Page last updated: 2024-10-27

gabapentin and Aura

gabapentin has been researched along with Aura in 261 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Research Excerpts

ExcerptRelevanceReference
"Gabapentin as monotherapy probably controlled seizures no better and no worse than comparator AEDs (lamotrigine, carbamazepine, oxcarbazepine, and topiramate)."9.41Gabapentin monotherapy for epilepsy: A review. ( Abakumova, T; Hoyle, CHV; Ziganshina, LE, 2023)
"To evaluate the efficacy and safety of gabapentin (GBP) in idiopathic or crypto/symptomatic partial epilepsy in adults."9.12[Efficacy, safety and effect on the quality of life of gabapentin in adult epilepsy--results of a prospective open-label quasi naturalistic Hungarian multicenter study (phase human-IV)]. ( Rajna, P; Szíjártó, E, 2006)
"To determine the relative tolerability and efficacy of two newer antiepileptic drugs, lamotrigine (LTG) and gabapentin (GBP), as compared to carbamazepine (CBZ) in older patients with epilepsy."9.11New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. ( Boardman, KD; Carter, GS; Collins, JF; Felicetta, J; Frederick, T; Marks, W; Pryor, F; Ramsay, RE; Rowan, AJ; Spitz, M; Tomyanovich, ML; Towne, A; Uthman, BM, 2005)
"This randomised, double-blind study compared the newer antiepileptic drugs (AEDs) gabapentin (GBP) and lamotrigine (LTG) as monotherapy in newly diagnosed epilepsy."9.10Gabapentin versus lamotrigine monotherapy: a double-blind comparison in newly diagnosed epilepsy. ( Anhut, H; Brodie, MJ; Chadwick, DW; Garofalo, EA; Maton, S; Messmer, SL; Murray, G; Otte, A; Sauermann, W, 2002)
"A retrospective audit of the perceived efficacy and tolerability of adjunctive gabapentin (GBT) therapy in patients with intractable epilepsy was carried out."9.09An audit of the perceived efficacy and tolerability of gabapentin therapy in an out-patient cohort with chronic epilepsy. ( Duncan, JS; Langan, Y; Sander, JW, 1999)
"To evaluate the efficacy and safety of gabapentin (GBP) in partial epilepsy in children."9.09Gabapentin in childhood epilepsy: a prospective evaluation of efficacy and safety. ( Boenigk, HE; Borusiak, P; Korn-Merker, E, 2000)
"The aim of this study was to evaluate the efficacy and safety of gabapentin in patients with learning disabilities and resistant epilepsy, comparing the effects of gabapentin with lamotrigine on efficacy, behaviour and mood."9.09A randomized open-label study of gabapentin and lamotrigine in adults with learning disability and resistant epilepsy. ( Brown, S; Crawford, P; Kerr, M, 2001)
" Global improvement data from five double-blind clinical trials of gabapentin as add-on therapy in patients with epilepsy were reviewed to assess the effects of gabapentin on mood."9.08Effect of gabapentin (Neurontin) [corrected] on mood and well-being in patients with epilepsy. ( Dimond, KR; Lamoreaux, L; Pande, AC; Pierce, MW, 1996)
"To study the interaction between gabapentin (GBP) and high-protein meals, 12 patients with epilepsy were administered this drug both while in a fasting state and after a high-protein meal."9.08Oral gabapentin disposition in patients with epilepsy after a high-protein meal. ( Baraldo, M; Benetello, P; Fortunato, M; Furlanut, M; Pea, F; Testa, G; Tognon, A, 1997)
"The effect of gabapentin on cognition and quality of life (QoL) in patients with epilepsy was investigated using a controlled pre- and post-treatment design."9.08Effects of gabapentin on cognition and quality of life in patients with epilepsy. ( Emmers, E; Mortimore, C; Trimble, M, 1998)
" Controlled trials in elderly patients with epilepsy demonstrate efficacy and tolerability comparable to gabapentin."8.84Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia. ( Nanry, K; Ramsay, E; Sajatovic, M; Thompson, T, 2007)
" However, a MEDLINE search using the search terms gabapentin and epilepsy, spanning back to the year 1986, produced numerous published reports from randomized, placebo-controlled and open-label trials, as well as case reports."8.82Gabapentin dosing in the treatment of epilepsy. ( Gidal, BE; McLean, MJ, 2003)
"To provide a qualitative, systematic update and review of the pharmacology, pharmacokinetics, efficacy in mood disorders, adverse effects, and costs of lamotrigine."8.81Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002)
"This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice."7.91Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ, 2019)
" He had been administered phenytoin and gabapentin for the treatment of symptomatic traumatic epilepsy 8 years before."7.88Hypothyroidism induced by phenytoin and gabapentin: A Case Report. ( Ishii, K; Miyake, Z; Tamaoka, A, 2018)
"To characterize and quantify the variability of serial gabapentin concentrations in elderly patients with epilepsy."7.85Factors in Variability of Serial Gabapentin Concentrations in Elderly Patients with Epilepsy. ( Birnbaum, AK; Collins, JF; Conway, JM; Eberly, LE; Leppik, IE; Macias, FM; Ramsay, RE, 2017)
