gabapentin has been researched along with Disease Models, Animal in 278 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The current study evaluated the pharmacological activity of gabapentin (GBP) and its salicylaldehyde derivative (gabapentsal; [2-(1-(((2-hydroxybenzylidene) amino) methyl) cyclohexyl) acetic acid]; GPS) in well-established mouse models of nociceptive pain, inflammatory edema, and pyrexia at doses of 25-100 mg/kg." | 8.02 | Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia. ( Ahmad, N; Akbar, S; Amin, MU; Islam, NU; Khurram, M; Sewell, RDE; Shahid, M; Subhan, F; Ullah, I; Ullah, N; Ullah, R, 2021) |
| "The current study was undertaken to evaluate the effect of combined therapy of gabapentin and pantoprazole against forestomach and pylorus ligation-induced gastric esophageal reflux disease (GERD) in albino Wistar rats." | 7.96 | Combined therapy of gabapentin with pantoprazole exhibited better protective action against forestomach and pylorus ligation-induced gastric esophageal reflux disease in albino Wistar rats. ( Arya, P; Kaithwas, G, 2020) |
| "This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice." | 7.91 | Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ, 2019) |
| "Cannabidiol and cannabidiol-enriched products have recently attracted much attention as an add-on therapy for epilepsy, especially drug-resistant seizures." | 7.91 | Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies. ( Nieoczym, D; Socała, K; Szafarz, M; Wlaź, P; Wyska, E, 2019) |
| "In a 5-year follow-up study in a hospital in southern China, it was shown that intervertebral foramen (IVF) injection of ozone at the involved segmental levels could significantly alleviate paroxysmal spontaneous pain and mechanical allodynia in patients with chronic, intractable postherpetic neuralgia (PHN) and improve the quality of life." | 7.85 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated CCI-induced static- (days 10-30) and dynamic-allodynia (days 15-30), suppressed cold-allodynia (days 10-30), heat- (days 15-30) and mechano-hyperalgesia (days 5-30) indicating a local action." | 7.85 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Consistent with the effects upon allodynia, both gabapentin and ketorolac produced a preference for the drug-paired compartment in the early phase of the K/BxN model, while gabapentin, but not ketorolac, resulted in a place preference during late phase." | 7.83 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "The results confirm activity in chronic pain models predicted from affinity for the gabapentin site and suggests, at least partially, that α2δ-subunits of presynaptic voltage-gated calcium channels are involved in mediating this effect." | 7.83 | Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain. ( Belozertseva, I; Danysz, W; Franke, L; Nagel, J; Valastro, B, 2016) |
| "These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy." | 7.80 | Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014) |
| " We compared the efficacy of orally administered morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition (TNT) model." | 7.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| " The von Frey filaments, acetone drop, and radiant heat test were performed to assess the degree of mechanical allodynia, thermal allodynia and thermal hyperalgesia respectively, at different time intervals, i." | 7.78 | Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. ( Amin, B; Hosseinzadeh, H, 2012) |
| "The aim of the present study was to investigate the possible antinociceptive effects of systemic administration of tramadol and gabapentin either alone or in combination on acute pain models in mice." | 7.78 | The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain. ( Alaçam, B; Aydin, ON; Ek, RO; Şen, S; Temoçin, S; Uğur, B, 2012) |
| " The anticonvulsant gabapentin, which is widely used as an analgesic agent, also reduces anxiety." | 7.77 | The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity. ( Coelho, AM; Cryan, JF; Dinan, TG; Fitzgerald, P; Lee, K; O' Mahony, SM; Winchester, W, 2011) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 7.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| "Gabapentin, an anticonvulsant, is widely accepted as an alternative therapeutic agent for neuropathic pain and has proved to produce analgesic effects in a mouse model of visceral pain." | 7.76 | Analgesic effects of gabapentin on mechanical hypersensitivity in a rat model of chronic pancreatitis. ( Chen, H; Liao, XZ; Mao, YF; Sun, JH; Xiong, YC; Xu, H; Zhou, MT, 2010) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 7.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "These data demonstrated the comparable efficacy of gabapentin with morphine in visceral pain." | 7.74 | Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. ( Meymandi, MS; Sepehri, G, 2008) |
| "The anticonvulsant gabapentin (GBP) has been shown effective for the treatment of neuropathic pain, although its mechanism of action remains unclear." | 7.73 | Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action. ( Aiyar, J; Anker, N; Belley, M; Bristow, L; Campbell, B; Cohen, C; Park, KT; Ren, K; Stearns, B; Urban, MO, 2005) |
| "Not all neuropathic pain patients gain relief from current therapies that include the anticonvulsant, gabapentin, thought to modulate calcium channel function." | 7.73 | Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. ( Dickenson, AH; Hunt, SP; Rahman, W; Rygh, LJ; Suzuki, R; Webber, M, 2005) |
| " In this study the co-administration of gabapentin with morphine is evaluated in acute model of pain." | 7.73 | Gabapentin enhances the analgesic response to morphine in acute model of pain in male rats. ( Meymandi, MS; Mobasher, M; Sepehri, G, 2006) |
| "The effects of the gamma-aminobutyric acid (GABA)-potentiating drug gabapentin (1-(aminomethyl) cyclohexaneacetic acid) on severity of dystonia were examined in a hamster model of idiopathic paroxysmal dystonic choreoathetosis." | 7.70 | Gabapentin decreases the severity of dystonia at low doses in a genetic animal model of paroxysmal dystonic choreoathetosis. ( Löscher, W; Richter, A, 1999) |
| "Gabapentin is a recently introduced antiepileptic drug for the treatment of partial seizures." | 6.40 | Gabapentin for treatment of epilepsy in children. ( Holmes, GL, 1997) |
| "Gabapentin is a commonly prescribed antiepileptic agent for seizures, which is also used for pain and addiction management." | 5.91 | Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition. ( Ali, G; Alkahramaan, YMSA; Arif, M; Gohar, A; Khan, MS; Rashid, U; Rauf, K; Sewell, RDE, 2023) |
| "Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population." | 5.46 | sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017) |
| "Cathepsin S inhibitors attenuate mechanical allodynia in preclinical neuropathic pain models." | 5.43 | Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. ( Classon, B; Edenius, C; Grabowska, U; Henderson, I; Hewitt, E; Lindström, E; Malcangio, M; Pitcher, T; Rizoska, B; Sahlberg, BL; Tunblad, K, 2016) |
| "Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset." | 5.42 | A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. ( Abbas, M; Ali, G; Sewell, RD; Shahid, M; Subhan, F; Zeb, J, 2015) |
| "Gabapentin was used to provide an anxiolytic effect on drug-free days." | 5.38 | Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats. ( Açikmeşe, B; Enginar, N; Hatipoğlu, I; Haznedar, S, 2012) |
| " As a corollary, they also show that long-term use of ETH and GAB is devoid of adverse behavioral and cognitive effects." | 5.38 | Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome. ( Corrales, A; Flórez, J; García, S; Martínez, P; Martínez-Cué, C; Rueda, N; Sharma, A; Vidal, V, 2012) |
| "Behavioural assessments of tail muscle spasticity and mean arterial blood pressure responses to noxious somatic and/or visceral stimulation were used to test the effects of GBP on these abnormal reflexes." | 5.37 | Gabapentin for spasticity and autonomic dysreflexia after severe spinal cord injury. ( Duale, H; Kitzman, PH; Lyttle, TS; O'Dell, CR; Patel, SP; Rabchevsky, AG, 2011) |
| "6 h, oral bioavailability of 37% and 90%) with anti-inflammatory activity (ED 50 = 37 micromol/kg, mouse) and efficacy in pain models (thermal hyperalgesia, ED 50 = 72 micromol/kg, rat)." | 5.35 | Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. ( Adair, RM; Altenbach, RJ; Bettencourt, BM; Brioni, JD; Cowart, MD; Drizin, I; Esbenshade, TA; Fix-Stenzel, SR; Honore, P; Hsieh, GC; Liu, H; Marsh, KC; McPherson, MJ; Milicic, I; Miller, TR; Sullivan, JP; Wetter, JM; Wishart, N; Witte, DG, 2008) |
| "In both neuropathic pain models, rats exhibited mechanical hypersensitivity, whereas a significant increase in anxiety-like behaviour was observed only in CCI rats (time spent in open arms decreased significantly from 99+/-15." | 5.35 | Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. ( Arndt, K; Ceci, A; Doods, H; Roeska, K; Treede, RD, 2008) |
| "No causal treatment of ataxias is available at the moment, and so symptomatic and disease-modifying therapies are regarded as a reliable possibility for this complex group of movement disorders." | 5.35 | Gabapentin treatment improves motor coordination in a mice model of progressive ataxia. ( Calzà, L; D'Intino, G; Ferraro, L; Giardino, L; Gusciglio, M; Massella, A; Sivilia, S, 2009) |
| "Acute seizure activity was behaviorally scored and hemispheric brain atrophy measured." | 5.35 | Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. ( Comi, AM; Johnston, MV; Kadam, SD; Mulholland, JD; Traa, BS, 2008) |
| "The degree of allodynia was most marked following 10 min of irradiation." | 5.32 | Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003) |
| " This dosage produced a substantial but non-significant decrease in the incidence of postherpetic pain-related responses." | 5.32 | Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. ( Kuraishi, Y; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2004) |
| "This study aims to evaluate the anti-nociceptive effects of ECa 233 and its synergistic effect with gabapentin on chronic neuropathic orofacial pain after 3 weeks infraorbital nerve chronic constriction injury in mice." | 4.12 | Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice. ( Buapratoom, A; Khongsombat, O; Tantisira, MH; Wanasuntronwong, A, 2022) |
| "The current study was conducted to evaluate the cardioprotective effect of gabapentin (Gaba), a Ca + 2 channel blocker with emerging pharmacological merits, against DOX-induced cardiotoxicity." | 4.02 | Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling. ( Amin, MN; Said, E; Samra, YA, 2021) |
| " The current study evaluated the pharmacological activity of gabapentin (GBP) and its salicylaldehyde derivative (gabapentsal; [2-(1-(((2-hydroxybenzylidene) amino) methyl) cyclohexyl) acetic acid]; GPS) in well-established mouse models of nociceptive pain, inflammatory edema, and pyrexia at doses of 25-100 mg/kg." | 4.02 | Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia. ( Ahmad, N; Akbar, S; Amin, MU; Islam, NU; Khurram, M; Sewell, RDE; Shahid, M; Subhan, F; Ullah, I; Ullah, N; Ullah, R, 2021) |
| "The current study was undertaken to evaluate the effect of combined therapy of gabapentin and pantoprazole against forestomach and pylorus ligation-induced gastric esophageal reflux disease (GERD) in albino Wistar rats." | 3.96 | Combined therapy of gabapentin with pantoprazole exhibited better protective action against forestomach and pylorus ligation-induced gastric esophageal reflux disease in albino Wistar rats. ( Arya, P; Kaithwas, G, 2020) |
| "This study investigated the effect of gabapentin on lower urinary tract dysfunction focusing on urethral activities and cystitis-induced hyperalgesia in a mouse model of painful bladder syndrome/interstitial cystitis (PBS/IC)." | 3.91 | Investigations of urethral sphincter activity in mice with bladder hyperalgesia before and after drug administration of gabapentin. ( Chang, HH; Chen, JJ; Choi, H; Do, R; Ghoniem, G; Lin, CT; Yeh, JC; Zi, X, 2019) |
| "This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice." | 3.91 | Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ, 2019) |
| "Cannabidiol and cannabidiol-enriched products have recently attracted much attention as an add-on therapy for epilepsy, especially drug-resistant seizures." | 3.91 | Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies. ( Nieoczym, D; Socała, K; Szafarz, M; Wlaź, P; Wyska, E, 2019) |
| " Mechanical allodynia and thermal hyperalgesia were measured to confirm neuropathic pain induction following before and after gabapentin (GBP) treatment." | 3.88 | Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2018) |
| "In a 5-year follow-up study in a hospital in southern China, it was shown that intervertebral foramen (IVF) injection of ozone at the involved segmental levels could significantly alleviate paroxysmal spontaneous pain and mechanical allodynia in patients with chronic, intractable postherpetic neuralgia (PHN) and improve the quality of life." | 3.85 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "The combination of low-dose KML29:gabapentin additively attenuated mechanical allodynia and synergistically reduced cold allodynia." | 3.85 | The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice. ( Banks, ML; Bradshaw, HB; Crowe, MS; Kinsey, SG; Leishman, E; Prather, PL; Wilson, CD, 2017) |
| "Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated CCI-induced static- (days 10-30) and dynamic-allodynia (days 15-30), suppressed cold-allodynia (days 10-30), heat- (days 15-30) and mechano-hyperalgesia (days 5-30) indicating a local action." | 3.85 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| " Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIoN-CCI rats." | 3.85 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "Consistent with the effects upon allodynia, both gabapentin and ketorolac produced a preference for the drug-paired compartment in the early phase of the K/BxN model, while gabapentin, but not ketorolac, resulted in a place preference during late phase." | 3.83 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "Based on clinical studies regarding the beneficial effect of gabapentin in depression, we aimed to evaluate the antidepressant-like properties of gabapentin in mice and also the participation of nitric oxide (NO)/cyclic guanosine monophosphate pathway in this effect." | 3.83 | Involvement of NO/cGMP pathway in the antidepressant-like effect of gabapentin in mouse forced swimming test. ( Akhlaghipour, G; Ameli, S; Dehpour, A; Haj-Mirzaian, A; Kordjazy, N; Ostadhadi, S, 2016) |
| "The results confirm activity in chronic pain models predicted from affinity for the gabapentin site and suggests, at least partially, that α2δ-subunits of presynaptic voltage-gated calcium channels are involved in mediating this effect." | 3.83 | Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain. ( Belozertseva, I; Danysz, W; Franke, L; Nagel, J; Valastro, B, 2016) |
| ") gabapentin (GBP), carbamazepine (CBZ) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on learning and memory, anxiety, and locomotor activity in rats with lithium-pilocarpine-induced status epilepticus (SE)." | 3.83 | Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats. ( Gulec Suyen, G; Isbil-Buyukcoskun, N; Kahveci, N; Ozluk, K; Sengun, E, 2016) |
| " Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)." | 3.83 | Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016) |
| " In particular, 14 and 15 were found to be more potent than morphine for both acute and inflammatory pain models and 100-fold more potent than gabapentin in a diabetic neuropathic pain model." | 3.81 | Antinociceptive Grayanoids from the Roots of Rhododendron molle. ( Li, Y; Liu, Y; Liu, YB; Lv, HN; Ma, SG; Qu, J; Yu, SS; Zhang, JJ, 2015) |
