Page last updated: 2024-10-27

gabapentin and Breast Cancer

gabapentin has been researched along with Breast Cancer in 42 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Research Excerpts

ExcerptRelevanceReference
"Preoperative administration of gabapentin reduced intraoperative propofol requirements and postoperative analgesic consumption in breast cancer patients undergoing total mastectomy."9.17Effect of gabapentin pretreatment on propofol consumption, hemodynamic variables, and postoperative pain relief in breast cancer surgery. ( Bala, I; Bharti, N; Narayan, V; Singh, G, 2013)
"Gabapentin is used for the treatment of hot flashes and neuropathic pain in breast cancer survivors, and is commonly used off-label for the treatment of anxiety."9.16A randomized, controlled, double-blinded clinical trial of gabapentin 300 versus 900 mg versus placebo for anxiety symptoms in breast cancer survivors. ( Amos, E; Heckler, C; Jacobs, A; Kirshner, JJ; Lavigne, JE; Lord, R; Mathews, JL; Morrow, GR; Mustian, K; Palesh, O, 2012)
"Breast cancer survivors prefer venlafaxine over gabapentin for treating hot flashes."9.14Multicenter, randomized, cross-over clinical trial of venlafaxine versus gabapentin for the management of hot flashes in breast cancer survivors. ( Bordeleau, L; Ennis, M; Goodwin, PJ; Haq, R; Jugovic, O; Loprinzi, CL; Pritchard, KI; Warr, D, 2010)
"To assess the efficacy and the tolerability of gabapentin 900 mg/day compared to vitamin E for the control of vasomotor symptoms in 115 women with breast cancer."9.14Non-hormonal treatment of hot flushes in breast cancer survivors: gabapentin vs. vitamin E. ( Biglia, N; Bounous, V; Marenco, D; Moggio, G; Peano, E; Ponzone, R; Sgandurra, P; Sismondi, P; Tomasi Cont, N, 2009)
"In this pilot study, 22 women with breast cancer on tamoxifen therapy with at least two hot flashes a day took oral gabapentin at 300 mg three times a day for 4 weeks."9.11Pilot study using gabapentin for tamoxifen-induced hot flashes in women with breast cancer. ( Griggs, JJ; Guttuso, TJ; Morrow, GR; Pandya, KJ; Roscoe, JA; Rosenblatt, JD; Sahasrabudhe, DM; Thummala, AR, 2004)
"In an anecdotal report, complete resolution of chemotherapy-induced nausea was seen in a patient with breast cancer, after she was placed on the anticonvulsant gabapentin."9.10Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer. ( Griggs, J; Guttuso, T; Roscoe, J, 2003)
"The purpose of this meta-analysis from randomized controlled trials (RCTs) was to determine the efficacy and safety of the preoperative use of gabapentin for the treatment of acute and chronic postoperative pain following breast cancer surgery."8.98The efficacy of gabapentin in reducing pain intensity and morphine consumption after breast cancer surgery: A meta-analysis. ( Huang, Q; Jiang, Y; Li, J; Lin, H; Rong, Z; Wang, T; Xiong, J; Zhang, Q; Zhang, S, 2018)
" We included studies enrolling adult patients undergoing breast cancer surgery who were randomly assigned to preoperative gabapentin or pregabalin versus placebo or active control and assessed acute (≤24 h) or chronic (≥2 months) pain."8.95Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials. ( Busse, JW; Choi, S; Clarke, H; Devereaux, PJ; Dhaliwal, J; Khan, JS; Rai, AS, 2017)
"Hot flashes are a common and debilitating symptom among survivors of breast cancer."6.80Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial. ( Bowman, MA; Bruner, D; DeMichele, A; Farrar, JT; Mao, JJ; Xie, SX, 2015)
"Gabapentin is an anticonvulsant that the United States Food and Drug Administration approved as an adjunct therapy for partial seizures and postherpetic neuralgia."6.45Use of gabapentin in patients experiencing hot flashes. ( Brown, JN; Wright, BR, 2009)
" Women with breast cancer were randomized into two groups of paclitaxel chemotherapy with gabapentin 300 mg/three times a day orally or placebo for 2 weeks started at day 1 of each paclitaxel cycle."5.30Efficacy of gabapentin for the prevention of paclitaxel induced peripheral neuropathy: A randomized placebo controlled clinical trial. ( Aghili, M; Akrami, S; Esmati, E; Ghalehtaki, R; Kalaghchi, B; Mousavi, N; Sotoudeh, S; Zare, M, 2019)
"Preoperative administration of gabapentin reduced intraoperative propofol requirements and postoperative analgesic consumption in breast cancer patients undergoing total mastectomy."5.17Effect of gabapentin pretreatment on propofol consumption, hemodynamic variables, and postoperative pain relief in breast cancer surgery. ( Bala, I; Bharti, N; Narayan, V; Singh, G, 2013)
"Gabapentin is used for the treatment of hot flashes and neuropathic pain in breast cancer survivors, and is commonly used off-label for the treatment of anxiety."5.16A randomized, controlled, double-blinded clinical trial of gabapentin 300 versus 900 mg versus placebo for anxiety symptoms in breast cancer survivors. ( Amos, E; Heckler, C; Jacobs, A; Kirshner, JJ; Lavigne, JE; Lord, R; Mathews, JL; Morrow, GR; Mustian, K; Palesh, O, 2012)
"Breast cancer survivors prefer venlafaxine over gabapentin for treating hot flashes."5.14Multicenter, randomized, cross-over clinical trial of venlafaxine versus gabapentin for the management of hot flashes in breast cancer survivors. ( Bordeleau, L; Ennis, M; Goodwin, PJ; Haq, R; Jugovic, O; Loprinzi, CL; Pritchard, KI; Warr, D, 2010)
"To assess the efficacy and the tolerability of gabapentin 900 mg/day compared to vitamin E for the control of vasomotor symptoms in 115 women with breast cancer."5.14Non-hormonal treatment of hot flushes in breast cancer survivors: gabapentin vs. vitamin E. ( Biglia, N; Bounous, V; Marenco, D; Moggio, G; Peano, E; Ponzone, R; Sgandurra, P; Sismondi, P; Tomasi Cont, N, 2009)
"In this pilot study, 22 women with breast cancer on tamoxifen therapy with at least two hot flashes a day took oral gabapentin at 300 mg three times a day for 4 weeks."5.11Pilot study using gabapentin for tamoxifen-induced hot flashes in women with breast cancer. ( Griggs, JJ; Guttuso, TJ; Morrow, GR; Pandya, KJ; Roscoe, JA; Rosenblatt, JD; Sahasrabudhe, DM; Thummala, AR, 2004)
" Fifty patients scheduled for breast cancer surgery were blindly randomized to receive gabapentin, eutectic mixture of local anesthetics cream, and ropivacaine in the wound or three placebos."5.11Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer. ( Fassoulaki, A; Melemeni, A; Sarantopoulos, C; Triga, A, 2005)