"These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy."7.80Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014)
"To assess whether there is a change in seizure activity in dogs with refractory epilepsy that are receiving appropriate doses of phenobarbitone and/or potassium bromide, when gabapentin is added to the therapeutic regimen."7.73Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005)
"The objective of this study was to assess the safety of gabapentin (Neurontin) exposure in human pregnancy."7.72Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry. ( Montouris, G, 2003)
"To compare the long-term retention of gabapentin (GBP), lamotrigine (LTG), and vigabatrin (VGB) by patients with chronic epilepsy and the reasons for treatment discontinuation."7.70The long-term use of gabapentin, lamotrigine, and vigabatrin in patients with chronic epilepsy. ( Chadwick, DW; Fenwick, PB; Mawer, GE; Sander, JW; Wong, IC, 1999)
" We reported that daily dosing increased brain gamma-aminobutyric acid (GABA) in patients with epilepsy."7.70Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy patients. ( Hyder, F; Mattson, RH; Petroff, OA; Rothman, DL, 2000)
"We sought to determine the long-term retention rates of lamotrigine (LTG), gabapentin (GBP), and topiramate (TPM) therapy for patients at a tertiary referral clinic for chronic, refractory epilepsy."7.70Long-term retention rates of lamotrigine, gabapentin, and topiramate in chronic epilepsy. ( Lhatoo, SD; Polizzi, G; Sander, JW; Wong, IC, 2000)
"Gabapentin (GBP) is a non-metabolized antiepileptic drug that is eliminated by renal excretion and displays saturable, dose dependent absorption."6.69Gabapentin bioavailability: effect of dose and frequency of administration in adult patients with epilepsy. ( Bockbrader, HN; DeCerce, J; Gidal, BE; Gonzalez, J; Kruger, S; Pitterle, ME; Ramsay, RE; Rutecki, P, 1998)
"Gabapentin is an antiepileptic drug (AED) by design expected to mimic the action of the neurotransmitter gamma-aminobutyric acid (GABA)."6.44Gabapentin: a Ca2+ channel alpha 2-delta ligand far beyond epilepsy therapy. ( Striano, P; Striano, S, 2008)
"Gabapentin is a recently introduced antiepileptic drug for the treatment of partial seizures."6.40Gabapentin for treatment of epilepsy in children. ( Holmes, GL, 1997)
"Gabapentin appears to be a useful new AED."6.39Gabapentin: a new agent for the management of epilepsy. ( Andrews, CO; Fischer, JH, 1994)
"Felbamate was licensed in 1993 for use as adjunctive therapy or monotherapy in adults with partial or tonic-clonic seizures and as adjunctive therapy for children with the Lennox-Gastaut syndrome."6.39Guidelines for treating epilepsy in the age of felbamate, vigabatrin, lamotrigine, and gabapentin. ( Laxer, KD, 1994)
"Gabapentin is an antiepileptic drug with an unknown mechanism of action apparently dissimilar to that of other antiepileptic agents, and possessing some desirable pharmacokinetic traits."6.38Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. ( Goa, KL; Sorkin, EM, 1993)
"Gabapentin as monotherapy probably controlled seizures no better and no worse than comparator AEDs (lamotrigine, carbamazepine, oxcarbazepine, and topiramate)."5.41Gabapentin monotherapy for epilepsy: A review. ( Abakumova, T; Hoyle, CHV; Ziganshina, LE, 2023)
" GBP plasma concentrations in the neonates declined with an estimated half-life of 14 h."5.33Pharmacokinetics of gabapentin during delivery, in the neonatal period, and lactation: does a fetal accumulation occur during pregnancy? ( Ohman, I; Tomson, T; Vitols, S, 2005)
"The influence of age and administered daily dosage on the plasma concentrations of gabapentin (GBP) at steady state was evaluated in a group of 41 children and young adults (aged 3-30 years) receiving long-term adjunctive treatment with GBP for the management of refractory partial-onset seizures."5.32Plasma gabapentin concentrations in children with epilepsy: influence of age, relationship with dosage, and preliminary observations on correlation with clinical response. ( Bonanni, P; Bonomi, I; Ferrari, AR; Gatti, G; Guerrini, R; Perucca, E, 2003)
"Epilepsy is a common condition in people with learning disabilities with many patients continuing to suffer from seizures despite antiepileptic drug (AED) treatment."5.30A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. ( Bhaumik, S; Branford, D; Duggirala, C; Ismail, IA, 1997)
"To evaluate the efficacy and safety of gabapentin (GBP) in idiopathic or crypto/symptomatic partial epilepsy in adults."5.12[Efficacy, safety and effect on the quality of life of gabapentin in adult epilepsy--results of a prospective open-label quasi naturalistic Hungarian multicenter study (phase human-IV)]. ( Rajna, P; Szíjártó, E, 2006)
"To compare clinicians' choice of one of the standard epilepsy drug treatments (carbamazepine or valproate) versus appropriate comparator new drugs."5.12A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial. ( Appleton, R; Baker, GA; Chadwick, DW; Doughty, J; Eaton, B; Gamble, C; Jacoby, A; Marson, AG; Shackley, P; Smith, DF; Tudur-Smith, C; Vanoli, A; Williamson, PR, 2007)