| " Sleep disruption-induced hypersensitivity was pharmacologically characterized with drugs relevant for pain treatment, including gabapentin (30 mg/kg and 50 mg/kg), Ica-6p (Kv7." | 3.81 | Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat. ( Gilmour, G; Kennedy, JD; Schuh-Hofer, S; Treede, RD; Wafford, KA; Wodarski, R; Yurek, DA, 2015) |
| " Two distinct FAAH inhibitory compounds, URB597 and PF-3845 were tested, and contrasted with standard antinociceptive gabapentin or vehicle treatment, for attenuation of tactile allodynia, cold allodynia, and mechanical hyperalgesia." | 3.81 | Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy. ( Jergova, S; Nasirinezhad, F; Pearson, JP; Sagen, J, 2015) |
| "Mechanical allodynia in SNL rats was attenuated by gabapentin (100 mg/kg) and AQU-118 (in a dose-dependent manner)." | 3.81 | Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain. ( Davis, SF; Fairchild, DD; Hain, HS; Hanania, T; Henry, MA; Hu, A; Malekiani, SA; Nix, D; Patil, MJ; Sucholeiki, I; Sucholeiki, R, 2015) |
| "Synthetic approaches to gabapentin bioconjugates that overcome the tendency of gabapentin to cyclize into its γ-lactam are studied." | 3.80 | Gabapentin hybrid peptides and bioconjugates. ( Alamry, KA; Goncalves, K; Ibrahim, MA; Katritzky, AR; Lebedyeva, IO; Neubert, J; Ostrov, DA; Patel, K; Sileno, SM; Steel, PJ, 2014) |
| "These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy." | 3.80 | Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014) |
| " Our data have demonstrated that pentylenetetrazole (PTZ)-induced seizures did not alter ATP, ADP, and AMP hydrolysis in brain membrane fractions." | 3.79 | Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish. ( Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM, 2013) |
| "Lysophosphatidic acid (LPA), an initiator of neuropathic pain, causes allodynia." | 3.78 | Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs. ( Kato, A; Ogawa, K; Shinohara, S; Takasu, K; Yoneda, Y, 2012) |
| " We compared the efficacy of orally administered morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition (TNT) model." | 3.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| " The von Frey filaments, acetone drop, and radiant heat test were performed to assess the degree of mechanical allodynia, thermal allodynia and thermal hyperalgesia respectively, at different time intervals, i." | 3.78 | Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. ( Amin, B; Hosseinzadeh, H, 2012) |
| " A recent study from our laboratory revealed that gabapentin, a recommended first-line treatment for multiple neuropathic conditions, could also efficiently antagonize thermal hyperalgesia evoked by complete Freund's adjuvant (CFA)-induced monoarthritis (MA)." | 3.78 | Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats. ( Deng, XM; Li, SS; Xu, B; Xu, H; Yang, JL; Zhang, WS; Zhang, YQ, 2012) |
| "The aim of the present study was to investigate the possible antinociceptive effects of systemic administration of tramadol and gabapentin either alone or in combination on acute pain models in mice." | 3.78 | The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain. ( Alaçam, B; Aydin, ON; Ek, RO; Şen, S; Temoçin, S; Uğur, B, 2012) |
| "We showed a preventative effect of intrathecal gabapentin on the development of nerve injury-induced mechanical allodynia and thermal hyperalgesia." | 3.77 | Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. ( Chen, CC; Cheng, JK; Chu, LC; Hung, YC; Lin, CS; Tsaur, ML; Wang, TY, 2011) |
| " The anticonvulsant gabapentin, which is widely used as an analgesic agent, also reduces anxiety." | 3.77 | The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity. ( Coelho, AM; Cryan, JF; Dinan, TG; Fitzgerald, P; Lee, K; O' Mahony, SM; Winchester, W, 2011) |
| "The present study was performed to investigate whether or not carvedilol (a beta-adrenoreceptor antagonist) potentiates the anticonvulsive activity of gabapentin against ICES (Increasing current electroshock) and PTZ (Pentylenetetrazole) induced seizures in mice." | 3.77 | Influence of carvedilol on anticonvulsant effect of gabapentin. ( Goel, A; Goel, R; Kumar, Y, 2011) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 3.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| "Gabapentin, an anticonvulsant, is widely accepted as an alternative therapeutic agent for neuropathic pain and has proved to produce analgesic effects in a mouse model of visceral pain." | 3.76 | Analgesic effects of gabapentin on mechanical hypersensitivity in a rat model of chronic pancreatitis. ( Chen, H; Liao, XZ; Mao, YF; Sun, JH; Xiong, YC; Xu, H; Zhou, MT, 2010) |
| "To characterize the interactions between levetiracetam and the antiepileptic drugs gabapentin, tiagabine, and vigabatrin in suppressing pentylenetetrazole-induced clonic seizures in mice, type II isobolographic analysis was used." | 3.75 | Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M, 2009) |
| "Our data suggest that activation of spinal or dorsal root ganglion HCN channels or both is not involved in formalin-induced pain, and intrathecal gabapentin does not act as an HCN channel activator to achieve its antinociceptive effect in the formalin test." | 3.75 | Intrathecal gabapentin does not act as a hyperpolarization-activated cyclic nucleotide-gated channel activator in the rat formalin test. ( Chen, CC; Cheng, JK; Huang, YJ; Lin, CF; Lin, CS; Tsaur, ML, 2009) |
| " Isobolographic analysis was used in two mouse experimental models of epilepsy: the maximal electroshock seizure threshold test and pentylenetetrazole-induced seizures." | 3.74 | Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2008) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 3.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "We investigated efficacy of prolonged intraventricular gabapentin (GBP) infusion in the rat flurothyl epilepsy model." | 3.74 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| "These data demonstrated the comparable efficacy of gabapentin with morphine in visceral pain." | 3.74 | Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. ( Meymandi, MS; Sepehri, G, 2008) |
| " The three models were benchmarked using compounds known to be active in neuropathic pain patients and nerve injury animal models, including gabapentin, amitriptyline and clonidine." | 3.74 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| "Gabapentin (GBP; 1-(aminomethyl)cyclohexane acetic acid) is used clinically in the treatment of pain." | 3.74 | Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study. ( Chapman, V; Governo, RJ; Marsden, CA; Morris, PG, 2008) |
| "There is evidence supporting the antinociceptive effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in various models of neuropathic pain as well as inflammatory somatic pain." | 3.74 | The antinociceptive effects of anticonvulsants in a mouse visceral pain model. ( Boskovic, B; Milovanovic, S; Paranos, S; Prostran, MS; Stepanovic-Petrovic, RM; Tomic, MA; Ugresic, ND; Vuckovic, SM, 2008) |
| "To examine the in vivo effects of PD-0200347, an alpha(2)delta ligand of voltage-activated Ca(2+) channels and a compound chemically related to pregabalin and gabapentin, on the development of cartilage structural changes in an experimental dog model of osteoarthritis (OA)." | 3.73 | Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes. ( Boileau, C; Boily, M; Brunet, J; El-Kattan, A; Flory, C; Martel-Pelletier, J; Pelletier, JP; Schrier, D; Tardif, G, 2005) |
| "The anticonvulsant gabapentin (GBP) has been shown effective for the treatment of neuropathic pain, although its mechanism of action remains unclear." | 3.73 | Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action. ( Aiyar, J; Anker, N; Belley, M; Bristow, L; Campbell, B; Cohen, C; Park, KT; Ren, K; Stearns, B; Urban, MO, 2005) |
| "The 5-HT re-uptake inhibitor fluoxetine (3-30 mg/kg), the NA re-uptake inhibitor reboxetine (3-30 mg/kg), the dual 5-HT and NA re-uptake inhibitor venlafaxine (3-100 mg/kg) and the dual DA and NA re-uptake inhibitor bupropion (3-30 mg/kg) were tested after intraperitoneal administration in rat models of acute, persistent and neuropathic pain." | 3.73 | Anti-nociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain. ( Blackburn-Munro, G; Nielsen, AN; Pedersen, LH, 2005) |
| " Anticonvulsant and acute neurotoxic adverse effect profiles of combinations of GBP and TGB with other AEDs at fixed ratios of 1:3, 1:1 and 3:1 were investigated in pentylenetetrazole (PTZ)-induced seizures and the chimney test (as a measure of motor impairment) in mice so as to identify optimal combinations." | 3.73 | Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. ( Czuczwar, SJ; Luszczki, JJ, 2005) |
| "Not all neuropathic pain patients gain relief from current therapies that include the anticonvulsant, gabapentin, thought to modulate calcium channel function." | 3.73 | Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. ( Dickenson, AH; Hunt, SP; Rahman, W; Rygh, LJ; Suzuki, R; Webber, M, 2005) |
| " The effects of diacerhein were compared with those of gabapentin, a drug used clinically for the management of neuropathic pain." | 3.73 | The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice. ( Calixto, JB; Campos, MM; Medeiros, R; Quintão, NLM; Santos, ARS, 2005) |
| " In this study the co-administration of gabapentin with morphine is evaluated in acute model of pain." | 3.73 | Gabapentin enhances the analgesic response to morphine in acute model of pain in male rats. ( Meymandi, MS; Mobasher, M; Sepehri, G, 2006) |
| "A series of mutual prodrugs derived from gabapentin, pregabalin, memantine, venlafaxine were synthesized and their pharmacological properties to treat neuropathic pain were investigated in a rat model of chronic sciatic nerve constriction injury (CCI)." | 3.72 | Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury. ( Bo-Hua, Z; He, L; Hong-Ju, Y; Jun-Wei, W; Nan, Z; Wei-Guo, S; Wei-Xiu, Y; Zhe-Hui, G; Zheng-Hua, G; Zhi-Pu, L; Zhong-Wei, J, 2004) |
| "To clarify molecular substrates involved in the development of radicular pain, and to investigate the responsiveness of radicular pain to gabapentin." | 3.71 | Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain. ( Abe, M; Han, W; Kurihara, T; Shinomiya, K; Tanabe, T, 2002) |
| "The effects of the gamma-aminobutyric acid (GABA)-potentiating drug gabapentin (1-(aminomethyl) cyclohexaneacetic acid) on severity of dystonia were examined in a hamster model of idiopathic paroxysmal dystonic choreoathetosis." | 3.70 | Gabapentin decreases the severity of dystonia at low doses in a genetic animal model of paroxysmal dystonic choreoathetosis. ( Löscher, W; Richter, A, 1999) |
| "The novel anti-epileptic drugs lamotrigine, felbamate and gabapentin were compared in rat experimental models of acute (tail flick) and chronic pain: the chronic constriction injury and spinal nerve ligation models." | 3.69 | The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. ( Fontana, DJ; Gogas, KR; Hedley, LR; Hunter, JC; Jacobson, LO; Kassotakis, L; Thompson, J, 1997) |
| "Gabapentin was administered orally and intracerebroventricularly to rats on the day after paw incision, and withdrawal threshold to paw pressure was measured." | 2.73 | Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. ( Curry, R; DeGoes, S; Eisenach, JC; Hayashida, K, 2007) |
| "Mycophenolic acid was detected in all cats." | 2.61 | ( Abrams, G; Adolfsson, E; Agarwal, PK; Akkan, AG; Al Alhareth, NS; Alves, VGL; Armentano, R; Bahroos, E; Baig, M; Baldridge, KK; Barman, S; Bartolucci, C; Basit, A; Bertoli, SV; Bian, L; Bigatti, G; Bobenko, AI; Boix, PP; Bokulic, T; Bolink, HJ; Borowiec, J; Bulski, W; Burciaga, J; Butt, NS; Cai, AL; Campos, AM; Cao, G; Cao, Y; Čapo, I; Caruso, ML; Chao, CT; Cheatum, CM; Chelminski, K; Chen, AJW; Chen, C; Chen, CH; Chen, D; Chen, G; Chen, H; Chen, LH; Chen, R; Chen, RX; Chen, X; Cherdtrakulkiat, R; Chirvony, VS; Cho, JG; Chu, K; Ciurlino, D; Coletta, S; Contaldo, G; Crispi, F; Cui, JF; D'Esposito, M; de Biase, S; Demir, B; Deng, W; Deng, Z; Di Pinto, F; Domenech-Ximenos, B; Dong, G; Drácz, L; Du, XJ; Duan, LJ; Duan, Y; Ekendahl, D; Fan, W; Fang, L; Feng, C; Followill, DS; Foreman, SC; Fortunato, G; Frew, R; Fu, M; Gaál, V; Ganzevoort, W; Gao, DM; Gao, X; Gao, ZW; Garcia-Alvarez, A; Garza, MS; Gauthier, L; Gazzaz, ZJ; Ge, RS; Geng, Y; Genovesi, S; Geoffroy, V; Georg, D; Gigli, GL; Gong, J; Gong, Q; Groeneveld, J; Guerra, V; Guo, Q; Guo, X; Güttinger, R; Guyo, U; Haldar, J; Han, DS; Han, S; Hao, W; Hayman, A; He, D; Heidari, A; Heller, S; Ho, CT; Ho, SL; Hong, SN; Hou, YJ; Hu, D; Hu, X; Hu, ZY; Huang, JW; Huang, KC; Huang, Q; Huang, T; Hwang, JK; Izewska, J; Jablonski, CL; Jameel, T; Jeong, HK; Ji, J; Jia, Z; Jiang, W; Jiang, Y; Kalumpha, M; Kang, JH; Kazantsev, P; Kazemier, BM; Kebede, B; Khan, SA; Kiss, J; Kohen, A; Kolbenheyer, E; Konai, MM; Koniarova, I; Kornblith, E; Krawetz, RJ; Kreouzis, T; Kry, SF; Laepple, T; Lalošević, D; Lan, Y; Lawung, R; Lechner, W; Lee, KH; Lee, YH; Leonard, C; Li, C; Li, CF; Li, CM; Li, F; Li, J; Li, L; Li, S; Li, X; Li, Y; Li, YB; Li, Z; Liang, C; Lin, J; Lin, XH; Ling, M; Link, TM; Liu, HH; Liu, J; Liu, M; Liu, W; Liu, YP; Lou, H; Lu, G; Lu, M; Lun, SM; Ma, Z; Mackensen, A; Majumdar, S; Martineau, C; Martínez-Pastor, JP; McQuaid, JR; Mehrabian, H; Meng, Y; Miao, T; Miljković, D; Mo, J; Mohamed, HSH; Mohtadi, M; Mol, BWJ; Moosavi, L; Mosdósi, B; Nabu, S; Nava, E; Ni, L; Novakovic-Agopian, T; Nyamunda, BC; Nyul, Z; Önal, B; Özen, D; Özyazgan, S; Pajkrt, E; Palazon, F; Park, HW; Patai, Á; Patai, ÁV; Patzke, GR; Payette, G; Pedoia, V; Peelen, MJCS; Pellitteri, G; Peng, J; Perea, RJ; Pérez-Del-Rey, D; Popović, DJ; Popović, JK; Popović, KJ; Posecion, L; Povall, J; Prachayasittikul, S; Prachayasittikul, V; Prat-González, S; Qi, B; Qu, B; Rakshit, S; Ravelli, ACJ; Ren, ZG; Rivera, SM; Salo, P; Samaddar, S; Samper, JLA; Samy El Gendy, NM; Schmitt, N; Sekerbayev, KS; Sepúlveda-Martínez, Á; Sessolo, M; Severi, S; Sha, Y; Shen, FF; Shen, X; Shen, Y; Singh, P; Sinthupoom, N; Siri, S; Sitges, M; Slovak, JE; Solymosi, N; Song, H; Song, J; Song, M; Spingler, B; Stewart, I; Su, BL; Su, JF; Suming, L; Sun, JX; Tantimavanich, S; Tashkandi, JM; Taurbayev, TI; Tedgren, AC; Tenhunen, M; Thwaites, DI; Tibrewala, R; Tomsejm, M; Triana, CA; Vakira, FM; Valdez, M; Valente, M; Valentini, AM; Van de Winckel, A; van der Lee, R; Varga, F; Varga, M; Villarino, NF; Villemur, R; Vinatha, SP; Vincenti, A; Voskamp, BJ; Wang, B; Wang, C; Wang, H; Wang, HT; Wang, J; Wang, M; Wang, N; Wang, NC; Wang, Q; Wang, S; Wang, X; Wang, Y; Wang, Z; Wen, N; Wesolowska, P; Willis, M; Wu, C; Wu, D; Wu, L; Wu, X; Wu, Z; Xia, JM; Xia, X; Xia, Y; Xiao, J; Xiao, Y; Xie, CL; Xie, LM; Xie, S; Xing, Z; Xu, C; Xu, J; Yan, D; Yan, K; Yang, S; Yang, X; Yang, XW; Ye, M; Yin, Z; Yoon, N; Yoon, Y; Yu, H; Yu, K; Yu, ZY; Zhang, B; Zhang, GY; Zhang, H; Zhang, J; Zhang, M; Zhang, Q; Zhang, S; Zhang, W; Zhang, X; Zhang, Y; Zhang, YW; Zhang, Z; Zhao, D; Zhao, F; Zhao, P; Zhao, W; Zhao, Z; Zheng, C; Zhi, D; Zhou, C; Zhou, FY; Zhu, D; Zhu, J; Zhu, Q; Zinyama, NP; Zou, M; Zou, Z, 2019) |
| "The analgesic effect in neuropathic pain is well evidenced but the role in postoperative pain is less certain." | 2.58 | Analgesic mechanisms of gabapentinoids and effects in experimental pain models: a narrative review. ( Chincholkar, M, 2018) |
| " Rodent models of CIPN have been developed using a range of dosing regimens to reproduce pain-like behaviours akin to patient-reported symptoms." | 2.53 | Chemotherapy-induced painful neuropathy: pain-like behaviours in rodent models and their response to commonly used analgesics. ( Duggett, NA; Flatters, SJL; Hopkins, HL, 2016) |
