gabapentin and Burns
gabapentin has been researched along with Burns in 17 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "A retrospective review of charts and pharmacy records of gabapentin and pregabalin dispensed to control pruritus and/or pain was conducted for burn survivors up to 20 years of age." | 7.88 | Use of gabapentin and pregabalin for pruritus and neuropathic pain associated with major burn injury: A retrospective chart review. ( Amin, A; Kaul, I; Meyer, WJ; Rosenberg, L; Rosenberg, M, 2018) |
| "Compared with that before treatment, the itching degree of patients with light, moderate, and severe itching in placebo group was not relieved after treatment; the itching degree of patients with moderate or severe itching in cetirizine group was alleviated after treatment, but not in patients with light itching; itching degree of all patients in gabapentin group was significantly relieved after treatment." | 7.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "During treatment and post-treatment phases, patients receiving Gp had cumulative morphine consumption and a mean daily pain score significantly lower than controls." | 7.74 | Effects of gabapentin on morphine consumption and pain in severely burned patients. ( Cuignet, O; Pirson, J; Soudon, O; Zizi, M, 2007) |
| "We describe the use of gabapentin for the treatment of itching in wound healing in 35 children." | 7.72 | Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study. ( Mendham, JE, 2004) |
| "Gabapentin is an antiepileptic drug which has been successfully used to manage neuropathic pain, and is reporting to be successful in management of all forms of itch." | 6.76 | A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus. ( Ahuja, RB; Gupta, G; Gupta, R; Shrivastava, P, 2011) |
| "Gabapentin has established efficacy in the reduction of burn-induced hyperalgesia and allodynia in animal and human experimental burn models." | 5.35 | Successful use of gabapentin in acute pain management following burn injury: a case series. ( Cramond, T; Gray, P; Williams, B, 2008) |
| "A retrospective review of charts and pharmacy records of gabapentin and pregabalin dispensed to control pruritus and/or pain was conducted for burn survivors up to 20 years of age." | 3.88 | Use of gabapentin and pregabalin for pruritus and neuropathic pain associated with major burn injury: A retrospective chart review. ( Amin, A; Kaul, I; Meyer, WJ; Rosenberg, L; Rosenberg, M, 2018) |
| "We studied 23 patients with severe pruritus scoring at least 5 on the visual analogue scale (VAS) and refractory to antihistamine and gabapentin administration." | 3.88 | Effect of cold pack therapy for management of burn scar pruritus: A pilot study. ( Cho, YS; Joo, SY; Kim, JB; Seo, CH, 2018) |
| "Compared with that before treatment, the itching degree of patients with light, moderate, and severe itching in placebo group was not relieved after treatment; the itching degree of patients with moderate or severe itching in cetirizine group was alleviated after treatment, but not in patients with light itching; itching degree of all patients in gabapentin group was significantly relieved after treatment." | 3.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "During treatment and post-treatment phases, patients receiving Gp had cumulative morphine consumption and a mean daily pain score significantly lower than controls." | 3.74 | Effects of gabapentin on morphine consumption and pain in severely burned patients. ( Cuignet, O; Pirson, J; Soudon, O; Zizi, M, 2007) |
| "We describe the use of gabapentin for the treatment of itching in wound healing in 35 children." | 3.72 | Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study. ( Mendham, JE, 2004) |
| "Gabapentin is an antiepileptic drug which has been successfully used to manage neuropathic pain, and is reporting to be successful in management of all forms of itch." | 2.76 | A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus. ( Ahuja, RB; Gupta, G; Gupta, R; Shrivastava, P, 2011) |
| "Post-burn pruritus is the pruritus that occurs after burn during the rehabilitation and healing process of burn wounds." | 2.66 | Post-Burn Pruritus. ( Chung, BY; Jung, MJ; Kang, SY; Kim, HB; Kim, HO; Kwak, IS; Park, CW, 2020) |
| "Post burn pruritus is a well recognised symptom in almost all burn patients." | 2.48 | Post burn pruritus--a review of current treatment options. ( Gupta, AK; Lamba, S; Paul, MK; Prabha, R; Rao, AL; Zachariah, JR, 2012) |
| "Chronic neuropathic pain (CNP) after burn injury to the hand/upper extremity is relatively common, but not well described in the literature." | 1.62 | Chronic Neuropathic Pain Following Hand Burns: Etiology, Treatment, and Long-Term Outcomes. ( Dellon, AL; Hultman, CS; Klifto, KM; Lifchez, SD; Yesantharao, PS, 2021) |
| "Gabapentin has analgesic efficacy for neuropathic pain and is increasingly used in burn care." | 1.51 | The Effects of Early Neuropathic Pain Control With Gabapentin on Long-Term Chronic Pain and Itch in Burn Patients. ( Carrougher, GJ; Gibran, NS; Kneib, CJ; Mandell, SP; Muffley, LA; Sibbett, SH, 2019) |
