gabapentin has been researched along with Emesis in 14 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain." | 9.69 | Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023) |
| "Gabapentin and intravenous patient-controlled analgesia (PCA) can reduce postoperative pain scores, postoperative opioid use, and time to completing physical therapy compared to PCA alone after posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS)." | 9.41 | Gabapentin and intrathecal morphine combination therapy results in decreased oral narcotic use and more consistent pain scores after posterior spinal fusion for adolescent idiopathic scoliosis. ( Caird, MS; Hong, RA; Leis, A; Li, Y; Robbins, C; Swallow, J, 2021) |
| "Gabapentin/placebo was started the day of chemotherapy and continued through day 5 for the first chemotherapy cycle, whereas dex was titrated down on days 2-4." | 6.79 | Phase III double-blind, placebo-controlled study of gabapentin for the prevention of delayed chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy, NCCTG N08C3 (Alliance). ( Barton, DL; Blair, SC; Diekmann, B; Fuloria, J; Jaslowski, AJ; Kottschade, LA; Loprinzi, CL; Lyss, AP; Mazurczak, MA; Sloan, JA; Terstriep, S; Thanarajasingam, G, 2014) |
| "Gabapentin is a low-cost strategy to improve complete control of CINV, specially delayed CINV control." | 6.77 | Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study. ( Carrasco, MM; Cruz, FM; da Costa Miranda, M; da Cunha Vieira, M; de Afonseca, SO; de Iracema Gomes Cubero, D; de Souza Fêde, AB; del Giglio, A; Lera, AT; Lerner, T; Pinczowski, H; Schindler, F; Taranto, P, 2012) |
| "The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain." | 5.69 | Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023) |
| "Gabapentin and intravenous patient-controlled analgesia (PCA) can reduce postoperative pain scores, postoperative opioid use, and time to completing physical therapy compared to PCA alone after posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS)." | 5.41 | Gabapentin and intrathecal morphine combination therapy results in decreased oral narcotic use and more consistent pain scores after posterior spinal fusion for adolescent idiopathic scoliosis. ( Caird, MS; Hong, RA; Leis, A; Li, Y; Robbins, C; Swallow, J, 2021) |
| " Other outcomes were overall pain during well-defined mobilizations and at rest and sedation during the first 48 hours and from days 2-6, morphine use, anxiety, depression, sleep quality, and nausea, vomiting, dizziness, concentration difficulty, headache, visual disturbances, and adverse reactions." | 5.20 | Analgesic and sedative effects of perioperative gabapentin in total knee arthroplasty: a randomized, double-blind, placebo-controlled dose-finding study. ( Hansen, LT; Husted, H; Kehlet, H; Laursen, MB; Lunn, TH, 2015) |
| " The complications of vomiting, nausea, dizziness and pruritus were also compiled to assess the safety of gabapentin and pregabalin." | 4.93 | The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis. ( Ding, W; Mao, Y; Wu, L, 2016) |
| "Gabapentin/placebo was started the day of chemotherapy and continued through day 5 for the first chemotherapy cycle, whereas dex was titrated down on days 2-4." | 2.79 | Phase III double-blind, placebo-controlled study of gabapentin for the prevention of delayed chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy, NCCTG N08C3 (Alliance). ( Barton, DL; Blair, SC; Diekmann, B; Fuloria, J; Jaslowski, AJ; Kottschade, LA; Loprinzi, CL; Lyss, AP; Mazurczak, MA; Sloan, JA; Terstriep, S; Thanarajasingam, G, 2014) |
| "Gabapentin is a low-cost strategy to improve complete control of CINV, specially delayed CINV control." | 2.77 | Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study. ( Carrasco, MM; Cruz, FM; da Costa Miranda, M; da Cunha Vieira, M; de Afonseca, SO; de Iracema Gomes Cubero, D; de Souza Fêde, AB; del Giglio, A; Lera, AT; Lerner, T; Pinczowski, H; Schindler, F; Taranto, P, 2012) |
| "The patient was initially treated for her abdominal pain and vomiting." | 1.35 | Drug use in porphyria: a therapeutic dilemma. ( Jimmy, B; Jose, J; Saravu, K; Shastry, BA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 5 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Swallow, J | 1 |
| Robbins, C | 1 |
| Caird, MS | 1 |
| Leis, A | 1 |
| Hong, RA | 1 |
| Hung, KC | 1 |
| Wu, SC | 1 |
| Chiang, MH | 1 |
| Hsu, CW | 1 |
| Chen, JY | 1 |
| Huang, PW | 1 |
| Sun, CK | 1 |
| Brant, AR | 1 |
| Reeves, MF | 1 |
| Ye, PP | 1 |
| Scott, RK | 1 |
| Floyd, S | 1 |
| Tefera, E | 1 |
| Lotke, PS | 1 |
| Jouybar, R | 1 |
| Kazemifar, S | 1 |
| Asmarian, N | 1 |