| "Once established, postherpetic neuralgia is particularly difficult to treat, and is often resistant to conventional analgesics." | 2.47 | [Development of animal models of herpetic pain and postherpetic neuralgia and elucidation of the mechanisms of the onset and inhibition of allodynia]. ( Takasaki, I, 2011) |
| "Gabapentin was originally designed as an anti-convulsant gamma-aminobutyric acid (GABA) mimetic capable of crossing the blood-brain barrier." | 2.42 | Cellular and molecular action of the putative GABA-mimetic, gabapentin. ( Chung, FZ; Gonzalez, MI; Lee, K; Maneuf, YP; Pinnock, RD; Sutton, KS, 2003) |
| "Gabapentin is a recently introduced antiepileptic drug for the treatment of partial seizures." | 2.40 | Gabapentin for treatment of epilepsy in children. ( Holmes, GL, 1997) |
| "Gabapentin is a commonly prescribed antiepileptic agent for seizures, which is also used for pain and addiction management." | 1.91 | Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition. ( Ali, G; Alkahramaan, YMSA; Arif, M; Gohar, A; Khan, MS; Rashid, U; Rauf, K; Sewell, RDE, 2023) |
| "Neuropathic pain was induced by spared nerve injury (SNI) of the sciatic nerve." | 1.72 | Heme oxygenase-1 in the spinal cord plays crucial roles in the analgesic effects of pregabalin and gabapentin in a spared nerve-injury mouse model. ( Godai, K; Moriyama, T, 2022) |
| "Treatment with gabapentin led to recovered behaviour and DH neuronal activity pattern in CFA-treated animals." | 1.62 | Dorsal horn disinhibition and movement-induced behaviour in a rat model of inflammatory arthritis. ( Locke, S; Ribeiro-da-Silva, A; Yousefpour, N, 2021) |
| "In behavioral studies, mechanical allodynia was induced by intraplantar injection of cisplatin (40 μg/paw) in Sprague Dawley rats, and behavioral assessments were made 24 h after injection." | 1.62 | Involvement of selective GABA-A receptor subtypes in amelioration of cisplatin-induced neuropathic pain by 2'-chloro-6-methyl flavone (2'-Cl-6MF). ( Abdelhalim, A; Ahmad, W; Al-Harrasi, A; Altaf, N; Ghaffar, R; Halim, SA; Karim, N; Khan, A; Khan, I, 2021) |
| "Neuropathic pain is a chronic debilitating condition caused by injury or disease of the nerves of the somatosensory system." | 1.62 | Synergistic interaction between trazodone and gabapentin in rodent models of neuropathic pain. ( Amato, A; Di Giorgio, FP; di Matteo, A; Durando, L; Garrone, B; Milanese, C; Pistillo, L; Tongiani, S, 2021) |
| "Gabapentin (GBP) is an established drug that has been used in the management of symptoms of neuropathy but it is associated with unwanted side effects such as sedation and motor incoordination." | 1.62 | A novel gabapentin analogue assuages neuropathic pain response in chronic sciatic nerve constriction model in rats. ( Ahmad, N; Akbar, S; Amin, MU; Islam, NU; Khurram, M; Sewell, RDE; Shahid, M; Subhan, F; Ullah, I; Ullah, N; Ullah, R, 2021) |
| "Furthermore, the induced vulvodynia was validated by investigating the potentiation of a flinch response threshold, upon topical application and systemic administration of gabapentin, a commonly used medication for treating neuropathic pain." | 1.62 | Chemotherapeutic Agent-Induced Vulvodynia, an Experimental Model. ( Jo, S; Murthy, SN; Rangappa, S; Repka, MA; Shankar, VK, 2021) |
| "Gabapentin has antihyperalgesic action, decreasing central sensitization in neuropathic pain models; this effect depends on the mobilization of endogenous pain control pathways." | 1.56 | Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation. ( Buffon, AC; Heymanns, AC; Horewicz, VV; Javornik, MA; Martins, DF; Piovezan, AP; Salm, DC, 2020) |
| "Tramadol was 1." | 1.51 | Interleukin-1beta in synergism gabapentin with tramadol in murine model of diabetic neuropathy. ( Miranda, HF; Noriega, V; Poblete, P; Prieto, JC; Sierralta, F; Zepeda, RJ, 2019) |
| "Chronic pain is the most common non-motor symptom among Parkinson's disease (PD) patients, with 1." | 1.51 | Effects of subthalamic deep brain stimulation with gabapentin and morphine on mechanical and thermal thresholds in 6-hydroxydopamine lesioned rats. ( Feustel, P; Kaszuba, BC; Maietta, T; Pilitsis, JG; Shin, DS; Slyer, J; Stapleton, A; Walling, I, 2019) |
| "Sinomenine can enhance the efficacy of gabapentin or ligustrazine hydrochloride in rodent models of peripheral or central neuropathic pain, without introducing tolerance or other notable side effects." | 1.51 | Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain. ( Gao, T; Jiang, JD; Li, T; Shi, T; Wiesenfeld-Hallin, Z; Xu, XJ, 2019) |
| "Static and dynamic mechanical allodynia was evaluated using von Frey hair filaments and cotton buds, respectively." | 1.51 | Attenuation of vincristine-induced neuropathy by synthetic cyclohexenone-functionalized derivative in mice model. ( Ali, G; Khan, J; Khan, R; Ullah, R; Ullah, S, 2019) |
| "Neuropathic pain is among the most common and difficult-to-treat types of chronic pain and is associated with sodium channel malfunction." | 1.48 | Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. ( Liang, X; Su, R; Yu, G, 2018) |
| "Left sciatic nerve ligation was used as neuropathic pain model." | 1.48 | Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats. ( Abdelwahab, S; Abdelzaher, WY; Ibrahim, MA; Rofaeil, RR, 2018) |
| "Von Frey filaments were used to assess tactile allodynia." | 1.48 | Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain. ( Barragán-Iglesias, P; Delgado-Lezama, R; Granados-Soto, V; Hong, E; Loeza-Alcocer, E; Oidor-Chan, VH; Pineda-Farias, JB; Price, TJ; Salinas-Abarca, AB; Sánchez-Mendoza, A; Velazquez-Lagunas, I, 2018) |
| "Compound 10 exhibited diabetic neuropathic pain-alleviating effects in a streptozotocin-induced peripheral diabetic neuropathy (PDN) model." | 1.46 | Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives. ( Choi, YJ; Hong, JR; Keum, G; Nam, G, 2017) |
| "A distinct acute, severe form of neuropathic pain, called insulin neuritis or treatment-induced painful neuropathy of diabetes (TIND), may also occur shortly after initiation of intensive glycemic control, with an incidence rate of up to 10." | 1.46 | Murine model and mechanisms of treatment-induced painful diabetic neuropathy. ( Anaya, CJ; Enriquez, C; Jolivalt, CG; Marquez, A; Nicodemus, JM, 2017) |
| "Gabapentin (GBP) is a first-line therapy for neuropathic pain, but its mechanisms and sites of action remain uncertain." | 1.46 | Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain. ( Bannister, K; Dickenson, AH; King, T; Navratilova, E; Oyarzo, J; Porreca, F; Qu, C; Xie, JY, 2017) |
| "Treatment with gabapentin, but not amitriptyline, was associated with a complete attenuation of hind paw mechanical hypersensitivity observed with indinavir treatment." | 1.46 | A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy. ( Bennett, DLH; Calvo, M; Huang, W; Pheby, T; Rice, ASC, 2017) |
| "Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population." | 1.46 | sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017) |
| "Using 3 rat models of neuropathic pain of toxic (oxaliplatin/OXA), metabolic (streptozocin/STZ), and traumatic (sciatic nerve ligation/CCI [chronic constriction nerve injury]) etiologies, we investigated the antihypersensitivity effect of acute and repeated agomelatine administration." | 1.46 | Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence. ( Authier, N; Bertrand, M; Chapuy, E; Chenaf, C; Courteix, C; Eschalier, A; Gabriel, C; Libert, F; Marchand, F; Mocaër, E, 2017) |
| "The Dunning rat model of prostate cancer was used." | 1.43 | Gabapentin, an Analgesic Used Against Cancer-Associated Neuropathic Pain: Effects on Prostate Cancer Progression in an In Vivo Rat Model. ( Altun, S; Bugan, I; Djamgoz, MB; Karagoz, Z, 2016) |
| "The pharmacotherapy for neuropathic pain includes gabapentin and tramadol, but these are only partially effective when given alone." | 1.43 | Antinociceptive Interaction of Tramadol with Gabapentin in Experimental Mononeuropathic Pain. ( Aranda, N; Castillo, R; Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Zanetta, P, 2016) |
| "Preclinical Research Neuropathic pain is particularly difficult to treat because of its diverse etiologies and underlying pathophysiological mechanisms." | 1.43 | Antinociceptive Interactions Between Meloxicam and Gabapentin in Neuropathic Pain Depend on the Ratio used in Combination in Rats. ( Corona-Ramos, JN; Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ; Medina-López, JR, 2016) |
| "After MPNL, mechanical allodynia was established, and mice quickly recovered from the surgery without any significant motor impairment." | 1.43 | Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. ( Alves-Filho, JC; Bassi, GS; Bozzo, TA; Cunha, FQ; Cunha, TM; Ferreira, SH; Kusuda, R; Sant'Anna, MB; Souza, GR, 2016) |
| " Dose-response curves (DRC) and isobolographic analysis were used to confirm their synergistic antihyperalgesic and anti-allodynic responses in a rat neuropathic pain model involving chronic constriction injury of the sciatic nerve and in von Frey and acetone tests." | 1.43 | The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury. ( Corona-Ramos, JN; De la O-Arciniega, M; Déciga-Campos, M; Domínguez-Ramírez, AM; Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ; Medina-López, JR, 2016) |
| "Cathepsin S inhibitors attenuate mechanical allodynia in preclinical neuropathic pain models." | 1.43 | Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. ( Classon, B; Edenius, C; Grabowska, U; Henderson, I; Hewitt, E; Lindström, E; Malcangio, M; Pitcher, T; Rizoska, B; Sahlberg, BL; Tunblad, K, 2016) |
| "Robust allodynia was observed in all three ligation groups." | 1.42 | Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit. ( Baker, KB; Lanthorn, TH; Mason, S; Rajan, I; Savelieva, KV; Vogel, P; Ye, GL, 2015) |
| "Gabapentin was effective in transiently reversing mechanical allodynia in those mice with lowered thresholds." | 1.42 | Differences in cisplatin-induced mechanical allodynia in male and female mice. ( Corr, M; Woller, SA; Yaksh, TL, 2015) |
| "Diclofenac treatment produced dose-related reversal of CRANE at 0." | 1.42 | Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats. ( Bannon, AW; Joshi, SK; Zhu, CZ, 2015) |
| "A hallmark of peripheral neuropathic pain (PNP) is chronic spontaneous pain and/or hypersensitivity to normally painful stimuli (hyperalgesia) or normally nonpainful stimuli (allodynia)." | 1.42 | Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in rats. ( Al Otaibi, M; Djouhri, L; Sathish, J; Smith, T, 2015) |
| "Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset." | 1.42 | A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. ( Abbas, M; Ali, G; Sewell, RD; Shahid, M; Subhan, F; Zeb, J, 2015) |
| "Mice were tested for tactile mechanical hyperalgesia at 1, 2, and 3 weeks following procedures." | 1.42 | Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor. ( Batisti, AP; Daruge-Neto, E; Emer, AA; Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Prado, MR; Santos, AR, 2015) |
| " Time-course data for the dose-response effects were analyzed using two-way analysis of variance and the posthoc Tukey-Kramer multiple-comparison test." | 1.40 | Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. ( Hashimoto, R; Hosokawa, K; Mashimo, T; Nakae, A; Nakai, K, 2014) |
| "Gabapentin has shown to be effective in animals and humans with acute postoperative and chronic pain." | 1.40 | Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms. ( Eisenach, JC; Hayashida, K; Severino, AL; Suto, T, 2014) |
| "Gabapentin has been shown to disrupt the interaction of thrombospondin (TSP) with α2δ-1, an auxiliary calcium channel subunit." | 1.40 | Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation. ( Andresen, L; Dulla, CG; Hampton, D; Maguire, J; Morel, L; Taylor-Weiner, A; Yang, Y, 2014) |
| "Although mouse models of experimental autoimmune encephalomyelitis (EAE) have provided insight on the pathobiology of MS-induced neuropathic pain, concurrent severe motor impairments confound quantitative assessment of pain behaviors over the disease course." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| "Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0." | 1.38 | Interactions of pregabalin with gabapentin, levetiracetam, tiagabine and vigabatrin in the mouse maximal electroshock-induced seizure model: a type II isobolographic analysis. ( Filip, D; Florek-Luszczki, M; Luszczki, JJ, 2012) |
| "Gabapentin was used to provide an anxiolytic effect on drug-free days." | 1.38 | Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats. ( Açikmeşe, B; Enginar, N; Hatipoğlu, I; Haznedar, S, 2012) |
| "The L5 spinal nerve ligation induced tactile allodynia, an increase of CD11b expression, and an increase in the protein expression level of the voltage-dependent Ca(2+) channel α(2)/δ-1 subunit in the spinal dorsal horn on the injured side." | 1.38 | Spinal mechanism underlying the antiallodynic effect of gabapentin studied in the mouse spinal nerve ligation model. ( Adachi-Akahane, S; Ito, M; Kuroda, M; Morimoto, S; Oda, S; Sugiyama, A, 2012) |
| "Gabapentin 400 μg attenuated mechanical hyperalgesia for 7 days compared with the control group." | 1.38 | Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model. ( Imamachi, N; Narai, Y; Saito, Y, 2012) |
| " As a corollary, they also show that long-term use of ETH and GAB is devoid of adverse behavioral and cognitive effects." | 1.38 | Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome. ( Corrales, A; Flórez, J; García, S; Martínez, P; Martínez-Cué, C; Rueda, N; Sharma, A; Vidal, V, 2012) |
| "Gabapentin (GBP) is an anticonvulsant that acts at the α2δ-1 submit of the L-type calcium channel." | 1.38 | Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma. ( Barres, BA; Graber, KD; Jin, S; Li, H; McDonald, W; Prince, DA, 2012) |
| "In ethidium bromide treated rats, gabapentin administered at 300 mg/kg increased cortical MDA by 66%." | 1.38 | The effect of gabapentin on oxidative stress in a model of toxic demyelination in rat brain. ( Abdel-Salam, OM; Khadrawy, YA; Mohammed, NA; Youness, ER, 2012) |
| "Neuropathic pain is a chronic pain condition that occurs and persists in a heterogeneous group of etiologically different diseases characterized by a primary lesion or dysfunction of the peripheral or central nervous system." | 1.37 | Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones. ( Arjun, M; Menon, N; Semwal, A; Sriram, D; Yogeeswari, P, 2011) |
| "Behavioural assessments of tail muscle spasticity and mean arterial blood pressure responses to noxious somatic and/or visceral stimulation were used to test the effects of GBP on these abnormal reflexes." | 1.37 | Gabapentin for spasticity and autonomic dysreflexia after severe spinal cord injury. ( Duale, H; Kitzman, PH; Lyttle, TS; O'Dell, CR; Patel, SP; Rabchevsky, AG, 2011) |
| "Many drugs approved for neuropathic pain engage spinal noradrenergic and cholinergic systems for analgesia." | 1.37 | A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury. ( Eisenach, JC; Hayashida, K, 2011) |
| "Mechanical allodynia was assessed by measuring the forepaw withdrawal threshold to von Frey filaments, and cold allodynia was evaluated by measuring the time spent in lifting or licking the forepaw after applying acetone to it." | 1.37 | A novel rat forelimb model of neuropathic pain produced by partial injury of the median and ulnar nerves. ( Back, SK; Eun, JS; Kim, MA; Na, HS; Yi, H, 2011) |
| "Gabapentin failed to suppress the scratching behavior induced by the intradermal injection of compound 48/80 in normal mice." | 1.37 | Gabapentin and pregabalin inhibit the itch-associated response induced by the repeated application of oxazolone in mice. ( Manabe, H; Matsumoto, Y; Miura, H; Tsukumo, Y; Yano, H, 2011) |
