Page last updated: 2024-10-27

gabapentin and Cognition Disorders

gabapentin has been researched along with Cognition Disorders in 20 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"The purpose of this article was to report a case of chorea that developed in an elderly man being treated with gabapentin for severe anxiety."7.75Chorea associated with gabapentin use in an elderly man. ( Attupurath, R; Aziz, R; Muralee, S; Tampi, RR; Wollman, D, 2009)
"To review and summarize the currently available data on the use of anticonvulsant mood stabilizers (carbamazepine, valproic acid, gabapentin, lamotrigine, topiramate) in the treatment of behavioral and psychological symptoms of dementia (BPSD); to determine whether these medications can be recommended for routine clinical use."4.84Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review. ( Konovalov, S; Muralee, S; Tampi, RR, 2008)
"The purpose of this article was to report a case of chorea that developed in an elderly man being treated with gabapentin for severe anxiety."3.75Chorea associated with gabapentin use in an elderly man. ( Attupurath, R; Aziz, R; Muralee, S; Tampi, RR; Wollman, D, 2009)
"Musculoskeletal pain is a widespread complex regional pain syndrome associated with altered emotional and cognitive functioning along with heightened physical disability that has become a global health concern."1.62Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin. ( Bhatti, R; Garg, S; Kaur, A; Kaur, H; Singh, L; Singh, N, 2021)
"Our findings reveal that neuropathic pain-related cognitive impairments in male mice are correlated to bilateral morphological changes in PV interneurons and layer 5/6 IL pyramidal neuron AIS."1.48Neuropathic Pain Creates an Enduring Prefrontal Cortex Dysfunction Corrected by the Type II Diabetic Drug Metformin But Not by Gabapentin. ( Ahmad, A; Kroener, S; Mejia, G; Mwirigi, J; Pradhan, G; Price, T; Shiers, S, 2018)
" There is also a fairly broad consensus that gabapentin is safe and well tolerated, but the side-effect profile of gabapentin has not been adequately assessed in pain populations."1.33Adverse effects of gabapentin and lack of anti-allodynic efficacy of amitriptyline in the streptozotocin model of painful diabetic neuropathy. ( Bourin, C; Chen, P; Hogan, JB; Leet, JE; Lindner, MD; Machet, F; McElroy, JF; Stock, DA, 2006)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.00)18.2507
2000's13 (65.00)29.6817
2010's4 (20.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Kaur, A1
Singh, L1
Garg, S1
Kaur, H1
Singh, N1
Bhatti, R1
Shiers, S1
Pradhan, G1
Mwirigi, J1
Mejia, G1
Ahmad, A1
Kroener, S1
Price, T1
Attupurath, R1
Aziz, R1
Wollman, D1
Muralee, S2
Tampi, RR2
Blake, MG1
Boccia, MM1
Carcaboso, AM1
Chiappetta, DA1
Höcht, C1
Krawczyk, MC1
Sosnik, A1
Baratti, CM1
Cavanna, AE1
Ali, F1
Rickards, HE1
McCorry, D1
Grégoire, S1
Michaud, V1
Chapuy, E1
Eschalier, A1
Ardid, D1
Joffe, H1
Soares, CN1
Cohen, LS1
Salinsky, MC1
Storzbach, D1
Spencer, DC1
Oken, BS1
Landry, T1
Dodrill, CB1
Horvath, J1
Coeytaux, A1
Jallon, P1
Landis, T1
Temperli, P1
Burkhard, PR1
Aharonovich, E1
Hasin, DS1
Brooks, AC1
Liu, X1
Bisaga, A1
Nunes, EV1
Lindner, MD1
Bourin, C1
Chen, P1
McElroy, JF1
Leet, JE1
Hogan, JB1
Stock, DA1
Machet, F1
Povedano, M1
Gascón, J1
Gálvez, R1
Ruiz, M1
Rejas, J1
Konovalov, S1
Baillieux, H1
Verslegers, W1
Paquier, P1
De Deyn, PP1
Mariën, P1
Leach, JP1
Girvan, J1
Paul, A1
Brodie, MJ1
Martin, R2
Kuzniecky, R2
Ho, S1
Hetherington, H1
Pan, J1
Sinclair, K2
Gilliam, F2
Faught, E2
Meador, K1
Turrentine, L1
Aldenkamp, AP1
Goldberg, JF1
Burdick, KE1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Metformin on Chronic Pain After Thoracic Surgery in Diabetic Patients[NCT04089813]200 participants (Anticipated)Observational2019-09-10Not yet recruiting
Treatment of Crack-cocaine Addiction Through Cognitive Neuromodulation of the Prefrontal Cortex Produced by Transcranial Direct Current Stimulation.[NCT01337297]Phase 1/Phase 220 participants (Actual)Interventional2011-06-30Completed
Neural Mechanistic Explanations for Differential Drug Abuse Treatment Outcomes[NCT01678833]7 participants (Actual)Observational2012-07-19Completed
Medications After Adolescent Bariatric Surgery Protocol for Inadequate Weight Loss Following Sleeve Gastrectomy in Adolescents and Young Adults: A Pilot Feasibility Study[NCT04572217]Phase 20 participants (Actual)Interventional2022-06-30Withdrawn (stopped due to No available funding)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Abstinence

