gabapentin has been researched along with Drug Overdose in 40 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
Excerpt | Relevance | Reference |
---|---|---|
"To examine associations between gabapentinoids and adverse outcomes related to coordination disturbances (head or body injuries, or both and road traffic incidents or offences), mental health (suicidal behaviour, unintentional overdoses), and criminality." | 7.91 | Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: population based cohort study in Sweden. ( D'Onofrio, BM; Fazel, S; Larsson, H; Molero, Y; Sharp, DJ, 2019) |
"The goal of this study was to establish and compare baseline data on the prevalence of gabapentin identified through postmortem toxicology testing among drug overdose decedents in several geographically diverse states/jurisdictions with differing levels of drug overdose fatality burdens in 2015." | 7.88 | Prevalence of gabapentin in drug overdose postmortem toxicology testing results. ( Bunn, TL; Christy, D; Kirschke, D; Light, T; Miller, A; Slavova, S; Thompson, G; White, JR; Winecker, R, 2018) |
"Gabapentinoids were involved in 2115 (2." | 5.48 | Intentional Drug Overdose Involving Pregabalin and Gabapentin: Findings from the National Self-Harm Registry Ireland, 2007-2015. ( Arensman, E; Ashcroft, DM; Daly, C; Griffin, E; Perry, IJ; Webb, RT, 2018) |
"gov, and US FDA data, indexed through 28 July 2016, utilizing the following searches: pregabalin OR gabapentin OR gabapentinoid AND one of the following: abuse, misuse, overdose, or substance-related disorders[MESH], was conducted." | 4.95 | Abuse and Misuse of Pregabalin and Gabapentin. ( Evoy, KE; Morrison, MD; Saklad, SR, 2017) |
"Clinically significant side effects of the new anticonvulsants, such as metabolic acidosis from topiramate, autoimmune reactions from lamotrigine, hyponatremia from oxcarbazepine, or psychosis from levitiracetam can cause serious morbidity and mortality if unrecognized." | 4.86 | Emergent complications of the newer anticonvulsants. ( Dang, CV; Nelson, L; Wade, JF; Wasserberger, J, 2010) |
"To examine associations between gabapentinoids and adverse outcomes related to coordination disturbances (head or body injuries, or both and road traffic incidents or offences), mental health (suicidal behaviour, unintentional overdoses), and criminality." | 3.91 | Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: population based cohort study in Sweden. ( D'Onofrio, BM; Fazel, S; Larsson, H; Molero, Y; Sharp, DJ, 2019) |
"The goal of this study was to establish and compare baseline data on the prevalence of gabapentin identified through postmortem toxicology testing among drug overdose decedents in several geographically diverse states/jurisdictions with differing levels of drug overdose fatality burdens in 2015." | 3.88 | Prevalence of gabapentin in drug overdose postmortem toxicology testing results. ( Bunn, TL; Christy, D; Kirschke, D; Light, T; Miller, A; Slavova, S; Thompson, G; White, JR; Winecker, R, 2018) |
" Given its faster onset, increased bioavailability and potency, and nonsaturable absorption, pregabalin's pharmacokinetics theoretically enhance its misuse liability versus gabapentin." | 2.72 | Gabapentinoid Pharmacology in the Context of Emerging Misuse Liability. ( Covvey, JR; Evoy, KE; Peckham, AM; Tidgewell, KJ, 2021) |
"Gabapentin is an anticonvulsant that is being used for an increasing number of off-label indications." | 2.71 | Characterization of gabapentin overdose using a poison center case series. ( Dahl, B; Gorman, S; Klein-Schwartz, W; Shepherd, JG, 2003) |
