Page last updated: 2024-10-27

gabapentin and Conjugate Nystagmus

gabapentin has been researched along with Conjugate Nystagmus in 22 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Research Excerpts

ExcerptRelevanceReference
"A prospective examiner-blind, cross-over study was conducted to compare the efficacy of memantine (40 or 60 mg/day) and gabapentin (1,200 mg/day) as therapy for acquired fixational pendular nystagmus (APN) in 11 patients with multiple sclerosis."9.14Acquired pendular nystagmus in multiple sclerosis: an examiner-blind cross-over treatment study of memantine and gabapentin. ( Albrecht, H; Dieterich, M; Pöllmann, W; Starck, M; Straube, A, 2010)
"The aim of this study was to report relief of optokinetic-triggered vertigo (OKTV) with low-dose gabapentin in three patients with periodic vestibulocerebellar ataxia [episodic ataxia type 4 (EA4); OMIM 606552]."8.02Gabapentin Relieves Vertigo of Periodic Vestibulocerebellar Ataxia: 3 Cases and Possible Mechanism. ( Coin, JT; Vance, JM, 2021)
"The authors retrospectively analysed Snellen visual acuity (VA), subjective visual function, and eye movement recordings of 23 patients with nystagmus (13 secondary to multiple sclerosis, three associated with other neurological diseases, two idiopathic infantile, and five with associated ocular diseases) treated with gabapentin or memantine."7.73The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study. ( Gottlob, I; McLean, RJ; Proudlock, FA; Sarvananthan, N; Shery, T, 2006)
"A prospective examiner-blind, cross-over study was conducted to compare the efficacy of memantine (40 or 60 mg/day) and gabapentin (1,200 mg/day) as therapy for acquired fixational pendular nystagmus (APN) in 11 patients with multiple sclerosis."5.14Acquired pendular nystagmus in multiple sclerosis: an examiner-blind cross-over treatment study of memantine and gabapentin. ( Albrecht, H; Dieterich, M; Pöllmann, W; Starck, M; Straube, A, 2010)
"The aim of this study was to report relief of optokinetic-triggered vertigo (OKTV) with low-dose gabapentin in three patients with periodic vestibulocerebellar ataxia [episodic ataxia type 4 (EA4); OMIM 606552]."4.02Gabapentin Relieves Vertigo of Periodic Vestibulocerebellar Ataxia: 3 Cases and Possible Mechanism. ( Coin, JT; Vance, JM, 2021)
"The authors retrospectively analysed Snellen visual acuity (VA), subjective visual function, and eye movement recordings of 23 patients with nystagmus (13 secondary to multiple sclerosis, three associated with other neurological diseases, two idiopathic infantile, and five with associated ocular diseases) treated with gabapentin or memantine."3.73The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study. ( Gottlob, I; McLean, RJ; Proudlock, FA; Sarvananthan, N; Shery, T, 2006)
"A 40-year-old patient with acquired horizontal and vertical nystagmus and severe oscillopsia secondary to multiple sclerosis had combined treatment with gabapentin and a vertical Kestenbaum-type procedure."3.71Combined pharmacologic and surgical approach to acquired nystagmus due to multiple sclerosis. ( Constantinescu, CS; Gottlob, I; Jain, S; Proudlock, F, 2002)
"The most common causes of acquired pendular nystagmus (APN) are multiple sclerosis (MS) and oculopalatal tremor (OPT), both of which result in poor visual quality of life."2.94Gabapentin and Memantine for Treatment of Acquired Pendular Nystagmus: Effects on Visual Outcomes. ( Abouaf, L; Berthiller, J; Colombet, B; Nerrant, E; Pollet-Villard, F; Tilikete, C; Vie, AL; Vighetto, A; Vukusic, S, 2020)
"Acquired brain injury can cause eye movement disorders which may include: strabismus, gaze deficits and nystagmus, causing visual symptoms of double, blurred or 'juddery' vision and reading difficulties."2.58Interventions for eye movement disorders due to acquired brain injury. ( Dodridge, CS; Evans, JR; Garcia-Finana, M; Hanna, K; Howard, C; Jarvis, KA; Maan, T; MacDiarmid, SL; Noonan, CP; North, L; Rodgers, H; Rowe, FJ, 2018)
"Acquired pendular nystagmus may respond to gabapentin or memantine; downbeat and upbeat nystagmus to aminopyridines; and periodic alternating nystagmus to baclofen."2.48The pharmacological treatment of acquired nystagmus. ( Kennard, C; Mehta, AR, 2012)
"BACKGROUND Acquired pendular nystagmus (APN) is a back and forth, oscillatory eye movement in which the 2 oppositely directed slow phases have similar waveforms."1.72Pharmacological and Behavioral Strategies to Improve Vision in Acquired Pendular Nystagmus. ( Abegg, M; Brügger, D; Kerkeni, H; Mantokoudis, G; Zee, DS, 2022)
"Treatment with gabapentin was initiated for OPT presumed secondary to neuro-Behçet disease."1.42Neuro-Behçet disease presenting with oculopalatal tremor. ( Espino Barros Palau, A; Foroozan, R; Lee, AG; Morgan, ML, 2015)
"Ocular oscillations, with features of pendular nystagmus, appeared early during training of both horizontal and vertical pursuit in all four monkeys."1.37Oscillatory eye movements resembling pendular nystagmus in normal juvenile macaques. ( Akao, T; Barnes, G; Belton, T; Fukushima, J; Fukushima, K; Kase, M; Kurkin, S; Leigh, RJ; Shichinohe, N, 2011)
"Acquired pendular nystagmus (APN) occurs with multiple sclerosis (MS) and oculopalatal tremor (OPT); distinct features of the nystagmus have led to the development of separate models for their pathogenesis."1.37Pharmacological tests of hypotheses for acquired pendular nystagmus. ( Leigh, RJ; Optican, LM; Shaikh, AG; Thurtell, MJ, 2011)
"Acquired Pendular Nystagmus (APN) may cause distressing visual symptoms in patients who are already suffering a severe general disease."1.31Improvement of acquired pendular nystagmus by gabapentin: case report. ( Fabre, K; Smet-Dieleman, H; Zeyen, T, 2001)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (9.09)18.2507
2000's9 (40.91)29.6817
2010's8 (36.36)24.3611
2020's3 (13.64)2.80

