gabapentin has been researched along with Depression in 30 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our goal was to compare the effects of gabapentin and pregabalin on improving sleep quality and depression among hemodialysis patients with PPN." | 9.17 | Gabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: a randomized prospective crossover trial. ( Atalay, H; Biyik, Z; Gaipov, A; Guney, F; Solak, Y; Turk, S, 2013) |
| "The purpose of this, open-label, non-comparative study, was to evaluate the efficacy on quality of life and the efficacy of gabapentin monotherapy in patients with chronic radiculopathy." | 9.14 | Gabapentin monotherapy in patients with chronic radiculopathy: the efficacy and impact on life quality. ( Deniz, O; Erdal, A; Gureser, G; Karatay, S; Senel, K; Ugur, M; Yildirim, K, 2009) |
| "Gabapentin can relieve chronic pain and depression-like behavior in rats with chronic pain and depression, and promote neurogenesis of hippocampal dentate gyrus neurons." | 8.12 | Effect of gabapentin on neurogenesis in hippocampal dentate gyrus of adult rats with co-disease of chronic pain and depression. ( Jiang, X; Tan, Y; Yang, L; Zeng, W, 2022) |
| "Gabapentin is a commonly prescribed antiepileptic agent for seizures, which is also used for pain and addiction management." | 5.91 | Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition. ( Ali, G; Alkahramaan, YMSA; Arif, M; Gohar, A; Khan, MS; Rashid, U; Rauf, K; Sewell, RDE, 2023) |
| "Symptoms consistent with bruxism are a common chief complaint in dental practice." | 5.30 | Antidepressant-induced bruxism successfully treated with gabapentin. ( Brown, ES; Hong, SC, 1999) |
| " Our goal was to compare the effects of gabapentin and pregabalin on improving sleep quality and depression among hemodialysis patients with PPN." | 5.17 | Gabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: a randomized prospective crossover trial. ( Atalay, H; Biyik, Z; Gaipov, A; Guney, F; Solak, Y; Turk, S, 2013) |
| "The purpose of this, open-label, non-comparative study, was to evaluate the efficacy on quality of life and the efficacy of gabapentin monotherapy in patients with chronic radiculopathy." | 5.14 | Gabapentin monotherapy in patients with chronic radiculopathy: the efficacy and impact on life quality. ( Deniz, O; Erdal, A; Gureser, G; Karatay, S; Senel, K; Ugur, M; Yildirim, K, 2009) |
| "Gabapentin can relieve chronic pain and depression-like behavior in rats with chronic pain and depression, and promote neurogenesis of hippocampal dentate gyrus neurons." | 4.12 | Effect of gabapentin on neurogenesis in hippocampal dentate gyrus of adult rats with co-disease of chronic pain and depression. ( Jiang, X; Tan, Y; Yang, L; Zeng, W, 2022) |
| "Based on clinical studies regarding the beneficial effect of gabapentin in depression, we aimed to evaluate the antidepressant-like properties of gabapentin in mice and also the participation of nitric oxide (NO)/cyclic guanosine monophosphate pathway in this effect." | 3.83 | Involvement of NO/cGMP pathway in the antidepressant-like effect of gabapentin in mouse forced swimming test. ( Akhlaghipour, G; Ameli, S; Dehpour, A; Haj-Mirzaian, A; Kordjazy, N; Ostadhadi, S, 2016) |
| "Cocaine dependence is a major public health problem with no available robustly effective pharmacotherapy." | 2.79 | Clinical efficacy of sertraline alone and augmented with gabapentin in recently abstinent cocaine-dependent patients with depressive symptoms. ( Cargile, C; Chopra, MP; Guise, JB; Kosten, TR; Mancino, MJ; McGaugh, J; Oliveto, A; Sanders, N; Thostenson, J; Williams, DK, 2014) |
| "Gabapentin 2400 mg/day was given in case of treatment failure or if imipramine treatment was not possible." | 2.71 | Therapeutic outcome in neuropathic pain: relationship to evidence of nervous system lesion. ( Bach, FW; Jensen, TS; Rasmussen, PV; Sindrup, SH, 2004) |