"Epilepsy affects 1." | 2.41 | New antiepileptic drugs and preparations. ( Jagoda, A; Yoon, Y, 2000) |
"Gabapentin was present in 7." | 1.72 | Characteristics of fatal gabapentinoid-related poisoning in Australia, 2000-2020. ( Darke, S; Duflou, J; Farrell, M; Lappin, J; Peacock, A, 2022) |
"Persons with opioid use disorder (OUD) are at increased risk for gabapentin misuse." | 1.56 | Prescribed and non-prescribed gabapentin use among persons seeking inpatient opioid detoxification. ( Anderson, BJ; Bailey, GL; Conti, MT; Kenney, SR; Stein, MD, 2020) |
"To evaluate the association between perioperative coadministration of gabapentinoids and opioids with inpatient opioid-related adverse events in surgical patients." | 1.56 | Association of Gabapentinoids With the Risk of Opioid-Related Adverse Events in Surgical Patients in the United States. ( Bateman, BT; Bykov, K; Franklin, JM; Patorno, E; Vine, SM, 2020) |
"Gabapentin is a gamma-aminobutyric acid (GABA) analog approved by the Food and Drug Administration (FDA) for partial seizures and post-herpetic neuralgia." | 1.51 | Trending gabapentin exposures in Kentucky after legislation requiring use of the state prescription drug monitoring program for all opioid prescriptions ( Bhandari, B; Bosse, GM; Faryar, KA; Price, TG; Webb, AN, 2019) |
" Pharmacovigilance data from the Food and Drug Administration Adverse Event Reporting System (FAERS) provides a useful examination of adverse drug event (ADE) reporting for safety signal detection." | 1.51 | Reports of gabapentin and pregabalin abuse, misuse, dependence, or overdose: An analysis of the Food And Drug Administration Adverse Events Reporting System (FAERS). ( Covvey, JR; Evoy, KE; Hultgren, KE; Ochs, L; Peckham, AM, 2019) |
"Gabapentinoids were involved in 2115 (2." | 1.48 | Intentional Drug Overdose Involving Pregabalin and Gabapentin: Findings from the National Self-Harm Registry Ireland, 2007-2015. ( Arensman, E; Ashcroft, DM; Daly, C; Griffin, E; Perry, IJ; Webb, RT, 2018) |
" In the dose-response analysis, moderate-dose (OR 2." | 1.46 | Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case-control study. ( Antoniou, T; Gomes, T; Juurlink, DN; Mamdani, MM; Paterson, JM; van den Brink, W, 2017) |
"Gabapentin is an antiepileptic drug that is prescribed for both FDA-approved and multiple off-label conditions, and has a relatively safe side-effect profile." | 1.37 | Suicide by gabapentin overdose. ( Middleton, O, 2011) |
"Quetiapine overdose is associated with coma, QTc prolongation and hypotension." | 1.31 | Massive gabapentin and presumptive quetiapine overdose. ( Cutino, L; Dunaway, MD; Spiller, HA, 2002) |
"Gabapentin is an antiepileptic agent that is indicated for use as adjunctive therapy for partial seizures." | 1.30 | A case of sustained massive gabapentin overdose without serious side effects. ( Radtke, RA; St Clair, EW; Verma, A, 1999) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 5 (12.50) | 18.2507 |
2000's | 5 (12.50) | 29.6817 |
2010's | 17 (42.50) | 24.3611 |
2020's | 13 (32.50) | 2.80 |
Authors | Studies |
---|---|
Bouchard, J | 1 |
Yates, C | 1 |
Calello, DP | 1 |
Gosselin, S | 1 |
Roberts, DM | 1 |
Lavergne, V | 1 |
Hoffman, RS | 1 |
Ostermann, M | 1 |
Peng, A | 1 |
Ghannoum, M | 1 |
Aindow, S | 1 |
Crossin, R | 1 |
Toop, L | 1 |
Hudson, B | 1 |
Mattson, CL | 1 |
Chowdhury, F | 1 |
Gilson, TP | 1 |
Kuehn, BM | 2 |
Laribi, M | 1 |
Chaouali, N | 1 |
Jaballah, S | 1 |
Amira, D | 1 |
Hedhili, A | 1 |
Reinert, JP | 1 |
Dunn, RL | 1 |
Stein, MD | 1 |
Kenney, SR | 1 |
Anderson, BJ | 1 |
Conti, MT | 1 |
Bailey, GL | 1 |
