Page last updated: 2024-10-27

gabapentin and Cerebral Palsy

gabapentin has been researched along with Cerebral Palsy in 8 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Cerebral Palsy: A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)

Research Excerpts

ExcerptRelevanceReference
"Trihexyphenidyl alone is as effective as combination of gabapentin with trihexyphenidyl in decreasing the severity of dystonia at 12 wk."9.69Gabapentin as Add-on Therapy to Trihexyphenidyl in Children with Dyskinetic Cerebral Palsy: A Randomized, Controlled Trial. ( Dabla, S; Kumar, S; Shankar Kaushik, J; Verma, S, 2023)
"Gabapentin is often used to manage pain in children with dystonic cerebral palsy, however the evidence for its effectiveness in this population is limited."8.02A pilot feasibility study of gabapentin for managing pain in children with dystonic cerebral palsy. ( Antolovich, G; Baker, F; Chalkiadis, G; Copeland, L; Harvey, A; McKinnon, C; Orsini, F; Rice, J; Scheinberg, A; Stewart, K; Thorley, M; Waugh, MC, 2021)
"Trihexyphenidyl alone is as effective as combination of gabapentin with trihexyphenidyl in decreasing the severity of dystonia at 12 wk."5.69Gabapentin as Add-on Therapy to Trihexyphenidyl in Children with Dyskinetic Cerebral Palsy: A Randomized, Controlled Trial. ( Dabla, S; Kumar, S; Shankar Kaushik, J; Verma, S, 2023)
"Gabapentin is often used to manage pain in children with dystonic cerebral palsy, however the evidence for its effectiveness in this population is limited."4.02A pilot feasibility study of gabapentin for managing pain in children with dystonic cerebral palsy. ( Antolovich, G; Baker, F; Chalkiadis, G; Copeland, L; Harvey, A; McKinnon, C; Orsini, F; Rice, J; Scheinberg, A; Stewart, K; Thorley, M; Waugh, MC, 2021)
"Epilepsy is common in individuals who are mentally retarded and/or otherwise multiply handicapped."2.39The role of the old and the new antiepileptic drugs in special populations: mental and multiple handicaps. ( Mattson, RH, 1996)
"Oral baclofen was used by all doctors and was the first choice of 10 of 11."1.48Oral medication prescription practices of tertiary-based specialists for dystonia in children with cerebral palsy. ( Harvey, A; Reddihough, D; Scheinberg, A; Williams, K, 2018)
"Six children with cerebral palsy are presented who developed neuropathic pain following multilevel orthopedic surgery."1.33Neuropathic pain following multilevel surgery in children with cerebral palsy: a case series and review. ( Lauder, GR; White, MC, 2005)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's1 (12.50)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Kumar, S1
Shankar Kaushik, J1
Verma, S1
Dabla, S1
Harvey, A2
Waugh, MC1
Rice, J1
Antolovich, G1
Copeland, L1
Orsini, F1
Scheinberg, A2
McKinnon, C1
Thorley, M1
Baker, F1
Chalkiadis, G1
Stewart, K1
Reddihough, D1
Williams, K1
Arvio, M1
Merikanto, J1
Lauder, GR2
White, MC1
Nordmann, GR1
Grier, DJ1
Mattson, RH1
Krach, LE1

Reviews

2 reviews available for gabapentin and Cerebral Palsy

ArticleYear
The role of the old and the new antiepileptic drugs in special populations: mental and multiple handicaps.
    Epilepsia, 1996, Volume: 37 Suppl 6

    Topics: Acetates; Amines; Anticonvulsants; Cerebral Palsy; Cyclohexanecarboxylic Acids; Disabled Persons; Dr

1996
Pharmacotherapy of spasticity: oral medications and intrathecal baclofen.
    Journal of child neurology, 2001, Volume: 16, Issue:1

    Topics: Acetates; Administration, Oral; Amines; Anti-Anxiety Agents; Baclofen; Benzodiazepines; Cerebral Pal

2001

Trials

1 trial available for gabapentin and Cerebral Palsy

ArticleYear
Gabapentin as Add-on Therapy to Trihexyphenidyl in Children with Dyskinetic Cerebral Palsy: A Randomized, Controlled Trial.
    Indian journal of pediatrics, 2023, Volume: 90, Issue:9

    Topics: Adolescent; Cerebral Palsy; Dystonia; Gabapentin; Humans; Trihexyphenidyl

2023

Other Studies

5 other studies available for gabapentin and Cerebral Palsy

ArticleYear
A pilot feasibility study of gabapentin for managing pain in children with dystonic cerebral palsy.
    BMC pediatrics, 2021, 08-28, Volume: 21, Issue:1

    Topics: Adolescent; Australia; Cerebral Palsy; Child; Child, Preschool; Feasibility Studies; Female; Gabapen

2021
Oral medication prescription practices of tertiary-based specialists for dystonia in children with cerebral palsy.
    Journal of paediatrics and child health, 2018, Volume: 54, Issue:4

    Topics: Administration, Oral; Adolescent; Australia; Baclofen; Central Nervous System Agents; Cerebral Palsy

2018
[A relief from neural pain--gabapentin helped against hip ache in a girl with cerebral palsy].
    Duodecim; laaketieteellinen aikakauskirja, 2001, Volume: 117, Issue:14

    Topics: Acetates; Adolescent; Amines; Analgesics; Arthralgia; Cerebral Palsy; Cyclohexanecarboxylic Acids; F

2001
Neuropathic pain following multilevel surgery in children with cerebral palsy: a case series and review.
    Paediatric anaesthesia, 2005, Volume: 15, Issue:5

    Topics: Adolescent; Amines; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Cerebral Palsy; Chi

2005
Computed tomography guided lumbar sympathetic block for complex regional pain syndrome in a child: a case report and review.
    European journal of pain (London, England), 2006, Volume: 10, Issue:5

    Topics: Amines; Amitriptyline; Analgesics; Anesthetics, Local; Antidepressive Agents, Tricyclic; Autonomic N

2006