"To determine the relative tolerability and efficacy of two newer antiepileptic drugs, lamotrigine (LTG) and gabapentin (GBP), as compared to carbamazepine (CBZ) in older patients with epilepsy."5.11New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. ( Boardman, KD; Carter, GS; Collins, JF; Felicetta, J; Frederick, T; Marks, W; Pryor, F; Ramsay, RE; Rowan, AJ; Spitz, M; Tomyanovich, ML; Towne, A; Uthman, BM, 2005)
"This randomised, double-blind study compared the newer antiepileptic drugs (AEDs) gabapentin (GBP) and lamotrigine (LTG) as monotherapy in newly diagnosed epilepsy."5.10Gabapentin versus lamotrigine monotherapy: a double-blind comparison in newly diagnosed epilepsy. ( Anhut, H; Brodie, MJ; Chadwick, DW; Garofalo, EA; Maton, S; Messmer, SL; Murray, G; Otte, A; Sauermann, W, 2002)
"The aim of the study was to find out the percentage of patients with localization-related epilepsy achieving complete seizure control with gabapentin (GBP) add-on therapy."5.09Gabapentin add-on treatment: how many patients become seizure-free? An open-label multicenter study. ( Elger, CE; Mayer, T; Schütte, W; Wolf, P, 1999)
"A retrospective audit of the perceived efficacy and tolerability of adjunctive gabapentin (GBT) therapy in patients with intractable epilepsy was carried out."5.09An audit of the perceived efficacy and tolerability of gabapentin therapy in an out-patient cohort with chronic epilepsy. ( Duncan, JS; Langan, Y; Sander, JW, 1999)
"To evaluate the efficacy and safety of gabapentin (GBP) in partial epilepsy in children."5.09Gabapentin in childhood epilepsy: a prospective evaluation of efficacy and safety. ( Boenigk, HE; Borusiak, P; Korn-Merker, E, 2000)
"Our objective was to determine, in three separate studies, the effects of controlled-release carbamazepine (CBZ-CR), lamotrigine (LTG), and gabapentin (GBP) on nocturnal sleep in epilepsy."5.09Effect of anticonvulsants on nocturnal sleep in epilepsy. ( Diomedi, M; Gigli, GL; Marciani, MG; Placidi, F; Romigi, A; Scalise, A, 2000)
"The aim of this study was to evaluate the efficacy and safety of gabapentin in patients with learning disabilities and resistant epilepsy, comparing the effects of gabapentin with lamotrigine on efficacy, behaviour and mood."5.09A randomized open-label study of gabapentin and lamotrigine in adults with learning disability and resistant epilepsy. ( Brown, S; Crawford, P; Kerr, M, 2001)
"Gabapentin was administered in single doses of 10 mg/kg (N=48 healthy subjects, age 1 month-12 years) or in multiple doses of 10-65 mg/kg per day (N=205 patients with epilepsy, age 2 months-13 years) at 08:00, 14:00, and 20:00."5.09Population pharmacokinetics of gabapentin in infants and children. ( Bockbrader, HN; Garofalo, E; Ouellet, D; Shapiro, DY; Wesche, DL, 2001)
" Global improvement data from five double-blind clinical trials of gabapentin as add-on therapy in patients with epilepsy were reviewed to assess the effects of gabapentin on mood."5.08Effect of gabapentin (Neurontin) [corrected] on mood and well-being in patients with epilepsy. ( Dimond, KR; Lamoreaux, L; Pande, AC; Pierce, MW, 1996)
"To study the interaction between gabapentin (GBP) and high-protein meals, 12 patients with epilepsy were administered this drug both while in a fasting state and after a high-protein meal."5.08Oral gabapentin disposition in patients with epilepsy after a high-protein meal. ( Baraldo, M; Benetello, P; Fortunato, M; Furlanut, M; Pea, F; Testa, G; Tognon, A, 1997)
"The effect of gabapentin on cognition and quality of life (QoL) in patients with epilepsy was investigated using a controlled pre- and post-treatment design."5.08Effects of gabapentin on cognition and quality of life in patients with epilepsy. ( Emmers, E; Mortimore, C; Trimble, M, 1998)
"A systematic review of FORCTs and randomised controlled trials (RCT) of topiramate, levetiracetam and gabapentin as adjuvant therapy in refractory adult epilepsy was conducted."4.84Reporting and analysis of open-label extension studies of anti-epileptic drugs. ( Hemming, K; Hutton, JL; Maguire, MJ; Marson, AG, 2008)
" The USA guideline for epilepsy treatment recommends that patients with newly diagnosed epilepsy can be treated with gabapentin, lamotrigine, topiramate, and oxcarbazepine."4.84[Newer antiepileptic drugs]. ( Matsuura, M, 2007)
" Controlled trials in elderly patients with epilepsy demonstrate efficacy and tolerability comparable to gabapentin."4.84Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia. ( Nanry, K; Ramsay, E; Sajatovic, M; Thompson, T, 2007)
" Finally, we consider the link between alpha2delta subunits and disease, both in terms of spontaneous and engineered mouse mutants that show cerebellar ataxia and spike-wave epilepsy, and in terms of neuropathic pain and the mechanism of action of the gabapentinoid drugs - small-molecule ligands of the alpha2delta-1 and alpha2delta-2 subunits."4.84Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels. ( Davies, A; Dolphin, AC; Douglas, L; Hendrich, J; Van Minh, AT; Wratten, J, 2007)