| "Accordingly, we hypothesized that tactile allodynia post SCI is mediated by an upregulation of Ca(v)α2δ-1 in dorsal spinal cord." | 1.37 | Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states. ( Boroujerdi, A; Kim, D; Luo, DZ; Sharp, K; Steward, O; Zeng, J, 2011) |
| "Long-lasting hyperalgesia was induced in male Sprague Dawley rats with subcutaneous fentanyl (4 injections, 60 μg/kg per injection at 15-minute intervals) resulting in a total dose of 240 μg/kg." | 1.37 | The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction. ( Benhamou, D; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2011) |
| "In rats with four ligatures, prominent mechanical allodynia and thermal hyperalgesia developed; these behavioral signs were not prominent in rats with two ligatures." | 1.37 | Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. ( Buldum, D; Gunduz, O; Guven, R; Oltulu, C; Ulugol, A, 2011) |
| "Current clinical treatments for neuropathic pain include amitriptyline, a tricyclic antidepressant with mixed pharmacology that is also clinically reported to impair cognitive performance; and gabapentin, a compound that selectively interacts with alpha2delta-1 calcium channel subunits." | 1.36 | Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: effects of amitriptyline and gabapentin. ( Arneric, SP; Buccafusco, JJ; Snutch, TP; Terry, AV; Vazdarjanova, A, 2010) |
| "Mechanical hyperalgesia was fully reversed by three analgesic drugs used in treating neuropathic SCI pain, but their duration of action differed significantly, showing a rank order of amitriptyline (24-48 h)≫morphine (6 h)>gabapentin (2 h)." | 1.36 | Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. ( Densmore, VS; Kalous, A; Keast, JR; Osborne, PB, 2010) |
| "Gabapentin and clonidine were concomitantly administered in a fixed-dose ratio proportional to the predetermined ED(50) of these drugs, thereby obtaining a dose-response curve for the drug combination and its ED(50)." | 1.36 | Intrathecal gabapentin and clonidine synergistically inhibit allodynia in spinal nerve-ligated rats. ( Asada, A; Funao, T; Mori, T; Nishikawa, K; Yamama, Y, 2010) |
| " Single, parenteral dosing of donepezil (1, 1." | 1.36 | Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies. ( Andersen, LM; Bjerrum, OJ; Folkesson, A; Honoré, PH; Kristensen, P, 2010) |
| " The PWT in PSL mice was dose-dependently increased by intraperitoneal injection of gabapentin, but the anti-allodynic effects varied according to its dosing time." | 1.36 | Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain. ( Hamamura, K; Inoue, K; Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Tsuda, M; Uchida, T; Yoshida, M, 2010) |
| "6 h, oral bioavailability of 37% and 90%) with anti-inflammatory activity (ED 50 = 37 micromol/kg, mouse) and efficacy in pain models (thermal hyperalgesia, ED 50 = 72 micromol/kg, rat)." | 1.35 | Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. ( Adair, RM; Altenbach, RJ; Bettencourt, BM; Brioni, JD; Cowart, MD; Drizin, I; Esbenshade, TA; Fix-Stenzel, SR; Honore, P; Hsieh, GC; Liu, H; Marsh, KC; McPherson, MJ; Milicic, I; Miller, TR; Sullivan, JP; Wetter, JM; Wishart, N; Witte, DG, 2008) |
| "CCI also evoked mechanical allodynia that was fully developed on a week post-operation, but showed no recovery for at least 8 weeks." | 1.35 | Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats. ( Kurebayashi, Y; Nakazato-Imasato, E, 2009) |
| "Gabapentin is a structural analog of GABA that has anticonvulsant properties." | 1.35 | Cellular and behavioral interactions of gabapentin with alcohol dependence. ( Cruz, MT; Gilpin, NW; Koob, GF; Morse, AC; O'Dell, LE; Roberto, M; Siggins, GR, 2008) |
| "In both neuropathic pain models, rats exhibited mechanical hypersensitivity, whereas a significant increase in anxiety-like behaviour was observed only in CCI rats (time spent in open arms decreased significantly from 99+/-15." | 1.35 | Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. ( Arndt, K; Ceci, A; Doods, H; Roeska, K; Treede, RD, 2008) |
| "Neuropathic pain was induced in male Sprague-Dawley rats by a surgical ligation of left L5 nerve." | 1.35 | Protective effects of gabapentin on allodynia and alpha 2 delta 1-subunit of voltage-dependent calcium channel in spinal nerve-ligated rats. ( Ahn, HJ; Bae, CD; Cho, HS; Choi, SJ; Gwak, MS; Hahm, TS; Kim, HS; Kim, JA; Lee, SM; Lim, SW; Sim, WS, 2009) |
| " Here we determined the antinociceptive effect of chronic administration of neramexane and compared its effect with that of memantine and gabapentin in a rat model of diabetic neuropathic pain." | 1.35 | Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. ( Chen, SR; Pan, HL; Samoriski, G, 2009) |
| "gabapentin was studied by isobolographic analysis." | 1.35 | Antinociceptive effects of NCX-701 (nitro-paracetamol) in neuropathic rats: enhancement of antinociception by co-administration with gabapentin. ( Curros-Criado, MM; Herrero, JF, 2009) |
| "No causal treatment of ataxias is available at the moment, and so symptomatic and disease-modifying therapies are regarded as a reliable possibility for this complex group of movement disorders." | 1.35 | Gabapentin treatment improves motor coordination in a mice model of progressive ataxia. ( Calzà, L; D'Intino, G; Ferraro, L; Giardino, L; Gusciglio, M; Massella, A; Sivilia, S, 2009) |
| "Vgx rats showed sustained hyperalgesia in the gastrocnemius muscle without tissue damage (no increase in vgx-induced plasma creatine phosphokinase or lactose dehydrogenase levels) accompanied by hypersensitivity to colonic distension." | 1.35 | Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats. ( Furuta, S; Horie, S; Kuzumaki, N; Matsumoto, K; Narita, M; Shimizu, T; Suzuki, T, 2009) |
| "Inhibition of herpetic allodynia by repeated oral administration of gabapentin (100 mg/kg) alleviated the overexpression of mRNA of pronociceptin, as well as the severity of postherpetic allodynia." | 1.35 | Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice. ( Andoh, T; Kuraishi, Y; Sasaki, A; Shiraki, K; Takahata, H; Takasaki, I; Takeshima, H, 2008) |
| "Pelvic pain was detected 5 days after antigen instillation and was sustained beyond 30 days, indicating the development of chronic pain." | 1.35 | Experimental autoimmune prostatitis induces chronic pelvic pain. ( Rudick, CN; Schaeffer, AJ; Thumbikat, P, 2008) |
| "Acute seizure activity was behaviorally scored and hemispheric brain atrophy measured." | 1.35 | Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. ( Comi, AM; Johnston, MV; Kadam, SD; Mulholland, JD; Traa, BS, 2008) |
| " We used a repeated dosing paradigm because there are precedents showing that repeated drug exposure may be necessary to demonstrate analgesia in neuropathic pain models." | 1.34 | Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit. ( Bennett, GJ; Boroujerdi, A; Luo, ZD; Xiao, W, 2007) |
| "Animal models of neuropathic pain have enabled the identification of key pathophysiological changes occurring within nociceptive pathways as a result of injury, and serve an invaluable role for preclinical screening of novel analgesic candidates." | 1.34 | The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Jensen, DG; Rode, F; Thomsen, M, 2007) |
| "Both spastic behavior and electromyography (EMG) activity were significantly decreased at 1 and 3 h post-GBP injection when compared with the activity level following administration of saline." | 1.34 | Gabapentin suppresses spasticity in the spinal cord-injured rat. ( Dwyer, MK; Kitzman, PH; Uhl, TL, 2007) |
| "In contrast, analgesia, sedation and catalepsy were not observed in this dose range, but were apparent at 100 mg/kg." | 1.33 | Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. ( Boulet, JM; Chaffer, SM; Elsemore, DA; Gottshall, SL; Harrison, JE; Koetzner, L; Lee, G; Mark, L; Miller, W; Pearson, MS; Rabadi, L; Rotshteyn, Y; Shan, S; Tafesse, L; Toth, M; Turchin, PI; Valenzano, KJ; Whiteside, GT, 2005) |
| "Similar bilateral hyperalgesia was observed when axotomy was performed using silk thread instead of chromic gut." | 1.33 | Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy. ( Miki, S; Senba, E; Yasuda, T; Yoshinaga, N, 2005) |
| "Signs of allodynia also extended to the sciatic nerve territory." | 1.33 | Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain. ( Beaulieu, P; Desbiens, K; Leblond, F; Pichette, V; Walczak, JS, 2005) |
| "The degree of allodynia was most marked following 10 min of irradiation." | 1.32 | Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003) |
| "3." | 1.32 | Pharmacological characterisation of a rat model of incisional pain. ( Boulet, J; Gottshall, S; Harrison, J; Mark, L; Pearson, M; Walker, K; Whiteside, GT, 2004) |
| "The present study compares postoperative pain scores in male and female rats and how they respond to analgesic interventions." | 1.32 | Postoperative pain and analgesic responses are similar in male and female Sprague-Dawley rats. ( Buvanendran, A; Kroin, JS; Nagalla, SK; Tuman, KJ, 2003) |
| "ent/ent mice develop ataxia by postnatal day 13-15, followed by paroxysmal dyskinesia a few days later." | 1.32 | entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse. ( Becker, CM; Becker, K; Boison, D; Brill, J; Gouder, N; Hofmann, F; Klocke, R; Klugbauer, N; Paul, D, 2004) |
| " This dosage produced a substantial but non-significant decrease in the incidence of postherpetic pain-related responses." | 1.32 | Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. ( Kuraishi, Y; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2004) |
| "Nonconvulsive seizures (NCSs) after traumatic and ischemic brain injury are often refractory to antiepileptic drug therapy and are associated with a decline in patient outcome." | 1.32 | Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia. ( Hartings, JA; Lu, XM; Moreton, JE; Tortella, FC; Williams, AJ, 2004) |
| "Electroconvulsions were produced by means of an alternating current (ear-clip electrodes, 0." | 1.31 | Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis. ( Borowicz, KK; Czuczwar, SJ; Luszczki, J; Swiader, M, 2002) |
| "The initial hyperalgesia induced by 0." | 1.31 | Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002) |
| "Allodynia and hyperalgesia appeared on day 5 post-inoculation." | 1.31 | Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. ( Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2000) |
| "Kindled seizures were produced on day 16 of life by repeatedly applying an electrical current stimulus to the amygdala electrode." | 1.31 | Anticonvulsant efficacy of gabapentin on kindling in the immature brain. ( Lado, FA; Moshé, SL; Sperber, EF, 2001) |
| "Subjective tinnitus is a common and often debilitating disorder that is difficult to study because it is a perceptual state without an objective stimulus correlate." | 1.31 | Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model. ( Bauer, CA; Brozoski, TJ, 2001) |
| "Lamotrigine was the only drug which antagonized tonic convulsions in the MES test (ED50 = 36 mumol/kg)." | 1.30 | Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin. ( Dalby, NO; Nielsen, EB, 1997) |
| "Gabapentin dose-dependently attenuated myoclonus in posthypoxic rats for more than 3 h." | 1.29 | Antimyoclonic effect of gabapentin in a posthypoxic animal model of myoclonus. ( Kanthasamy, AG; Truong, DD; Vu, TQ; Yun, RJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (3.96) | 18.2507 |
| 2000's | 89 (32.01) | 29.6817 |
| 2010's | 154 (55.40) | 24.3611 |
| 2020's | 24 (8.63) | 2.80 |
| Authors | Studies |
|---|---|
| Hong-Ju, Y | 1 |
| He, L | 1 |
| Wei-Guo, S | 1 |
| Nan, Z | 1 |
| Wei-Xiu, Y | 1 |
| Zhong-Wei, J | 1 |
| Jun-Wei, W | 1 |
| Zheng-Hua, G | 1 |
| Bo-Hua, Z | 1 |
| Zhi-Pu, L | 1 |
| Zhe-Hui, G | 1 |
| Burgos-Lepley, CE | 1 |
| Thompson, LR | 2 |
| Kneen, CO | 1 |
| Osborne, SA | 2 |
| Bryans, JS | 2 |
| Capiris, T | 1 |
| Suman-Chauhan, N | 1 |
| Dooley, DJ | 1 |
| Donovan, CM | 1 |
| Field, MJ | 3 |
| Vartanian, MG | 2 |
| Kinsora, JJ | 2 |
| Lotarski, SM | 2 |
| El-Kattan, A | 3 |
| Walters, K | 1 |
| Cherukury, M | 1 |
| Taylor, CP | 4 |
| Wustrow, DJ | 2 |
| Schwarz, JB | 2 |
| Yogeeswari, P | 2 |
| Ragavendran, JV | 1 |
| Sriram, D | 2 |
| Nageswari, Y | 1 |
| Kavya, R | 1 |
| Sreevatsan, N | 1 |
| Vanitha, K | 1 |
| Stables, J | 1 |
| Farina, C | 1 |
| Gagliardi, S | 1 |
| Ghelardini, C | 1 |
| Martinelli, M | 1 |
| Norcini, M | 1 |
| Parini, C | 1 |
| Petrillo, P | 1 |
| Ronzoni, S | 1 |
| Cowart, MD | 1 |
| Altenbach, RJ | 1 |
| Liu, H | 2 |
| Hsieh, GC | 2 |
| Drizin, I | 1 |
| Milicic, I | 1 |
| Miller, TR | 1 |
| Witte, DG | 1 |
| Wishart, N | 1 |
| Fix-Stenzel, SR | 1 |
| McPherson, MJ | 1 |
| Adair, RM | 1 |
| Wetter, JM | 1 |
| Bettencourt, BM | 1 |
| Marsh, KC | 1 |
| Sullivan, JP | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Blakemore, DC | 1 |
| Carnell, P | 1 |
| Kinsella, N | 1 |
| Kinsora, JK | 1 |
| Meltzer, LT | 1 |
| Williams, SC | 1 |
| Menon, N | 1 |
| Semwal, A | 1 |
| Arjun, M | 1 |
| Woo, HM | 1 |
| Lee, YS | 1 |
| Roh, EJ | 1 |
| Seo, SH | 3 |
| Song, CM | 1 |
| Chung, HJ | 1 |
| Pae, AN | 4 |
| Shin, KJ | 1 |
| Walls, TH | 1 |
| Grindrod, SC | 1 |
| Beraud, D | 1 |
| Zhang, L | 1 |
| Baheti, AR | 1 |
| Dakshanamurthy, S | 1 |
| Patel, MK | 1 |
| Brown, ML | 1 |
| MacArthur, LH | 1 |
| Hoyt, SB | 1 |
| London, C | 1 |
| Abbadie, C | 2 |
| Felix, JP | 1 |
| Garcia, ML | 1 |
| Jochnowitz, N | 1 |
| Karanam, BV | 1 |
| Li, X | 3 |
| Lyons, KA | 1 |
| McGowan, E | 1 |
| Priest, BT | 1 |
| Smith, MM | 1 |
| Warren, VA | 1 |
| Thomas-Fowlkes, BS | 1 |
| Kaczorowski, GJ | 1 |
| Duffy, JL | 1 |
| Lebedyeva, IO | 1 |
| Ostrov, DA | 1 |
| Neubert, J | 1 |
| Steel, PJ | 1 |
| Patel, K | 1 |
| Sileno, SM | 1 |
| Goncalves, K | 1 |
| Ibrahim, MA | 2 |
| Alamry, KA | 1 |
| Katritzky, AR | 1 |
| Cho, GH | 1 |
| Kim, T | 2 |
| Son, WS | 2 |
| Min, SJ | 2 |
| Cho, YS | 2 |
| Keum, G | 3 |
| Jeong, KS | 2 |
| Koh, HY | 1 |
| Lee, J | 3 |
| Nam, M | 1 |
| Kwak, J | 1 |
| Ko, MK | 1 |
| Lim, EJ | 1 |
| Baek, DJ | 1 |
| Li, Y | 5 |
| Liu, YB | 1 |
| Zhang, JJ | 1 |
| Liu, Y | 1 |
| Ma, SG | 1 |
| Qu, J | 1 |
| Lv, HN | 1 |
| Yu, SS | 1 |
| Kim, JH | 1 |
| Nam, G | 3 |
| Hong, JR | 2 |
| Choi, YJ | 1 |
| Choo, H | 1 |
| Wu, YJ | 1 |
| Guernon, J | 1 |
| McClure, A | 1 |
| Luo, G | 1 |
| Rajamani, R | 1 |
| Ng, A | 1 |
| Easton, A | 1 |
| Newton, A | 1 |
| Bourin, C | 1 |
| Parker, D | 1 |
| Mosure, K | 1 |
| Barnaby, O | 1 |
| Soars, MG | 1 |
| Knox, RJ | 1 |
| Matchett, M | 1 |
| Pieschl, R | 2 |
| Herrington, J | 1 |
| Chen, P | 1 |
| Sivarao, DV | 1 |
| Bristow, LJ | 1 |
| Meanwell, NA | 1 |
| Bronson, J | 2 |
| Olson, R | 1 |
| Thompson, LA | 1 |
| Dzierba, C | 2 |
| Lim, SM | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Ramdas, V | 1 |
| Talwar, R | 1 |
| Kanoje, V | 1 |
| Loriya, RM | 1 |
| Banerjee, M | 1 |
| Patil, P | 1 |
| Joshi, AA | 1 |
| Datrange, L | 1 |
| Das, AK | 1 |
| Walke, DS | 1 |
| Kalhapure, V | 1 |
| Khan, T | 1 |
| Gote, G | 1 |
| Dhayagude, U | 1 |
| Deshpande, S | 1 |
| Shaikh, J | 1 |
| Chaure, G | 1 |
| Pal, RR | 1 |
| Parkale, S | 1 |
| Suravase, S | 1 |
| Bhoskar, S | 1 |
| Gupta, RV | 1 |
| Kalia, A | 1 |
| Yeshodharan, R | 1 |
| Azhar, M | 1 |
| Daler, J | 1 |
| Mali, V | 1 |
| Sharma, G | 1 |
| Kishore, A | 1 |
| Vyawahare, R | 1 |
| Agarwal, G | 1 |
| Pareek, H | 1 |
| Budhe, S | 1 |
| Nayak, A | 1 |
| Warude, D | 1 |
| Gupta, PK | 1 |
| Joshi, P | 1 |
| Joshi, S | 1 |
| Darekar, S | 1 |
| Pandey, D | 1 |
| Wagh, A | 1 |
| Nigade, PB | 1 |
| Mehta, M | 1 |
| Patil, V | 1 |
| Modi, D | 1 |
| Pawar, S | 1 |
| Verma, M | 1 |
| Singh, M | 1 |
| Das, S | 1 |
| Gundu, J | 1 |
| Nemmani, K | 1 |
| Bock, MG | 1 |