Authors

AuthorsStudies
Kerkeni, H1
Brügger, D1
Mantokoudis, G1
Abegg, M1
Zee, DS1
Coin, JT1
Vance, JM1
Rowe, FJ1
Hanna, K1
Evans, JR1
Noonan, CP1
Garcia-Finana, M1
Dodridge, CS1
Howard, C1
Jarvis, KA1
MacDiarmid, SL1
Maan, T1
North, L1
Rodgers, H1
Nerrant, E1
Abouaf, L1
Pollet-Villard, F1
Vie, AL1
Vukusic, S1
Berthiller, J1
Colombet, B1
Vighetto, A1
Tilikete, C1
Morgan, ML1
Espino Barros Palau, A1
Lee, AG1
Foroozan, R1
Kalla, R1
Spiegel, R1
Wagner, J1
Rettinger, N1
Jahn, K1
Strupp, M1
Nebbioso, M1
D'Innocenzo, D1
Rapone, S1
Di Benedetto, G1
Grenga, R1
McLean, RJ2
Gottlob, I5
Starck, M1
Albrecht, H1
Pöllmann, W1
Dieterich, M1
Straube, A2
Thurtell, MJ2
Joshi, AC1
Leone, AC1
Tomsak, RL1
Kosmorsky, GS1
Stahl, JS2
Leigh, RJ5
Pieh-Beisse, C1
Lagrèze, WA1
Shichinohe, N1
Barnes, G1
Akao, T1
Kurkin, S1
Fukushima, J1
Kase, M1
Belton, T1
Fukushima, K1
Shaikh, AG1
Optican, LM1
Mehta, AR1
Kennard, C1
Jain, S1
Proudlock, F2
Constantinescu, CS1
Fabre, K1
Smet-Dieleman, H1
Zeyen, T1
Rahman, W1
Shery, T1
Proudlock, FA1
Sarvananthan, N2
Choudhuri, I1
Averbuch-Heller, L2
Tusa, RJ1
Fuhry, L1
Rottach, KG2
Ganser, GL1
Heide, W1
Büttner, U1
von Maydell, RD1
Collins, SD1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Examining the Effect of Eye Gaze Technology on Children With Cortical Visual Impairment and Its Impact on Occupational Performance[NCT06067607]10 participants (Anticipated)Interventional2023-02-01Recruiting
Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187]8 participants (Actual)Interventional2009-11-30Terminated (stopped due to PI left institution)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for gabapentin and Conjugate Nystagmus

ArticleYear
Interventions for eye movement disorders due to acquired brain injury.
    The Cochrane database of systematic reviews, 2018, 03-05, Volume: 3

    Topics: 4-Aminopyridine; Abducens Nerve Diseases; Amifampridine; Amines; Baclofen; Botulinum Toxins; Brain I

2018
[Pharmacotherapy of central oculomotor disorders].
    Der Nervenarzt, 2008, Volume: 79, Issue:12

    Topics: 4-Aminopyridine; Amifampridine; Amines; Baclofen; Cyclohexanecarboxylic Acids; Diagnosis, Differenti

2008
[Nystagmus in ophthalmology].
    La Clinica terapeutica, 2009, Volume: 160, Issue:2

    Topics: Amines; Baclofen; Cyclohexanecarboxylic Acids; Diagnostic Techniques, Ophthalmological; Eye Diseases

2009
The pharmacological treatment of nystagmus: a review.
    Expert opinion on pharmacotherapy, 2009, Volume: 10, Issue:11

    Topics: Amines; Animals; Baclofen; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans;