| " This study examined the single-dose pharmacokinetic profiles of Li in 13 patients receiving placebo and then steady-state gabapentin (mean daily dose: 3,646." | 2.69 | Gabapentin does not alter single-dose lithium pharmacokinetics. ( Corá-Locatelli, G; Dunn, RT; Frye, MA; Grothe, D; Ketter, TA; Kimbrell, TA; Piscitelli, S; Post, RM; Vanderham, E, 1998) |
| "The most common risk factor for shingles and its potential sequela, PHN, is advanced age." | 2.42 | Post-herpetic neuralgia case study: optimizing pain control. ( Baron, R, 2004) |
| "The incidence of melanoma is rising rapidly, and the use of this regimen is becoming increasingly common." | 2.41 | Adjuvant therapy of melanoma with interferon-alpha-2b is associated with mania and bipolar syndromes. ( Everett, JR; Gadd, MA; Greenberg, DB; Haluska, FG; Jonasch, E; Mihm, MA; Ott, M; Ryan, BF; Sober, AJ; Tanabe, KK, 2000) |
| "Gabapentin is a commonly prescribed antiepileptic agent for seizures, which is also used for pain and addiction management." | 1.91 | Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition. ( Ali, G; Alkahramaan, YMSA; Arif, M; Gohar, A; Khan, MS; Rashid, U; Rauf, K; Sewell, RDE, 2023) |
| "Gabapentin treatment was initiated after baseline evaluation, and the RDD and visual analog scale (VAS) score were both evaluated regularly during the 2-week study period." | 1.72 | Rate-Dependent Depression: A Predictor of the Therapeutic Efficacy in Treating Painful Diabetic Peripheral Neuropathy. ( Calcutt, NA; Guan, Y; Lin, Z; Wang, Z; Xie, C; Zhou, X; Zhu, D; Zhu, Y, 2022) |
| "Many patients with chronic pain conditions suffer from depression." | 1.62 | Dynamic Change of Endocannabinoid Signaling in the Medial Prefrontal Cortex Controls the Development of Depression After Neuropathic Pain. ( Chao, D; Feng, Y; Hillard, CJ; Hogan, QH; Mecca, CM; Pan, B; Pawela, CP; Rodriguez-Garcia, DM; Segel, I; Yu, G; Zhang, Z, 2021) |
| "The analysis of the case of vulvodynia coexisting with depression." | 1.46 | Vulvodynia and depression - a case study. ( Derewianka-Polak, M; Dziwota, EA; Gerhant, A; Olajossy, M; Perzyńska-Starkiewicz, A, 2017) |
| "Intracranial stab wounds are low-velocity, penetrating injuries to the brain and fatality and outcome significantly depend on route, depth and location of cranial penetration." | 1.39 | Self-inflicted trans-oral intracranial stab wound. ( Han, ZA; Kim, JH; Kim, SW, 2013) |
| "Anxiety and depression are often also present." | 1.35 | Fibromyalgia: poorly understood; treatments are disappointing. ( , 2009) |
| "Symptoms consistent with bruxism are a common chief complaint in dental practice." | 1.30 | Antidepressant-induced bruxism successfully treated with gabapentin. ( Brown, ES; Hong, SC, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.67) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 14 (46.67) | 24.3611 |
| 2020's | 5 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, X | 1 |
| Zhu, Y | 1 |
| Wang, Z | 1 |
| Lin, Z | 1 |
| Zhu, D | 1 |
| Xie, C | 1 |
| Calcutt, NA | 1 |
| Guan, Y | 1 |
| Zeng, W | 1 |
| Tan, Y | 1 |
| Yang, L | 1 |
| Jiang, X | 1 |
| Gohar, A | 1 |
| Ali, G | 1 |
| Rashid, U | 1 |
| Rauf, K | 1 |
| Arif, M | 1 |
| Khan, MS | 1 |
| Alkahramaan, YMSA | 1 |
| Sewell, RDE | 1 |
| Kim, J | 1 |
| Lee, SH | 1 |
| Kim, TH | 1 |
| Mecca, CM | 1 |
| Chao, D | 1 |
| Yu, G | 1 |
| Feng, Y | 1 |
| Segel, I | 1 |
| Zhang, Z | 1 |
| Rodriguez-Garcia, DM | 1 |
| Pawela, CP | 1 |
| Hillard, CJ | 1 |
| Hogan, QH | 1 |
| Pan, B | 1 |
| Gerhant, A | 1 |
| Dziwota, EA | 1 |
| Perzyńska-Starkiewicz, A | 1 |
| Derewianka-Polak, M | 1 |
| Olajossy, M | 1 |
| Till, SR | 1 |
| As-Sanie, S | 1 |
| Schrepf, A | 1 |
| Kim, SW | 1 |
| Kim, JH | 1 |
| Han, ZA | 1 |
| Marchiori, ÉC | 1 |
| Barber, JS | 1 |
| Williams, WB | 1 |
| Bui, PQ | 1 |