Torrance, N | 1 |
Veluchamy, A | 1 |
Zhou, Y | 1 |
Fletcher, EH | 1 |
Moir, E | 1 |
Hebert, HL | 1 |
Donnan, PT | 1 |
Watson, J | 1 |
Colvin, LA | 1 |
Smith, BH | 1 |
Evoy, KE | 4 |
Sadrameli, S | 1 |
Contreras, J | 1 |
Covvey, JR | 3 |
Peckham, AM | 3 |
Morrison, MD | 2 |
Bykov, K | 1 |
Bateman, BT | 1 |
Franklin, JM | 1 |
Vine, SM | 1 |
Patorno, E | 1 |
Kriikku, P | 1 |
Ojanperä, I | 1 |
Tidgewell, KJ | 1 |
Darke, S | 1 |
Duflou, J | 1 |
Peacock, A | 1 |
Farrell, M | 1 |
Lappin, J | 1 |
Lyndon, A | 1 |
Audrey, S | 1 |
Wells, C | 1 |
Burnell, ES | 1 |
Ingle, S | 1 |
Hill, R | 1 |
Hickman, M | 1 |
Henderson, G | 1 |
Hargrove, SL | 1 |
Bunn, TL | 2 |
Slavova, S | 2 |
Quesinberry, D | 1 |
Corey, T | 1 |
Ralston, W | 1 |
Singleton, MD | 1 |
Ingram, V | 1 |
Gomes, T | 1 |
Juurlink, DN | 1 |
Antoniou, T | 1 |
Mamdani, MM | 1 |
Paterson, JM | 1 |
van den Brink, W | 1 |
Bonnet, U | 1 |
Scherbaum, N | 1 |
Daly, C | 1 |
Griffin, E | 1 |
Ashcroft, DM | 1 |
Webb, RT | 1 |
Perry, IJ | 1 |
Arensman, E | 1 |
Miller, A | 1 |
White, JR | 1 |
Kirschke, D | 1 |
Light, T | 1 |
Christy, D | 1 |
Thompson, G | 1 |
Winecker, R | 1 |
Faryar, KA | 1 |
Webb, AN | 1 |
Bhandari, B | 1 |
Price, TG | 1 |
Bosse, GM | 1 |
Tharp, AM | 1 |
Hobron, K | 1 |
Wright, T | 1 |
Molero, Y | 1 |
Larsson, H | 1 |
D'Onofrio, BM | 1 |
Sharp, DJ | 1 |
Fazel, S | 1 |
Ochs, L | 1 |
Hultgren, KE | 1 |
Schauer, SG | 1 |
Varney, SM | 1 |
Sullivan, RW | 1 |
Ryzewski, M | 1 |
Holland, MG | 1 |
Marraffa, JM | 1 |
Spence, D | 1 |
Saklad, SR | 1 |
Wade, JF | 1 |
Dang, CV | 1 |
Nelson, L | 1 |
Wasserberger, J | 1 |
Middleton, O | 1 |
Spiller, HA | 1 |
Dunaway, MD | 1 |
Cutino, L | 1 |
Klein-Schwartz, W | 1 |
Shepherd, JG | 1 |
Gorman, S | 1 |
Dahl, B | 1 |
Rasimas, JJ | 1 |
Burkhart, KK | 1 |
Fischer, JH | 1 |
Barr, AN | 1 |
Rogers, SL | 1 |
Fischer, PA | 1 |
Trudeau, VL | 1 |
Fernández, MC | 1 |
Walter, FG | 1 |
Petersen, LR | 1 |
Walkotte, SM | 1 |
Stevenson, CM | 1 |
Kim, J | 1 |
Fleisher, D | 1 |
Stopforth, J | 1 |
Verma, A | 1 |
St Clair, EW | 1 |
Radtke, RA | 1 |
Yoon, Y | 1 |
Jagoda, A | 1 |
Jones, H | 1 |
Aguila, E | 1 |
Farber, HW | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Linking Opioid Dependent Patients From Inpatient Detoxification to Primary Care[NCT01751789] | 335 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
Pattern of Acute Antipsychotic Drug- Toxicity in Children at Assiut University Children Hospital[NCT06125275] | 50 participants (Anticipated) | Observational | 2023-10-30 | Not yet recruiting | |||
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
Intervention | Intensity score (Mean) |
---|---|
Topical KeAmLi Combo | 62.7 |
Topical Ketamine | 63.1 |
Topical Amitriptyline | 69.2 |
Topical Lidocaine | 65.8 |
Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
Intervention | mN (Mean) | |
---|---|---|
Mechanical Detection Threshold | Mechanical Pain Threshold | |
Topical Amitriptyline | 3.573423965 | 152.4768146 |
Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
Topical Ketamine | 3.464204768 | 135.9 |
Topical Lidocaine | 3.546037659 | 126.9 |
Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
Intervention | Degrees celsius (Mean) | |
---|---|---|
Warm Detection Threshold | Heat Pain Threshold | |
Topical Amitriptyline | 33.9 | 40.0 |
Topical KeAmLi Combo | 33.6 | 39.8 |
Topical Ketamine | 34.0 | 40.0 |
Topical Lidocaine | 33.7 | 39.4 |
Topical Vehicle | 33.8 | 39.7 |
9 reviews available for gabapentin and Drug Overdose
Article | Year |
---|---|
Extracorporeal Treatment for Gabapentin and Pregabalin Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup.
