gabapentin has been researched along with Generalized Vulvodynia in 12 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset." | 5.42 | A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. ( Abbas, M; Ali, G; Sewell, RD; Shahid, M; Subhan, F; Zeb, J, 2015) |
| "In this cohort, extended-release gabapentin, as compared with a placebo, did not reduce tampon test pain." | 5.27 | Gabapentin for the Treatment of Vulvodynia: A Randomized Controlled Trial. ( Bachmann, GA; Brown, CS; Foster, DC; Wan, J, 2018) |
| "Gabapentin was more effective than placebo in improving overall sexual function (adjusted mean difference, 1." | 2.90 | Effect of gabapentin on sexual function in vulvodynia: a randomized, placebo-controlled trial. ( Bachmann, GA; Brown, CS; Foster, DC; Phillips, NA; Rawlinson, LA; Wood, R; Yu, X, 2019) |
| "Vulvodynia is a genital pain syndrome occurring in 7% to 8% of women." | 2.52 | Vulvodynia. ( Edwards, L, 2015) |
| "Although some vulvodynia-afflicted patients derive symptom relief from anticonvulsants, there is, as yet, insufficient evidence to support the recommendation of anticonvulsant pharmacotherapy in the treatment of vulvodynia." | 2.49 | A systematic review of the utility of anticonvulsant pharmacotherapy in the treatment of vulvodynia pain. ( Leo, RJ, 2013) |
| "Furthermore, the induced vulvodynia was validated by investigating the potentiation of a flinch response threshold, upon topical application and systemic administration of gabapentin, a commonly used medication for treating neuropathic pain." | 1.62 | Chemotherapeutic Agent-Induced Vulvodynia, an Experimental Model. ( Jo, S; Murthy, SN; Rangappa, S; Repka, MA; Shankar, VK, 2021) |
| "The analysis of the case of vulvodynia coexisting with depression." | 1.46 | Vulvodynia and depression - a case study. ( Derewianka-Polak, M; Dziwota, EA; Gerhant, A; Olajossy, M; Perzyńska-Starkiewicz, A, 2017) |
| "Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset." | 1.42 | A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. ( Abbas, M; Ali, G; Sewell, RD; Shahid, M; Subhan, F; Zeb, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (91.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Rangappa, S | 1 |
| Shankar, VK | 1 |
| Jo, S | 1 |
| Repka, MA | 1 |
| Murthy, SN | 1 |
| van Beekhuizen, HJ | 1 |
| Oost, J | 1 |
| van der Meijden, WI | 1 |
| Gerhant, A | 1 |
| Dziwota, EA | 1 |
| Perzyńska-Starkiewicz, A | 1 |
| Derewianka-Polak, M | 1 |
| Olajossy, M | 1 |
| Brown, CS | 4 |
| Bachmann, GA | 4 |
| Wan, J | 1 |
| Foster, DC | 4 |
| Phillips, NA | 1 |
| Rawlinson, LA | 3 |
| Yu, X | 1 |
| Wood, R | 1 |
| Bautrant, E | 1 |
| Porta, O | 1 |
| Murina, F | 1 |
| Mühlrad, H | 1 |
| Levêque, C | 1 |
| Riant, T | 1 |
| Ploteau, S | 1 |
| Valancogne, G | 1 |
| Levesque, A | 1 |
| Leo, RJ | 1 |
| Wan, JY | 2 |
| Edwards, L | 1 |
| Ali, G | 2 |
| Subhan, F | 2 |
| Abbas, M | 1 |
| Zeb, J | 1 |
| Shahid, M | 2 |
| Sewell, RD | 1 |
| Bachour, CC | 1 |
| Akbar, S | 1 |
| Karim, N | 1 |
| Ahmad, N | 1 |
| Mahmood, W | 1 |
| Fawad, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Controlled Trial of Gabapentin in Vulvodynia: Biological Correlates of Response[NCT01301001] | 230 participants (Actual) | Interventional | 2012-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Coital pain on an 11-point Numeric Rating Scale (0 = no pain at all; 10 = worse pain ever), assessed after each sexual intercourse event. The number of sexual intercourse events was averaged during final week of each treatment arm. (NCT01301001)
Timeframe: Week 6 of each treatment arm
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 3.97 |
| Gabapentin | 3.85 |
Tampon pain on a 11-point Numeric Rating Scale (0 = no pain at all; 10 = worse pain ever). One tampon was inserted each week. Tampon pain was assessed during last week of maintenance phase (7 days). (NCT01301001)
Timeframe: Week 6 for each treatment arm
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 4.29 |
| Gabapentin | 3.96 |
Overall vulvodynia pain on an 11-point Numeric Rating Scale (0 = no pain at all; 10 = worse pain ever). Pain was assessed daily during the last week of treatment. Daily scores were averaged. (NCT01301001)
Timeframe: Week 6 for each treatment arm
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 2.88 |
| Gabapentin | 2.71 |
3 reviews available for gabapentin and Generalized Vulvodynia
| Article | Year |
|---|---|
Provoked vulvar vestibulodynia: Epidemiology in Europe, physio-pathology, consensus for first-line treatment and evaluation of second-line treatments.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Botulinum Toxins; Cognitive Behavioral Therapy; Consensus; | 2019 |
A systematic review of the utility of anticonvulsant pharmacotherapy in the treatment of vulvodynia pain.
Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; H | 2013 |
Vulvodynia.
Topics: Administration, Cutaneous; Amines; Analgesics; Anesthetics, Local; Antidepressive Agents; Cyclohexan | 2015 |
3 trials available for gabapentin and Generalized Vulvodynia
| Article | Year |
|---|---|
Gabapentin for the Treatment of Vulvodynia: A Randomized Controlled Trial.
Topics: Adult; Analgesics; Cross-Over Studies; Delayed-Action Preparations; Diagnostic Techniques, Obstetric | 2018 |
Effect of gabapentin on sexual function in vulvodynia: a randomized, placebo-controlled trial.
Topics: Adult; Confidence Intervals; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; F | 2019 |
Rationale and design of a multicenter randomized clinical trial of extended release gabapentin in provoked vestibulodynia and biological correlates of response.
Topics: Amines; Analgesics; Cross-Over Studies; Cyclohexanecarboxylic Acids; Delayed-Action Preparations; Do | 2013 |
6 other studies available for gabapentin and Generalized Vulvodynia
| Article | Year |
|---|---|
Chemotherapeutic Agent-Induced Vulvodynia, an Experimental Model.
Topics: Analgesics; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Disease Models, Anima | 2021 |
Generalized unprovoked vulvodynia; A retrospective study on the efficacy of treatment with amitriptyline, gabapentin or pregabalin.
Topics: Adult; Aged; Aged, 80 and over; Amines; Amitriptyline; Analgesics; Cyclohexanecarboxylic Acids; Fema | 2018 |
Vulvodynia and depression - a case study.
Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Depression; Female; Gabapentin; gamma-Aminobutyric | 2017 |
A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin.
Topics: Administration, Topical; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetes Mellitus | 2015 |
Recruitment methods in a clinical trial of provoked vulvodynia: Predictors of enrollment.
Topics: Adult; Age Factors; Amines; Analgesics; Black or African American; Clinical Trials as Topic; Communi | 2017 |
6-Methoxyflavanone attenuates mechanical allodynia and vulvodynia in the streptozotocin-induced diabetic neuropathic pain.
Topics: Amines; Animals; Computer Simulation; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Female; Fl | 2016 |