| Sharma, S | 1 |
| Bakhle, D | 1 |
| Kamboj, RK | 1 |
| Palle, VP | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Belgi, A | 1 |
| Burnley, JV | 1 |
| MacRaild, CA | 1 |
| Chhabra, S | 1 |
| Elnahriry, KA | 1 |
| Robinson, SD | 1 |
| Gooding, SG | 1 |
| Tae, HS | 1 |
| Bartels, P | 1 |
| Sadeghi, M | 1 |
| Zhao, FY | 1 |
| Wei, H | 1 |
| Spanswick, D | 1 |
| Adams, DJ | 1 |
| Norton, RS | 1 |
| Robinson, AJ | 1 |
| Brito, BE | 1 |
| García, MA | 1 |
| De Gouveia, YM | 1 |
| Bolaños, P | 1 |
| Devis, S | 1 |
| Bernal, G | 1 |
| Tortorici-Brito, VA | 1 |
| Baute, L | 1 |
| Díaz-Serrano, G | 1 |
| Tortorici, V | 1 |
| Buapratoom, A | 1 |
| Wanasuntronwong, A | 1 |
| Khongsombat, O | 1 |
| Tantisira, MH | 1 |
| Godai, K | 1 |
| Moriyama, T | 1 |
| Ozcan, S | 1 |
| Kelestemur, MM | 1 |
| Hekim, MG | 1 |
| Bulmus, O | 1 |
| Bulut, F | 1 |
| Bilgin, B | 1 |
| Canpolat, S | 1 |
| Ozcan, M | 1 |
| Zhang, XY | 1 |
| Barakat, A | 1 |
| Diaz-delCastillo, M | 1 |
| Vollert, J | 1 |
| Sena, ES | 1 |
| Heegaard, AM | 2 |
| Rice, ASC | 2 |
| Soliman, N | 1 |
| Lee, N | 1 |
| Nho, B | 1 |
| Ko, KR | 1 |
| Kim, S | 1 |
| Khan, FA | 1 |
| Ali, G | 5 |
| Rahman, K | 1 |
| Khan, Y | 1 |
| Ayaz, M | 1 |
| Mosa, OF | 1 |
| Nawaz, A | 1 |
| Hassan, SSU | 1 |
| Bungau, S | 1 |
| Gohar, A | 1 |
| Rashid, U | 1 |
| Rauf, K | 1 |
| Arif, M | 1 |
| Khan, MS | 1 |
| Alkahramaan, YMSA | 1 |
| Sewell, RDE | 4 |
| Bobenko, AI | 1 |
| Heller, S | 1 |
| Schmitt, N | 1 |
| Cherdtrakulkiat, R | 1 |
| Lawung, R | 1 |
| Nabu, S | 1 |
| Tantimavanich, S | 1 |
| Sinthupoom, N | 1 |
| Prachayasittikul, S | 1 |
| Prachayasittikul, V | 1 |
| Zhang, B | 2 |
| Wu, C | 1 |
| Zhang, Z | 2 |
| Yan, K | 1 |
| Li, C | 2 |
| Li, L | 3 |
| Zheng, C | 1 |
| Xiao, Y | 1 |
| He, D | 1 |
| Zhao, F | 1 |
| Su, JF | 1 |
| Lun, SM | 1 |
| Hou, YJ | 1 |
| Duan, LJ | 1 |
| Wang, NC | 1 |
| Shen, FF | 1 |
| Zhang, YW | 1 |
| Gao, ZW | 1 |
| Li, J | 7 |
| Du, XJ | 1 |
| Zhou, FY | 1 |
| Yin, Z | 1 |
| Zhu, J | 2 |
| Yan, D | 1 |
| Lou, H | 1 |
| Yu, H | 1 |
| Feng, C | 1 |
| Wang, Z | 1 |
| Wang, Y | 6 |
| Hu, X | 1 |
| Li, Z | 5 |
| Shen, Y | 1 |
| Hu, D | 1 |
| Chen, H | 2 |
| Wu, X | 1 |
| Duan, Y | 1 |
| Zhi, D | 1 |
| Zou, M | 2 |
| Zhao, Z | 1 |
| Zhang, X | 2 |
| Yang, X | 2 |
| Zhang, J | 2 |
| Wang, H | 2 |
| Popović, KJ | 1 |
| Popović, DJ | 1 |
| Miljković, D | 1 |
| Lalošević, D | 1 |
| Čapo, I | 1 |
| Popović, JK | 1 |
| Liu, M | 1 |
| Song, H | 2 |
| Xing, Z | 1 |
| Lu, G | 1 |
| Chen, D | 1 |
| Valentini, AM | 1 |
| Di Pinto, F | 1 |
| Coletta, S | 1 |
| Guerra, V | 1 |
| Armentano, R | 1 |
| Caruso, ML | 1 |
| Gong, J | 1 |
| Wang, N | 1 |
| Bian, L | 1 |
| Wang, M | 1 |
| Ye, M | 1 |
| Wen, N | 1 |
| Fu, M | 1 |
| Fan, W | 1 |
| Meng, Y | 1 |
| Dong, G | 1 |
| Lin, XH | 1 |
| Liu, HH | 1 |
| Gao, DM | 1 |
| Cui, JF | 1 |
| Ren, ZG | 1 |
| Chen, RX | 1 |
| Önal, B | 1 |
| Özen, D | 1 |
| Demir, B | 1 |
| Akkan, AG | 1 |
| Özyazgan, S | 1 |
| Payette, G | 1 |
| Geoffroy, V | 1 |
| Martineau, C | 1 |
| Villemur, R | 1 |
| Jameel, T | 1 |
| Baig, M | 1 |
| Gazzaz, ZJ | 1 |
| Tashkandi, JM | 1 |
| Al Alhareth, NS | 1 |
| Khan, SA | 1 |
| Butt, NS | 1 |
| Wang, J | 4 |
| Geng, Y | 1 |
| Zhang, Y | 5 |
| Wang, X | 2 |
| Liu, J | 2 |
| Basit, A | 1 |
| Miao, T | 1 |
| Liu, W | 1 |
| Jiang, W | 1 |
| Yu, ZY | 1 |
| Wu, L | 2 |
| Qu, B | 1 |
| Sun, JX | 1 |
| Cai, AL | 1 |
| Xie, LM | 1 |
| Groeneveld, J | 1 |
| Ho, SL | 1 |
| Mackensen, A | 1 |
| Mohtadi, M | 1 |
| Laepple, T | 1 |
| Genovesi, S | 1 |
| Nava, E | 1 |
| Bartolucci, C | 1 |
| Severi, S | 1 |
| Vincenti, A | 1 |
| Contaldo, G | 1 |
| Bigatti, G | 1 |
| Ciurlino, D | 1 |
| Bertoli, SV | 1 |
| Slovak, JE | 1 |
| Hwang, JK | 1 |
| Rivera, SM | 1 |
| Villarino, NF | 1 |
| Li, S | 1 |
| Cao, G | 1 |
| Ling, M | 1 |
| Ji, J | 1 |
| Zhao, D | 1 |
| Sha, Y | 1 |
| Gao, X | 1 |
| Liang, C | 2 |
| Guo, Q | 1 |
| Zhou, C | 1 |
| Ma, Z | 1 |
| Xu, J | 1 |
| Wang, C | 1 |
| Zhao, W | 1 |
| Xia, X | 1 |
| Jiang, Y | 1 |
| Peng, J | 2 |
| Jia, Z | 1 |
| Li, F | 1 |
| Chen, X | 3 |
| Mo, J | 1 |
| Zhang, S | 2 |
| Huang, T | 1 |
| Zhu, Q | 1 |
| Wang, S | 1 |
| Ge, RS | 1 |
| Fortunato, G | 1 |
| Lin, J | 2 |
| Agarwal, PK | 1 |
| Kohen, A | 1 |
| Singh, P | 1 |
| Cheatum, CM | 1 |
| Zhu, D | 1 |
| Hayman, A | 1 |
| Kebede, B | 1 |
| Stewart, I | 1 |
| Chen, G | 1 |
| Frew, R | 1 |
| Guo, X | 1 |
| Gong, Q | 1 |
| Borowiec, J | 1 |
| Han, S | 1 |
| Zhang, M | 1 |
| Willis, M | 1 |
| Kreouzis, T | 1 |
| Yu, K | 1 |
| Chirvony, VS | 1 |
| Sekerbayev, KS | 1 |
| Pérez-Del-Rey, D | 1 |
| Martínez-Pastor, JP | 1 |
| Palazon, F | 1 |
| Boix, PP | 1 |
| Taurbayev, TI | 1 |
| Sessolo, M | 1 |
| Bolink, HJ | 1 |
| Lu, M | 1 |
| Lan, Y | 1 |
| Xiao, J | 1 |
| Song, M | 1 |
| Chen, C | 1 |
| Huang, Q | 1 |
| Cao, Y | 1 |
| Ho, CT | 1 |
| Qi, B | 1 |
| Wang, Q | 1 |
| Zhang, W | 1 |
| Fang, L | 1 |
| Xie, CL | 1 |
| Chen, R | 1 |
| Yang, S | 1 |
| Xia, JM | 1 |
| Zhang, GY | 1 |
| Chen, CH | 1 |
| Yang, XW | 1 |
| Domenech-Ximenos, B | 1 |
| Garza, MS | 1 |
| Prat-González, S | 1 |
| Sepúlveda-Martínez, Á | 1 |
| Crispi, F | 1 |
| Perea, RJ | 1 |
| Garcia-Alvarez, A | 1 |
| Sitges, M | 1 |
| Kalumpha, M | 1 |
| Guyo, U | 1 |
| Zinyama, NP | 1 |
| Vakira, FM | 1 |
| Nyamunda, BC | 1 |
| Varga, M | 1 |
| Drácz, L | 1 |
| Kolbenheyer, E | 1 |
| Varga, F | 1 |
| Patai, ÁV | 1 |
| Solymosi, N | 1 |
| Patai, Á | 1 |
| Kiss, J | 1 |
| Gaál, V | 1 |
| Nyul, Z | 1 |
| Mosdósi, B | 1 |
| Valdez, M | 1 |
| Moosavi, L | 1 |
| Heidari, A | 1 |
| Novakovic-Agopian, T | 1 |
| Kornblith, E | 1 |
| Abrams, G | 1 |
| McQuaid, JR | 1 |
| Posecion, L | 1 |
| Burciaga, J | 1 |
| D'Esposito, M | 1 |
| Chen, AJW | 1 |
| Samy El Gendy, NM | 1 |
| Wesolowska, P | 1 |
| Georg, D | 1 |
| Lechner, W | 1 |
| Kazantsev, P | 1 |
| Bokulic, T | 1 |
| Tedgren, AC | 1 |
| Adolfsson, E | 1 |
| Campos, AM | 1 |
| Alves, VGL | 1 |
| Suming, L | 1 |
| Hao, W | 1 |
| Ekendahl, D | 1 |
| Koniarova, I | 1 |
| Bulski, W | 1 |
| Chelminski, K | 1 |
| Samper, JLA | 1 |
| Vinatha, SP | 1 |
| Rakshit, S | 1 |
| Siri, S | 1 |
| Tomsejm, M | 1 |
| Tenhunen, M | 1 |
| Povall, J | 1 |
| Kry, SF | 1 |
| Followill, DS | 1 |
| Thwaites, DI | 1 |
| Izewska, J | 1 |
| Kang, JH | 2 |
| Yoon, Y | 1 |
| Song, J | 1 |
| Van de Winckel, A | 1 |
| Gauthier, L | 1 |
| Chao, CT | 1 |
| Lee, YH | 1 |
| Li, CM | 1 |
| Han, DS | 1 |
| Huang, JW | 1 |
| Huang, KC | 1 |
| Ni, L | 1 |
| Güttinger, R | 1 |
| Triana, CA | 1 |
| Spingler, B | 1 |
| Baldridge, KK | 1 |
| Patzke, GR | 1 |
| Shen, X | 1 |
| Wang, B | 1 |
| Xie, S | 1 |
| Deng, W | 1 |
| Wu, D | 1 |
| Zhang, Q | 1 |
| Voskamp, BJ | 1 |
| Peelen, MJCS | 1 |
| Ravelli, ACJ | 1 |
| van der Lee, R | 1 |
| Mol, BWJ | 1 |
| Pajkrt, E | 1 |
| Ganzevoort, W | 1 |
| Kazemier, BM | 1 |
| Tibrewala, R | 1 |
| Bahroos, E | 1 |
| Mehrabian, H | 1 |
| Foreman, SC | 1 |
| Link, TM | 1 |
| Pedoia, V | 1 |
| Majumdar, S | 1 |
| Jablonski, CL | 1 |
| Leonard, C | 1 |
| Salo, P | 1 |
| Krawetz, RJ | 1 |
| Yoon, N | 1 |
| Hong, SN | 1 |
| Cho, JG | 1 |
| Jeong, HK | 1 |
| Lee, KH | 1 |
| Park, HW | 1 |
| Barman, S | 1 |
| Konai, MM | 1 |
| Samaddar, S | 1 |
| Haldar, J | 1 |
| Mohamed, HSH | 1 |
| Li, CF | 1 |
| Hu, ZY | 1 |
| Deng, Z | 1 |
| Chen, LH | 1 |
| Su, BL | 1 |
| Chu, K | 1 |
| Liu, YP | 1 |
| Li, YB | 1 |
| Zhang, H | 1 |
| Xu, C | 1 |
| Zou, Z | 1 |
| Wu, Z | 1 |
| Xia, Y | 1 |
| Zhao, P | 1 |
| Wang, HT | 1 |
| de Biase, S | 1 |
| Pellitteri, G | 1 |
| Gigli, GL | 1 |
| Valente, M | 1 |
| Sun, W | 4 |
| Larson, MJ | 1 |
| Kiyoshi, CM | 1 |
| Annett, AJ | 1 |
| Stalker, WA | 1 |
| Tedeschi, A | 1 |
| Arya, P | 1 |
| Kaithwas, G | 1 |
| Luszczki, JJ | 7 |
| Panasiuk, A | 1 |
| Zagaja, M | 1 |
| Karwan, S | 1 |
| Bojar, H | 1 |
| Plewa, Z | 1 |
| Florek-Łuszczki, M | 1 |
| Locke, S | 1 |
| Yousefpour, N | 1 |
| Ribeiro-da-Silva, A | 1 |
| Déciga-Campos, M | 2 |
| Villafán-Gutiérrez, R | 1 |
| Espinosa-Juárez, JV | 3 |
| Jaramillo-Morales, OA | 3 |
| López-Muñoz, FJ | 3 |
| Samra, YA | 1 |
| Amin, MN | 1 |
| Said, E | 1 |
| Karim, N | 1 |
| Khan, I | 1 |
| Abdelhalim, A | 1 |
| Halim, SA | 1 |
| Khan, A | 1 |
| Altaf, N | 1 |
| Ahmad, W | 1 |
| Ghaffar, R | 1 |
| Al-Harrasi, A | 1 |
| Buffon, AC | 1 |
| Javornik, MA | 1 |
| Heymanns, AC | 1 |
| Salm, DC | 1 |
| Horewicz, VV | 1 |
| Martins, DF | 2 |
| Piovezan, AP | 2 |
| Yoshizumi, M | 1 |
| Watanabe, C | 1 |
| Mizoguchi, H | 1 |
| Garrone, B | 1 |
| di Matteo, A | 1 |
| Amato, A | 1 |
| Pistillo, L | 1 |
| Durando, L | 1 |
| Milanese, C | 1 |
| Di Giorgio, FP | 1 |
| Tongiani, S | 1 |
| Ahmad, N | 4 |
| Subhan, F | 5 |
| Islam, NU | 2 |
| Shahid, M | 5 |
| Ullah, N | 2 |
| Ullah, R | 3 |
| Akbar, S | 3 |
| Amin, MU | 2 |
| Khurram, M | 2 |
| Ullah, I | 2 |
| Rangappa, S | 1 |
| Shankar, VK | 1 |
| Jo, S | 1 |
| Repka, MA | 1 |
| Murthy, SN | 1 |
| Louis, JV | 1 |
| Lu, Y | 1 |
| Tian, Y | 1 |
| Hong, Y | 1 |
| Dandapani, K | 1 |
| Naidu, S | 1 |
| Vikramadithyan, RK | 1 |
| Sarvasiddhi, SK | 1 |
| Nara, SJ | 1 |
| Macor, JE | 1 |
| Albright, C | 1 |
| Kostich, W | 1 |
| Li, YW | 1 |
| Stepanović-Petrović, R | 1 |
| Micov, A | 1 |
| Tomić, M | 1 |
| Pecikoza, U | 1 |
| Yaksh, TL | 5 |
| Schwarcz, R | 1 |
| Snodgrass, HR | 1 |
| Nicodemus, JM | 1 |
| Enriquez, C | 1 |
| Marquez, A | 1 |
| Anaya, CJ | 1 |
| Jolivalt, CG | 1 |
| Lyndon, A | 1 |
| Audrey, S | 1 |
| Wells, C | 1 |
| Burnell, ES | 1 |
| Ingle, S | 1 |
| Hill, R | 1 |
| Hickman, M | 1 |
| Henderson, G | 1 |
| Bögli, SY | 1 |
| Afthinos, M | 1 |
| Huang, MY | 1 |
| Sahn, JJ | 1 |
| Mejia, GL | 1 |
| Ray, PR | 1 |
| Martin, SF | 1 |
| Price, TJ | 2 |
| Luo, WJ | 1 |
| Yang, F | 6 |
| Zheng, W | 1 |
| Wang, XL | 2 |
| Wu, FF | 1 |
| Wang, JL | 1 |
| Wang, JS | 2 |
| Guan, SM | 1 |
| Chen, J | 3 |
| Jeong, KY | 1 |
| Mesgari, M | 1 |
| Krüger, J | 1 |
| Riemer, CT | 1 |
| Khaleghi Ghadiri, M | 1 |
| Kovac, S | 1 |
| Gorji, A | 1 |
| Bannister, K | 1 |
| Qu, C | 1 |
| Navratilova, E | 1 |
| Oyarzo, J | 1 |
| Xie, JY | 1 |
| King, T | 1 |
| Dickenson, AH | 4 |
| Porreca, F | 1 |
| Chaumette, T | 1 |
| Chapuy, E | 2 |
| Berrocoso, E | 1 |
| Llorca-Torralba, M | 1 |
| Bravo, L | 1 |
| Mico, JA | 1 |
| Chalus, M | 1 |
| Eschalier, A | 3 |
| Ardid, D | 2 |
| Marchand, F | 2 |
| Sors, A | 1 |
| Sun, D | 1 |
| Yang, J | 3 |
| Wang, D | 1 |
| Wang, L | 1 |
| Yu, Q | 1 |
| Qin, S | 1 |
| Tang, R | 1 |
| Crowe, MS | 1 |
| Wilson, CD | 1 |
| Leishman, E | 1 |
| Prather, PL | 1 |
| Bradshaw, HB | 1 |
| Banks, ML | 1 |
| Kinsey, SG | 1 |
| Takahashi, DK | 1 |
| Jin, S | 2 |
| Prince, DA | 2 |
| Shepherd, AJ | 1 |
| Mohapatra, DP | 1 |
| Liang, X | 1 |
| Yu, G | 1 |
| Su, R | 1 |
| Abdelzaher, WY | 1 |
| Rofaeil, RR | 1 |
| Abdelwahab, S | 1 |
| Barragán-Iglesias, P | 1 |
| Oidor-Chan, VH | 1 |
| Loeza-Alcocer, E | 1 |
| Pineda-Farias, JB | 1 |
| Velazquez-Lagunas, I | 1 |
| Salinas-Abarca, AB | 1 |
| Hong, E | 1 |
| Sánchez-Mendoza, A | 1 |
| Delgado-Lezama, R | 1 |
| Granados-Soto, V | 1 |
| Chincholkar, M | 1 |
| Aman, Y | 1 |
| Pitcher, T | 2 |
| Ballard, C | 1 |
| Malcangio, M | 2 |
| Atwal, N | 1 |
| Casey, SL | 1 |
| Mitchell, VA | 1 |
| Vaughan, CW | 1 |
| Miranda, HF | 2 |
| Poblete, P | 1 |
| Sierralta, F | 2 |
| Noriega, V | 2 |
| Prieto, JC | 2 |
| Zepeda, RJ | 1 |
| Yeh, JC | 1 |
| Do, R | 1 |
| Choi, H | 1 |
| Lin, CT | 1 |
| Chen, JJ | 1 |
| Zi, X | 1 |
| Chang, HH | 1 |
| Ghoniem, G | 1 |
| Tutka, P | 1 |
| Mróz, K | 1 |
| Mróz, T | 1 |
| Buszewicz, G | 1 |
| Aebisher, D | 1 |
| Bartusik-Aebisher, D | 1 |
| Kołodziejczyk, P | 1 |
| Łuszczki, JJ | 1 |
| Hu, R | 1 |
| Feng, M | 1 |
| Yao, W | 1 |
| Zhang, C | 1 |
| Wan, L | 1 |
| Ter Heegde, F | 1 |
| Luiz, AP | 1 |
| Santana-Varela, S | 1 |
| Chessell, IP | 1 |
| Welsh, F | 1 |
| Wood, JN | 1 |
| Chenu, C | 1 |
| da Cunha Leal, P | 1 |
| Rey Moura, EC | 1 |
| Jorge Dino Cossetti, R | 1 |
| Ramos do Nascimento, J | 1 |
| Portela Bogéa Serra, IC | 1 |
| de Paulo Ribeiro, B | 1 |
| Álvares Marques Vale, A | 1 |
| Silva de Azevedo Dos Santos, AP | 1 |
| Fernandes do Nascimento, FR | 1 |
| Kimiko Sakata, R | 1 |
| Ola, MS | 1 |
| Alhomida, AS | 1 |
| LaNoue, KF | 1 |
| Kaszuba, BC | 1 |
| Maietta, T | 1 |
| Walling, I | 1 |
| Feustel, P | 1 |
| Stapleton, A | 1 |
| Shin, DS | 1 |
| Slyer, J | 1 |
| Pilitsis, JG | 1 |
| Gao, T | 1 |
| Shi, T | 1 |
| Wiesenfeld-Hallin, Z | 3 |
| Li, T | 1 |
| Jiang, JD | 1 |
| Xu, XJ | 3 |
| Khan, J | 1 |
| Khan, R | 1 |
| Ullah, S | 1 |
| Sadler, KE | 1 |
| Langer, SN | 1 |
| Menzel, AD | 1 |
| Moehring, F | 1 |
| Erb, AN | 1 |
| Brandow, AM | 1 |
| Stucky, CL | 1 |
| Socała, K | 2 |
| Wyska, E | 1 |
| Szafarz, M | 1 |
| Nieoczym, D | 2 |
| Wlaź, P | 2 |
| Banote, RK | 1 |
| Koutarapu, S | 1 |
| Chennubhotla, KS | 1 |
| Chatti, K | 1 |
| Kulkarni, P | 1 |
| Hooker, BA | 1 |
| Tobon, G | 1 |
| Baker, SJ | 1 |
| Zhu, C | 1 |
| Hesterman, J | 1 |
| Schmidt, K | 1 |
| Rajagovindan, R | 1 |
| Chandran, P | 1 |
| Joshi, SK | 3 |
| Bannon, AW | 3 |
| Hoppin, J | 1 |
| Beaver, J | 1 |
| Fox, GB | 1 |
| Day, M | 1 |
| Upadhyay, J | 1 |
| Yezierski, RP | 1 |
| Green, M | 1 |
| Murphy, K | 1 |
| Vierck, CJ | 1 |
| Nakai, K | 1 |
| Nakae, A | 1 |
| Hashimoto, R | 1 |
| Mashimo, T | 1 |
| Hosokawa, K | 1 |
| Suto, T | 1 |
| Severino, AL | 1 |
| Eisenach, JC | 5 |
| Hayashida, K | 3 |
| Ye, GL | 1 |
| Savelieva, KV | 1 |
| Vogel, P | 1 |
| Baker, KB | 1 |
| Mason, S | 1 |
| Lanthorn, TH | 1 |
| Rajan, I | 1 |
| Simmons, RM | 2 |
| Forster, B | 1 |
| Guo, W | 1 |
| Knopp, KL | 1 |
| Montserrat-de la Paz, S | 1 |
| García-Giménez, MD | 1 |
| Ángel-Martín, M | 1 |
| Fernández-Arche, A | 1 |
| Wilson, B | 1 |
| Lavanya, Y | 1 |
| Priyadarshini, SR | 1 |
| Ramasamy, M | 1 |
| Jenita, JL | 1 |
| Andresen, L | 1 |
| Hampton, D | 1 |
| Taylor-Weiner, A | 1 |
| Morel, L | 1 |
| Yang, Y | 3 |
| Maguire, J | 1 |
| Dulla, CG | 1 |
| Mohammed, AS | 1 |
| Ewais, MM | 1 |
| Tawfik, MK | 1 |
| Essawy, SS | 1 |
| Wodarski, R | 1 |
| Schuh-Hofer, S | 1 |
| Yurek, DA | 1 |
| Wafford, KA | 1 |
| Gilmour, G | 1 |
| Treede, RD | 2 |
| Kennedy, JD | 1 |
| Khan, N | 1 |
| Woodruff, TM | 1 |
| Smith, MT | 1 |
| Lin, HC | 1 |
| Huang, YH | 1 |
| Chao, TH | 1 |
| Lin, WY | 1 |
| Sun, WZ | 1 |
| Yen, CT | 1 |
| Hirsch, S | 1 |
| Dickenson, A | 1 |
| Corradini, L | 2 |
| Fu, H | 2 |
| Lu, YF | 2 |
| Yu, YQ | 2 |
| Costigan, M | 1 |
| Nasirinezhad, F | 1 |
| Jergova, S | 1 |
| Pearson, JP | 1 |
| Sagen, J | 1 |
| Matsumura, S | 1 |
| Taniguchi, W | 1 |
| Nishida, K | 1 |
| Nakatsuka, T | 1 |
| Ito, S | 1 |
| Woller, SA | 2 |
| Corr, M | 3 |
| Zhu, CZ | 2 |
| Zhang, MM | 1 |
| Tu, K | 1 |
| Feng, B | 1 |
| Zhang, ZN | 1 |
| Lei, J | 1 |
| Li, YQ | 1 |
| Du, JQ | 1 |
| Chen, T | 1 |
| Smith, T | 1 |
| Al Otaibi, M | 1 |
| Sathish, J | 1 |
| Djouhri, L | 1 |
| Hung, CH | 1 |
| Wang, JC | 1 |
| Strichartz, GR | 1 |
| Abbas, M | 1 |
| Zeb, J | 1 |
| Sewell, RD | 2 |
| Henry, MA | 1 |
| Fairchild, DD | 1 |
| Patil, MJ | 1 |
| Hanania, T | 1 |
| Hain, HS | 1 |
| Davis, SF | 1 |
| Malekiani, SA | 1 |
| Hu, A | 1 |
| Sucholeiki, R | 1 |
| Nix, D | 1 |
| Sucholeiki, I | 1 |
| Nakazato-Imasato, E | 1 |
| Kurebayashi, Y | 1 |
| Bugan, I | 1 |
| Karagoz, Z | 1 |
| Altun, S | 1 |
| Djamgoz, MB | 1 |
| Castel, D | 1 |
| Sabbag, I | 1 |
| Brenner, O | 1 |
| Meilin, S | 1 |
| Prado, MR | 1 |
| Daruge-Neto, E | 1 |
| Batisti, AP | 1 |
| Emer, AA | 1 |
| Mazzardo-Martins, L | 1 |
| Santos, AR | 3 |
| Zhang, YB | 1 |
| Guo, ZD | 1 |
| Li, MY | 1 |
| Fong, P | 1 |
| Zhang, JG | 1 |
| Zhang, CW | 1 |
| Gong, KR | 1 |
| Yang, MF | 1 |
| Niu, JZ | 1 |
| Ji, XM | 1 |
| Lv, GW | 1 |
| Park, HJ | 1 |
| Sandor, K | 2 |
| McQueen, J | 1 |
| Svensson, CI | 4 |
| Papathanasiou, T | 1 |
| Juul, RV | 1 |
| Kreilgaard, M | 1 |
| Lund, TM | 1 |
| Gould, SA | 1 |
| Doods, H | 2 |
| Lamla, T | 1 |
| Pekcec, A | 1 |
| Ostadhadi, S | 1 |
| Kordjazy, N | 1 |
| Haj-Mirzaian, A | 1 |
| Ameli, S | 1 |