Topics: Drug Overdose; Frailty; Gabapentin; Humans; Poisoning; Pregabalin; Renal Dialysis | 2022 |
[Drug abuse of pregabalin - state of the situation, risks and means of control].
Topics: Anticonvulsants; Drug Overdose; Gabapentin; Humans; Pregabalin; Substance-Related Disorders | 2023 |
Management of overdoses of loperamide, gabapentin, and modafinil: a literature review.
Topics: Drug Overdose; Emergency Treatment; Gabapentin; Humans; Loperamide; Modafinil; Substance-Related Dis | 2019 |
Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update.
Topics: Animals; Drug Overdose; Gabapentin; Humans; Pregabalin | 2021 |
Gabapentinoid Pharmacology in the Context of Emerging Misuse Liability.
Topics: Area Under Curve; Calcium Channel Blockers; Drug Overdose; Gabapentin; Half-Life; Humans; Metabolic | 2021 |
How addictive are gabapentin and pregabalin? A systematic review.
Topics: Amines; Analgesics; Behavior, Addictive; Cyclohexanecarboxylic Acids; Databases, Bibliographic; Drug | 2017 |
Abuse and Misuse of Pregabalin and Gabapentin.
Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Overdose; Gabapentin; gamma-Aminobutyric Acid; | 2017 |
Emergent complications of the newer anticonvulsants.
Topics: Acidosis; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Overdose; Fructo | 2010 |
New antiepileptic drugs and preparations.
Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; | 2000 |
1 trial available for gabapentin and Drug Overdose
Article | Year |
---|---|
Characterization of gabapentin overdose using a poison center case series.
Topics: Acetates; Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Child; Child, Prescho | 2003 |
30 other studies available for gabapentin and Drug Overdose
Article | Year |
---|---|
Managing the misuse potential and risk of psychological harm from gabapentinoids in primary care in New Zealand.
Topics: Drug Overdose; Gabapentin; Humans; New Zealand; Primary Health Care; Risk Factors | 2021 |
Notes from the Field: Trends in Gabapentin Detection and Involvement in Drug Overdose Deaths - 23 States and the District of Columbia, 2019-2020.
Topics: Analgesics, Opioid; District of Columbia; Drug Overdose; Gabapentin; Humans; United States | 2022 |
Gabapentin Increasingly Implicated in Overdose Deaths.
Topics: Analgesics; Analgesics, Opioid; Drug Overdose; Gabapentin; Humans | 2022 |
Growing Role of Gabapentin in Opioid-Related Overdoses Highlights Misuse Potential and Off-label Prescribing Practices.
Topics: Analgesics, Opioid; Central Nervous System Agents; Drug Overdose; Gabapentin; Humans; Off-Label Use; | 2022 |
Prescribed and non-prescribed gabapentin use among persons seeking inpatient opioid detoxification.
Topics: Analgesics, Opioid; Drug Overdose; Female; Gabapentin; Humans; Inpatients; Male; Opioid-Related Diso | 2020 |
Trends in gabapentinoid prescribing, co-prescribing of opioids and benzodiazepines, and associated deaths in Scotland.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Benzodiazep | 2020 |
Association of Gabapentinoids With the Risk of Opioid-Related Adverse Events in Surgical Patients in the United States.