" However, a MEDLINE search using the search terms gabapentin and epilepsy, spanning back to the year 1986, produced numerous published reports from randomized, placebo-controlled and open-label trials, as well as case reports."4.82Gabapentin dosing in the treatment of epilepsy. ( Gidal, BE; McLean, MJ, 2003)
"The introduction of these new antiepileptic drugs, from felbamate to levetiracetam, raised hope of control of epilepsy with fewer adverse effects and improved quality of life."4.81New antiepileptic drug therapies. ( Bergin, AM; Connolly, M, 2002)
"To provide a qualitative, systematic update and review of the pharmacology, pharmacokinetics, efficacy in mood disorders, adverse effects, and costs of lamotrigine."4.81Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002)
"Gabapentin (GBP) is a antiepileptic drug (AED) indicated as adjunct therapy for treatment of partial seizures, with and without secondary generalization, in patients 12 and older with epilepsy."4.80Gabapentin. ( Morris, GL, 1999)
"To evaluate the efficacy and tolerability of the newly developed antiepileptic drugs gabapentin, lamotrigine, tiagabine, topiramate, vigabatrin, and zonisamide in patients with refractory partial epilepsy."4.79New antiepileptic drugs: a systematic review of their efficacy and tolerability. ( Chadwick, DW; Kadir, ZA; Marson, AG, 1996)
"Gabapentin, lamotrigine, tiagabine, topiramate, vigabatrin, and zonisamide are all administered as add-on therapy for treatment of patients with refractory epilepsy."4.79Clinical administration of new antiepileptic drugs: an overview of safety and efficacy. ( Chadwick, DW; Kadir, Z; Marson, T, 1996)
"Since 1994, three new antiepileptic drugs, felbamate, lamotrigene, and gabapentin, have been released for the treatment of epilepsy."4.79A review of the newer antiepileptic drugs and the ketogenic diet. ( Barron, TF; Hunt, SL, 1997)
"Gabapentin (GBP), lamotrigine (LTG), tiagabine (TGB), topiramate (TPM), vigabatrin (VGB), and zonisamide (ZNS) are all in use as "add-on" treatment for patients with refractory epilepsy."4.79The new antiepileptic drugs: a systematic review of their efficacy and tolerability. ( Chadwick, DW; Hutton, JL; Kadir, ZA; Marson, AG, 1997)
" Felbamate (FBM) is effective in the treatment of partial seizures and Lennox-Gastaut epilepsy."4.78Advances in the pharmacotherapy of epilepsy. ( Ramsay, RE, 1993)
" We compared new users of recently approved versus established medications for management of diabetic peripheral neuropathy (pregabalin versus gabapentin), Parkinson disease psychosis (pimavanserin versus quetiapine), and epilepsy (brivaracetam versus levetiracetam)."4.31Channeling of New Neuropsychiatric Drugs-Impact on Safety and Effectiveness Studies. ( Abraham, DS; Blank, LJ; Gray, SL; Hennessy, S; Leonard, CE; Nguyen, TPP; Thibault, D; Weintraub, D; Willis, AW, 2023)
"The present study identifies a significant positive association between ASM and LUTI incidence and antibiotic prescriptions in patients with epilepsy treated with pregabalin, whereas a protective effect was found for carbamazepine in women only."4.12Association between anti-seizure medication and the risk of lower urinary tract infection in patients with epilepsy. ( Ehrenberg, C; Gremke, N; Kalder, M; Kostev, K; Möller, L; Printz, M, 2022)
"This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice."3.91Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ, 2019)
" He had been administered phenytoin and gabapentin for the treatment of symptomatic traumatic epilepsy 8 years before."3.88Hypothyroidism induced by phenytoin and gabapentin: A Case Report. ( Ishii, K; Miyake, Z; Tamaoka, A, 2018)
"To characterize and quantify the variability of serial gabapentin concentrations in elderly patients with epilepsy."3.85Factors in Variability of Serial Gabapentin Concentrations in Elderly Patients with Epilepsy. ( Birnbaum, AK; Collins, JF; Conway, JM; Eberly, LE; Leppik, IE; Macias, FM; Ramsay, RE, 2017)
"We compared persistence of antiepileptic drugs (AEDs) including carbamazepine, oxcarbazepine, gabapentin, lamotrigine, topiramate, valproic acid, and phenytoin in an Asian population with epilepsy."3.83Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study. ( Hsieh, CY; Huang, CW; Lai, EC; Lin, SJ; Setoguchi, S; Su, CC; Yang, YK, 2016)
"Gabapentin and pregabalin are antiepileptic drugs (AEDs) with epilepsy and neuropathic pain indications."3.81Experience from therapeutic drug monitoring and gender aspects of gabapentin and pregabalin in clinical practice. ( Baftiu, A; Beiske, G; Burns, ML; Johannessen Landmark, C; Johannessen, SI, 2015)
"These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy."3.80Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014)
"In this study of older adults with epilepsy, lamotrigine was the most effective AED as measured by 12-month retention and seizure freedom, with levetiracetam a close second."3.76Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy. ( Arif, H; Bazil, CW; Buchsbaum, R; Hirsch, LJ; Pierro, J; Resor, SR; Sims, J; Whalen, M, 2010)