| Akhlaghipour, G | 1 |
| Dehpour, A | 1 |
| Li, CL | 1 |
| He, T | 1 |
| Wang, RR | 1 |
| Lee-Kubli, CA | 1 |
| Ingves, M | 1 |
| Henry, KW | 1 |
| Shiao, R | 1 |
| Collyer, E | 1 |
| Tuszynski, MH | 1 |
| Campana, WM | 1 |
| Zanetta, P | 1 |
| Castillo, R | 1 |
| Aranda, N | 1 |
| Belozertseva, I | 1 |
| Nagel, J | 1 |
| Valastro, B | 1 |
| Franke, L | 1 |
| Danysz, W | 1 |
| Corona-Ramos, JN | 2 |
| Medina-López, JR | 2 |
| Hopkins, HL | 1 |
| Duggett, NA | 1 |
| Flatters, SJL | 1 |
| Ceretta, APC | 1 |
| Schaffer, LF | 1 |
| de Freitas, CM | 1 |
| Reinheimer, JB | 1 |
| Dotto, MM | 1 |
| Fachinetto, R | 1 |
| Sant'Anna, MB | 1 |
| Kusuda, R | 1 |
| Bozzo, TA | 1 |
| Bassi, GS | 1 |
| Alves-Filho, JC | 1 |
| Cunha, FQ | 1 |
| Ferreira, SH | 1 |
| Souza, GR | 1 |
| Cunha, TM | 1 |
| De la O-Arciniega, M | 1 |
| Domínguez-Ramírez, AM | 1 |
| Kimura, M | 1 |
| Hayashida, KI | 1 |
| Hewitt, E | 1 |
| Rizoska, B | 1 |
| Tunblad, K | 1 |
| Henderson, I | 1 |
| Sahlberg, BL | 1 |
| Grabowska, U | 1 |
| Classon, B | 1 |
| Edenius, C | 1 |
| Lindström, E | 1 |
| Tio, M | 1 |
| Wen, R | 1 |
| Lim, YL | 1 |
| Ling, SC | 1 |
| Zhao, Y | 1 |
| Tan, EK | 1 |
| Gulec Suyen, G | 1 |
| Isbil-Buyukcoskun, N | 1 |
| Kahveci, N | 1 |
| Sengun, E | 1 |
| Ozluk, K | 1 |
| Yin, K | 1 |
| Deuis, JR | 1 |
| Lewis, RJ | 1 |
| Vetter, I | 1 |
| Meleine, M | 1 |
| Boudieu, L | 1 |
| Gelot, A | 1 |
| Muller, E | 1 |
| Lashermes, A | 1 |
| Matricon, J | 1 |
| Silberberg, C | 1 |
| Theodorou, V | 1 |
| Carvalho, FA | 1 |
| Huang, W | 1 |
| Calvo, M | 1 |
| Pheby, T | 2 |
| Bennett, DLH | 1 |
| Fawad, K | 1 |
| Kaufmann, D | 1 |
| West, PJ | 1 |
| Smith, MD | 1 |
| Yagen, B | 1 |
| Bialer, M | 1 |
| Devor, M | 1 |
| White, HS | 1 |
| Brennan, KC | 1 |
| Matagne, V | 1 |
| Ehinger, Y | 1 |
| Saidi, L | 1 |
| Borges-Correia, A | 1 |
| Barkats, M | 1 |
| Bartoli, M | 1 |
| Villard, L | 1 |
| Roux, JC | 1 |
| Chenaf, C | 1 |
| Libert, F | 1 |
| Courteix, C | 1 |
| Bertrand, M | 1 |
| Gabriel, C | 1 |
| Mocaër, E | 1 |
| Authier, N | 1 |
| Ding, W | 1 |
| You, Z | 1 |
| Shen, S | 1 |
| Lim, G | 1 |
| Doheny, JT | 1 |
| Chen, L | 1 |
| Zhu, S | 1 |
| Mao, J | 1 |
| Roberto, M | 1 |
| Gilpin, NW | 1 |
| O'Dell, LE | 1 |
| Cruz, MT | 1 |
| Morse, AC | 1 |
| Siggins, GR | 1 |
| Koob, GF | 1 |
| Roeska, K | 1 |
| Arndt, K | 1 |
| Ceci, A | 1 |
| Wood, PL | 1 |
| Mahmood, SA | 1 |
| Moskal, JR | 1 |
| Ratnaraj, N | 2 |
| Patsalos, PN | 2 |
| Czuczwar, SJ | 6 |
| Nishiyori, M | 1 |
| Ueda, H | 1 |
| Dudra-Jastrzebska, M | 1 |
| Andres-Mach, MM | 1 |
| Sielski, M | 1 |
| Hahm, TS | 1 |
| Ahn, HJ | 1 |
| Bae, CD | 1 |
| Kim, HS | 1 |
| Lim, SW | 1 |
| Cho, HS | 1 |
| Lee, SM | 1 |
| Sim, WS | 1 |
| Kim, JA | 1 |
| Gwak, MS | 1 |
| Choi, SJ | 1 |
| Czubak, A | 1 |
| Nowakowska, E | 1 |
| Kus, K | 1 |
| Sadowski, C | 1 |
| Matschay, A | 1 |
| Lin, CF | 1 |
| Tsaur, ML | 2 |
| Lin, CS | 2 |
| Chen, CC | 2 |
| Huang, YJ | 1 |
| Cheng, JK | 2 |
| Mao, YF | 2 |
| Liu, XR | 1 |
| Liao, XZ | 2 |
| Lv, YH | 1 |
| Xu, H | 3 |
| Deng, XM | 2 |
| Yan, SK | 1 |
| Xiong, YC | 2 |
| Zhang, WD | 1 |
| Chen, SR | 3 |
| Samoriski, G | 1 |
| Pan, HL | 3 |
| Curros-Criado, MM | 1 |
| Herrero, JF | 1 |
| Massella, A | 1 |
| Gusciglio, M | 1 |
| D'Intino, G | 1 |
| Sivilia, S | 1 |
| Ferraro, L | 1 |
| Calzà, L | 1 |
| Giardino, L | 1 |
| Furuta, S | 1 |
| Shimizu, T | 1 |
| Narita, M | 4 |
| Matsumoto, K | 1 |
| Kuzumaki, N | 1 |
| Horie, S | 1 |
| Suzuki, T | 2 |
| Andreou, AP | 1 |
| Shields, KG | 1 |
| Goadsby, PJ | 1 |
| Cuellar-Herrera, M | 1 |
| Peña, F | 1 |
| Alcantara-Gonzalez, D | 1 |
| Neri-Bazan, L | 1 |
| Rocha, L | 1 |
| Blake, MG | 1 |
| Boccia, MM | 1 |
| Carcaboso, AM | 1 |
| Chiappetta, DA | 1 |
| Höcht, C | 1 |
| Krawczyk, MC | 1 |
| Sosnik, A | 1 |
| Baratti, CM | 1 |
| Buccafusco, JJ | 1 |
| Terry, AV | 1 |
| Vazdarjanova, A | 1 |
| Snutch, TP | 1 |
| Arneric, SP | 1 |
| Quintão, NL | 1 |
| da Silva, GF | 1 |
| Antonialli, CS | 1 |
| Rocha, LW | 1 |
| Cechinel Filho, V | 1 |
| Cicció, JF | 1 |
| Zhou, MT | 1 |
| Sun, JH | 1 |
| Flatters, SJ | 1 |
| Rabchevsky, AG | 1 |
| Patel, SP | 1 |
| Duale, H | 1 |
| Lyttle, TS | 1 |
| O'Dell, CR | 1 |
| Kitzman, PH | 2 |
| Munro, G | 2 |
| Dyhr, H | 2 |
| Grunnet, M | 1 |
| Densmore, VS | 1 |
| Kalous, A | 1 |
| Keast, JR | 1 |
| Osborne, PB | 1 |
| Christianson, CA | 1 |
| Firestein, GS | 1 |
| Mobargha, A | 1 |
| Yamama, Y | 1 |
| Nishikawa, K | 1 |
| Funao, T | 1 |
| Mori, T | 1 |
| Asada, A | 1 |
| Folkesson, A | 1 |
| Honoré, PH | 1 |
| Andersen, LM | 1 |
| Kristensen, P | 1 |
| Bjerrum, OJ | 2 |
| Emmez, H | 1 |
| Börcek, AÖ | 1 |
| Kaymaz, M | 1 |
| Kaymaz, F | 1 |
| Durdağ, E | 1 |
| Civi, S | 1 |
| Gülbahar, O | 1 |
| Aykol, S | 1 |
| Paşaoğlu, A | 1 |
| Yi, H | 1 |
| Kim, MA | 1 |
| Back, SK | 2 |
| Eun, JS | 1 |
| Na, HS | 2 |
| Kusunose, N | 1 |
| Koyanagi, S | 1 |
| Hamamura, K | 1 |
| Matsunaga, N | 1 |
| Yoshida, M | 1 |
| Uchida, T | 1 |
| Tsuda, M | 1 |
| Inoue, K | 1 |
| Ohdo, S | 1 |
| Tsukumo, Y | 1 |
| Matsumoto, Y | 1 |
| Miura, H | 1 |
| Yano, H | 1 |
| Manabe, H | 1 |
| Boroujerdi, A | 2 |
| Zeng, J | 1 |
| Sharp, K | 1 |
| Kim, D | 1 |
| Steward, O | 1 |
| Luo, DZ | 1 |
| Takasaki, I | 4 |
| Chu, LC | 1 |
| Hung, YC | 1 |
| Wang, TY | 1 |
| Van Elstraete, AC | 1 |
| Sitbon, P | 1 |
| Benhamou, D | 1 |
| Mazoit, JX | 1 |
| O' Mahony, SM | 1 |
| Coelho, AM | 1 |
| Fitzgerald, P | 1 |
| Lee, K | 2 |
| Winchester, W | 1 |
| Dinan, TG | 1 |
| Cryan, JF | 1 |
| Cidral-Filho, FJ | 1 |
| da Silva, MD | 1 |
| Moré, AO | 1 |
| Córdova, MM | 1 |
| Werner, MF | 1 |
| Lo, FS | 1 |
| Zhao, S | 1 |
| Erzurumlu, RS | 1 |
| Gunduz, O | 1 |
| Oltulu, C | 1 |
| Guven, R | 1 |
| Buldum, D | 1 |
| Ulugol, A | 1 |
| Filip, D | 1 |
| Florek-Luszczki, M | 1 |
| Ewan, EE | 1 |
| Martin, TJ | 1 |
| Açikmeşe, B | 1 |
| Haznedar, S | 1 |
| Hatipoğlu, I | 1 |
| Enginar, N | 1 |
| Mills, CD | 1 |
| Zhong, C | 1 |
| Mikusa, J | 1 |
| Lewis, LG | 1 |
| Gauvin, D | 1 |
| Lee, CH | 1 |
| Decker, MW | 1 |
| Rueter, LE | 1 |
| Ogawa, K | 1 |
| Takasu, K | 1 |
| Shinohara, S | 1 |
| Yoneda, Y | 1 |
| Kato, A | 1 |
| Storm, A | 1 |
| Hansen, MK | 1 |
| Marcher, L | 1 |
| Erichsen, HK | 1 |
| Sheykhzade, M | 1 |
| Goel, R | 1 |
| Goel, A | 1 |
| Kumar, Y | 1 |
| Miyazaki, R | 1 |
| Yamamoto, T | 1 |
| Morimoto, S | 1 |
| Ito, M | 1 |
| Oda, S | 1 |
| Sugiyama, A | 1 |
| Kuroda, M | 1 |
| Adachi-Akahane, S | 1 |
| Narai, Y | 1 |
| Imamachi, N | 1 |
| Saito, Y | 1 |
| Prelle, K | 1 |
| Igl, BW | 1 |
| Obendorf, M | 1 |
| Girbig, D | 1 |
| Lehmann, T | 1 |
| Patchev, VK | 1 |
| Amin, B | 1 |
| Hosseinzadeh, H | 1 |
| Yang, JL | 1 |
| Xu, B | 1 |
| Li, SS | 1 |
| Zhang, WS | 1 |
| Zhang, YQ | 1 |
| Vidal, V | 1 |
| García, S | 1 |
| Martínez, P | 1 |
| Corrales, A | 1 |
| Flórez, J | 1 |
| Rueda, N | 1 |
| Sharma, A | 1 |
| Martínez-Cué, C | 1 |
| Inceoglu, B | 1 |
| Wagner, KM | 1 |
| Bettaieb, A | 1 |
| Schebb, NH | 1 |
| Hwang, SH | 1 |
| Morisseau, C | 1 |
| Haj, FG | 1 |
| Hammock, BD | 1 |
| Li, H | 1 |
| Graber, KD | 1 |
| McDonald, W | 1 |
| Barres, BA | 1 |
| Aydin, ON | 1 |
| Ek, RO | 1 |
| Temoçin, S | 1 |
| Uğur, B | 1 |
| Alaçam, B | 1 |
| Şen, S | 1 |
| Bas, DB | 1 |
| Su, J | 1 |
| Agalave, NM | 1 |
| Lundberg, J | 1 |
| Codeluppi, S | 1 |
| Baharpoor, A | 1 |
| Nandakumar, KS | 1 |
| Holmdahl, R | 1 |
| Abdel-Salam, OM | 1 |
| Khadrawy, YA | 1 |
| Mohammed, NA | 1 |
| Youness, ER | 1 |
| Zhang, JL | 1 |
| Yang, JP | 1 |
| Zhang, JR | 1 |
| Li, RQ | 1 |
| Jan, JJ | 1 |
| Zhuang, Q | 1 |
| Siebel, AM | 1 |
| Piato, AL | 1 |
| Schaefer, IC | 1 |
| Nery, LR | 1 |
| Bogo, MR | 1 |
| Bonan, CD | 1 |
| Lee, BS | 1 |
| Jun, IG | 1 |
| Kim, SH | 1 |
| Park, JY | 1 |
| Abe, M | 1 |
| Kurihara, T | 1 |
| Han, W | 1 |
| Shinomiya, K | 1 |
| Tanabe, T | 1 |
| Borowicz, KK | 1 |
| Swiader, M | 1 |
| Luszczki, J | 1 |
| Colpaert, FC | 1 |
| Tarayre, JP | 1 |
| Koek, W | 1 |
| Pauwels, PJ | 1 |
| Bardin, L | 1 |
| Cosi, C | 1 |
| Carilla-Durand, E | 1 |
| Assié, MB | 1 |
| Vacher, B | 1 |
| Luo, ZD | 2 |
| Calcutt, NA | 1 |
| Higuera, ES | 1 |
| Valder, CR | 1 |
| Song, YH | 1 |
| Myers, RR | 1 |
| Gilron, I | 1 |
| Biederman, J | 1 |
| Jhamandas, K | 1 |
| Hong, M | 1 |
| Maneuf, YP | 1 |
| Gonzalez, MI | 1 |
| Sutton, KS | 1 |
| Chung, FZ | 1 |
| Pinnock, RD | 1 |
| Gustafsson, H | 1 |
| Flood, K | 1 |
| Berge, OG | 1 |
| Brodin, E | 1 |
| Olgart, L | 1 |
| Stiller, CO | 1 |
| Whiteside, GT | 2 |
| Harrison, J | 1 |
| Boulet, J | 1 |
| Mark, L | 2 |
| Pearson, M | 1 |
| Gottshall, S | 1 |
| Walker, K | 1 |
| Kroin, JS | 1 |
| Buvanendran, A | 1 |
| Nagalla, SK | 1 |
| Tuman, KJ | 1 |
| Brill, J | 1 |
| Klocke, R | 1 |
| Paul, D | 1 |
| Boison, D | 1 |
| Gouder, N | 1 |
| Klugbauer, N | 1 |
| Hofmann, F | 1 |
| Becker, CM | 1 |
| Becker, K | 1 |
| Wu, WP | 1 |
| Hao, JX | 1 |
| Ongini, E | 2 |
| Impagnatiello, F | 1 |
| Presotto, C | 1 |
| Dost, R | 1 |
| Rostock, A | 1 |
| Rundfeldt, C | 1 |
| Kanai, A | 1 |
| Sarantopoulos, C | 1 |
| McCallum, JB | 1 |
| Hogan, Q | 1 |
| Kuraishi, Y | 3 |
| Nojima, H | 2 |
| Shiraki, K | 3 |
| Takahata, H | 3 |
| Williams, AJ | 1 |
| Tortella, FC | 1 |
| Lu, XM | 1 |
| Moreton, JE | 1 |
| Hartings, JA | 1 |
| Iyengar, S | 1 |
| Webster, AA | 1 |
| Hemrick-Luecke, SK | 1 |
| Xu, JY | 1 |
| Ilag, VL | 1 |
| Decosterd, I | 1 |
| Allchorne, A | 1 |
| Woolf, CJ | 1 |
| Rodrigues-Filho, R | 1 |
| Campos, MM | 2 |
| Ferreira, J | 1 |
| Bertelli, JA | 1 |
| Calixto, JB | 2 |
| Zucker, B | 1 |
| Ludin, DE | 1 |
| Gerds, TA | 1 |
| Lücking, CH | 1 |
| Landwehrmeyer, GB | 1 |
| Feuerstein, TJ | 2 |
| Won, SY | 1 |
| Hong, SK | 1 |
| Boileau, C | 1 |
| Martel-Pelletier, J | 1 |
| Brunet, J | 1 |
| Tardif, G | 1 |
| Schrier, D | 1 |
| Flory, C | 1 |
| Boily, M | 1 |
| Pelletier, JP | 1 |
| Urban, MO | 1 |
| Ren, K | 1 |
| Park, KT | 1 |
| Campbell, B | 1 |
| Anker, N | 1 |
| Stearns, B | 1 |
| Aiyar, J | 1 |
| Belley, M | 1 |
| Cohen, C | 1 |
| Bristow, L | 1 |
| Valenzano, KJ | 1 |
| Tafesse, L | 1 |
| Lee, G | 1 |
| Harrison, JE | 1 |
| Boulet, JM | 1 |
| Gottshall, SL | 1 |
| Pearson, MS | 1 |
| Miller, W | 1 |
| Shan, S | 1 |
| Rabadi, L | 1 |
| Rotshteyn, Y | 1 |
| Chaffer, SM | 1 |
| Turchin, PI | 1 |
| Elsemore, DA | 1 |
| Toth, M | 1 |
| Koetzner, L | 1 |
| Yasuda, T | 2 |
| Miki, S | 2 |
| Yoshinaga, N | 2 |
| Senba, E | 1 |
| Walczak, JS | 1 |
| Pichette, V | 1 |
| Leblond, F | 1 |
| Desbiens, K | 1 |
| Beaulieu, P | 1 |
| Andres, MM | 1 |
| Shi, W | 1 |
| Zhong, B | 1 |
| Yang, H | 1 |
| Pedersen, LH | 1 |
| Nielsen, AN | 1 |
| Blackburn-Munro, G | 2 |
| Suzuki, R | 2 |
| Rahman, W | 1 |
| Rygh, LJ | 1 |
| Webber, M | 1 |
| Hunt, SP | 1 |
| Garry, EM | 1 |
| Delaney, A | 1 |
| Anderson, HA | 1 |
| Sirinathsinghji, EC | 1 |
| Clapp, RH | 1 |
| Martin, WJ | 1 |
| Kinchington, PR | 2 |
| Krah, DL | 1 |
| Fleetwood-Walker, SM | 1 |
| Quintão, NLM | 1 |
| Medeiros, R | 1 |
| Santos, ARS | 1 |
| Colbry, NL | 1 |
| Zhu, Z | 1 |
| Nichelson, B | 1 |
| Barta, NS | 1 |
| Lin, K | 1 |
| Hudack, RA | 1 |
| Gibbons, SE | 1 |
| Galatsis, P | 1 |
| DeOrazio, RJ | 1 |
| Manning, DD | 1 |
| Dickerson, MR | 1 |
| Thorpe, AJ | 1 |
| Donevan, SD | 1 |
| Bove, SE | 1 |
| Laemont, KD | 1 |
| Brooker, RM | 1 |
| Osborn, MN | 1 |
| Sanchez, BM | 1 |
| Guzman, RE | 1 |
| Hook, KE | 1 |
| Juneau, PL | 1 |
| Connor, JR | 1 |
| Kilgore, KS | 1 |
| Picazo, A | 1 |
| Castañeda-Hernández, G | 1 |
| Ortiz, MI | 1 |
| Meymandi, MS | 2 |
| Sepehri, G | 2 |
| Mobasher, M | 1 |
| Xiao, W | 1 |
| Bennett, GJ | 1 |
| Angelotti, T | 1 |
| Fauman, E | 1 |
| Hasnie, FS | 1 |
| Breuer, J | 1 |
| Parker, S | 1 |
| Wallace, V | 1 |
| Blackbeard, J | 1 |
| Lever, I | 1 |
| Rice, AS | 1 |
| Coderre, TJ | 1 |
| Kumar, N | 1 |
| Lefebvre, CD | 1 |
| Yu, JS | 1 |
| Miura, Y | 1 |
| DeGoes, S | 1 |
| Curry, R | 1 |
| Oommen, J | 1 |
| Kraus, AC | 1 |
| Fisher, RS | 1 |
| Rode, F | 1 |
| Thomsen, M | 1 |
| Broløs, T | 1 |
| Jensen, DG | 1 |
| Nakajima, M | 1 |
| Miyoshi, K | 1 |
| Nagumo, Y | 1 |
| Miyatake, M | 1 |
| Yajima, Y | 1 |
| Yanagida, K | 1 |
| Yamazaki, M | 1 |
| Gil, DW | 1 |
| Cheevers, CV | 1 |
| Donello, JE | 1 |
| Uhl, TL | 1 |
| Dwyer, MK | 1 |
| Hota, D | 1 |
| Bansal, V | 1 |
| Pattanaik, S | 1 |
| Governo, RJ | 1 |
| Morris, PG | 1 |
| Marsden, CA | 1 |
| Chapman, V | 1 |
| Sasaki, A | 1 |
| Andoh, T | 2 |
| Takeshima, H | 1 |
| Rudick, CN | 1 |
| Schaeffer, AJ | 1 |
| Thumbikat, P | 1 |
| Benbouzid, M | 1 |
| Choucair-Jaafar, N | 1 |
| Yalcin, I | 1 |
| Waltisperger, E | 1 |
| Muller, A | 1 |
| Freund-Mercier, MJ | 1 |
| Barrot, M | 1 |
| Traa, BS | 1 |
| Mulholland, JD | 1 |
| Kadam, SD | 1 |
| Johnston, MV | 1 |
| Comi, AM | 1 |
| Stepanovic-Petrovic, RM | 1 |
| Tomic, MA | 1 |
| Vuckovic, SM | 1 |
| Paranos, S | 1 |
| Ugresic, ND | 1 |
| Prostran, MS | 1 |
| Milovanovic, S | 1 |
| Boskovic, B | 1 |
| Kanthasamy, AG | 1 |
| Vu, TQ | 1 |
| Yun, RJ | 1 |
| Truong, DD | 1 |
| McLean, MJ | 1 |
| Hosford, DA | 1 |
| Hunter, JC | 1 |
| Gogas, KR | 1 |
| Hedley, LR | 1 |
| Jacobson, LO | 1 |
| Kassotakis, L | 1 |
| Thompson, J | 1 |
| Fontana, DJ | 1 |
| Dalby, NO | 1 |
| Nielsen, EB | 1 |
| Holmes, GL | 1 |
| Lücke, A | 1 |
| Musshoff, U | 1 |
| Köhling, R | 1 |
| Osterfeld, M | 1 |
| Mayer, T | 1 |
| Wolf, P | 1 |
| Schütte, W | 1 |
| Speckmann, EJ | 1 |
| Richter, A | 1 |
| Löscher, W | 1 |
| Yoon, MH | 1 |
| Maj, R | 1 |
| Fariello, RG | 1 |
| Pevarello, P | 1 |
| Varasi, M | 1 |
| McArthur, RA | 1 |
| Salvati, P | 1 |
| LaBuda, CJ | 1 |
| Fuchs, PN | 1 |
| Hughes, J | 1 |
| Singh, L | 1 |
| Nitta, M | 1 |
| Nemoto, H | 1 |
| Jehle, T | 1 |
| Lagrèze, WA | 1 |
| Briscini, L | 1 |
| Bertorelli, R | 1 |
| Christensen, D | 1 |
| Gautron, M | 1 |
| Guilbaud, G | 1 |
| Kayser, V | 1 |
| Lado, FA | 1 |
| Sperber, EF | 1 |
| Moshé, SL | 1 |
| Bauer, CA | 1 |
| Brozoski, TJ | 1 |
| Iwamoto, T | 1 |
| Sato, S | 1 |
| Dufour, F | 1 |
| Nalecz, KA | 1 |
| Nalecz, MJ | 1 |
| Nehlig, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903] | Phase 4 | 77 participants (Actual) | Interventional | 2018-05-15 | Completed | ||
| Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia[NCT02024568] | Phase 2 | 38 participants (Anticipated) | Interventional | 2013-12-31 | Not yet recruiting | ||
| Comparison of Oral Lamotrigine Versus Pregabalin for Control of Acute and Chronic Pain Following Modified Radical Mastectomy: Controlled Double-blind Study[NCT03419949] | 0 participants | Expanded Access | Available | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)
| Intervention | score on 10-point scale (Mean) |
|---|---|
| Standard of Care | 2.26 |
| Postoperative Gabapentin Regimen | 2.46 |
Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 3.84 |
| Postoperative Gabapentin Regimen | 3.54 |
Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 5.73 |
| Postoperative Gabapentin Regimen | 6.38 |
Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 0.36 |
| Postoperative Gabapentin Regimen | 0.17 |
Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 7.83 |
| Postoperative Gabapentin Regimen | 8.48 |
Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | days (Mean) |
|---|---|
| Standard of Care | 14.8 |
| Postoperative Gabapentin Regimen | 18.7 |
Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).
| Intervention | morphine equivalents (Mean) |
|---|---|
| Standard of Care | 287.0 |
| Postoperative Gabapentin Regimen | 281.1 |
10 reviews available for gabapentin and Disease Models, Animal
| Article | Year |
|---|---|
Systematic review and meta-analysis of studies in which burrowing behaviour was assessed in rodent models of disease-associated persistent pain.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Disease M | 2022 |
Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P | 2019 |
Analgesic mechanisms of gabapentinoids and effects in experimental pain models: a narrative review.