| Karami, A | 1 |
| Khademi, S | 1 |
| Chaghazardi, S | 1 |
| Hedari, M | 1 |
| Bazargan-Hejazi, S | 1 |
| Mohammadi, R | 1 |
| Ahmadi, A | 1 |
| Guttuso, T | 2 |
| Barton, DL | 1 |
| Thanarajasingam, G | 1 |
| Sloan, JA | 1 |
| Diekmann, B | 1 |
| Fuloria, J | 1 |
| Kottschade, LA | 1 |
| Lyss, AP | 1 |
| Jaslowski, AJ | 1 |
| Mazurczak, MA | 1 |
| Blair, SC | 1 |
| Terstriep, S | 1 |
| Loprinzi, CL | 1 |
| Lunn, TH | 1 |
| Husted, H | 1 |
| Laursen, MB | 1 |
| Hansen, LT | 1 |
| Kehlet, H | 1 |
| Kottschade, L | 1 |
| Novotny, P | 1 |
| Lyss, A | 1 |
| Mazurczak, M | 1 |
| Loprinzi, C | 1 |
| Barton, D | 1 |
| Mao, Y | 1 |
| Wu, L | 1 |
| Ding, W | 1 |
| Jose, J | 1 |
| Saravu, K | 1 |
| Shastry, BA | 1 |
| Jimmy, B | 1 |
| Cruz, FM | 1 |
| de Iracema Gomes Cubero, D | 1 |
| Taranto, P | 1 |
| Lerner, T | 1 |
| Lera, AT | 1 |
| da Costa Miranda, M | 1 |
| da Cunha Vieira, M | 1 |
| de Souza Fêde, AB | 1 |
| Schindler, F | 1 |
| Carrasco, MM | 1 |
| de Afonseca, SO | 1 |
| Pinczowski, H | 1 |
| del Giglio, A | 1 |
| Mariano Da Silva, H | 1 |
| Alcantara, MC | 1 |
| Bordini, CA | 1 |
| Speciali, JG | 1 |
| Vitticore, P | 1 |
| Holloway, RG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gabapentin as an Adjunct for Pain Management During Dilation and Evacuation: A Double-blind Randomized Controlled Trial[NCT03635905] | Phase 4 | 130 participants (Actual) | Interventional | 2017-05-26 | Completed | ||
| Comparison of Gabapentin and Metoclopramide for Treating Hyperemesis Gravidarum[NCT02163434] | Phase 2 | 31 participants (Actual) | Interventional | 2014-06-30 | Completed | ||
| Randomized Prospective Study Comparing Variable Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy[NCT05172570] | Phase 3 | 120 participants (Anticipated) | Interventional | 2021-04-06 | Recruiting | ||
| PUCE Study: Prevention of Unmitigated Chemotherapy-induced Emesis[NCT03996863] | 0 participants (Actual) | Interventional | 2019-08-01 | Withdrawn (stopped due to Drexel Oncology was shut down a few days before first patient in.) | |||
| "Preoperative Gabapentin and Its Effects on Postoperative Analgesia in Patients Undergoing Cosmetic Breast Surgery"[NCT05997355] | 100 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Efficacy of Olanzapine, Netupitant and Palonosetron in Controlling Nausea and Vomiting Associated With Highly Emetogenic Chemotherapy in Patients With Breast Cancer[NCT04669132] | Phase 2 | 50 participants (Actual) | Interventional | 2020-12-17 | Completed | ||
| Clinical Trial of Gabapentin in the Prevention of Nausea Ond Vomiting Induced by Chemotherapy, a Randomized, Double-blind, Placebo Controled Study[NCT01052844] | Phase 3 | 80 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Score range: 6-30 with higher score indicating a worse outcome. (NCT02163434)
Timeframe: 1 week
| Intervention | units on a scale (Mean) |
|---|---|
| Gabapentin | 6.35 |
| Metoclopramide | 13.22 |
Score range: 2-10 with higher score indicating a worse outcome. (NCT02163434)
Timeframe: 1 week
| Intervention | units on a scale (Mean) |
|---|---|
| Gabapentin | 2.01 |
| Metoclopramide | 3.69 |
Score range: 0-15 with higher score indicating a better outcome. (NCT02163434)
Timeframe: 1 week
| Intervention | units on a scale (Mean) |
|---|---|
| Gabapentin | 7.86 |
| Metoclopramide | 4.01 |
Scores: 0=no, 1=yes. Thus, a higher score indicates a better outcome. (NCT02163434)
Timeframe: 1 week
| Intervention | units on a scale (Mean) |
|---|---|
| Gabapentin | 0.67 |
| Metoclopramide | 0.14 |
Score range: 0-4 with higher score indicating a better outcome. (NCT02163434)
Timeframe: 1 week
| Intervention | units on a scale (Mean) |
|---|---|
| Gabapentin | 2.22 |
| Metoclopramide | 0.63 |
(NCT02163434)
Timeframe: 1 week
| Intervention | Participants (Count of Participants) |
|---|---|
| Gabapentin | 5 |
| Metoclopramide | 5 |
The CR was defined as no emetic episodes and no nausea episodes from day 1 to day 5 (0-120h) (NCT01052844)
Timeframe: 5 days
| Intervention | participants (Number) |
|---|---|
| Control Group | 17 |
| Gabapentin | 26 |
Complete response during delayed-onset phase was defined as the absence of any episode of nausea or vomiting and no use of rescue medication when occurring during the period from days 2 through 5 after chemotherapy (NCT01052844)
Timeframe: 6 days
| Intervention | participants (Number) |
|---|---|
| Control Group | 21 |
| Gabapentin | 29 |
3 reviews available for gabapentin and Emesis
| Article | Year |
|---|---|
Analgesic Efficacy of Gabapentin and Pregabalin in Patients Undergoing Laparoscopic Bariatric Surgeries: a Systematic Review and Meta-analysis.