"In an anecdotal report, complete resolution of chemotherapy-induced nausea was seen in a patient with breast cancer, after she was placed on the anticonvulsant gabapentin."5.10Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer. ( Griggs, J; Guttuso, T; Roscoe, J, 2003)
"The purpose of this meta-analysis from randomized controlled trials (RCTs) was to determine the efficacy and safety of the preoperative use of gabapentin for the treatment of acute and chronic postoperative pain following breast cancer surgery."4.98The efficacy of gabapentin in reducing pain intensity and morphine consumption after breast cancer surgery: A meta-analysis. ( Huang, Q; Jiang, Y; Li, J; Lin, H; Rong, Z; Wang, T; Xiong, J; Zhang, Q; Zhang, S, 2018)
" We included studies enrolling adult patients undergoing breast cancer surgery who were randomly assigned to preoperative gabapentin or pregabalin versus placebo or active control and assessed acute (≤24 h) or chronic (≥2 months) pain."4.95Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials. ( Busse, JW; Choi, S; Clarke, H; Devereaux, PJ; Dhaliwal, J; Khan, JS; Rai, AS, 2017)
"Clonidine, SSRIs and SNRIs, gabapentin and relaxation therapy showed a mild to moderate effect on reducing hot flushes in women with a history of breast cancer."4.86Non-hormonal interventions for hot flushes in women with a history of breast cancer. ( Capurro, D; Corbalán, J; Letelier, LM; Moreno, G; Pantoja, T; Rada, G; Vera, C, 2010)
"Centrally active agents (eg, venlafaxine, paroxetine, gabapentin) are regarded as the most promising nonhormonal treatments for hot flashes in breast cancer survivors."4.84Therapeutic options for the management of hot flashes in breast cancer survivors: an evidence-based review. ( Bordeleau, L; Goodwin, P; Loprinzi, C; Pritchard, K, 2007)
"To report a case of recurrent hot flashes unresponsive to gabapentin in a postmenopausal patient with a positive family history of breast cancer."3.81Treating recurrent postmenopausal vasomotor symptoms in a patient with a positive family history for breast cancer. ( Lake, J; Leong, C, 2015)
"A new study published in the Journal of Clinical Oncology has ascertained the efficacy of selective serotonin-reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors and gabapentin to decrease menopausal hot flashes."3.76Therapy: nonhormonal treatment of hot flashes-a viable alternative? ( Nachtigall, LE, 2010)
"116 consecutive patients scheduled for breast cancer surgery were prospectively scored according to pain, PONV and sedation after being introduced to a combined evidence-based, empiric multimodal opioid-sparing prevention and treatment regime consisting of Paracetamol, Celecoxib, Dextromethorphan, Gabapetin, Dexamethason and Ondansetron."3.74[Multimodal treatment of pain and nausea in breast cancer surgery]. ( Callesen, T; Gärtner, R; Kehlet, H; Kroman, N, 2008)
" We present a case of asterixis as a cause of falls and near falls in a patient with metastatic breast cancer and normal mental status who was receiving gabapentin."3.73Asterixis related to gabapentin as a cause of falls. ( Babiy, M; Hand, M; Herklotz, M; Stubblefield, MD, 2005)
"Hot flashes are a common and debilitating symptom among survivors of breast cancer."2.80Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial. ( Bowman, MA; Bruner, D; DeMichele, A; Farrar, JT; Mao, JJ; Xie, SX, 2015)
"Of 200 consecutive breast cancer patients, 191 received the full package."2.75Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. ( Callesen, T; Gärtner, R; Kehlet, H; Kroman, N, 2010)
"A third of female patients with cancer report dissatisfaction with the quality and length of physician-patient discussions about reproductive health, including menopause."2.58Managing menopausal symptoms after cancer: an evidence-based approach for primary care. ( Hickey, M; Marino, JL; McNamara, HC, 2018)
"Gabapentin is an anticonvulsant that the United States Food and Drug Administration approved as an adjunct therapy for partial seizures and postherpetic neuralgia."2.45Use of gabapentin in patients experiencing hot flashes. ( Brown, JN; Wright, BR, 2009)
"In men with prostate cancer, hot flushes occur after surgical or medical castration."2.43Treatment of hot flushes in breast and prostate cancer. ( Adelson, KB; Hershman, DL; Loprinzi, CL, 2005)
"5 mg/d, are reasonable initial dosages, and if symptoms do not improve within a week or two, the dosage can be doubled."2.42Management of hot flashes in breast cancer survivors and men with prostate cancer. ( Stearns, V, 2004)
"Menopausal symptoms following breast cancer can occur at an earlier age, be more severe and significantly influence a woman's overall wellbeing, in particular, sexual function, quality of life and adherence to treatment."1.48The Management of Menopausal Symptoms in Women Following Breast Cancer: An Overview. ( Baber, R; Phua, C, 2018)
"Women affected by breast cancer (BC) will often go through menopause at an earlier age and display more frequent and severe symptoms than women who have a natural menopause."1.40Treatment of climacteric symptoms in breast cancer patients: a retrospective study from a medication databank. ( Ameye, L; Antoine, C; Paesmans, M; Rozenberg, S, 2014)
"Delirium is still one of the most common and distressing symptoms in palliative care patients."1.38Reversible delirium in an advanced cancer patient. ( Jagsch, C; Kierner, KA; Watzke, HH, 2012)
"Menopausal symptom management after breast cancer may be complex, and we present a novel model of care using a multidisciplinary approach."1.36The multidisciplinary management of menopausal symptoms after breast cancer: a unique model of care. ( Doherty, DA; Emery, LI; Gregson, J; Hickey, M; Saunders, CM, 2010)
"To describe isolated generalized polymyoclonus and the outcomes of etiologic evaluations at the time of diagnosis."1.34Whole-body tremulousness: isolated generalized polymyoclonus. ( Ahlskog, JE; Bower, JH; Glass, GA; Josephs, KA; Lennon, VA; McKeon, A; Pittock, SJ, 2007)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's15 (35.71)29.6817
2010's24 (57.14)24.3611
2020's3 (7.14)2.80