abstinence to the use of crack-cocaine up to 3 months after the completion of two-weeks of treatment sessions with active-tDCS or sham-tDCS. (NCT01337297)
Timeframe: Two days after the end of tDCS treatment (one session every other day, 5 sessions), that is, on the 12nd day from the beginning.

Interventionpercentage of participants (Number)
Active-tDCS71.4
Sham-tDCS16.6

Reviews

4 reviews available for gabapentin and Cognition Disorders

ArticleYear
Behavioral and cognitive effects of anti-epileptic drugs.
    Discovery medicine, 2010, Volume: 9, Issue:45

    Topics: Amines; Anticonvulsants; Antidepressive Agents; Behavior; Cognition; Cognition Disorders; Cyclohexan

2010
Assessment and treatment of hot flushes and menopausal mood disturbance.
    The Psychiatric clinics of North America, 2003, Volume: 26, Issue:3

    Topics: Acetates; Aging; Amines; Anti-Anxiety Agents; Cognition Disorders; Cyclohexanecarboxylic Acids; Fema

2003
Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review.
    International psychogeriatrics, 2008, Volume: 20, Issue:2

    Topics: Aggression; Amines; Anticonvulsants; Carbamazepine; Cognition Disorders; Cyclohexanecarboxylic Acids

2008
Cognitive side effects of anticonvulsants.
    The Journal of clinical psychiatry, 2001, Volume: 62 Suppl 14

    Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cognition Disorders; Cyclohexane

2001

Trials

4 trials available for gabapentin and Cognition Disorders

ArticleYear
Effects of topiramate and gabapentin on cognitive abilities in healthy volunteers.
    Neurology, 2005, Mar-08, Volume: 64, Issue:5

    Topics: Activities of Daily Living; Adult; Amines; Anticonvulsants; Brain; Cognition; Cognition Disorders; C

2005
Gabapentin and cognition: a double blind, dose ranging, placebo controlled study in refractory epilepsy.
    Journal of neurology, neurosurgery, and psychiatry, 1997, Volume: 62, Issue:4

    Topics: Acetates; Adolescent; Adult; Aged; Amines; Analysis of Variance; Anticonvulsants; Cognition Disorder

1997
Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults.
    Neurology, 1999, Jan-15, Volume: 52, Issue:2

    Topics: Acetates; Adult; Affect; Amines; Anticonvulsants; Cognition Disorders; Cyclohexanecarboxylic Acids;

1999
Comparative cognitive effects of carbamazepine and gabapentin in healthy senior adults.
    Epilepsia, 2001, Volume: 42, Issue:6

    Topics: Acetates; Age Factors; Aged; Amines; Anticonvulsants; Attention; Carbamazepine; Cognition; Cognition

2001

Other Studies

12 other studies available for gabapentin and Cognition Disorders

ArticleYear
Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin.
    Journal of molecular neuroscience : MN, 2021, Volume: 71, Issue:2

    Topics: Analgesics; Animals; Anxiety; Brain Chemistry; Cognition Disorders; Cytokines; Drug Evaluation, Prec