Topics: Analgesics; Animals; Calcium Channels; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; | 2018 |
Chemotherapy-induced painful neuropathy: pain-like behaviours in rodent models and their response to commonly used analgesics.
Topics: Amines; Analgesics, Opioid; Animals; Antidepressive Agents; Antineoplastic Agents; Cisplatin; Cycloh | 2016 |
[Development of animal models of herpetic pain and postherpetic neuralgia and elucidation of the mechanisms of the onset and inhibition of allodynia].
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Cyclooxygenase Inhibitors | 2011 |
Cellular and molecular action of the putative GABA-mimetic, gabapentin.
Topics: Acetates; Amines; Analgesics; Animals; Anticonvulsants; Anxiety; Brain; Cyclohexanecarboxylic Acids; | 2003 |
Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery.
Topics: Amines; Amino Acid Sequence; Animals; Anticonvulsants; Calcium Channels; Cyclohexanecarboxylic Acids | 2007 |
[A new aspect in the research on antiepileptic drugs].
Topics: Acetamides; Amines; Animals; Anticonvulsants; Benzodiazepines; Carbamates; Cyclohexanecarboxylic Aci | 2007 |
Gabapentin.
Topics: Acetates; Adult; Amines; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Cyclohexanecarbo | 1995 |
Gabapentin for treatment of epilepsy in children.
Topics: Acetates; Adolescent; Adult; Amines; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Cycl | 1997 |
1 trial available for gabapentin and Disease Models, Animal
| Article | Year |
|---|---|
Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery.
Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Analgesics, Opioid; Animals; Bee Venoms; Behavior, | 2007 |
267 other studies available for gabapentin and Disease Models, Animal
| Article | Year |
|---|---|
Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury.
Topics: Amines; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Cyclohexanols; Disease Models, Animal | 2004 |
Carboxylate bioisosteres of gabapentin.
Topics: Amines; Animals; Anticonvulsants; Carboxylic Acids; Cyclohexanecarboxylic Acids; Disease Models, Ani | 2006 |
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Imidazoles; Neuralgia; Pain Threshold; Pyrroles; | 2008 |
Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.
Topics: Amines; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Histamine Antagonists; Ligands; M | 2008 |
Synthesis and in vivo evaluation of 3,4-disubstituted gababutins.
Topics: Amines; Amino Acids; Animals; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Cyclopentanes; Disea | 2010 |
Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Discovery; Female; Furans; Humans; Hydrazones; Hyp | 2011 |
Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Drug Design; Dr | 2011 |
Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent.
Topics: Animals; Disease Models, Animal; Drug Design; Female; Fluorescence; Fluorescent Dyes; Models, Molecu | 2012 |
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.
Topics: Animals; Benzazepines; Disease Models, Animal; Neuralgia; Rats; Sodium Channel Blockers | 2013 |
Gabapentin hybrid peptides and bioconjugates.
Topics: Acylation; Amines; Analgesics; Animals; Behavior, Animal; Crystallography, X-Ray; Cyclization; Cyclo | 2014 |
Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: a potential treatment for neuropathic pain.
Topics: Administration, Oral; Analgesics; Animals; Disease Models, Animal; Isoxazoles; Neuralgia; Protein Bi | 2015 |
Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain.
Topics: Administration, Oral; Analgesics; Animals; Cells, Cultured; Disease Models, Animal; Drug Discovery; | 2015 |
Antinociceptive Grayanoids from the Roots of Rhododendron molle.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Diterpenes; Drugs, | 2015 |
Synthesis and evaluation of 6-pyrazoylamido-3N-substituted azabicyclo[3,1,0]hexane derivatives as T-type calcium channel inhibitors for treatment of neuropathic pain.
Topics: Administration, Oral; Animals; Azabicyclo Compounds; Calcium Channel Blockers; Calcium Channels, T-T | 2016 |
Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Diabetic Neuropathies; Disease Models, | 2017 |
Neuropathic pain-alleviating effects of pyrazole-conjugated arylsulfonamides as 5-HT
Topics: Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2017 |
Discovery of non-zwitterionic aryl sulfonamides as Na
Topics: Administration, Oral; Animals; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Dru | 2017 |
Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model.
Topics: Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Calcium Signaling; Disease | 2019 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Discovery of Potent, Selective, and State-Dependent Na
Topics: Animals; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Disease Models, Animal; Drug Des | 2020 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Alkyne-Bridged α-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models.
Topics: Alkynes; Analgesics; Animals; Cells, Cultured; Conotoxins; Conus Snail; Disease Models, Animal; Fema | 2021 |
Concomitant Antihyperalgesic and Antitumor Effects of Gabapentin in a Murine Cancer Pain Model.
Topics: Analgesics; Animals; Antineoplastic Agents; Cancer Pain; Cell Line, Tumor; Disease Models, Animal; D | 2021 |
Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Chronic Pain; Disease Models, Animal; Dose-Res | 2022 |
Heme oxygenase-1 in the spinal cord plays crucial roles in the analgesic effects of pregabalin and gabapentin in a spared nerve-injury mouse model.
Topics: Analgesics; Animals; Disease Models, Animal; Gabapentin; Heme Oxygenase-1; Male; Mice; Mice, Inbred | 2022 |
Asprosin, a novel therapeutic candidate for painful neuropathy: an experimental study in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Fibrillin-1; Gabapentin; Hyperalgesia; Male; Mice; Mice | 2022 |
Gabapentin inhibits the analgesic effects and nerve regeneration process induced by hepatocyte growth factor (HGF) in a peripheral nerve injury model: Implication for the use of VM202 and gabapentinoids for peripheral neuropathy.
Topics: Analgesics; Animals; Axons; Disease Models, Animal; DNA; Gabapentin; Genetic Therapy; Hepatocyte Gro | 2022 |
Efficacy of 2-Hydroxyflavanone in Rodent Models of Pain and Inflammation: Involvement of Opioidergic and GABAergic Anti-Nociceptive Mechanisms.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cisplatin; Disease Models, Animal; Edema; Flavanones; | 2022 |
Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Ascorbic Acid; Behavior, Animal; Cogni | 2023 |
Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury.
Topics: Animals; Axons; Disease Models, Animal; Female; Gabapentin; Male; Mice; Mice, Transgenic; Nerve Rege | 2020 |
Combined therapy of gabapentin with pantoprazole exhibited better protective action against forestomach and pylorus ligation-induced gastric esophageal reflux disease in albino Wistar rats.
Topics: Afferent Pathways; Animals; Disease Models, Animal; Drug Therapy, Combination; Gabapentin; Gastric E | 2020 |
Polygonogram and isobolographic analysis of interactions between various novel antiepileptic drugs in the 6-Hz corneal stimulation-induced seizure model in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Electro | 2020 |
Dorsal horn disinhibition and movement-induced behaviour in a rat model of inflammatory arthritis.
Topics: Adjuvants, Immunologic; Analgesics; Animals; Arthralgia; Arthritis; Behavior, Animal; Disease Models | 2021 |
Synergistic interaction between haloperidol and gabapentin in a model of neuropathic nociception in rat.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug | 2021 |
Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cardiotox | 2021 |
Involvement of selective GABA-A receptor subtypes in amelioration of cisplatin-induced neuropathic pain by 2'-chloro-6-methyl flavone (2'-Cl-6MF).
Topics: Analgesics; Animals; Antineoplastic Agents; Benzodiazepines; Cisplatin; Disease Models, Animal; Dose | 2021 |
Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation.
Topics: Analgesics; Animals; Disease Models, Animal; Endocannabinoids; Gabapentin; Hyperalgesia; Male; Mice; | 2020 |
Gabapentin reduces painful bladder hypersensitivity in rats with lipopolysaccharide-induced chronic cystitis.
Topics: Analgesics; Animals; Cystitis; Cystitis, Interstitial; Disease Models, Animal; Female; Gabapentin; L | 2021 |
Synergistic interaction between trazodone and gabapentin in rodent models of neuropathic pain.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Depressive Disorder, Major; Disease Models, Animal; Drug S | 2021 |
A novel gabapentin analogue assuages neuropathic pain response in chronic sciatic nerve constriction model in rats.
Topics: Analgesics; Animals; Behavior, Animal; Chronic Disease; Constriction; Disease Models, Animal; Excita | 2021 |
Chemotherapeutic Agent-Induced Vulvodynia, an Experimental Model.
Topics: Analgesics; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Disease Models, Anima | 2021 |
Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia.
Topics: Aldehydes; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Carrageenan; Disease Models, | 2021 |
[
Topics: Amines; Animals; Autoradiography; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-R | 2017 |
Levetiracetam synergizes with gabapentin, pregabalin, duloxetine and selected antioxidants in a mouse diabetic painful neuropathy model.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Antioxidants; Cyclohexanecarboxylic Acids; Diabetes Me | 2017 |
Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.
Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dizocilpine | 2017 |
Murine model and mechanisms of treatment-induced painful diabetic neuropathy.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Disease Models, Animal; Enzyme | 2017 |
Risk to heroin users of polydrug use of pregabalin or gabapentin.
Topics: Adult; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Intera | 2017 |
Effect of Gabapentin/Memantine on the Infantile Nystagmus Syndrome in the Zebrafish Model: Implications for the Therapy of Ocular Motor Diseases.
Topics: Amines; Animals; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Disease Models, Animal; Exci | 2017 |
Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice.
Topics: Amines; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin | 2017 |
Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Follow-Up Studies; | 2017 |
Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI.
Topics: Amines; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Amino | 2018 |
Gabapentin prevents cortical spreading depolarization-induced disinhibition.
Topics: Action Potentials; Amines; Animals; Cortical Spreading Depression; Cyclohexanecarboxylic Acids; Dise | 2017 |
Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric | 2017 |
Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma- | 2018 |
Gabapentin regulates expression of FGF2 and FGFR1 in dorsal root ganglia via microRNA-15a in the arthritis rat model.
Topics: Amines; Animals; Arthritis, Experimental; Cyclohexanecarboxylic Acids; Disease Models, Animal; Fibro | 2017 |
The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia.
Topics: Amines; Analgesics; Animals; Antineoplastic Agents; Behavior, Animal; Cisplatin; Cyclohexanecarboxyl | 2017 |
The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice.
Topics: Amines; Analgesics; Animals; Benzodioxoles; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dos | 2017 |
Gabapentin Prevents Progressive Increases in Excitatory Connectivity and Epileptogenesis Following Neocortical Trauma.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain Mapping; Disease Models, Animal; Electric Stimulat | 2018 |
Pharmacological validation of voluntary gait and mechanical sensitivity assays associated with inflammatory and neuropathic pain in mice.
Topics: Analgesics; Animals; Buprenorphine; Carbazoles; Disease Models, Animal; Female; Freund's Adjuvant; G | 2018 |
Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain.
Topics: Amines; Analgesics; Animals; Antineoplastic Agents; Blood Pressure; Cyclohexanecarboxylic Acids; Dis | 2018 |
Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; D | 2018 |
Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain.
Topics: Activating Transcription Factor 3; Amines; Animals; Animals, Newborn; Astrocytes; Cyclohexanecarboxy | 2018 |
Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analgesics; Analgesics, Opioid; Animals; Arthralg | 2019 |
THC and gabapentin interactions in a mouse neuropathic pain model.
Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Dro | 2019 |
Interleukin-1beta in synergism gabapentin with tramadol in murine model of diabetic neuropathy.
Topics: Analgesics; Animals; Diabetic Neuropathies; Disease Models, Animal; Drug Synergism; Drug Therapy, Co | 2019 |
Investigations of urethral sphincter activity in mice with bladder hyperalgesia before and after drug administration of gabapentin.
Topics: Analgesics; Animals; Cystitis; Disease Models, Animal; Electromyography; Gabapentin; Hyperalgesia; M | 2019 |
Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Androgens; Androsterone; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2019 |
Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors.
Topics: 8,11,14-Eicosatrienoic Acid; Analgesics; Animals; Cerebral Hemorrhage; Disease Models, Animal; Gabap | 2019 |
Noninvasive Mechanical Joint Loading as an Alternative Model for Osteoarthritic Pain.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Behavior, Animal; Cartilag | 2019 |
High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites.
Topics: Analgesics; Animals; Arginase; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Chemokine CCL2; Disease M | 2019 |
Gabapentin Attenuates Oxidative Stress and Apoptosis in the Diabetic Rat Retina.
Topics: Amino Acids; Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Mode | 2019 |
Effects of subthalamic deep brain stimulation with gabapentin and morphine on mechanical and thermal thresholds in 6-hydroxydopamine lesioned rats.
Topics: Animals; Chronic Pain; Deep Brain Stimulation; Disease Models, Animal; Gabapentin; Male; Morphine; O | 2019 |
Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; Gabapentin; Male; Mice; Mice, Inbred C5 | 2019 |
Attenuation of vincristine-induced neuropathy by synthetic cyclohexenone-functionalized derivative in mice model.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Behavior, Animal; Disease Mode | 2019 |
Gabapentin alleviates chronic spontaneous pain and acute hypoxia-related pain in a mouse model of sickle cell disease.
Topics: Acute Disease; Anemia, Sickle Cell; Animals; Calcium Channels, L-Type; Chronic Pain; Disease Models, | 2019 |
Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies.
Topics: Animals; Anticonvulsants; Brain; Cannabidiol; Chromatography, High Pressure Liquid; Disease Models, | 2019 |
Oral gabapentin suppresses pentylenetetrazole-induced seizure-like behavior and cephalic field potential in adult zebrafish.
Topics: Action Potentials; Administration, Oral; Amines; Analysis of Variance; Animals; Anticonvulsants; Bra | 2013 |
Gabapentin-induced pharmacodynamic effects in the spinal nerve ligation model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2014 |
Effects of gabapentin on thermal sensitivity following spinal nerve ligation or spinal cord compression.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Cyclohexanecarboxylic Acids; D | 2013 |
Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats.
Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Animals; Cranial Nerve Injuries; Cyclohexanecarbox | 2014 |
Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms.
Topics: Amines; Amino Acid Transport System X-AG; Animals; Astrocytes; Cyclohexanecarboxylic Acids; Disease | 2014 |
Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Gabapentin; gamma-Amin | 2015 |
A method to enhance the magnitude of tactile hypersensitivity following spinal nerve ligation in rats.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma- | 2014 |
Validation and additional support for an experimental animal model of fibromyalgia.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Dinoprostone; Disease Models, Animal; Female; Fibromya | 2015 |
Albumin nanoparticles for the delivery of gabapentin: preparation, characterization and pharmacodynamic studies.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug C | 2014 |
Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation.
Topics: Age Factors; Amines; Animals; Animals, Newborn; Anticonvulsants; Calcium Channels; Cyclohexanecarbox | 2014 |
Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Epilepsy; Female; Gabapentin; | 2014 |
Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat.
Topics: Amines; Animals; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapenti | 2015 |
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxyli | 2014 |
Gabapentin reverses central hypersensitivity and suppresses medial prefrontal cortical glucose metabolism in rats with neuropathic pain.
Topics: Amines; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Fluorodeoxyglucose F18; | 2014 |
Anesthesia influences neuronal activity and drug effectiveness in neuropathic rats.
Topics: Action Potentials; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2014 |
Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma- | 2014 |
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.
Topics: Amidohydrolases; Amines; Analgesics; Animals; Benzamides; Carbamates; Cyclohexanecarboxylic Acids; D | 2015 |
In vivo two-photon imaging of structural dynamics in the spinal dorsal horn in an inflammatory pain model.
Topics: Acute Disease; Amines; Animals; Calcium Channel Blockers; Calcium Channels; Cyclohexanecarboxylic Ac | 2015 |
Differences in cisplatin-induced mechanical allodynia in male and female mice.
Topics: Amines; Analgesics; Animals; Antineoplastic Agents; Cisplatin; Cyclohexanecarboxylic Acids; Disease | 2015 |
Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats.
Topics: Adjuvants, Immunologic; Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxy | 2015 |
The excitatory synaptic transmission of the nucleus of solitary tract was potentiated by chronic myocardial infarction in rats.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Excitatory Postsyn | 2015 |
Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in rats.
Topics: Amines; Animals; Axotomy; Cyclohexanecarboxylic Acids; Disease Models, Animal; Excitatory Amino Acid | 2015 |
Spontaneous Chronic Pain After Experimental Thoracotomy Revealed by Conditioned Place Preference: Morphine Differentiates Tactile Evoked Pain From Spontaneous Pain.
Topics: Amines; Analgesics; Analysis of Variance; Animals; Conditioning, Operant; Cyclohexanecarboxylic Acid | 2015 |
A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin.
Topics: Administration, Topical; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetes Mellitus | 2015 |
Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain.
Topics: Administration, Oral; Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapent | 2015 |
Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats.
Topics: Amines; Analgesics; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Disease Models, Animal; G | 2009 |
Gabapentin, an Analgesic Used Against Cancer-Associated Neuropathic Pain: Effects on Prostate Cancer Progression in an In Vivo Rat Model.
Topics: Amines; Analgesics; Animals; Carcinogenesis; Cells, Cultured; Cyclohexanecarboxylic Acids; Disease M | 2016 |
Peripheral Neuritis Trauma in Pigs: A Neuropathic Pain Model.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Re | 2016 |
Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor.
Topics: Amines; Analgesics; Animals; Caffeine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapent | 2015 |
Gabapentin Effects on PKC-ERK1/2 Signaling in the Spinal Cord of Rats with Formalin-Induced Visceral Inflammatory Pain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amines; Animals; Behavior, Animal; Cell Membrane; Cyc | 2015 |
The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation.
Topics: Amines; Analgesics; Animals; Arthritis; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapen | 2016 |
Co-administration of morphine and gabapentin leads to dose dependent synergistic effects in a rat model of postoperative pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Rela | 2016 |
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; D | 2016 |
Involvement of NO/cGMP pathway in the antidepressant-like effect of gabapentin in mouse forced swimming test.
Topics: Amines; Animals; Antidepressive Agents; Behavior, Animal; Cyclic GMP; Cyclohexanecarboxylic Acids; D | 2016 |
Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α(2)δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity.
Topics: Amines; Analgesics; Animals; Blotting, Western; Calcium Channels; Cyclohexanecarboxylic Acids; Disea | 2016 |
Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury.
Topics: Amines; Animals; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Carbenoxolone; Connexin | 2016 |
Antinociceptive Interaction of Tramadol with Gabapentin in Experimental Mononeuropathic Pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Rela | 2016 |
Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain.
Topics: Amines; Animals; Chronic Pain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Freund's Adjuvan | 2016 |
Antinociceptive Interactions Between Meloxicam and Gabapentin in Neuropathic Pain Depend on the Ratio used in Combination in Rats.
Topics: Amines; Analgesics; Animals; Area Under Curve; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2016 |
Gabapentin prevents behavioral changes on the amphetamine-induced animal model of schizophrenia.
Topics: Amines; Amphetamine; Animals; Behavior, Animal; Calcium Channel Blockers; Cyclohexanecarboxylic Acid | 2016 |
Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization.
Topics: Activating Transcription Factor 3; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease | 2016 |
The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2016 |
Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.
Topics: Amines; Analgesics; Animals; Antihypertensive Agents; Atropine; Bronchodilator Agents; Clonidine; CR | 2016 |
Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain.
Topics: Amines; Animals; Behavior, Animal; Cathepsins; Cyclohexanecarboxylic Acids; Dipeptides; Disease Mode | 2016 |
FUS-linked essential tremor associated with motor dysfunction in Drosophila.
