gabapentin has been researched along with Complex Partial Epilepsy in 18 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Excerpt | Relevance | Reference |
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"Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults." | 7.69 | Gabapentin associated with aggressive behavior in pediatric patients with seizures. ( Lo, W; Nahata, MC; Tallian, KB; Tsao, CY, 1996) |
"Gabapentin (GBP) is a non-protein-bound gamma amino acid which is not subjected to metabolic degradation in man." | 6.68 | Seizure frequency and CSF parameters in a double-blind placebo controlled trial of gabapentin in patients with intractable complex partial seizures. ( Ben-Menachem, E; Hamberger, A; Hedner, T; Persson, LI; Söderfelt, B, 1995) |
" The second patient complained of impotence after a rash while taking phenytoin and carbamazepine." | 3.70 | Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000) |
"Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults." | 3.69 | Gabapentin associated with aggressive behavior in pediatric patients with seizures. ( Lo, W; Nahata, MC; Tallian, KB; Tsao, CY, 1996) |
"Gabapentin (GBP) is a non-protein-bound gamma amino acid which is not subjected to metabolic degradation in man." | 2.68 | Seizure frequency and CSF parameters in a double-blind placebo controlled trial of gabapentin in patients with intractable complex partial seizures. ( Ben-Menachem, E; Hamberger, A; Hedner, T; Persson, LI; Söderfelt, B, 1995) |
"Gabapentin appears to increase human brain GABA levels." | 2.68 | The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. ( Behar, KL; Lamoureux, D; Mattson, RH; Petroff, OA; Rothman, DL, 1996) |
"Gabapentin was well tolerated by patients in both dosage groups, and no patients exited the study due to adverse events, despite rapid initiation of full dose within 24 hours." | 2.68 | Gabapentin monotherapy: I. An 8-day, double-blind, dose-controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 88/89. ( Bergey, GK; Blume, WT; Crockatt, JG; Garofalo, E; LaMoreaux, L; Leiderman, DB; Morrell, MJ; Morris, HH; Penovich, PE; Pierce, M; Rosenfeld, W, 1997) |
" Results of outcome measures, including time to exit, completion rate, and mean time on monotherapy, showed no significant differences among dosage groups." | 2.68 | Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multicenter study of conversion from polytherapy in outpatients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 82/83. ( Abou-Khalil, B; Beydoun, A; Cantrell, D; Fischer, J; Garofalo, E; Greiner, M; Harden, C; Hayes, A; Labar, DR; Pierce, M; Ramsay, RE; Sackellares, JC; Uthman, BM, 1997) |
"Gabapentin is an anti-epileptic drug (AED) that was approved in 1993 for the adjunct treatment of complex partial seizures (CPS) with and without generalization." | 2.41 | Gabapentin: a unique anti-epileptic agent. ( Dougherty, JA; Rhoney, DH, 2001) |
"Gabapentin has been accepted worldwide as a novel antiepileptic drug with a favourable tolerability profile." | 1.30 | Isolated ataxia as an idiosyncratic side-effect under gabapentin. ( Bittermann, HJ; Herrendorf, G; Kurth, C; Steinhoff, BJ, 1997) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 13 (72.22) | 18.2507 |
2000's | 5 (27.78) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Crespo Pérez, L | 1 |
Moreira Vicente, V | 1 |
Cano Ruiz, A | 1 |
Gobernado Serrano, JM | 1 |
Cobo Ibañez, N | 1 |
Milicua Salamero, JM | 1 |
Petroff, OA | 3 |
Hyder, F | 1 |
Rothman, DL | 2 |
Mattson, RH | 3 |
Wolf, SM | 1 |
Shinnar, S | 1 |
Kang, H | 1 |
Gil, KB | 1 |
Moshé, SL | 1 |
Short, C | 1 |
Cooke, L | 1 |
Fromm, GH | 1 |
Ben-Menachem, E | 1 |
Söderfelt, B | 1 |
Hamberger, A | 1 |
Hedner, T | 1 |
Persson, LI | 1 |
Behar, KL | 1 |
Lamoureux, D | 1 |
Tallian, KB | 1 |
Nahata, MC | 1 |
Lo, W | 1 |
Tsao, CY | 1 |
Bergey, GK | 1 |
Morris, HH | 2 |
Rosenfeld, W | 1 |
Blume, WT | 1 |
Penovich, PE | 1 |
Morrell, MJ | 1 |
Leiderman, DB | 1 |
Crockatt, JG | 1 |
LaMoreaux, L | 1 |
Garofalo, E | 2 |
Pierce, M | 2 |
Beydoun, A | 1 |
Fischer, J | 1 |
Labar, DR | 1 |
Harden, C | 1 |
Cantrell, D | 1 |
Uthman, BM | 1 |
Sackellares, JC | 1 |