Authors

AuthorsStudies
Coraci, D1
Giovannini, S1
Loreti, C1
Fusco, A1
Padua, L1
Kennedy, GT1
Hill, CM1
Huang, Y1
So, A1
Fosnot, J1
Wu, L1
Farrar, JT2
Tchou, J1
Shan, D1
Zou, L1
Liu, X1
Shen, Y1
Cai, Y1
Zhang, J1
Woyka, J1
Cobin, RH1
Goodman, NF1
Rai, AS1
Khan, JS1
Dhaliwal, J1
Busse, JW1
Choi, S1
Devereaux, PJ1
Clarke, H1
Marino, JL1
McNamara, HC1
Hickey, M2
Phua, C1
Baber, R1
Jiang, Y1
Li, J1
Lin, H1
Huang, Q1
Wang, T1
Zhang, S1
Zhang, Q1
Rong, Z1
Xiong, J1
da Cunha Leal, P1
Rey Moura, EC1
Jorge Dino Cossetti, R1
Ramos do Nascimento, J1
Portela Bogéa Serra, IC1
de Paulo Ribeiro, B1
Álvares Marques Vale, A1
Silva de Azevedo Dos Santos, AP1
Fernandes do Nascimento, FR1
Kimiko Sakata, R1
Aghili, M1
Zare, M1
Mousavi, N1
Ghalehtaki, R1
Sotoudeh, S1
Kalaghchi, B1
Akrami, S1
Esmati, E1
Bharti, N1
Bala, I1
Narayan, V1
Singh, G1
Antoine, C1
Ameye, L1
Paesmans, M1
Rozenberg, S1
Leong, C1
Lake, J1
Mao, JJ2
Bowman, MA1
Xie, SX2
Bruner, D1
DeMichele, A1
Garland, SN1
Li, Q1
Seluzicki, C1
Basal, C1
Gärtner, R3
Callesen, T3
Kroman, N3
Kehlet, H4
Brown, JN1
Wright, BR1
Biglia, N1
Sgandurra, P1
Peano, E1
Marenco, D1
Moggio, G1
Bounous, V1
Tomasi Cont, N1
Ponzone, R1
Sismondi, P1
Kontos, M1
Agbaje, OF1
Rymer, J1
Fentiman, IS1
Nachtigall, LE1
Amr, YM1
Yousef, AA1
Emery, LI1
Gregson, J1
Doherty, DA1
Saunders, CM1
Rada, G1
Capurro, D1
Pantoja, T1
Corbalán, J1
Moreno, G1
Letelier, LM1
Vera, C1
Bordeleau, L2
Pritchard, KI1
Loprinzi, CL2
Ennis, M1
Jugovic, O1
Warr, D1
Haq, R1
Goodwin, PJ1
Kierner, KA1
Jagsch, C1
Watzke, HH1
Lavigne, JE1
Heckler, C1
Mathews, JL1
Palesh, O1
Kirshner, JJ1
Lord, R1
Jacobs, A1
Amos, E1
Morrow, GR2
Mustian, K1
Sarkissian, A1
Neher, JO1
Singh, R1
St Anna, L1
Lefkowits, CC1
Arnold, RM1
Fassoulaki, A2
Patris, K1
Sarantopoulos, C2
Hogan, Q1
Guttuso, T1
Roscoe, J1
Griggs, J1
Pandya, KJ1
Thummala, AR1
Griggs, JJ1
Rosenblatt, JD1
Sahasrabudhe, DM1
Guttuso, TJ1
Roscoe, JA1
Stearns, V1
Hsu, C1
Sliwa, JA1
Babiy, M1
Stubblefield, MD1
Herklotz, M1
Hand, M1
Adelson, KB1
Hershman, DL1
Triga, A1
Melemeni, A1
Pritchard, K1
Goodwin, P1
Loprinzi, C1
McKeon, A1
Pittock, SJ1
Glass, GA1
Josephs, KA1
Bower, JH1
Lennon, VA1
Ahlskog, JE1