Topics: Amines; Animals; Animals, Genetically Modified; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2016 |
Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amines; Animals; Behavior, Animal; Carbamazepine; Cognition; C | 2016 |
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
Topics: Amines; Amitriptyline; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; Gai | 2016 |
Comparative effects of α2δ-1 ligands in mouse models of colonic hypersensitivity.
Topics: Amines; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Dextran Sulfate; Disease Models, Ani | 2016 |
A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy.
Topics: Amines; Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Cyclohexanec | 2017 |
Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model.
Topics: Administration, Topical; Amines; Analgesics; Animals; Constriction, Pathologic; Cyclohexanecarboxyli | 2017 |
sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain.
Topics: Amides; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin | 2017 |
A codon-optimized Mecp2 transgene corrects breathing deficits and improves survival in a mouse model of Rett syndrome.
Topics: Amines; Animals; Apnea; Codon; Cyclohexanecarboxylic Acids; Dependovirus; Disease Models, Animal; Di | 2017 |
Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence.
Topics: Acetamides; Adrenergic alpha-2 Receptor Antagonists; Amines; Animals; Antineoplastic Agents; Constri | 2017 |
An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Functional Lateral | 2017 |
Cellular and behavioral interactions of gabapentin with alcohol dependence.
Topics: Alcoholism; Amines; Amygdala; Animals; Behavior, Animal; Central Nervous System Depressants; Cyclohe | 2008 |
Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin.
Topics: Amines; Analgesics; Animals; Anxiety; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapenti | 2008 |
Antinociceptive action of GLYX-13: an N-methyl-D-aspartate receptor glycine site partial agonist.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2008 |
Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclohexanecarboxylic Acids; Disease Mode | 2008 |
Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia.
Topics: Amines; Analgesia; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Ad | 2008 |
Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug I | 2009 |
Protective effects of gabapentin on allodynia and alpha 2 delta 1-subunit of voltage-dependent calcium channel in spinal nerve-ligated rats.
Topics: Amines; Analgesics; Animals; Calcium Channels; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids | 2009 |
Effect of gabapentin on cognitive processes in rats not exposed and exposed to tobacco smoke during fetal life.
Topics: Amines; Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Cognition; Cyclohexanecar | 2008 |
Intrathecal gabapentin does not act as a hyperpolarization-activated cyclic nucleotide-gated channel activator in the rat formalin test.
Topics: Amines; Analgesics; Animals; Cardiotonic Agents; Cyclic Nucleotide-Gated Cation Channels; Cyclohexan | 2009 |
Blood serum profiling of the rat spinal nerve ligation model using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.
Topics: Amines; Analgesics; Animals; Biomarkers; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic | 2009 |
Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Cyclopentanes; Diabetes Mellitus, Experime | 2009 |
Antinociceptive effects of NCX-701 (nitro-paracetamol) in neuropathic rats: enhancement of antinociception by co-administration with gabapentin.
Topics: Acetaminophen; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dos | 2009 |
Gabapentin treatment improves motor coordination in a mice model of progressive ataxia.
Topics: Age Factors; Amines; Analysis of Variance; Animals; Ataxia; Atrophy; Cell Count; Cerebellum; Chromat | 2009 |
Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats.
Topics: Amines; Amitriptyline; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Diaphragm; Disease | 2009 |
GABA and valproate modulate trigeminovascular nociceptive transmission in the thalamus.
Topics: Amines; Animals; Anticonvulsants; Cerebral Arteries; Cyclohexanecarboxylic Acids; Disease Models, An | 2010 |
Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electric Stim | 2010 |
Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice.
Topics: Amines; Animals; Anticonvulsants; Cognition Disorders; Cyclohexanecarboxylic Acids; Disease Models, | 2010 |
Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: effects of amitriptyline and gabapentin.
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Animals; Cyclohexanecarboxylic Acids; D | 2010 |
Chemical composition and evaluation of the anti-hypernociceptive effect of the essential oil extracted from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Bicyclic Monoterpenes; Carr | 2010 |
Analgesic effects of gabapentin on mechanical hypersensitivity in a rat model of chronic pancreatitis.
Topics: Amines; Analgesics; Animals; Calcium Channels; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids | 2010 |
Effect of analgesic standards on persistent postoperative pain evoked by skin/muscle incision and retraction (SMIR).
Topics: Amines; Analgesics; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Dermatologic Surgical Pro | 2010 |
Gabapentin for spasticity and autonomic dysreflexia after severe spinal cord injury.
Topics: Amines; Animals; Autonomic Dysreflexia; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; | 2011 |
Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594.
Topics: Amines; Analgesics; Animals; Azetidines; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-R | 2010 |
A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury.
Topics: Acetylcholine; Amines; Analgesics; Animals; Carbazoles; Choline O-Acetyltransferase; Clonidine; Cycl | 2011 |
Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin.
Topics: Amines; Amitriptyline; Analgesics; Animals; Cell Count; Cross-Over Studies; Cyclohexanecarboxylic Ac | 2010 |
Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis.
Topics: Activating Transcription Factor 3; Amines; Analgesics; Analysis of Variance; Animals; Arthritis, Rhe | 2010 |
Intrathecal gabapentin and clonidine synergistically inhibit allodynia in spinal nerve-ligated rats.
Topics: Amines; Animals; Clonidine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relat | 2010 |
Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies.
Topics: Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic Acids; Disease Models, | 2010 |
Neuroprotective effects of gabapentin in experimental spinal cord injury.
Topics: Amines; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids; Di | 2010 |
A novel rat forelimb model of neuropathic pain produced by partial injury of the median and ulnar nerves.
Topics: Amines; Analgesics; Animals; Behavior, Animal; CD11b Antigen; Cold Temperature; Cyclohexanecarboxyli | 2011 |
Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain.
Topics: Amines; Animals; Calcium Channels; Circadian Rhythm; Cyclohexanecarboxylic Acids; Disease Models, An | 2010 |
Gabapentin and pregabalin inhibit the itch-associated response induced by the repeated application of oxazolone in mice.
Topics: Amines; Animals; Calcium Channels; Chronic Disease; Cyclohexanecarboxylic Acids; Disease Models, Ani | 2011 |
Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states.
Topics: Amines; Analgesics; Animals; Calcium Channels; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids | 2011 |
Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Cauda Equina; Cyclohexanecarboxylic Acids; Disease Models | 2011 |
The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction.
Topics: Amines; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Cyclohexanecarboxylic Acids; | 2011 |
The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity.
Topics: Amines; Animals; Anxiety; Comorbidity; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; | 2011 |
Manual acupuncture inhibits mechanical hypersensitivity induced by spinal nerve ligation in rats.
Topics: Acupuncture Points; Acupuncture Therapy; Amines; Analgesics; Analysis of Variance; Animals; Cyclohex | 2011 |
Astrocytes promote peripheral nerve injury-induced reactive synaptogenesis in the neonatal CNS.
Topics: Age Factors; Aldehyde Dehydrogenase 1 Family; Amines; Animals; Animals, Newborn; Astrocytes; Biophys | 2011 |
Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats.
Topics: Amines; Amitriptyline; Analgesics; Animals; Benzoxazines; Chronic Disease; Constriction; Cyclohexane | 2011 |
Interactions of pregabalin with gabapentin, levetiracetam, tiagabine and vigabatrin in the mouse maximal electroshock-induced seizure model: a type II isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Avoidance Learning; Confidence Intervals; Cyclohexanecarboxylic Ac | 2012 |
Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids.
Topics: Adenosine; Amines; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Cyclohexanecarboxylic | 2011 |
Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats.
Topics: Amines; Animals; Anti-Anxiety Agents; Anxiety; Cyclohexanecarboxylic Acids; Diazepam; Disease Models | 2012 |
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Anima | 2012 |
Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs.
Topics: Amines; Analgesics; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2012 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxet | 2012 |
Influence of carvedilol on anticonvulsant effect of gabapentin.
Topics: Amines; Analysis of Variance; Animals; Anticonvulsants; Brain; Carbazoles; Carvedilol; Convulsants; | 2011 |
The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model.
Topics: Administration, Oral; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cyclohexanecarb | 2012 |
Spinal mechanism underlying the antiallodynic effect of gabapentin studied in the mouse spinal nerve ligation model.
Topics: Amines; Analgesics; Animals; Calcium Channels; CD11b Antigen; Cyclohexanecarboxylic Acids; Disease M | 2012 |
Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarbo | 2012 |
Endpoints of drug discovery for menopausal vasomotor symptoms: interpretation of data from a proxy of disease.
Topics: Acetamides; Amines; Animals; Body Temperature Regulation; Cyclohexanecarboxylic Acids; Cyclohexanols | 2012 |
Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats.
Topics: Acetone; Amines; Analgesics; Animals; Behavior, Animal; Carotenoids; Constriction; Crocus; Cyclohexa | 2012 |
Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats.
Topics: Amines; Animals; Arthritis; Calcium Channels, L-Type; Chemokine CX3CL1; CX3C Chemokine Receptor 1; C | 2012 |
Sildenafil influences the anticonvulsant activity of vigabatrin and gabapentin in the timed pentylenetetrazole infusion test in mice.
Topics: Amines; Animals; Anticonvulsants; Avoidance Learning; Cyclohexanecarboxylic Acids; Disease Models, A | 2012 |
Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Cognition; Cyclohexanecarboxylic Acids; Disease | 2012 |
Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes.
Topics: Amines; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Dia | 2012 |
Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma.
Topics: Amines; Animals; Anticonvulsants; Blotting, Western; Brain Injuries; Cyclohexanecarboxylic Acids; Di | 2012 |
The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain.
Topics: Acute Pain; Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Mo | 2012 |
Collagen antibody-induced arthritis evokes persistent pain with spinal glial involvement and transient prostaglandin dependency.
Topics: Amines; Analgesics; Animals; Arthralgia; Arthritis, Experimental; Buprenorphine; Cyclohexanecarboxyl | 2012 |
The effect of gabapentin on oxidative stress in a model of toxic demyelination in rat brain.
Topics: Amines; Animals; Antioxidants; Cerebral Cortex; Cyclohexanecarboxylic Acids; Demyelinating Diseases; | 2012 |
Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Disease Models, Ani | 2013 |
Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Amines; Animals; Anticonvulsants; Brain; Cycloh | 2013 |
Intrathecal gabapentin increases interleukin-10 expression and inhibits pro-inflammatory cytokine in a rat model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Cyclohexanecarboxylic Acids; Cytokines; D | 2013 |
Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Calcium Channels; Cyclohexanecarboxylic Aci | 2002 |
Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis.
Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease M | 2002 |
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell | 2002 |
Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin.
Topics: Acetates; Amines; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Dis | 2002 |
Gabapentin blocks and reverses antinociceptive morphine tolerance in the rat paw-pressure and tail-flick tests.
Topics: Acetates; Amines; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2003 |
Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models | 2003 |
Pharmacological characterisation of a rat model of incisional pain.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Disease Model | 2004 |
Postoperative pain and analgesic responses are similar in male and female Sprague-Dawley rats.
Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Cholinesterase Inhibito | 2003 |
entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse.
Topics: Acetates; Alleles; Amines; Animals; Ataxia; Base Sequence; Blotting, Southern; Blotting, Western; Ca | 2004 |
A nitric oxide (NO)-releasing derivative of gabapentin, NCX 8001, alleviates neuropathic pain-like behavior after spinal cord and peripheral nerve injury.
Topics: Acetates; Amines; Animals; Aorta, Thoracic; Behavior, Animal; Cyclic GMP; Cyclohexanecarboxylic Acid | 2004 |
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation.
Topics: Acute Disease; Amines; Analgesics, Opioid; Animals; Carbamates; Cyclohexanecarboxylic Acids; Disease | 2004 |
Painful neuropathy alters the effect of gabapentin on sensory neuron excitability in rats.
Topics: Acetates; Action Potentials; Amines; Analgesics; Analysis of Variance; Animals; Calcium Channels; Cy | 2004 |
Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, A | 2004 |
Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia.
Topics: Amines; Animals; Anticonvulsants; Brain Infarction; Brain Injuries; Brain Ischemia; Cyclohexanecarbo | 2004 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cycl | 2004 |
Future Pain Drugs - Europe 2003. 15-16 September 2003, London, UK.
Topics: Acetaminophen; Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, A | 2003 |
Differential analgesic sensitivity of two distinct neuropathic pain models.
Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Animals; Cold Temperature; Cyclohexanecarboxylic A | 2004 |
Pharmacological characterisation of the rat brachial plexus avulsion model of neuropathic pain.
Topics: Acetates; Amines; Analgesics; Analysis of Variance; Animals; Brachial Plexus; Brachial Plexus Neurop | 2004 |
The biology and pharmacology of calcium channel alpha2-delta proteins Pfizer Satellite Symposium to the 2003 Society for Neuroscience Meeting. Sheraton New Orleans Hotel, New Orleans, LA November 10, 2003.
Topics: Acetates; Amines; Analgesics; Animals; Anticonvulsants; Binding Sites; Calcium Channels; Calcium Cha | 2004 |
Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington's disease.
Topics: Amines; Animals; Anticonvulsants; Aza Compounds; Corpus Striatum; Cyclohexanecarboxylic Acids; Disea | 2004 |
Gabapentin relieves mechanical, warm and cold allodynia in a rat model of peripheral neuropathy.
Topics: Amines; Animals; Cold Temperature; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Respons | 2004 |
Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes.
Topics: Administration, Oral; Amines; Animals; Cartilage, Articular; Chondrocytes; Cyclohexanecarboxylic Aci | 2005 |
Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action.
Topics: Acetates; Acute Disease; Amines; Analgesics; Animals; Benzylamines; Chronic Disease; Cyclohexanecarb | 2005 |
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Ataxia; Behavior, Ani | 2005 |
Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Diterpenes; Gabape | 2005 |
Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Axotomy; Cyclohexanecarboxyl | 2005 |
Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain.
Topics: Amines; Amitriptyline; Analgesics; Animals; Behavior, Animal; Benzoxazines; Blotting, Western; Cyclo | 2005 |
Synergistic interaction of gabapentin and oxcarbazepine in the mouse maximal electroshock seizure model--an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, | 2005 |
Design, synthesis, and preliminary evaluation of gabapentin-pregabalin mutual prodrugs in relieving neuropathic pain.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug | 2005 |
Anti-nociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain.
Topics: Amines; Analgesics; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Bupropio | 2005 |
Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2005 |
Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin.
Topics: Action Potentials; Amines; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Cell Count; | 2005 |
Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Ani | 2005 |
The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice.
Topics: Amines; Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acid | 2005 |
Differential pharmacological modulation of the spontaneous stimulus-independent activity in the rat spinal cord following peripheral nerve injury.
Topics: Action Potentials; Amines; Analgesics; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarbox | 2006 |
Carboxylate bioisosteres of pregabalin.
Topics: Amines; Animals; Anticonvulsants; Binding Sites; Carboxylic Acids; Cyclohexanecarboxylic Acids; Dise | 2006 |
Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia.
Topics: Amines; Analgesics; Animals; Arthralgia; Cyclohexanecarboxylic Acids; Cyclooxygenase 2 Inhibitors; D | 2006 |
Examination of the interaction between peripheral diclofenac and gabapentin on the 5% formalin test in rats.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acids; D | 2006 |
Gabapentin enhances the analgesic response to morphine in acute model of pain in male rats.
Topics: Amines; Analgesics, Opioid; Animals; Area Under Curve; Cyclohexanecarboxylic Acids; Disease Models, | 2006 |
Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit.
Topics: Amines; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Calcium Channels; | 2007 |
Further characterization of a rat model of varicella zoster virus-associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs.
Topics: Amines; Analgesics; Animals; Anti-Anxiety Agents; Anxiety Disorders; Cells, Cultured; Cyclohexanecar | 2007 |
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease | 2007 |
Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold.
Topics: Amines; Animals; Anticonvulsants; Brain; Brain Chemistry; Cerebral Cortex; Convulsants; Cyclohexanec | 2007 |
The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2007 |
Role of spinal voltage-dependent calcium channel alpha 2 delta-1 subunit in the expression of a neuropathic pain-like state in mice.
Topics: Amines; Analgesics; Animals; Calcium Channels; Cells, Cultured; Cyclohexanecarboxylic Acids; Disease | 2007 |
Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice.
Topics: Acetic Acid; Amines; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Cyclohexanecarbo | 2008 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarb | 2008 |
Gabapentin suppresses spasticity in the spinal cord-injured rat.
Topics: Amines; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cross-Over Studies; Cycloh | 2007 |
Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric | 2007 |
Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study.
Topics: Administration, Oral; Amines; Analgesics; Animals; Blood Pressure; Brain; Brain Mapping; Cyclohexane | 2008 |
Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice.
Topics: Acute Disease; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gab | 2008 |
Experimental autoimmune prostatitis induces chronic pelvic pain.
Topics: Amines; Analgesics; Anesthetics, Local; Animals; Autoimmune Diseases; Chronic Disease; Cyclohexaneca | 2008 |
Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Di | 2008 |
Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia.
Topics: Amines; Animals; Animals, Newborn; Anticonvulsants; Atrophy; Behavior, Animal; Body Temperature; Bra | 2008 |
The antinociceptive effects of anticonvulsants in a mouse visceral pain model.
Topics: Acetic Acid; Amines; Analgesics; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Cyclohex | 2008 |
Antimyoclonic effect of gabapentin in a posthypoxic animal model of myoclonus.
Topics: Acetates; Acoustic Stimulation; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; DDT; | 1996 |
Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamotrigine, vigabatrin, tiagabine, gabapentin, and topiramate against human absence seizures.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dru | 1997 |
The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain.
Topics: Acetates; Acute Disease; Amines; Analgesics; Animals; Anticonvulsants; Chronic Disease; Cyclohexanec | 1997 |
Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dos | 1997 |
Gabapentin potentiation of the antiepileptic efficacy of vigabatrin in an in vitro model of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Acetates; Amines; Animals; Anticonvulsants; Bicuculline; Cyclohexaneca | 1998 |
Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats.
Topics: Acetates; Afferent Pathways; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease | 1999 |
Gabapentin decreases the severity of dystonia at low doses in a genetic animal model of paroxysmal dystonic choreoathetosis.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cricetinae; Cyclohexanecarboxylic Acids; Disease Models, | 1999 |
Evaluation of interaction between gabapentin and ibuprofen on the formalin test in rats.
Topics: Acetates; Amines; Analgesics; Analgesics, Non-Narcotic; Animals; Blood Pressure; Cyclohexanecarboxyl | 1999 |
Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures.
Topics: Acetates; Alanine; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzylamines; Carba | 1999 |
Morphine and gabapentin decrease mechanical hyperalgesia and escape/avoidance behavior in a rat model of neuropathic pain.
Topics: Acetates; Amines; Analgesics; Animals; Avoidance Learning; Cyclohexanecarboxylic Acids; Disease Mode | 2000 |
Further evidence for the role of the alpha(2)delta subunit of voltage dependent calcium channels in models of neuropathic pain.
Topics: Acetates; Amines; Analgesics; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Disease Models | 2000 |
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; | 2000 |
[The effect of gabapentin and gabapentin-lactam on retinal ganglion cell survival. Situation after acute retinal ischemia in animal models].
Topics: Acetates; Amines; Animals; Anticonvulsants; Aza Compounds; Cell Survival; Convulsants; Cyclohexaneca | 2001 |
The putative OP(4) antagonist, [Nphe(1)]nociceptin(1-13)NH(2), prevents the effects of nociceptin in neuropathic rats.
Topics: Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Res | 2001 |
Effect of gabapentin and lamotrigine on mechanical allodynia-like behaviour in a rat model of trigeminal neuropathic pain.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models | 2001 |
Anticonvulsant efficacy of gabapentin on kindling in the immature brain.
Topics: Acetates; Age Factors; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Brain; Child; C | 2001 |
Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model.
Topics: Acetates; Amines; Animals; Cyclohexanecarboxylic Acids; Deafness; Diagnosis, Differential; Disease M | 2001 |
Antinociceptive effect of the novel compound OT-7100 in a diabetic neuropathy model.
Topics: Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Disease M | 2001 |
Metabolic approach of absence seizures in a genetic model of absence epilepsy, the GAERS: study of the leucine-glutamate cycle.
Topics: Acetates; Amines; Amino Acids, Branched-Chain; Animals; Brain; Carbon Monoxide; Cells, Cultured; Cer | 2001 |