Abou-Khalil, B | 1 |
Ramsay, RE | 1 |
Hayes, A | 1 |
Greiner, M | 1 |
Pierce, MW | 2 |
Shokry, A | 1 |
Steinhoff, BJ | 1 |
Herrendorf, G | 1 |
Bittermann, HJ | 1 |
Kurth, C | 1 |
Hamer, HM | 1 |
Dodrill, CB | 1 |
Arnett, JL | 1 |
Hayes, AG | 1 |
Garofalo, EA | 1 |
Greeley, CA | 1 |
Greiner, MJ | 1 |
Maj, R | 1 |
Fariello, RG | 1 |
Pevarello, P | 1 |
Varasi, M | 1 |
McArthur, RA | 1 |
Salvati, P | 1 |
Husain, AM | 1 |
Carwile, ST | 1 |
Miller, PP | 1 |
Radtke, RA | 1 |
Collins, TL | 1 |
Dougherty, JA | 1 |
Rhoney, DH | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
Intervention | mmol/kg (Mean) |
---|---|
N-Acetylcysteine | 3.90 |
Gabapentin | 3.93 |
Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
Intervention | mmol/kg (Mean) |
---|---|
N-Acetylcysteine | 21.59 |
Gabapentin | 21.69 |
Placebo Oral Tablet | 22.25 |
3 reviews available for gabapentin and Complex Partial Epilepsy
Article | Year |
---|---|
[Anticonvulsant hypersensitivity syndrome: an entity to be remembered].
Topics: Adolescent; Amines; Anemia, Hemolytic; Anticonvulsants; Astrocytoma; Brain Neoplasms; Carbamazepine; | 2009 |
Gabapentin: discussion.
Topics: Acetates; Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drugs, Inv | 1994 |
Gabapentin: a unique anti-epileptic agent.
Topics: Acetates; Adult; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Epilepsy, Complex Part | 2001 |
6 trials available for gabapentin and Complex Partial Epilepsy
Article | Year |
---|---|
Gabapentin toxicity in children manifesting as behavioral changes.
Topics: Acetates; Affect; Aggression; Amines; Anticonvulsants; Behavior; Child; Cyclohexanecarboxylic Acids; | 1995 |
Seizure frequency and CSF parameters in a double-blind placebo controlled trial of gabapentin in patients with intractable complex partial seizures.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Respon | 1995 |
The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Response | 1996 |
Gabapentin monotherapy: I. An 8-day, double-blind, dose-controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 88/89.
Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Rel | 1997 |
Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multicenter study of conversion from polytherapy in outpatients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 82/83.
Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecar | 1997 |
Cognitive abilities and adjustment with gabapentin: results of a multisite study.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Double-Blind Method; Epilepsy | 1999 |
9 other studies available for gabapentin and Complex Partial Epilepsy
Article | Year |
---|---|
Brain homocarnosine and seizure control of patients taking gabapentin or topiramate.
Topics: Adult; Amines; Anticonvulsants; Brain Chemistry; Carnosine; Cyclohexanecarboxylic Acids; Drug Therap | 2006 |
Hypomania induced by gabapentin.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Cyclohexanecarboxylic Acids; Dose-Response Rela | 1995 |
Gabapentin associated with aggressive behavior in pediatric patients with seizures.
Topics: Acetates; Adolescent; Age Factors; Aggression; Amines; Anticonvulsants; Child; Child Behavior Disord | 1996 |
[Trials with gabapentin monotherapy in patients with complex partial or secondary generalized seizures].
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Do | 1997 |
Isolated ataxia as an idiosyncratic side-effect under gabapentin.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cerebellar Ataxia; Cyclohexanecarboxylic Acids; Dose-Respo | 1997 |
Successful treatment with gabapentin in the presence of hypersensitivity syndrome to phenytoin and carbamazepine: a report of three cases.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Hypersens | 1999 |
Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures.
Topics: Acetates; Alanine; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzylamines; Carba | 1999 |
Improved sexual function in three men taking lamotrigine for epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; | 2000 |
A comparison of four new antiepileptic medications.
Topics: Acetates; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose | 2000 |