Clinical Trials (12)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Connective Tissue Manipulation on Menopausal Symptoms[NCT05293860]58 participants (Anticipated)Interventional2022-04-04Recruiting
"Preoperative Gabapentin and Its Effects on Postoperative Analgesia in Patients Undergoing Cosmetic Breast Surgery"[NCT05997355]100 participants (Anticipated)Interventional2023-09-01Not yet recruiting
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]Phase 477 participants (Actual)Interventional2018-05-15Completed
Early Acupuncture Treatment of Vasomotor Symptoms and Sleep Disorders in Breast Cancer Luteinising Hormone-releasing Hormone Analogues(LHRHa) Induced Menopause: AcuHOTFLASH Study[NCT05760222]90 participants (Anticipated)Interventional2021-11-25Recruiting
Self-acupressure for Cancer-related Symptom Cluster of Insomnia, Depression, and Anxiety in Cancer Patients: a Feasibility Randomized Controlled Trial[NCT03823456]114 participants (Anticipated)Interventional2018-12-04Recruiting
Acupuncture and Gabapentin for Hot Flashes Among Breast Cancer Survivors[NCT01005108]Phase 2120 participants (Actual)Interventional2009-01-31Completed
The Effect of Lidocaine to Prevent the Development of Chronic Post-Surgical Pain[NCT01619852]148 participants (Actual)Interventional2012-06-30Completed
Combined General Anesthesia Plus Paravertebral Block Versus General Anesthesia Plus Opioid Analgesia for Breast Cancer Surgery: A Prospective Randomized Trial[NCT01904266]60 participants (Actual)Interventional2013-05-31Completed
Multimodal Pain Treatment for Breast Cancer Surgery - a Prospective Cohort Study[NCT04875559]236 participants (Actual)Observational [Patient Registry]2021-04-19Completed
Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187]8 participants (Actual)Interventional2009-11-30Terminated (stopped due to PI left institution)
Comparative Evaluation of Osteopathy Treatment Efficacy in Pain Support After Breast Surgery in Oncology[NCT01403168]28 participants (Actual)Interventional2011-04-30Terminated (stopped due to Recruitment difficulties)
Comparison of Hypnotherapy Versus Gabapentin in the Treatment of Hot Flashes in Breast Cancer Survivors or Women at Risk of Developing Breast Cancer.[NCT00711529]Phase 327 participants (Actual)Interventional2008-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

Interventionscore on 10-point scale (Mean)
Standard of Care2.26
Postoperative Gabapentin Regimen2.46

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care3.84
Postoperative Gabapentin Regimen3.54

"VAS Score 3: How Well Are You Sleeping?"

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care5.73
Postoperative Gabapentin Regimen6.38

"VAS Score 4: How Bad is Your Nausea?"

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care0.36
Postoperative Gabapentin Regimen0.17

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care7.83
Postoperative Gabapentin Regimen8.48

Days Taking Opioids

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventiondays (Mean)
Standard of Care14.8
Postoperative Gabapentin Regimen18.7

Opioid Consumption

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Interventionmorphine equivalents (Mean)
Standard of Care287.0
Postoperative Gabapentin Regimen281.1

Number of Participants With Chronic Persistent Pain 3 Months After Surgery as Determined by Character Severity (Yes/no).

The participants development of chronic persistent pain 3 months after surgery as determined by character severity (yes/no). (NCT01619852)
Timeframe: 3 months

Interventionparticipants (Number)
Group L2
.9% Normal Saline Placebo6

Opioid Consumption

The amount of opioid analgesics consumed was converted to an equivalent dose of intravenous morphine. (NCT01619852)
Timeframe: 24 hours

Interventionequivalent dose of intravenous morphine (Median)
Group L34
.9% Normal Saline Placebo39

Postoperative Pain

Postoperative pain within the first 24 hours. Area under the numeric rating scale for pain versus time curve during the first 24 hours after surgery (score * hr). Numeric rating scale for pain on a scale of 0-10 (0 is no pain and 10 is high pain) versus time curve during the first 24 hours ( score * hr). The pain scores were collected upon arrival to recovery area, 30 minutes, 1 hour and every 6 hours up to 24 hours following the procedure. Minimum score is 60, Maximum score is 170. A higher value indicates more pain. (NCT01619852)
Timeframe: 24 hours

Interventionscore on a scale (Median)
Group L116
.9% Normal Saline Placebo119

Quality of Recovery

Quality of recovery (QoR-40 instrument) is a 40-item questionnaire that provides a global score and sub-scores across five dimensions: patient support, comfort, emotions, physical independence, and pain. Score range: 40 to 200. A score of 40 demonstrates poor recovery and a maximum score of 200 represents good recovery. The higher the score the better recovery after surgery. (NCT01619852)
Timeframe: 24 hours post operative

Interventionunits on a scale (Median)
Lidocaine (Group L)158
.9% Normal Saline Placebo169

Post-surgical Persistent Pain Using Validated Questionnaires (S-LANNS Questionnaire, McGill Questionnaire, Brief Pain Inventory) to Assess Pain Qualities in Accordance With IMMPACT Recommendations.