"Our study suggests that there are clinically significant differences among gabapentin, lamotrigine, levetiracetam, tiagabine, and topiramate as treatment for focal epilepsy in everyday practice."3.75Retention rates of new antiepileptic drugs in localization-related epilepsy: a single-center study. ( Auvinen, A; Fallah, M; Keränen, T; Peltola, J; Peltola, M; Raitanen, J, 2009)
"An 8-year-old boy with a neurodegenerative disease of unknown origin and an epilepsy disorder developed an urticarial rash and irritability 10 and 4 days, respectively, after the start of gabapentin 20 mg/kg 3 times a day for epilepsy control."3.75Probability of rash related to gabapentin therapy in a child. ( de Wildt, SN; Gijsen, VM; Ito, S, 2009)
"We investigated efficacy of prolonged intraventricular gabapentin (GBP) infusion in the rat flurothyl epilepsy model."3.74Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007)
"To assess whether there is a change in seizure activity in dogs with refractory epilepsy that are receiving appropriate doses of phenobarbitone and/or potassium bromide, when gabapentin is added to the therapeutic regimen."3.73Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005)
"Thirty patients were enrolled: 10 on gabapentin, 10 on lamotrigine and 10 on carbamazepine monotherapy for epilepsy."3.73Measuring the effects of antiepileptic medications on balance in older people. ( Blum, D; Fife, TD; Fisher, RS, 2006)
"The objective of this study was to assess the safety of gabapentin (Neurontin) exposure in human pregnancy."3.72Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry. ( Montouris, G, 2003)
" Hence, the standard of care for older patients with epilepsy should be reevaluated, although the vast use of phenytoin in this population suggests that change in practice patterns may be difficult."3.72Potentially inappropriate antiepileptic drugs for elderly patients with epilepsy. ( Berlowitz, D; Charbonneau, A; Cramer, J; Kazis, L; Knoefel, J; Mandell, A; Pugh, MJ, 2004)
"Gabapentin (1-(aminomethyl)cyclohexane acetic acid, CAS 601 42-96-3, GBP, Neurontin) and its derivative gabapentin-lactam (8-aza-spiro[5,4]decan-9-one, GBP-L) were determined by HPLC in the serum of patients with focal epilepsy treated with GBP."3.72Determination of gabapentin-lactam in serum of patients under gabapentin therapy. ( Feuerstein, TJ; Knörle, R; Schulze-Bonhage, A, 2004)
"This postmarketing surveillance study of lamotrigine (LTG) was performed to provide complementary data to large-scale Prescription-Event Monitoring study with a retrospective case records survey in five tertiary referral epilepsy centres in the United Kingdom."3.71Adverse event monitoring in lamotrigine patients: a pharmacoepidemiologic study in the United Kingdom. ( Mawer, GE; Sander, JW; Wong, IC, 2001)
" In the last decade, pregnancy registries have been activated by collaborative groups of physicians in Europe (EURAP), North America (NAREP), Australia and India (the latter two recently merged into EURAP), to enroll a large number of exposed women to be monitored prospectively with standardized methods, and by three pharmaceutical companies marketing lamotrigine, gabapentin and vigabatrin, as part of their post-marketing surveillance."3.71Pregnancy registries in epilepsy. ( Annegers, JF; Beghi, E, 2001)
" Gabapentin is a new antiepileptic drug not appreciably metabolized by the liver in humans, and it appears to be safe and effective in the maintenance therapy of epilepsy in these patients."3.70Treatment of seizures in acute intermittent porphyria: safety and efficacy of gabapentin. ( Brambilla, A; Erli, LC; Grandi, R; Mirabile, D; Zadra, M, 1998)
"To compare the long-term retention of gabapentin (GBP), lamotrigine (LTG), and vigabatrin (VGB) by patients with chronic epilepsy and the reasons for treatment discontinuation."3.70The long-term use of gabapentin, lamotrigine, and vigabatrin in patients with chronic epilepsy. ( Chadwick, DW; Fenwick, PB; Mawer, GE; Sander, JW; Wong, IC, 1999)
"To report on the occurrence of myoclonus in patients receiving gabapentin (GBP) for the treatment of epilepsy."3.70Myoclonus associated with the use of gabapentin. ( Asconapé, J; DellaBadia, J; Diedrich, A, 2000)
" We reported that daily dosing increased brain gamma-aminobutyric acid (GABA) in patients with epilepsy."3.70Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy patients. ( Hyder, F; Mattson, RH; Petroff, OA; Rothman, DL, 2000)
"We sought to determine the long-term retention rates of lamotrigine (LTG), gabapentin (GBP), and topiramate (TPM) therapy for patients at a tertiary referral clinic for chronic, refractory epilepsy."3.70Long-term retention rates of lamotrigine, gabapentin, and topiramate in chronic epilepsy. ( Lhatoo, SD; Polizzi, G; Sander, JW; Wong, IC, 2000)
"Gabapentin represents a significant advance in the management of epilepsy."3.69Gabapentin (NEURONTIN)--a novel anticonvulsant. ( Murdoch, LA, 1994)