| O'Ryan, FS | 1 |
| Mah, L | 1 |
| Hart, M | 1 |
| Mancino, MJ | 1 |
| McGaugh, J | 1 |
| Chopra, MP | 1 |
| Guise, JB | 1 |
| Cargile, C | 1 |
| Williams, DK | 1 |
| Thostenson, J | 1 |
| Kosten, TR | 1 |
| Sanders, N | 1 |
| Oliveto, A | 1 |
| Mehta, S | 1 |
| McIntyre, A | 1 |
| Dijkers, M | 1 |
| Loh, E | 1 |
| Teasell, RW | 1 |
| Kilic, FS | 1 |
| Ismailoglu, S | 1 |
| Kaygisiz, B | 1 |
| Oner, S | 1 |
| Evrensel, A | 1 |
| Ünsalver, BÖ | 1 |
| Lubelski, D | 1 |
| Thompson, NR | 1 |
| Agrawal, B | 1 |
| Abdullah, KG | 1 |
| Alvin, MD | 1 |
| Khalaf, T | 1 |
| Mazanec, DJ | 1 |
| Benzel, EC | 1 |
| Mroz, TE | 1 |
| Krishnaney, AA | 1 |
| Ostadhadi, S | 1 |
| Kordjazy, N | 1 |
| Haj-Mirzaian, A | 1 |
| Ameli, S | 1 |
| Akhlaghipour, G | 1 |
| Dehpour, A | 1 |
| Czubak, A | 1 |
| Nowakowska, E | 1 |
| Kus, K | 1 |
| Sadowski, C | 1 |
| Matschay, A | 1 |
| Yildirim, K | 1 |
| Deniz, O | 1 |
| Gureser, G | 1 |
| Karatay, S | 1 |
| Ugur, M | 1 |
| Erdal, A | 1 |
| Senel, K | 1 |
| Kaufman, KR | 1 |
| Struck, PJ | 1 |
| Valente, MM | 1 |
| Bortolotto, V | 1 |
| Cuccurazzu, B | 1 |
| Ubezio, F | 1 |
| Meneghini, V | 1 |
| Francese, MT | 1 |
| Canonico, PL | 1 |
| Grilli, M | 1 |
| Biyik, Z | 1 |
| Solak, Y | 1 |
| Atalay, H | 1 |
| Gaipov, A | 1 |
| Guney, F | 1 |
| Turk, S | 1 |
| Carter, AC | 1 |
| Nicholas, JJ | 1 |
| Baron, R | 1 |
| Rasmussen, PV | 1 |
| Sindrup, SH | 1 |
| Jensen, TS | 1 |
| Bach, FW | 1 |
| Rejas, J | 1 |
| Ribera, MV | 1 |
| Ruiz, M | 1 |
| Masrramón, X | 1 |
| Frye, MA | 1 |
| Kimbrell, TA | 1 |
| Dunn, RT | 1 |
| Piscitelli, S | 1 |
| Grothe, D | 1 |
| Vanderham, E | 1 |
| Corá-Locatelli, G | 1 |
| Post, RM | 1 |
| Ketter, TA | 1 |
| Brown, ES | 1 |
| Hong, SC | 1 |
| Greenberg, DB | 1 |
| Jonasch, E | 1 |
| Gadd, MA | 1 |
| Ryan, BF | 1 |
| Everett, JR | 1 |
| Sober, AJ | 1 |
| Mihm, MA | 1 |
| Tanabe, KK | 1 |
| Ott, M | 1 |
| Haluska, FG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy of Gabapentine and Splint Therapy in Bruxers: a Randomized Clinical Trial[NCT01255878] | 20 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for gabapentin and Depression
| Article | Year |
|---|---|
Psychology of Chronic Pelvic Pain: Prevalence, Neurobiological Vulnerabilities, and Treatment.
Topics: Antidepressive Agents, Tricyclic; Anxiety; Catastrophization; Chronic Pain; Cognitive Behavioral The | 2019 |
Gabapentin withdrawal: case report in an older adult and review of the literature.
Topics: Aged; Amines; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Depression; Female; Gabapentin; gamm | 2013 |
Gabapentinoids are effective in decreasing neuropathic pain and other secondary outcomes after spinal cord injury: a meta-analysis.
Topics: Amines; Analgesics; Anxiety; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Depression; Gaba | 2014 |
Post-herpetic neuralgia case study: optimizing pain control.
Topics: Acetates; Aged; Amines; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Cyclohexanecarb | 2004 |
Adjuvant therapy of melanoma with interferon-alpha-2b is associated with mania and bipolar syndromes.
Topics: Acetates; Adult; Amines; Anti-Anxiety Agents; Antimanic Agents; Antineoplastic Agents; Bipolar Disor | 2000 |
6 trials available for gabapentin and Depression
| Article | Year |
|---|---|
Clinical efficacy of sertraline alone and augmented with gabapentin in recently abstinent cocaine-dependent patients with depressive symptoms.
Topics: Adult; Amines; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Combined Modality Therapy; C | 2014 |
Gabapentin monotherapy in patients with chronic radiculopathy: the efficacy and impact on life quality.
Topics: Administration, Oral; Adult; Amines; Anticonvulsants; Chronic Disease; Cyclohexanecarboxylic Acids; | 2009 |
Gabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: a randomized prospective crossover trial.