The development of chronic pain 3 months after surgery determined by the Leads Assessment of Neuropathic Symptoms and Signs (LANSS) scale, a valid 7-item tool for identifying patients whose pain is dominated by neuropathic mechanisms. Each item is a binary response (yes or no) to the presence of symptoms (5 items) or clinical signs (2 items), range 0-24 points. A score ≥ 12, neuropathic mechanisms are likely to be contributing to the patient's pain. A score < 12 is unlikely to be contributing. McGill questionnaire (Sensory domain) - 11 descriptors rated on an intensity scale as 0=none, 1=mild, 2=moderate, 3=severe. The higher the score, greater the pain (range 0-33). McGill questionnaire (Motivational-affective) 4 affect descriptors rated on an intensity scale as 0=none, 1=mild, 2=moderate, 3=severe.The higher the score the greater the pain (range 0-12) Brief pain inventory - pain severity (0, no pain, 10 excruciating pain); Greater the score; greater the pain (range 0-10). (NCT01619852)
Timeframe: 3 months

,
Interventionunits on a scale (Median)
S-LANNSMcGill Questionaire-Sensory DiscrimationMcGill Questionaire-Motivational-affectiveBrief Pain Inventory
.9% Normal Saline Placebo3301
Group L3401

Hot Flash Related Daily Interference Score (HFRDIS)

The HFRDIS is a validated survey of 10 questions asking patients to rate ten hot flash-related symptoms on a scale of 0-10. The HFRDIS is a sum of the scores in each category, so that total score can range from 0 (no symptoms) to 100 (10 severe symptoms). These surveys were conducted at the time of enrollment (baseline), after four weeks of treatment, and at the conclusion of the study (8 weeks). All nine women who initiated hypnotherapy treatment completed the survey at the end of 8 weeks. One woman in the gabapentin arm did not submit a survey at 8 weeks. (NCT00711529)
Timeframe: Week 8

Interventionunits on a scale (HFRDIS) (Median)
Hypnotherapy26
Gabapentin22

Hot Flash Related Daily Interference Score (HFRDIS)

The HFRDIS is a validated survey of 10 questions asking patients to rate ten hot flash-related symptoms on a scale of 0-10. The HFRDIS is a sum of the scores in each category, so that total score can range from 0 (no symptoms) to 100 (10 severe symptoms). These surveys were conducted at the time of enrollment (baseline), after four weeks of treatment, and at the conclusion of the study (8 weeks). Of 11 eligible women in the hypnotherapy arm, 2 never initiated treatment, and 3 did not complete the survey at this time point. Of the 14 eligible women in the gabapentin arm, 3 never initiated treatment, and 3 dropped out of the study before the 4 week time point. (NCT00711529)
Timeframe: Week 4

Interventionunits on a scale (HFRDIS) (Median)
Hypnotherapy25.5
Gabapentin21.5

Hot Flash Related Daily Interference Score (HFRDIS)

The HFRDIS is a validated survey of 10 questions asking patients to rate ten symptoms on a scale of 0-10. The HFRDIS is a sum of the scores in each category, so that total score can range from 0 (no symptoms) to 100 (10 severe symptoms). These surveys were conducted at the time of enrollment (baseline), after four weeks of treatment, and at the conclusion of the study (8 weeks). All women who were randomized were included in the baseline analysis (with the exception of 2 women excluded from the hypnotherapy arm who were deemed ineligible after randomization). (NCT00711529)
Timeframe: Baseline

Interventionunits on a scale (HFRDIS) (Median)
Hypnotherapy58
Gabapentin45.5

Hot Flash Severity Score

The patients kept daily hot flash diaries, including the total number of hot flashes they characterized as mild, moderate,severe and very severe. Hot flash severity scores were calculated by assigning one point to each mild hot flash, two points for each moderate hot flash, three points for each severe hot flash and four points for each very severe hot flash. The hot flash severity score for a 24 hour period was the sum of these scores. The score was calculated for each day in the diary. For each subject, median scores were calculated for each week (7 day period) of participation. The median hot flash severity score for the first week was considered the baseline. The median hot flash severity score for the fourth week is considered the week 4 time point. The median hot flash severity score for the eighth week is considered the week 8 time point. The median result for the group was then calculated at each of the timepoints. (NCT00711529)
Timeframe: Baseline

Interventionunits on a scale (severity score) (Median)
Hypnotherapy10
Gabapentin7.5

