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gabapentin and Complex Partial Epilepsy

gabapentin has been researched along with Complex Partial Epilepsy in 18 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Research Excerpts

ExcerptRelevanceReference
"Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults."7.69Gabapentin associated with aggressive behavior in pediatric patients with seizures. ( Lo, W; Nahata, MC; Tallian, KB; Tsao, CY, 1996)
"Gabapentin (GBP) is a non-protein-bound gamma amino acid which is not subjected to metabolic degradation in man."6.68Seizure frequency and CSF parameters in a double-blind placebo controlled trial of gabapentin in patients with intractable complex partial seizures. ( Ben-Menachem, E; Hamberger, A; Hedner, T; Persson, LI; Söderfelt, B, 1995)
" The second patient complained of impotence after a rash while taking phenytoin and carbamazepine."3.70Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000)
"Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults."3.69Gabapentin associated with aggressive behavior in pediatric patients with seizures. ( Lo, W; Nahata, MC; Tallian, KB; Tsao, CY, 1996)
"Gabapentin (GBP) is a non-protein-bound gamma amino acid which is not subjected to metabolic degradation in man."2.68Seizure frequency and CSF parameters in a double-blind placebo controlled trial of gabapentin in patients with intractable complex partial seizures. ( Ben-Menachem, E; Hamberger, A; Hedner, T; Persson, LI; Söderfelt, B, 1995)
"Gabapentin appears to increase human brain GABA levels."2.68The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. ( Behar, KL; Lamoureux, D; Mattson, RH; Petroff, OA; Rothman, DL, 1996)
"Gabapentin was well tolerated by patients in both dosage groups, and no patients exited the study due to adverse events, despite rapid initiation of full dose within 24 hours."2.68Gabapentin monotherapy: I. An 8-day, double-blind, dose-controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 88/89. ( Bergey, GK; Blume, WT; Crockatt, JG; Garofalo, E; LaMoreaux, L; Leiderman, DB; Morrell, MJ; Morris, HH; Penovich, PE; Pierce, M; Rosenfeld, W, 1997)
" Results of outcome measures, including time to exit, completion rate, and mean time on monotherapy, showed no significant differences among dosage groups."2.68Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multicenter study of conversion from polytherapy in outpatients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 82/83. ( Abou-Khalil, B; Beydoun, A; Cantrell, D; Fischer, J; Garofalo, E; Greiner, M; Harden, C; Hayes, A; Labar, DR; Pierce, M; Ramsay, RE; Sackellares, JC; Uthman, BM, 1997)
"Gabapentin is an anti-epileptic drug (AED) that was approved in 1993 for the adjunct treatment of complex partial seizures (CPS) with and without generalization."2.41Gabapentin: a unique anti-epileptic agent. ( Dougherty, JA; Rhoney, DH, 2001)
"Gabapentin has been accepted worldwide as a novel antiepileptic drug with a favourable tolerability profile."1.30Isolated ataxia as an idiosyncratic side-effect under gabapentin. ( Bittermann, HJ; Herrendorf, G; Kurth, C; Steinhoff, BJ, 1997)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (72.22)18.2507
2000's5 (27.78)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Crespo Pérez, L1
Moreira Vicente, V1
Cano Ruiz, A1
Gobernado Serrano, JM1
Cobo Ibañez, N1
Milicua Salamero, JM1
Petroff, OA3
Hyder, F1
Rothman, DL2
Mattson, RH3
Wolf, SM1
Shinnar, S1
Kang, H1
Gil, KB1
Moshé, SL1
Short, C1
Cooke, L1
Fromm, GH1
Ben-Menachem, E1
Söderfelt, B1
Hamberger, A1
Hedner, T1
Persson, LI1
Behar, KL1
Lamoureux, D1
Tallian, KB1
Nahata, MC1
Lo, W1
Tsao, CY1
Bergey, GK1
Morris, HH2
Rosenfeld, W1
Blume, WT1
Penovich, PE1
Morrell, MJ1
Leiderman, DB1
Crockatt, JG1
LaMoreaux, L1
Garofalo, E2
Pierce, M2
Beydoun, A1
Fischer, J1
Labar, DR1
Harden, C1
Cantrell, D1
Uthman, BM1
Sackellares, JC1
Abou-Khalil, B1
Ramsay, RE1
Hayes, A1
Greiner, M1
Pierce, MW2
Shokry, A1
Steinhoff, BJ1
Herrendorf, G1
Bittermann, HJ1
Kurth, C1
Hamer, HM1
Dodrill, CB1
Arnett, JL1
Hayes, AG1
Garofalo, EA1
Greeley, CA1
Greiner, MJ1
Maj, R1
Fariello, RG1
Pevarello, P1
Varasi, M1
McArthur, RA1
Salvati, P1
Husain, AM1
Carwile, ST1
Miller, PP1
Radtke, RA1
Collins, TL1
Dougherty, JA1
Rhoney, DH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776]Phase 254 participants (Actual)Interventional2017-08-07Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Prefrontal GABA+ Concentrations

Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine3.90
Gabapentin3.93
Placebo Oral Tablet3.73

Prefrontal Glx Concentrations

Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine21.59
Gabapentin21.69
Placebo Oral Tablet22.25

Reviews

3 reviews available for gabapentin and Complex Partial Epilepsy

ArticleYear
[Anticonvulsant hypersensitivity syndrome: an entity to be remembered].
    Gastroenterologia y hepatologia, 2009, Volume: 32, Issue:10

    Topics: Adolescent; Amines; Anemia, Hemolytic; Anticonvulsants; Astrocytoma; Brain Neoplasms; Carbamazepine;

2009
Gabapentin: discussion.
    Epilepsia, 1994, Volume: 35 Suppl 5

    Topics: Acetates; Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drugs, Inv

1994
Gabapentin: a unique anti-epileptic agent.
    Neurological research, 2001, Volume: 23, Issue:8

    Topics: Acetates; Adult; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Epilepsy, Complex Part

2001

Trials

6 trials available for gabapentin and Complex Partial Epilepsy

ArticleYear
Gabapentin toxicity in children manifesting as behavioral changes.
    Epilepsia, 1995, Volume: 36, Issue:12

    Topics: Acetates; Affect; Aggression; Amines; Anticonvulsants; Behavior; Child; Cyclohexanecarboxylic Acids;

1995
Seizure frequency and CSF parameters in a double-blind placebo controlled trial of gabapentin in patients with intractable complex partial seizures.
    Epilepsy research, 1995, Volume: 21, Issue:3

    Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Respon

1995
The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy.
    Annals of neurology, 1996, Volume: 39, Issue:1

    Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Response

1996
Gabapentin monotherapy: I. An 8-day, double-blind, dose-controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 88/89.
    Neurology, 1997, Volume: 49, Issue:3

    Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Rel

1997
Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multicenter study of conversion from polytherapy in outpatients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 82/83.
    Neurology, 1997, Volume: 49, Issue:3

    Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecar

1997
Cognitive abilities and adjustment with gabapentin: results of a multisite study.
    Epilepsy research, 1999, Volume: 35, Issue:2

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Double-Blind Method; Epilepsy

1999

Other Studies

9 other studies available for gabapentin and Complex Partial Epilepsy

ArticleYear
Brain homocarnosine and seizure control of patients taking gabapentin or topiramate.
    Epilepsia, 2006, Volume: 47, Issue:3

    Topics: Adult; Amines; Anticonvulsants; Brain Chemistry; Carnosine; Cyclohexanecarboxylic Acids; Drug Therap

2006
Hypomania induced by gabapentin.
    The British journal of psychiatry : the journal of mental science, 1995, Volume: 166, Issue:5

    Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Cyclohexanecarboxylic Acids; Dose-Response Rela

1995
Gabapentin associated with aggressive behavior in pediatric patients with seizures.
    Epilepsia, 1996, Volume: 37, Issue:5

    Topics: Acetates; Adolescent; Age Factors; Aggression; Amines; Anticonvulsants; Child; Child Behavior Disord

1996
[Trials with gabapentin monotherapy in patients with complex partial or secondary generalized seizures].
    Praxis, 1997, Sep-10, Volume: 86, Issue:37

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Do

1997
Isolated ataxia as an idiosyncratic side-effect under gabapentin.
    Seizure, 1997, Volume: 6, Issue:6

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cerebellar Ataxia; Cyclohexanecarboxylic Acids; Dose-Respo

1997
Successful treatment with gabapentin in the presence of hypersensitivity syndrome to phenytoin and carbamazepine: a report of three cases.
    Seizure, 1999, Volume: 8, Issue:3

    Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Hypersens

1999
Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures.
    Epilepsia, 1999, Volume: 40, Issue:11

    Topics: Acetates; Alanine; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzylamines; Carba

1999
Improved sexual function in three men taking lamotrigine for epilepsy.
    Southern medical journal, 2000, Volume: 93, Issue:3

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial;

2000
A comparison of four new antiepileptic medications.
    Seizure, 2000, Volume: 9, Issue:4

    Topics: Acetates; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose

2000