Topics: Amines; Anti-Anxiety Agents; Calcium Channel Blockers; Cross-Over Studies; Cyclohexanecarboxylic Aci | 2013 |
Therapeutic outcome in neuropathic pain: relationship to evidence of nervous system lesion.
Topics: Acetates; Adult; Aged; Amines; Chi-Square Distribution; Cyclohexanecarboxylic Acids; Depression; Dos | 2004 |
Psychometric properties of the MOS (Medical Outcomes Study) Sleep Scale in patients with neuropathic pain.
Topics: Adult; Aged; Amines; Analgesics; Anxiety; Cyclohexanecarboxylic Acids; Depression; Disability Evalua | 2007 |
Gabapentin does not alter single-dose lithium pharmacokinetics.
Topics: Acetates; Amines; Antimanic Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids; Depression; Doubl | 1998 |
19 other studies available for gabapentin and Depression
| Article | Year |
|---|---|
Rate-Dependent Depression: A Predictor of the Therapeutic Efficacy in Treating Painful Diabetic Peripheral Neuropathy.
Topics: Depression; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Gabapentin; Humans; Pain | 2022 |
Effect of gabapentin on neurogenesis in hippocampal dentate gyrus of adult rats with co-disease of chronic pain and depression.
Topics: Animals; Brain-Derived Neurotrophic Factor; Chronic Pain; Dentate Gyrus; Depression; Gabapentin; Hip | 2022 |
Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Ascorbic Acid; Behavior, Animal; Cogni | 2023 |
Improvement of sleep quality after treatment in patients with lumbar spinal stenosis: a prospective comparative study between conservative versus surgical treatment.
Topics: Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Conservative Treatment; Decompres | 2020 |
Dynamic Change of Endocannabinoid Signaling in the Medial Prefrontal Cortex Controls the Development of Depression After Neuropathic Pain.
Topics: Animals; Brain Mapping; Chronic Pain; Depression; Endocannabinoids; Feeding Behavior; Female; GABAer | 2021 |
Vulvodynia and depression - a case study.
Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Depression; Female; Gabapentin; gamma-Aminobutyric | 2017 |
Self-inflicted trans-oral intracranial stab wound.
Topics: Amines; Analgesics; Antidepressive Agents; Brain Injuries; Cerebellum; Citalopram; Cyclohexanecarbox | 2013 |
Neuropathic pain following sagittal split ramus osteotomy of the mandible: prevalence, risk factors, and clinical course.
Topics: Adult; Age Factors; Amines; Anticonvulsants; Antidepressive Agents, Tricyclic; Cohort Studies; Cyclo | 2013 |
Effects of single and combined gabapentin use in elevated plus maze and forced swimming tests.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Anxiety; Cyclohexanecarboxylic Acids; Depression; D | 2014 |
Psychotic and depressive symptoms after gabapentin treatment.
Topics: Amines; Cyclohexanecarboxylic Acids; Depression; Excitatory Amino Acid Antagonists; Female; Gabapent | 2015 |
Prediction of quality of life improvements in patients with lumbar stenosis following use of membrane stabilizing agents.
Topics: Aged; Aged, 80 and over; Amines; Calcium Channel Blockers; Comorbidity; Cyclohexanecarboxylic Acids; | 2015 |
Involvement of NO/cGMP pathway in the antidepressant-like effect of gabapentin in mouse forced swimming test.
Topics: Amines; Animals; Antidepressive Agents; Behavior, Animal; Cyclic GMP; Cyclohexanecarboxylic Acids; D | 2016 |
Effect of gabapentin on cognitive processes in rats not exposed and exposed to tobacco smoke during fetal life.
Topics: Amines; Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Cognition; Cyclohexanecar | 2008 |
Fibromyalgia: poorly understood; treatments are disappointing.
Topics: Acetaminophen; Acupuncture Therapy; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Ant | 2009 |
Gabapentin-induced sexual dysfunction.
Topics: Adult; Amines; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Depression; Gabapentin; gamma-Amino | 2011 |
α2δ ligands act as positive modulators of adult hippocampal neurogenesis and prevent depression-like behavior induced by chronic restraint stress.
Topics: Amines; Animals; Calcium Channels; Cell Differentiation; Cyclohexanecarboxylic Acids; Depression; Ga | 2012 |
The importance of the complete history in the discovery of a potential suicide: a case report.
Topics: Acetates; Amines; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Bacterial Agents; Cyclohexanecarboxy | 2003 |
[Unclear chronic aches. Often depression plays a part therein].
Topics: Acetates; Amines; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Age | 2003 |
Antidepressant-induced bruxism successfully treated with gabapentin.
Topics: Acetates; Amines; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Bipolar Disorder; B | 1999 |