Topics: Aged; Analgesics, Opioid; Drug Overdose; Drug Therapy, Combination; Female; Gabapentin; Humans; Male | 2020 |
Pregabalin and gabapentin in non-opioid poisoning deaths.
Topics: Accidents; Adult; Aged; Aged, 80 and over; Analgesics; Chromatography, Liquid; Drug Overdose; Female | 2021 |
Characteristics of fatal gabapentinoid-related poisoning in Australia, 2000-2020.
Topics: Analgesics, Opioid; Drug Overdose; Female; Gabapentin; Humans; Male; Middle Aged; Pregabalin; Retros | 2022 |
Risk to heroin users of polydrug use of pregabalin or gabapentin.
Topics: Adult; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Intera | 2017 |
Establishment of a comprehensive drug overdose fatality surveillance system in Kentucky to inform drug overdose prevention policies, interventions and best practices.
Topics: Accident Prevention; Accidents; Adult; Analgesics, Opioid; Benchmarking; Death Certificates; Disable | 2018 |
Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case-control study.
Topics: Adult; Aged; Amines; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studi | 2017 |
Intentional Drug Overdose Involving Pregabalin and Gabapentin: Findings from the National Self-Harm Registry Ireland, 2007-2015.
Topics: Adult; Alcohol Drinking; Amines; Cyclohexanecarboxylic Acids; Drug Overdose; Emergency Service, Hosp | 2018 |
Prevalence of gabapentin in drug overdose postmortem toxicology testing results.
Topics: Adult; Amines; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Drug Overdose; Excitatory Amino Acid | 2018 |
Trending gabapentin exposures in Kentucky after legislation requiring use of the state prescription drug monitoring program for all opioid prescriptions
Topics: Adult; Analgesics, Opioid; Cross-Sectional Studies; Drug Interactions; Drug Overdose; Drug Prescript | 2019 |
Gabapentin-related Deaths: Patterns of Abuse and Postmortem Levels.
Topics: Accidents; Chromatography, Liquid; Driving Under the Influence; Drug Overdose; Female; Gabapentin; H | 2019 |
Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: population based cohort study in Sweden.
Topics: Accidents, Traffic; Adult; Aged; Drug Overdose; Drug Prescriptions; Female; Follow-Up Studies; Gabap | 2019 |
Reports of gabapentin and pregabalin abuse, misuse, dependence, or overdose: An analysis of the Food And Drug Administration Adverse Events Reporting System (FAERS).
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Analgesics; Anticonvulsants; Databases, Factua | 2019 |
Gabapentin overdose in a military beneficiary.
Topics: Amines; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Drug Overdose; Electrocardiography; Female | 2013 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Bad medicine: gabapentin and pregabalin.
Topics: Amines; Analgesics; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Drug Overdose; Female; Gabapen | 2013 |
Suicide by gabapentin overdose.
Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Depressive Disorder, Major; Drug Overdose; Fem | 2011 |
Massive gabapentin and presumptive quetiapine overdose.
Topics: Acetates; Amines; Anti-Anxiety Agents; Antipsychotic Agents; Coma; Cyclohexanecarboxylic Acids; Dibe | 2002 |
Cardiac conduction disturbances after an overdose of nefazodone and gabapentin.
Topics: Adult; Amines; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Cyclohexanecarboxylic | 2006 |
Lack of serious toxicity following gabapentin overdose.
Topics: Acetates; Adolescent; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Overdose; Female; G | 1994 |
Gabapentin, valproic acid, and ethanol intoxication: elevated blood levels with mild clinical effects.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Overd | 1996 |
Colonic absorption of antiepileptic agents.
Topics: Acetates; Amines; Animals; Anticonvulsants; Biological Transport; Chromatography, High Pressure Liqu | 1997 |
Overdose with gabapentin and lamotrigine.
Topics: Acetates; Adolescent; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Overdose; Female; G | 1997 |
A case of sustained massive gabapentin overdose without serious side effects.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cognition; Cyclohexanecarboxylic Acids; Drug Overdose; Epi | 1999 |
Gabapentin toxicity requiring intubation in a patient receiving long-term hemodialysis.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Overdose; Female; Gabapentin; g | 2002 |