2021
Neuropathic Pain Creates an Enduring Prefrontal Cortex Dysfunction Corrected by the Type II Diabetic Drug Metformin But Not by Gabapentin.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018, 08-15, Volume: 38, Issue:33

    Topics: Analgesics; Animals; Attention; Axons; Clonidine; Cognition Disorders; Discrimination, Psychological

2018
Chorea associated with gabapentin use in an elderly man.
    The American journal of geriatric pharmacotherapy, 2009, Volume: 7, Issue:4

    Topics: Aged; Amines; Analgesics; Anti-Dyskinesia Agents; Anxiety; Chorea; Cognition Disorders; Cyclohexanec

2009
Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice.
    Epilepsy & behavior : E&B, 2010, Volume: 17, Issue:2

    Topics: Amines; Animals; Anticonvulsants; Cognition Disorders; Cyclohexanecarboxylic Acids; Disease Models,

2010
Study of emotional and cognitive impairments in mononeuropathic rats: effect of duloxetine and gabapentin.
    Pain, 2012, Volume: 153, Issue:8

    Topics: Affective Symptoms; Amines; Analgesics; Animals; Antidepressive Agents; Cognition; Cognition Disorde

2012
Carbamazepine encephalopathy masquerading as Creutzfeldt-Jakob disease.
    Neurology, 2005, Aug-23, Volume: 65, Issue:4

    Topics: Aged; Amines; Analgesics, Non-Narcotic; Atrophy; Basal Ganglia; Brain; Brain Damage, Chronic; Carbam

2005
Cognitive deficits predict low treatment retention in cocaine dependent patients.
    Drug and alcohol dependence, 2006, Feb-28, Volume: 81, Issue:3

    Topics: Adult; Amines; Cocaine-Related Disorders; Cognition Disorders; Cognitive Behavioral Therapy; Cyclohe

2006
Cognitive deficits predict low treatment retention in cocaine dependent patients.
    Drug and alcohol dependence, 2006, Feb-28, Volume: 81, Issue:3

    Topics: Adult; Amines; Cocaine-Related Disorders; Cognition Disorders; Cognitive Behavioral Therapy; Cyclohe

2006
Cognitive deficits predict low treatment retention in cocaine dependent patients.
    Drug and alcohol dependence, 2006, Feb-28, Volume: 81, Issue:3

    Topics: Adult; Amines; Cocaine-Related Disorders; Cognition Disorders; Cognitive Behavioral Therapy; Cyclohe

2006
Cognitive deficits predict low treatment retention in cocaine dependent patients.
    Drug and alcohol dependence, 2006, Feb-28, Volume: 81, Issue:3

    Topics: Adult; Amines; Cocaine-Related Disorders; Cognition Disorders; Cognitive Behavioral Therapy; Cyclohe

2006
Adverse effects of gabapentin and lack of anti-allodynic efficacy of amitriptyline in the streptozotocin model of painful diabetic neuropathy.
    Experimental and clinical psychopharmacology, 2006, Volume: 14, Issue:1

    Topics: Amines; Amitriptyline; Animals; Cognition Disorders; Cyclohexanecarboxylic Acids; Diabetes Mellitus,

2006
Cognitive function impairment in patients with neuropathic pain under standard conditions of care.
    Journal of pain and symptom management, 2007, Volume: 33, Issue:1

    Topics: Adult; Aged; Amines; Analgesics; Cognition Disorders; Cohort Studies; Cyclohexanecarboxylic Acids; F

2007
Cerebellar cognitive affective syndrome associated with topiramate.
    Clinical neurology and neurosurgery, 2008, Volume: 110, Issue:5

    Topics: Amines; Anticonvulsants; Carbamazepine; Cerebellar Diseases; Cerebellum; Cognition Disorders; Cycloh

2008
Valproate and other anticonvulsants for psychiatric disorders.
    The Medical letter on drugs and therapeutics, 2000, Dec-11, Volume: 42, Issue:1094

    Topics: Abnormalities, Drug-Induced; Acetates; Adult; Amines; Anti-Anxiety Agents; Anticonvulsants; Bipolar

2000
Effects of antiepileptic drugs on cognition.
    Epilepsia, 2001, Volume: 42 Suppl 1

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Cyclohexanecarboxy

2001