kurebayashi, Y | 1 |
| Reda, HM | 1 |
| Zaitone, SA | 1 |
| Moustafa, YM | 1 |
| Ozbek, Z | 1 |
| Aydin, HE | 1 |
| Kocman, AE | 1 |
| Ozkara, E | 1 |
| Sahin, E | 1 |
| Bektur, E | 1 |
| Vural, M | 1 |
| Kose, A | 1 |
| Arslantas, A | 1 |
| Baycu, C | 1 |
| Ali, G | 1 |
| Fawad, K | 1 |
| Sewell, RD | 1 |
| Keskinbora, K | 1 |
| Aydinli, I | 1 |
| Omori, Y | 1 |
| Kagaya, K | 1 |
| Enomoto, R | 1 |
| Sasaki, A | 1 |
| Andoh, T | 1 |
| Nojima, H | 1 |
| Takahata, H | 1 |
| Kuraishi, Y | 1 |
| Quintão, NL | 1 |
| da Silva, GF | 1 |
| Antonialli, CS | 1 |
| Rocha, LW | 1 |
| Cechinel Filho, V | 1 |
| Cicció, JF | 1 |
| Pérez Villena, A | 1 |
| Duat Rodríguez, A | 1 |
| García Peñas, JJ | 1 |
| López Pino, MA | 1 |
| Luo, ZD | 1 |
| Calcutt, NA | 1 |
| Higuera, ES | 1 |
| Valder, CR | 1 |
| Song, YH | 1 |
| Svensson, CI | 1 |
| Myers, RR | 1 |
| Gustafsson, H | 1 |
| Flood, K | 1 |
| Berge, OG | 1 |
| Brodin, E | 1 |
| Olgart, L | 1 |
| Stiller, CO | 1 |
| Wu, WP | 1 |
| Hao, JX | 1 |
| Ongini, E | 1 |
| Impagnatiello, F | 1 |
| Presotto, C | 1 |
| Wiesenfeld-Hallin, Z | 1 |
| Xu, XJ | 1 |
| Decosterd, I | 1 |
| Allchorne, A | 1 |
| Woolf, CJ | 1 |
| Yasuda, T | 1 |
| Miki, S | 1 |
| Yoshinaga, N | 1 |
| Senba, E | 1 |
| Hama, AT | 1 |
| Borsook, D | 1 |
| Shi, W | 1 |
| Liu, H | 1 |
| Zhang, Y | 1 |
| Zhong, B | 1 |
| Yang, H | 1 |
| Castañé, A | 1 |
| Célérier, E | 1 |
| Martín, M | 1 |
| Ledent, C | 1 |
| Parmentier, M | 1 |
| Maldonado, R | 1 |
| Valverde, O | 1 |
| Gaida, W | 1 |
| Klinder, K | 1 |
| Arndt, K | 1 |
| Weiser, T | 1 |
| Quintão, NLM | 1 |
| Medeiros, R | 1 |
| Santos, ARS | 1 |
| Campos, MM | 1 |
| Calixto, JB | 1 |
| Takeuchi, Y | 1 |
| Takasu, K | 2 |
| Honda, M | 1 |
| Ono, H | 2 |
| Tanabe, M | 2 |
| Wallace, VC | 1 |
| Segerdahl, AR | 1 |
| Lambert, DM | 1 |
| Vandevoorde, S | 1 |
| Blackbeard, J | 1 |
| Pheby, T | 1 |
| Hasnie, F | 1 |
| Rice, AS | 1 |
| Saroyan, JM | 1 |
| Winfree, CJ | 1 |
| Schechter, WS | 1 |
| Roye, D | 1 |
| Gold, AP | 1 |
| Hota, D | 1 |
| Bansal, V | 1 |
| Pattanaik, S | 1 |
| Benbouzid, M | 1 |
| Choucair-Jaafar, N | 1 |
| Yalcin, I | 1 |
| Waltisperger, E | 1 |
| Muller, A | 1 |
| Freund-Mercier, MJ | 1 |
| Barrot, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Ambroxol on the Inflammatory Markers and Clinical Outcome of Patients With Diabetic Peripheral Neuropathy[NCT05558878] | 80 participants (Anticipated) | Interventional | 2022-10-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
30 other studies available for gabapentin and Lesion of Sciatic Nerve
| Article | Year |
|---|---|
Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury.
Topics: Amines; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Cyclohexanols; Disease Models, Animal | 2004 |
A novel gabapentin analogue assuages neuropathic pain response in chronic sciatic nerve constriction model in rats.