| "Gabapentin has established efficacy in the reduction of burn-induced hyperalgesia and allodynia in animal and human experimental burn models." | 1.35 | Successful use of gabapentin in acute pain management following burn injury: a case series. ( Cramond, T; Gray, P; Williams, B, 2008) |
| "Gabapentin is an anticonvulsant that may represent a novel class of drugs, which has novel spinal antihyperalgesic activity." | 1.30 | The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. ( Jun, JH; Yaksh, TL, 1998) |
| "Secondary hyperalgesia exhibited a tendency toward recovery over time." | 1.30 | Systemic gabapentin and S(+)-3-isobutyl-gamma-aminobutyric acid block secondary hyperalgesia. ( Jones, DL; Sorkin, LS, 1998) |
Research
Studies (17)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 5 (29.41) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Chaghazardi, S | 1 |
| Hedari, M | 1 |
| Bazargan-Hejazi, S | 1 |
| Mohammadi, R | 1 |
| Ahmadi, A | 1 |
| Natalwala, I | 1 |
| Kiely, J | 1 |
| Kilshaw, A | 1 |
| McKay, G | 1 |
| Chu, V | 1 |
| Phipps, A | 1 |
| Anwar, MU | 1 |
| Yarwood, J | 1 |
| Sandhu, R | 1 |
| Muthayya, P | 1 |
| Sloan, B | 1 |
| Lennertz, R | 1 |
| Zimmerman, H | 1 |
| McCormick, T | 1 |
| Hetzel, S | 1 |
| Faucher, L | 1 |
| Gibson, A | 1 |
| Chung, BY | 1 |
| Kim, HB | 1 |
| Jung, MJ | 1 |
| Kang, SY | 1 |
| Kwak, IS | 1 |
| Park, CW | 1 |
| Kim, HO | 1 |
| Klifto, KM | 1 |
| Yesantharao, PS | 1 |
| Dellon, AL | 1 |
| Hultman, CS | 1 |
| Lifchez, SD | 1 |
| Kaul, I | 1 |
| Amin, A | 1 |
| Rosenberg, M | 1 |
| Rosenberg, L | 1 |
| Meyer, WJ | 1 |
| Joo, SY | 1 |
| Kim, JB | 1 |
| Cho, YS | 2 |
| Seo, CH | 1 |
| Kneib, CJ | 1 |
| Sibbett, SH | 1 |
| Carrougher, GJ | 1 |
| Muffley, LA | 1 |
| Gibran, NS | 1 |
| Mandell, SP | 1 |
| Zheng, L | 1 |
| Bing, Z | 1 |
| Wei, L | 1 |
| Qiang, W | 1 |
| Ahuja, RB | 1 |
| Gupta, R | 1 |
| Gupta, G | 1 |
| Shrivastava, P | 1 |
| Zachariah, JR | 1 |
| Rao, AL | 1 |
| Prabha, R | 1 |
| Gupta, AK | 1 |
| Paul, MK | 1 |
| Lamba, S | 1 |
| Anand, S | 1 |
| Mendham, JE | 1 |
| Cuignet, O | 1 |
| Pirson, J | 1 |
| Soudon, O | 1 |
| Zizi, M | 1 |
| Gray, P | 1 |
| Williams, B | 1 |
| Cramond, T | 1 |
| Jun, JH | 1 |
| Yaksh, TL | 1 |
| Jones, DL | 1 |
| Sorkin, LS | 1 |
Clinical Trials (3)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of the Effects of Liquid Vaseline and Olive Oil on Itching and Scarring in Scald Burns[NCT06104540] | 24 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting | |||
| A pRospective, Case-controlled Evaluation of oLIceridine for Moderate or sEVEre Pain in Patients With Acute Burn Injuries. (RELIEVE)[NCT05465226] | Phase 4 | 31 participants (Actual) | Interventional | 2023-04-01 | Completed | ||
| The Effect of Neurontin on Pain Management in the Acutely Burned Patient[NCT01265056] | 53 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Difference in Psychological Outcomes on the Sickness Inventory Profile (SIP)
The sickness inventory profile (SIP) is a behaviorally based measure of health status. Scores range from 0-68 with higher numbers indicating worse outcomes. The study report total SIP score. The higher the score the worse the function. (NCT01265056)
Timeframe: First Clinic Follow Up After Discharge
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 34.9 |
| Gabapentin | 36.0 |
Opioid Consumption Between the Treatment and the Control Groups (Morphine Equivalents)
(NCT01265056)
Timeframe: From time of enrollment to 2 weeks after being discharged
| Intervention | morphine equivalents (Mean) |
|---|---|
| Placebo | 7.0 |
| Gabapentin | 6.7 |
Psychological Functioning as Evaluated by the Brief Symptom Inventory (BSI) Between Treatment and Placebo Groups
The Brief Symptom Inventory 18 (BSI 18) is designed with reliability in mind. The BSI 18 assessment gathers patient-reported data to help measure psychological distress and psychiatric disorders in medical and community populations. As the latest in an integrated series of test instruments that include the SCL-90-R®, BSI® (53 questions), and DPRS® instruments, the BSI 18 test offers a more effective, easy-to-administer tool to help support clinical decision-making and monitor progress throughout treatment. BSI-18 measures three dimensions with 6 questions a piece (somatization , depression , anxiety) and overall psychological distress scores (Global severity index, GSI). Each of the 18 items range from a score of 0-4; total score ranges from 0-72 with higher scores indicating worse function. The GSI score is calculated as the mean of the three subscales. The study reported the GSI score. Higher score is worse. (NCT01265056)
Timeframe: First Clinic Follow Up After Discharge
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 9 |
| Gabapentin | 7.3 |
Reviews
3 reviews available for gabapentin and Burns
| Article | Year |
|---|---|
Post-Burn Pruritus.