"We report two cases of unusual movement disorders associated with the use of gabapentin (GBP) in patients being treated for epilepsy who were otherwise neurologically intact."3.69Movement disorders associated with the use of gabapentin. ( Krahn, LE; Reeves, AL; Sharbrough, FW; So, EL, 1996)
"To evaluate the relationship of gabapentin therapy with choreoathetotic movements in mentally retarded patients treated with intractable epilepsy."3.69Choreoathetosis as a side effect of gabapentin therapy in severely neurologically impaired patients. ( Chudnow, RS; Dewey, RB; Lawson, CR, 1997)
"Epilepsy is a chronic disease of the central nervous system characterized by recurrent epileptic seizures."3.01Second Generation of Antiepileptic Drugs and Oxidative Stress. ( Czuczwar, SJ; Kamieniak, M; Kośmider, K; Miziak, B, 2023)
"The phenytoin treatment causes cerebellar defect and anemia."2.82The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. ( Agrawal, M; Dhurandhar, Y; Panda, SP, 2022)
" It has been suggested that this transportation is capacity limited, thus decreasing GBP bioavailability at higher doses."2.71The absorption of gabapentin following high dose escalation. ( Beran, RG; Berry, DJ; Clarke, LA; Hung, WT; Plunkeft, MJ, 2003)
"Gabapentin (GBP) is a non-metabolized antiepileptic drug that is eliminated by renal excretion and displays saturable, dose dependent absorption."2.69Gabapentin bioavailability: effect of dose and frequency of administration in adult patients with epilepsy. ( Bockbrader, HN; DeCerce, J; Gidal, BE; Gonzalez, J; Kruger, S; Pitterle, ME; Ramsay, RE; Rutecki, P, 1998)
" Two analyses of adverse events are presented: tolerability and safety."2.69Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study. ( Bernstein, P; Faught, RE; Holmes, GL; Magnus-Miller, L; McLean, MJ; Morrell, MJ; Privitera, MD; Rose-Legatt, A; Willmore, LJ, 1999)
" Furthermore, most preclinical antiepileptogenic studies lack information needed for translation, such as dose-blood level relationship, brain target engagement, and dose-response, and many use treatment parameters that cannot be applied clinically, for example, treatment initiation before or at the time of injury and dosing higher than tolerated human equivalent dosing."2.66Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? ( Bar-Klein, G; Friedman, A; Hameed, MQ; Jozwiak, S; Kaminski, RM; Klein, P; Klitgaard, H; Koepp, M; Löscher, W; Prince, DA; Rotenberg, A; Twyman, R; Vezzani, A; Wong, M, 2020)
"Epilepsy is one of the most common neurological complications in pregnancy; some women continue to use antiepileptic drugs (AEDs) to control seizures."2.66[Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding]. ( Furugen, A, 2020)
"Epilepsy is a common neurological condition with a worldwide prevalence of around 1%."2.55Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017)
"Epilepsy is a common neurological condition with a worldwide prevalence of around 1%."2.55Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017)
"Pediatric epilepsy is a common, chronic, and challenging physical illness for children and their families."2.46Psychiatric concerns in pediatric epilepsy. ( Bujoreanu, IS; DeMaso, DR; Ibeziako, P, 2010)
"Gabapentin is an antiepileptic drug (AED) by design expected to mimic the action of the neurotransmitter gamma-aminobutyric acid (GABA)."2.44Gabapentin: a Ca2+ channel alpha 2-delta ligand far beyond epilepsy therapy. ( Striano, P; Striano, S, 2008)
"A rationale for their use in migraine prophylaxis is the hypothesis that migraine and epilepsy share several common pathogenetic mechanisms."2.44Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms. ( Calabresi, P; Cupini, LM; Galletti, F; Rossi, C; Sarchielli, P, 2007)
" Individualization of dosage and avoidance of unnecessary polypharmacy are essential for safe utilization of anti-epileptic drugs."2.44[Epilepsy in the elderly]. ( Yoshino, A, 2007)
" For drugs that are eliminated renally completely unchanged (gabapentin, pregabalin and vigabatrin) or mainly unchanged (levetiracetam and topiramate), the pharmacokinetic variability is less pronounced and more predictable."2.43Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed? ( Johannessen, SI; Tomson, T, 2006)
"The pharmacokinetic properties of a drug are the primary deter-minant of the extent and duration of drug action, and influence susceptibility to clinically important drug interactions."2.42The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come? ( Johannessen, SI; Perucca, E, 2003)
"Many forms of epilepsy are intractable to current therapies and there is a pressing need to develop agents and strategies to not only suppress seizures, but also cure epilepsy."2.41Ca2+ channels and epilepsy. ( Jones, OT, 2002)
"Gabapentin is a drug that shares a similar structure to that of GABA, although its mechanism of action cannot be explained solely by a direct gaba mimetic effect."2.41[Characteristics and indications of gabapentin]. ( Sancho-Rieger, J, 2002)