Hot Flash Severity Score

The patients kept daily hot flash diaries, including the total number of hot flashes they characterized as mild, moderate,severe and very severe. Hot flash severity scores were calculated by assigning one point to each mild hot flash, two points for each moderate hot flash, three points for each severe hot flash and four points for each very severe hot flash. The hot flash severity score for a 24 hour period was the sum of these scores. The score was calculated for each day in the diary. For each subject, median scores were calculated for each week (7 day period) of participation. The median hot flash severity score for the first week was considered the baseline. The median hot flash severity score for the fourth week is considered the week 4 time point. The median hot flash severity score for the eighth week is considered the week 8 time point. The median result for the group was then calculated at each of the timepoints. (NCT00711529)
Timeframe: Week 4

Interventionunits on a scale (severity score) (Median)
Hypnotherapy6.5
Gabapentin4

Hot Flash Severity Score

The patients kept daily hot flash diaries, including the total number of hot flashes they characterized as mild, moderate,severe and very severe. Hot flash severity scores were calculated by assigning one point to each mild hot flash, two points for each moderate hot flash, three points for each severe hot flash and four points for each very severe hot flash. The hot flash severity score for a 24 hour period was the sum of these scores. The score was calculated for each day in the diary. For each subject, median scores were calculated for each week (7 day period) of participation. The median hot flash severity score for the first week was considered the baseline. The median hot flash severity score for the fourth week is considered the week 4 time point. The median hot flash severity score for the eighth week is considered the week 8 time point. The median result for the group was then calculated at each of the timepoints. (NCT00711529)
Timeframe: Week 8

Interventionunits on a scale (severity score) (Median)
Hypnotherapy1.5
Gabapentin5

Number of Daily Hot Flashes

"Patients kept daily diaries of their hot flashes. The absolute number of hot flashes in a 24 hour period is number of daily hot flashes. The median number was calculated for each week of data. The median number of daily hot flashes for the first week (7 days) of participation is used as baseline. The median number of daily hot flashes for the fourth week (over 7 day interval) is reported for the week four time point. The median number of daily hot flashes for the eighth week (over 7 day interval) is reported for the week eight time point (study completion). A total of 15 diaries were submitted (7 hypnotherapy, 8 gabapentin). One person in each arm stopped recording in her diary before the 4 week mark." (NCT00711529)
Timeframe: Week 4

Interventiondaily hot flashes (Median)
Hypnotherapy4
Gabapentin4

Number of Daily Hot Flashes

"Patients kept daily diaries of their hot flashes. The absolute number of hot flashes in a 24 hour period is number of daily hot flashes. The median number was calculated for each week of data. The median number of daily hot flashes for the first week (7 days) of participation is used as baseline. The median number of daily hot flashes for the fourth week (over 7 day interval) is reported for the week four time point. The median number of daily hot flashes for the eighth week (over 7 day interval) is reported for the week eight time point (study completion). Of the 13 women randomized to the hypnotherapy arm, 2 women were ineligible and therefore not included in analysis. Two women were unable to initiate treatment and did not submit diaries. An additional two women completed treatment but lost their diaries, leaving 7 diaries for analysis at baseline. Of the 14 randomized to receive gabapentin, 6 dropped out of the study and did not submit diaries." (NCT00711529)
Timeframe: Baseline

Interventiondaily hot flashes (Median)
Hypnotherapy5
Gabapentin4.5

Number of Daily Hot Flashes

"Patients kept daily diaries of their hot flashes. The absolute number of hot flashes in a 24 hour period is number of daily hot flashes. The median number was calculated for each week of data. The median number of daily hot flashes for the first week (7 days) of participation is used as baseline. The median number of daily hot flashes for the fourth week (over 7 day interval) is reported for the week four time point. The median number of daily hot flashes for the eighth week (over 7 day interval) is reported for the week eight time point (study completion). One woman in the hypnotherapy arm and 3 women in the gabapentin arm stopped keeping their diary before the 8 week mark." (NCT00711529)
Timeframe: Week 8

Interventiondaily hot flashes (Median)
Hypnotherapy1
Gabapentin3

Reviews

11 reviews available for gabapentin and Breast Cancer

ArticleYear
Efficacy and safety of gabapentin and pregabalin in patients with vasomotor symptoms: a systematic review and meta-analysis.
    American journal of obstetrics and gynecology, 2020, Volume: 222, Issue:6

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Calcium Channel Blockers; Dizziness; Estrogen Rep

2020
Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2017, Volume: 70, Issue:10

    Topics: Amines; Analgesics; Breast Neoplasms; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin;

2017
Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2017, Volume: 70, Issue:10

    Topics: Amines; Analgesics; Breast Neoplasms; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin;

2017
Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2017, Volume: 70, Issue:10

    Topics: Amines; Analgesics; Breast Neoplasms; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin;

2017
Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2017, Volume: 70, Issue:10

    Topics: Amines; Analgesics; Breast Neoplasms; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin;

2017
Managing menopausal symptoms after cancer: an evidence-based approach for primary care.
    The Medical journal of Australia, 2018, 02-19, Volume: 208, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Amenorrhea; Anti-Anxiety Agents; Breast Neoplasms; Canc

2018
The efficacy of gabapentin in reducing pain intensity and morphine consumption after breast cancer surgery: A meta-analysis.
    Medicine, 2018, Volume: 97, Issue:38

    Topics: Amines; Breast Neoplasms; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Amino

2018
Use of gabapentin in patients experiencing hot flashes.
    Pharmacotherapy, 2009, Volume: 29, Issue:1

    Topics: Amines; Breast Neoplasms; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Female; Gabapentin;

2009
What can be done about hot flushes after treatment for breast cancer?
    Climacteric : the journal of the International Menopause Society, 2010, Volume: 13, Issue:1