Topics: Analgesics; Bariatric Surgery; Gabapentin; Humans; Laparoscopy; Nausea; Obesity, Morbid; Pain, Posto | 2022 |
Gabapentin's anti-nausea and anti-emetic effects: a review.
Topics: Amines; Animals; Antiemetics; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Gabapentin; gam | 2014 |
The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis.
Topics: Amines; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarboxylic Acids; Dizziness; Gabapent | 2016 |
8 trials available for gabapentin and Emesis
| Article | Year |
|---|---|
Gabapentin and intrathecal morphine combination therapy results in decreased oral narcotic use and more consistent pain scores after posterior spinal fusion for adolescent idiopathic scoliosis.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics, Opioid; Gabapentin; Humans; Kyphosis; Morphin | 2021 |
Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial.
Topics: Dilatation; Double-Blind Method; Female; Fentanyl; Gabapentin; Humans; Midazolam; Nausea; Pain; Pain | 2023 |
Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trial.
Topics: Adult; Anti-Anxiety Agents; Dexmedetomidine; Double-Blind Method; Gabapentin; Humans; Iran; Laminect | 2022 |
Comparing the Effect of Gabapentin, Ketamine, Dexmedetomidine, and Entonox on Pain Control in Burn Wound Dressing.
Topics: Adult; Analgesics; Bandages; Blood Pressure; Burns; Debridement; Dexmedetomidine; Female; Gabapentin | 2020 |
Phase III double-blind, placebo-controlled study of gabapentin for the prevention of delayed chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy, NCCTG N08C3 (Alliance).
Topics: Adult; Aged; Amines; Antineoplastic Agents; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug A | 2014 |
Analgesic and sedative effects of perioperative gabapentin in total knee arthroplasty: a randomized, double-blind, placebo-controlled dose-finding study.
Topics: Aged; Aged, 80 and over; Amines; Analgesics; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Cy | 2015 |
Chemotherapy-induced nausea and vomiting: incidence and characteristics of persistent symptoms and future directions NCCTG N08C3 (Alliance).
Topics: Adult; Aged; Amines; Antiemetics; Antineoplastic Agents; Cisplatin; Cyclohexanecarboxylic Acids; Dru | 2016 |
Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study.
Topics: Amines; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclohexanecarboxylic Acids; De | 2012 |
Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study.
Topics: Amines; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclohexanecarboxylic Acids; De | 2012 |
Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study.
Topics: Amines; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclohexanecarboxylic Acids; De | 2012 |
Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study.
Topics: Amines; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclohexanecarboxylic Acids; De | 2012 |
3 other studies available for gabapentin and Emesis
| Article | Year |
|---|---|
Drug use in porphyria: a therapeutic dilemma.
Topics: Abdominal Pain; Adult; Amines; Anticonvulsants; Antiemetics; Antihypertensive Agents; Chest Pain; Cy | 2008 |
Strictly unilateral headache reminiscent of hemicrania continua resistant to indomethacin but responsive to gabapentin.
Topics: Acetates; Adult; Amines; Anti-Inflammatory Agents, Non-Steroidal; Blepharoptosis; Cyclohexanecarboxy | 2002 |
Responsiveness of life-threatening refractory emesis to gabapentin-scopolamine therapy following posterior fossa surgery. Case report.
Topics: Amines; Antiemetics; Cholesteatoma; Cranial Fossa, Posterior; Cyclohexanecarboxylic Acids; Drug Ther | 2005 |