"Although antiepileptic drugs (AEDs) are commonly used to control and prevent seizures, their long-term use carries a considerable risk of morbidity."2.41Antiepileptic drug therapy for adults: when to initiate and how to choose. ( Sirven, JI, 2002)
" However, on rare occasions, they can progress to more severe cutaneous disorders, including Stevens-Johnson syndrome and toxic epidermal necrolysis."2.41Therapeutic safety monitoring: what to look for and when to look for it. ( Harden, CL, 2000)
"Epilepsy affects 1."2.41New antiepileptic drugs and preparations. ( Jagoda, A; Yoon, Y, 2000)
"Standard antiepileptic drugs (AEDs) have a number of pharmacokinetic shortcomings, and AEDs with more favorable profiles would be preferred."2.40Pharmacokinetics and interaction profile of topiramate: review and comparison with other newer antiepileptic drugs. ( Johannessen, SI, 1997)
"Standard antiepileptic drugs (AEDs) are associated with a wide variety of acute and chronic adverse events and with many interactions with each other and with non-AEDs that complicate patient management."2.40Overview of the safety of newer antiepileptic drugs. ( Shorvon, S; Stefan, H, 1997)
"Felbamate, however, has been linked with substantially increased incidence of aplastic anemia, and the other new AEDs have been studied for relatively short periods of time."2.40Pharmacologic and dietary therapies in epilepsy: conventional treatments and recent advances. ( Chapman, DP; Giles, WH, 1997)
"Gabapentin is a recently introduced antiepileptic drug for the treatment of partial seizures."2.40Gabapentin for treatment of epilepsy in children. ( Holmes, GL, 1997)
"Gamma-aminobutyric acid (GABA) plays a pivotal role in suppressing the origin and spread of seizure activity."2.40Measuring human brain GABA in vivo: effects of GABA-transaminase inhibition with vigabatrin. ( Petroff, OA; Rothman, DL, 1998)
"Successful treatment of seizure disorders in small animals requires proper patient assessment, understanding the principles of antiepileptic drug (AED) therapy, designing a strategy for pharmacotherapy, and plans for emergency treatment."2.40Antiepileptic drug therapy. ( Podell, M, 1998)
"Gabapentin is an antiepileptic drug used in the treatment of partial and generalized tonic-clonic seizures."2.40Gabapentin. Antiepileptic mechanism of action. ( Kelly, KM, 1998)
" Because dosing is often modest, cost should rarely be the overriding factor in choosing a drug for a patient with newly diagnosed epilepsy in the developed world."2.40Monostars: an aid to choosing an antiepileptic drug as monotherapy. ( Brodie, MJ, 1999)
"Gabapentin has few drug-drug interactions, none of which is clinically limiting."2.40Gabapentin in the management of convulsive disorders. ( McLean, MJ, 1999)
"To most effectively treat children with epilepsy syndromes, further research must be completed to validate the positive effects described in case reports, open-label clinical trials, and early controlled clinical trials."2.40Managing pediatric epilepsy syndromes with new antiepileptic drugs. ( Pellock, JM, 1999)
" For all drugs that are metabolized, half-life is shortened and clearance is increased when patients receive concomitant enzyme-inducing agents such as barbiturates, phenytoin, and carbamazepine."2.40The clinical pharmacokinetics of the new antiepileptic drugs. ( Perucca, E, 1999)
"Gabapentin appears to be a useful new AED."2.39Gabapentin: a new agent for the management of epilepsy. ( Andrews, CO; Fischer, JH, 1994)
"Epilepsy is one of the most common neurological disorders."2.39Newer antiepileptic drugs. Towards an improved risk-benefit ratio. ( Patsalos, PN; Sander, JW, 1994)
"Felbamate was licensed in 1993 for use as adjunctive therapy or monotherapy in adults with partial or tonic-clonic seizures and as adjunctive therapy for children with the Lennox-Gastaut syndrome."2.39Guidelines for treating epilepsy in the age of felbamate, vigabatrin, lamotrigine, and gabapentin. ( Laxer, KD, 1994)
"With the introduction of three new anti-epileptic drugs (AEDs) in the UK during the past 4 years as adjunctive add-on therapy, the possibility of AED pharmacokinetic interactions has become a relevant consideration."2.39Phenobarbitone to gabapentin: a guide to 82 years of anti-epileptic drug pharmacokinetic interactions. ( Patsalos, PN, 1994)
"Gabapentin is a new, water-soluble, antiepileptic agent with properties of an amino acid."2.39Clinical pharmacokinetics of gabapentin. ( McLean, MJ, 1994)
"Gabapentin, has shown significant promise in the treatment of patients with refractory partial seizures and secondarily generalized tonic-clonic seizures."2.39Clinical efficacy and safety of gabapentin. ( Ramsay, RE, 1994)
" ZNS daily dosage is 400-600 mg."2.39Antiepileptic drugs in development: prospects for the near future. ( Leppik, IE, 1994)
"Antiepileptic drugs (AEDs) in broad use today have a number of pharmacokinetic liabilities, including a propensity for clinically meaningful drug interactions."2.39Pharmacokinetic profile of topiramate in comparison with other new antiepileptic drugs. ( Perucca, E, 1996)