    Topics: Amines; Anesthetics, Local; Breast Neoplasms; Bupivacaine; Clonidine; Complementary Therapies; Cyclo

2010
Non-hormonal interventions for hot flushes in women with a history of breast cancer.
    The Cochrane database of systematic reviews, 2010, Sep-08, Issue:9

    Topics: Acupuncture Therapy; Amines; Breast Neoplasms; Clonidine; Cyclohexanecarboxylic Acids; Excitatory Am

2010
Clinical Inquiry: Do venlafaxine and gabapentin control hot flashes in women with a history of breast cancer?
    The Journal of family practice, 2012, Volume: 61, Issue:12

    Topics: Amines; Anti-Anxiety Agents; Breast Neoplasms; Constipation; Cyclohexanecarboxylic Acids; Cyclohexan

2012
Management of hot flashes in breast cancer survivors and men with prostate cancer.
    Current oncology reports, 2004, Volume: 6, Issue:4

    Topics: Amines; Anti-Anxiety Agents; Breast Neoplasms; Complementary Therapies; Contraceptives, Oral, Synthe

2004
Treatment of hot flushes in breast and prostate cancer.
    Expert opinion on pharmacotherapy, 2005, Volume: 6, Issue:7

    Topics: Amines; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cimicifuga; Contraindications; Cyclohexan

2005
Therapeutic options for the management of hot flashes in breast cancer survivors: an evidence-based review.
    Clinical therapeutics, 2007, Volume: 29, Issue:2

    Topics: Amines; Antidepressive Agents; Breast Neoplasms; Complementary Therapies; Cyclohexanecarboxylic Acid

2007

Trials

13 trials available for gabapentin and Breast Cancer

ArticleYear
Efficacy of gabapentin for the prevention of paclitaxel induced peripheral neuropathy: A randomized placebo controlled clinical trial.
    The breast journal, 2019, Volume: 25, Issue:2

    Topics: Adult; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Double-Blind Method; Female; Gabapentin;

2019
Effect of gabapentin pretreatment on propofol consumption, hemodynamic variables, and postoperative pain relief in breast cancer surgery.
    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2013, Volume: 51, Issue:1

    Topics: Adult; Amines; Analgesics; Anesthetics, Intravenous; Breast Neoplasms; Cyclohexanecarboxylic Acids;

2013
Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Amines; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Electroa

2015
Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Amines; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Electroa

2015
Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Amines; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Electroa

2015
Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Amines; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Electroa

2015
Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Amines; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Electroa

2015
Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Amines; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Electroa

2015
Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Amines; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Electroa

2015
Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Amines; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Electroa

2015
Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Amines; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Electroa

2015
Comparative effectiveness of electro-acupuncture versus gabapentin for sleep disturbances in breast cancer survivors with hot flashes: a randomized trial.
    Menopause (New York, N.Y.), 2017, Volume: 24, Issue:5

    Topics: Acupuncture Therapy; Adult; Aged; Amines; Anti-Anxiety Agents; Breast Neoplasms; Cyclohexanecarboxyl

2017
Non-hormonal treatment of hot flushes in breast cancer survivors: gabapentin vs. vitamin E.
    Climacteric : the journal of the International Menopause Society, 2009, Volume: 12, Issue:4

    Topics: Adult; Aged; Amines; Breast Neoplasms; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminob

2009
Evaluation of efficacy of the perioperative administration of Venlafaxine or gabapentin on acute and chronic postmastectomy pain.
    The Clinical journal of pain, 2010, Volume: 26, Issue:5

    Topics: Acute Disease; Adult; Amines; Analgesics; Breast Neoplasms; Chronic Disease; Cyclohexanecarboxylic A

2010
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery.
    Minerva anestesiologica, 2010, Volume: 76, Issue:10

    Topics: Acetaminophen; Aged; Amines; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Intra

2010
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery.
    Minerva anestesiologica, 2010, Volume: 76, Issue:10

    Topics: Acetaminophen; Aged; Amines; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Intra

2010
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery.
    Minerva anestesiologica, 2010, Volume: 76, Issue:10

    Topics: Acetaminophen; Aged; Amines; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Intra

2010
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery.
    Minerva anestesiologica, 2010, Volume: 76, Issue:10

    Topics: Acetaminophen; Aged; Amines; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Intra

2010
Multicenter, randomized, cross-over clinical trial of venlafaxine versus gabapentin for the management of hot flashes in breast cancer survivors.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-10, Volume: 28, Issue:35

    Topics: Amines; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Breast Neoplasms; Cross-Over

2010
A randomized, controlled, double-blinded clinical trial of gabapentin 300 versus 900 mg versus placebo for anxiety symptoms in breast cancer survivors.
    Breast cancer research and treatment, 2012, Volume: 136, Issue:2

    Topics: Amines; Anti-Anxiety Agents; Anxiety; Breast Neoplasms; Cyclohexanecarboxylic Acids; Female; Gabapen

2012
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:4

    Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Breast Neoplasms; Chr

2002
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:4

    Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Breast Neoplasms; Chr

2002
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:4

    Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Breast Neoplasms; Chr

2002
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:4

    Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Breast Neoplasms; Chr

2002
Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer.
    Lancet (London, England), 2003, May-17, Volume: 361, Issue:9370

    Topics: Acetates; Administration, Oral; Amines; Antineoplastic Combined Chemotherapy Protocols; Breast Neopl