Topics: Animals; Antipsychotic Agents; Burns; Gabapentin; Histamine Antagonists; Humans; Inflammation; Kerat | 2020 |
Post burn pruritus--a review of current treatment options.
Topics: Amines; Analgesics; Burns; Cyclohexanecarboxylic Acids; Emollients; Gabapentin; gamma-Aminobutyric A | 2012 |
Gabapentin for pruritus in palliative care.
Topics: Amines; Analgesics, Opioid; Burns; Cholestasis; Cyclohexanecarboxylic Acids; Dermatologic Agents; Ga | 2013 |
Trials
2 trials available for gabapentin and Burns
| Article | Year |
|---|---|
Comparing the Effect of Gabapentin, Ketamine, Dexmedetomidine, and Entonox on Pain Control in Burn Wound Dressing.
Topics: Adult; Analgesics; Bandages; Blood Pressure; Burns; Debridement; Dexmedetomidine; Female; Gabapentin | 2020 |
A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus.
Topics: Adolescent; Adult; Aged; Amines; Analgesics; Burns; Cetirizine; Child; Cyclohexanecarboxylic Acids; | 2011 |
Other Studies
12 other studies available for gabapentin and Burns
| Article | Year |
|---|---|
The Pinderfields hospital pain management protocol for enzymatic debridement of burns wounds.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Conduction; Ane | 2020 |
Perioperative Multimodal Analgesia Reduces Opioid Use Following Skin Grafting in Nonintubated Burn Patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Bandages; | 2020 |
Chronic Neuropathic Pain Following Hand Burns: Etiology, Treatment, and Long-Term Outcomes.
Topics: Burns; Gabapentin; Hand Injuries; Humans; Neuralgia; Pain Management | 2021 |
Use of gabapentin and pregabalin for pruritus and neuropathic pain associated with major burn injury: A retrospective chart review.
Topics: Adolescent; Analgesics; Burns; Child; Child, Preschool; Female; Gabapentin; Humans; Infant; Male; Ne | 2018 |
Effect of cold pack therapy for management of burn scar pruritus: A pilot study.
Topics: Adult; Burns; Cicatrix; Cryotherapy; Excitatory Amino Acid Antagonists; Female; Gabapentin; Histamin | 2018 |
The Effects of Early Neuropathic Pain Control With Gabapentin on Long-Term Chronic Pain and Itch in Burn Patients.
Topics: Adolescent; Adult; Analgesics; Burns; Female; Gabapentin; Humans; Male; Middle Aged; Neuralgia; Pain | 2019 |
[Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn].
Topics: Amines; Analgesics; Ascorbic Acid; Burns; Cetirizine; Cicatrix; Cyclohexanecarboxylic Acids; Gabapen | 2015 |
Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study.
Topics: Adolescent; Amines; Antipruritics; Burns; Child; Child Behavior Disorders; Child, Preschool; Cyclohe | 2004 |
Effects of gabapentin on morphine consumption and pain in severely burned patients.
Topics: Administration, Oral; Amines; Analgesics; Burns; Case-Control Studies; Cyclohexanecarboxylic Acids; | 2007 |
Successful use of gabapentin in acute pain management following burn injury: a case series.
Topics: Adult; Amines; Analgesics; Burns; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyri | 2008 |
The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat.
Topics: Acetates; Amines; Animals; Anticonvulsants; Burns; Cyclohexanecarboxylic Acids; Dose-Response Relati | 1998 |
Systemic gabapentin and S(+)-3-isobutyl-gamma-aminobutyric acid block secondary hyperalgesia.
Topics: Acetates; Amines; Animals; Anticonvulsants; Burns; Cyclohexanecarboxylic Acids; Dose-Response Relati | 1998 |