Topics: Analgesics; Animals; Behavior, Animal; Chronic Disease; Constriction; Disease Models, Animal; Excita | 2021 |
Dynamic Change of Endocannabinoid Signaling in the Medial Prefrontal Cortex Controls the Development of Depression After Neuropathic Pain.
Topics: Animals; Brain Mapping; Chronic Pain; Depression; Endocannabinoids; Feeding Behavior; Female; GABAer | 2021 |
Deep renal ectopia causing sciatic mononeuropathy.
Topics: Adolescent; Amines; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma | 2014 |
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.
Topics: Amidohydrolases; Amines; Analgesics; Animals; Benzamides; Carbamates; Cyclohexanecarboxylic Acids; D | 2015 |
Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice.
Topics: Amines; Analgesics; Animals; Cerebral Cortex; Cyclohexanecarboxylic Acids; Electroencephalography; G | 2015 |
Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats.
Topics: Amines; Analgesics; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Disease Models, Animal; G | 2009 |
Effect of levetiracetam versus gabapentin on peripheral neuropathy and sciatic degeneration in streptozotocin-diabetic mice: Influence on spinal microglia and astrocytes.
Topics: Amines; Animals; Astrocytes; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Diabetes | 2016 |
Neuroprotective Effect of Genistein in Peripheral Nerve Injury.
Topics: Amines; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyr | 2017 |
Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model.
Topics: Administration, Topical; Amines; Analgesics; Animals; Constriction, Pathologic; Cyclohexanecarboxyli | 2017 |
Treatment of neuropathic pain due to sciatic nerve injury following intramuscular injection with gabapentin in a child.
Topics: Amines; Child; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, | 2008 |
A mouse model of sural nerve injury-induced neuropathy: gabapentin inhibits pain-related behaviors and the hyperactivity of wide-dynamic range neurons in the dorsal horn.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Cold Temperature; Cyclohexanecarboxylic | 2009 |
Chemical composition and evaluation of the anti-hypernociceptive effect of the essential oil extracted from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Bicyclic Monoterpenes; Carr | 2010 |
Plexiform neurofibroma in an 8 year-old patient.
Topics: Amines; Analgesics; Child; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin.
Topics: Acetates; Amines; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Dis | 2002 |
Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models | 2003 |
A nitric oxide (NO)-releasing derivative of gabapentin, NCX 8001, alleviates neuropathic pain-like behavior after spinal cord and peripheral nerve injury.
Topics: Acetates; Amines; Animals; Aorta, Thoracic; Behavior, Animal; Cyclic GMP; Cyclohexanecarboxylic Acid | 2004 |
Differential analgesic sensitivity of two distinct neuropathic pain models.
Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Animals; Cold Temperature; Cyclohexanecarboxylic A | 2004 |
Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Axotomy; Cyclohexanecarboxyl | 2005 |
Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat.
Topics: Amines; Analgesics; Animals; Cold Temperature; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminob | 2005 |
Design, synthesis, and preliminary evaluation of gabapentin-pregabalin mutual prodrugs in relieving neuropathic pain.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug | 2005 |
Development and expression of neuropathic pain in CB1 knockout mice.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarboxylic Acids; Gabapentin; gamma-A | 2006 |
Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain.
Topics: Ambroxol; Amines; Analgesics; Animals; Behavior, Animal; Constriction, Pathologic; Cyclohexanecarbox | 2005 |
The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice.
Topics: Amines; Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acid | 2005 |
Neurochemical evidence that supraspinally administered gabapentin activates the descending noradrenergic system after peripheral nerve injury.
Topics: Amines; Analgesics; Animals; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids; Gaba | 2007 |
The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy.
Topics: Amides; Amines; Animals; Behavior, Animal; Camphanes; Cyclohexanecarboxylic Acids; Dose-Response Rel | 2007 |
Sciatic neuropathy after lower-extremity trauma: successful treatment of an uncommon pain and disability syndrome in an adolescent.
Topics: Accidents, Traffic; Adolescent; Amines; Analgesics; Bicycling; Causalgia; Cyclohexanecarboxylic Acid | 2007 |
Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric | 2007 |
Gabapentin produces PKA-dependent pre-synaptic inhibition of GABAergic synaptic transmission in LC neurons following partial nerve injury in mice.
Topics: Amines; Animals; Cyclic AMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Efferent Pathway | 2008 |
Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Di | 2008 |