2009
The pharmacological treatment of acquired nystagmus.
    Practical neurology, 2012, Volume: 12, Issue:3

    Topics: Amines; Aminopyridines; Baclofen; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid;

2012
Pharmacology of vertigo/nystagmus/oscillopsia.
    Current opinion in neurology, 2005, Volume: 18, Issue:1

    Topics: Amines; Benzodiazepines; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; GABA Agonis

2005

Trials

4 trials available for gabapentin and Conjugate Nystagmus

ArticleYear
Gabapentin and Memantine for Treatment of Acquired Pendular Nystagmus: Effects on Visual Outcomes.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2020, Volume: 40, Issue:2

    Topics: Adult; Cross-Over Studies; Excitatory Amino Acid Antagonists; Eye Movements; Female; Gabapentin; Hum

2020
Acquired pendular nystagmus in multiple sclerosis: an examiner-blind cross-over treatment study of memantine and gabapentin.
    Journal of neurology, 2010, Volume: 257, Issue:3

    Topics: Adult; Amines; Brain Stem; Clinical Protocols; Cross-Over Studies; Cyclohexanecarboxylic Acids; Dose

2010
Crossover trial of gabapentin and memantine as treatment for acquired nystagmus.
    Annals of neurology, 2010, Volume: 67, Issue:5

    Topics: Adult; Amines; Cross-Over Studies; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; E

2010
A double-blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus.
    Annals of neurology, 1997, Volume: 41, Issue:6

    Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Baclofen; Cyclohexanecarboxylic Acids; Double-Blind

1997

Other Studies

12 other studies available for gabapentin and Conjugate Nystagmus

ArticleYear
Pharmacological and Behavioral Strategies to Improve Vision in Acquired Pendular Nystagmus.
    The American journal of case reports, 2022, Jul-03, Volume: 23

    Topics: Eye Movements; Female; Gabapentin; Humans; Memantine; Middle Aged; Nystagmus, Pathologic; Vision Dis

2022
Gabapentin Relieves Vertigo of Periodic Vestibulocerebellar Ataxia: 3 Cases and Possible Mechanism.
    Movement disorders : official journal of the Movement Disorder Society, 2021, Volume: 36, Issue:5

    Topics: Ataxia; Gabapentin; Humans; Nystagmus, Pathologic; Vertigo

2021
Neuro-Behçet disease presenting with oculopalatal tremor.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2015, Volume: 35, Issue:1

    Topics: Adult; Amines; Anticonvulsants; Behcet Syndrome; Cyclohexanecarboxylic Acids; Female; Gabapentin; ga

2015
[Pharmacological treatment of nystagmus].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2011, Volume: 108, Issue:2

    Topics: 4-Aminopyridine; Amines; Anticonvulsants; Baclofen; Cyclohexanecarboxylic Acids; Dopamine Agents; Ga

2011
Oscillatory eye movements resembling pendular nystagmus in normal juvenile macaques.
    Investigative ophthalmology & visual science, 2011, Jun-01, Volume: 52, Issue:6

    Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Gabapentin; gamma-A

2011
Pharmacological tests of hypotheses for acquired pendular nystagmus.
    Annals of the New York Academy of Sciences, 2011, Volume: 1233

    Topics: Amines; Baclofen; Cerebellar Cortex; Cyclohexanecarboxylic Acids; Eye Movements; Gabapentin; gamma-A

2011
Combined pharmacologic and surgical approach to acquired nystagmus due to multiple sclerosis.
    American journal of ophthalmology, 2002, Volume: 134, Issue:5

    Topics: Acetates; Adult; Amines; Combined Modality Therapy; Cyclohexanecarboxylic Acids; Diplopia; Excitator

2002
Improvement of acquired pendular nystagmus by gabapentin: case report.
    Bulletin de la Societe belge d'ophtalmologie, 2001, Issue:282

    Topics: Acetates; Administration, Oral; Amines; Baclofen; Cyclohexanecarboxylic Acids; Female; Gabapentin; g

2001
Oral gabapentin treatment for symptomatic Heimann-Bielschowsky phenomenon.
    American journal of ophthalmology, 2006, Volume: 141, Issue:1

    Topics: Administration, Oral; Amines; Cyclohexanecarboxylic Acids; Electronystagmography; Excitatory Amino A

2006
The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study.
    The British journal of ophthalmology, 2006, Volume: 90, Issue:7

    Topics: Adolescent; Adult; Aged; Amines; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Gab

2006
Survey of management of acquired nystagmus in the United Kingdom.
    Eye (London, England), 2007, Volume: 21, Issue:9

    Topics: Amines; Baclofen; Cyclohexanecarboxylic Acids; Drug Utilization; Excitatory Amino Acid Antagonists;

2007
A pilot study of gabapentin as treatment for acquired nystagmus.
    Neuro-ophthalmology (Aeolus Press), 1996, Volume: 16, Issue:2

    Topics: Acetates; Adult; Amines; Anticonvulsants; Brain Stem; Cerebrovascular Disorders; Cyclohexanecarboxyl

1996