Page last updated: 2024-10-27

gabapentin and Cleft Palate

gabapentin has been researched along with Cleft Palate in 1 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Holmes, LB	1
Hernandez-Diaz, S	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Comparison of Gabapentin and Metoclopramide for Treating Hyperemesis Gravidarum[NCT02163434]			Phase 2	31 participants (Actual)	Interventional	2014-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Baseline Adjusted Mean Daily Motherisk-PUQE Total Scores (Pregnancy-unique Quantification of Emesis and Nausea Scale) for Days 5-7

Score range: 6-30 with higher score indicating a worse outcome. (NCT02163434)
Timeframe: 1 week

Intervention	units on a scale (Mean)
Gabapentin	6.35
Metoclopramide	13.22

Baseline Adjusted Mean Daily Nausea Scores From the Motherisk-PUQE for Days 5-7.

Score range: 2-10 with higher score indicating a worse outcome. (NCT02163434)
Timeframe: 1 week

Intervention	units on a scale (Mean)
Gabapentin	2.01
Metoclopramide	3.69

Baseline Adjusted Mean Daily Oral Nutrition Score for Days 5-7

Score range: 0-15 with higher score indicating a better outcome. (NCT02163434)
Timeframe: 1 week

Intervention	units on a scale (Mean)
Gabapentin	7.86
Metoclopramide	4.01

Desire to Continue Therapy at Study Endpoint

Scores: 0=no, 1=yes. Thus, a higher score indicates a better outcome. (NCT02163434)
Timeframe: 1 week

Intervention	units on a scale (Mean)
Gabapentin	0.67
Metoclopramide	0.14

Global Satisfaction of Treatment at the Study Endpoint.

Score range: 0-4 with higher score indicating a better outcome. (NCT02163434)
Timeframe: 1 week

Intervention	units on a scale (Mean)
Gabapentin	2.22
Metoclopramide	0.63

Percent of Subjects Requiring Repeat iv Hydration or Hospital Admission for HG From the Outpatient Setting.

(NCT02163434)
Timeframe: 1 week

Intervention	Participants (Count of Participants)
Gabapentin	5
Metoclopramide	5

Other Studies

1 other study available for gabapentin and Cleft Palate

Article	Year
Newer anticonvulsants: lamotrigine, topiramate and gabapentin. Birth defects research. Part A, Clinical and molecular teratology, 2012, Volume: 94, Issue:8 Topics: Abnormalities, Drug-Induced; Adult; Amines; Anticonvulsants; Case-Control Studies; Child; Child, Pre	2012