2003
Pilot study using gabapentin for tamoxifen-induced hot flashes in women with breast cancer.
    Breast cancer research and treatment, 2004, Volume: 83, Issue:1

    Topics: Acetates; Administration, Oral; Amines; Breast Neoplasms; Cyclohexanecarboxylic Acids; Female; Gabap

2004
Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:5

    Topics: Acute Disease; Adult; Amines; Analgesia; Anesthetics, Local; Breast Neoplasms; Chronic Disease; Cycl

2005

Other Studies

18 other studies available for gabapentin and Breast Cancer

ArticleYear
Management of neuropathic pain: A graph theory-based presentation of literature review.
    The breast journal, 2020, Volume: 26, Issue:3

    Topics: Breast Neoplasms; Gabapentin; Humans; Neuralgia; Paclitaxel

2020
Enhanced recovery after surgery (ERAS) protocol reduces perioperative narcotic requirement and length of stay in patients undergoing mastectomy with implant-based reconstruction.
    American journal of surgery, 2020, Volume: 220, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Breast Implantation; Breast Neoplasms; Dose-Response

2020
Consensus statement for non-hormonal-based treatments for menopausal symptoms.
    Post reproductive health, 2017, Volume: 23, Issue:2

    Topics: Amines; Anticonvulsants; Antihypertensive Agents; Behavior Therapy; Breast Neoplasms; Clonidine; Con

2017
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON MENOPAUSE-2017 UPDATE.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2017, Volume: 23, Issue:7

    Topics: Administration, Cutaneous; Administration, Oral; Aged; Amines; Breast Neoplasms; Cardiovascular Dise

2017
The Management of Menopausal Symptoms in Women Following Breast Cancer: An Overview.
    Drugs & aging, 2018, Volume: 35, Issue:8

    Topics: Amines; Breast Neoplasms; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid;

2018
High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites.
    BMC research notes, 2019, Jan-25, Volume: 12, Issue:1

    Topics: Analgesics; Animals; Arginase; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Chemokine CCL2; Disease M

2019
Treatment of climacteric symptoms in breast cancer patients: a retrospective study from a medication databank.
    Maturitas, 2014, Volume: 78, Issue:3

    Topics: Aged; Amines; Antidepressive Agents; Antineoplastic Agents; Aromatase Inhibitors; Belgium; Breast Ne

2014
Treating recurrent postmenopausal vasomotor symptoms in a patient with a positive family history for breast cancer.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2015, Volume: 30, Issue:1

    Topics: Aged; Amines; Breast Neoplasms; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric

2015
[Postoperative inconveniences after breast cancer surgery].
    Ugeskrift for laeger, 2008, Jun-02, Volume: 170, Issue:23

    Topics: Acetaminophen; Amines; Analgesics; Antiemetics; Antitussive Agents; Breast Neoplasms; Celecoxib; Cyc

2008
[Multimodal treatment of pain and nausea in breast cancer surgery].
    Ugeskrift for laeger, 2008, Jun-02, Volume: 170, Issue:23

    Topics: Adult; Aged; Aged, 80 and over; Amines; Analgesics; Antiemetics; Antitussive Agents; Breast Neoplasm

2008
Therapy: nonhormonal treatment of hot flashes-a viable alternative?
    Nature reviews. Endocrinology, 2010, Volume: 6, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Amines; Antidepressive Agents; Breast Neoplasms; Contraindications; Cy

2010
The multidisciplinary management of menopausal symptoms after breast cancer: a unique model of care.
    Menopause (New York, N.Y.), 2010, Volume: 17, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care Facilities; Amines; Anti-Anxiety Agents; Breast Neop

2010
Reversible delirium in an advanced cancer patient.
    Wiener medizinische Wochenschrift (1946), 2012, Volume: 162, Issue:1-2

    Topics: Amines; Analgesics; Analgesics, Opioid; Bone Neoplasms; Breast Neoplasms; Carcinoma, Intraductal, No

2012
Hot flashes in palliative care. Part 2 #262.
    Journal of palliative medicine, 2013, Volume: 16, Issue:1

    Topics: Amines; Analgesics; Antineoplastic Agents, Hormonal; Breast Neoplasms; Clonidine; Cyclohexanecarboxy

2013
Phantom breast pain as a source of functional loss.
    American journal of physical medicine & rehabilitation, 2004, Volume: 83, Issue:8

    Topics: Acetates; Activities of Daily Living; Amines; Anti-Anxiety Agents; Breast Neoplasms; Carcinoma in Si

2004
Asterixis related to gabapentin as a cause of falls.
    American journal of physical medicine & rehabilitation, 2005, Volume: 84, Issue:2

    Topics: Accidental Falls; Aged; Amines; Analgesics; Breast Neoplasms; Cyclohexanecarboxylic Acids; Diagnosis

2005
Perioperative analgesia to prevent chronic postmastectomy pain.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:2

    Topics: Amines; Anesthetics, Local; Breast Neoplasms; Chronic Disease; Cyclohexanecarboxylic Acids; Female;

2006
Whole-body tremulousness: isolated generalized polymyoclonus.
    Archives of neurology, 2007, Volume: 64, Issue:9

    Topics: Adult; Aged; Amines; Anticonvulsants; Autoimmunity; Breast Neoplasms; Clonazepam; Cyclohexanecarboxy

2007