" However, the pharmacokinetic properties of an AED determine its ease of use, i."2.39Important pharmacokinetic properties of antiepileptic drugs. ( Bourgeois, BF, 1995)
"This article surveys the pharmacokinetic parameters for the new antiepileptic drugs (AEDs): felbamate, gabapentin, lamotrigine, oxcarbazepine, tiagabine, topiramate, and vigabatrin."2.39Pharmacokinetics of new antiepileptic drugs. ( Gram, L, 1996)
"Epilepsy is common in individuals who are mentally retarded and/or otherwise multiply handicapped."2.39The role of the old and the new antiepileptic drugs in special populations: mental and multiple handicaps. ( Mattson, RH, 1996)
"For many years, the medical treatment of epilepsy was based on the use of the same few drugs, which were chosen according to the seizure type in a fairly standardized manner."2.39New antiepileptic drugs. ( Bourgeois, BF, 1996)
" Specific indications and dosage schedules have been provided."2.39New antiepileptic drugs. ( Brodie, MJ; Wilson, EA, 1996)
"Gabapentin is an antiepileptic drug with an unknown mechanism of action apparently dissimilar to that of other antiepileptic agents, and possessing some desirable pharmacokinetic traits."2.38Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. ( Goa, KL; Sorkin, EM, 1993)
"Epilepsy is a disorder of the central nervous system in which the clinical symptoms are recurrent seizures."2.38Advances in pharmacotherapy: recent developments in the treatment of epilepsy. ( Graves, NM; Leppik, IE, 1993)
"The diagnosis of myoclonus was more difficult than those of epilepsy, because the clarification of pathogenesis and definition of diagnosis was lacked."2.38[Diagnosis and therapy of epilepsy and myoclonus]. ( Okamoto, Y; Ota, K, 1993)
"Comorbid diagnosis of headache predicted use of topiramate and VPA, bipolar disease predicted use of LMT and VPA, pain predicted gabapentin, and schizophrenia was associated with VPAs use."1.91Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy. ( Amuan, ME; Henion, A; Lopez, MR; Panahi, S; Pugh, MJ; VanCott, AC, 2023)
"Gabapentin was the most common second- and third-line ASM."1.72Antiseizure medication treatment pathways for US Medicare beneficiaries with newly treated epilepsy. ( Burke, JF; Choi, H; Terman, SW; Youngerman, BE, 2022)
"Epilepsy is very difficult to treat and often involves the combination of two or more AEDs."1.56Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database. ( Hayashi, T; Noguchi, Y; Tachi, T; Takaoka, M; Teramachi, H, 2020)
"The predominant seizure types in NLLOE were focal to bilateral tonic-clonic seizures (30%) as well as focal onset impaired awareness motor seizures (IAMS) (22%) and focal onset impaired awareness nonmotor seizures (IANMS) (22%)."1.51Nonlesional late-onset epilepsy: Semiology, EEG, cerebrospinal fluid, and seizure outcome characteristics. ( Flöel, A; Hamann, L; Süße, M; von Podewils, F, 2019)
"Gabapentin has been increasingly used in various indications in recent years."1.51Therapeutic drug monitoring of gabapentin in various indications. ( Johannessen Landmark, C; Johannessen, SI; Kinge, E; Larsen Burns, M; Stokke Opdal, M, 2019)
"Gabapentin is an anticonvulsant medication with an indication from the US Food and Drug Administration for use in partial onset seizures and postherpetic neuralgia in the United States."1.51A Call for Caution in Prescribing Gabapentin to Individuals With Concurrent Polysubstance Abuse: A Case Report. ( Hasan, S; Martinez, GM; Olabisi, J; Ruekert, L, 2019)
"Levetiracetam treatment did not affect bone strength, bone mass, and bone turnover."1.46Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats. ( Izumo, N; Kanda, J; Kobayashi, Y; Onodera, K; Shimakura, T; Takahashi, HE; Wakabayashi, H; Yamamoto, N, 2017)
"CNS inflammation is characterized by a disturbance of glial cell functions."1.40Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation. ( Dambach, H; Faustmann, PM; Haase, CG; Hinkerohe, D; Hufnagel, A; Moinfar, Z; Prochnow, N; Stienen, MN, 2014)
"Gabapentin has been shown to disrupt the interaction of thrombospondin (TSP) with α2δ-1, an auxiliary calcium channel subunit."1.40Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation. ( Andresen, L; Dulla, CG; Hampton, D; Maguire, J; Morel, L; Taylor-Weiner, A; Yang, Y, 2014)
"Early treatment of epilepsy is warranted to avoid possible severe consequences."1.39Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle. ( Angeletti, G; Carbonetti, P; Del Casale, A; Fensore, C; Ferracuti, S; Girardi, P; Kotzalidis, GD; Lazanio, S; Muzi, A; Rapinesi, C; Savoja, V; Scatena, P; Serata, D; Tatarelli, R, 2013)
"Gabapentin (GAB) is a newer second-line antiepileptic drug (AED) used in children."1.38Retention rate of Gabapentin in children with intractable epilepsies at 1 year. ( Ali, I; Gupta, R; Lewis, TG; Mills, JK; Mordekar, SR; Mughal, K; Ruslan, NE; Sasidharan, L; Sharma, R; Siddiqua, A; Ugar, A; Wassmer, E; Whitehouse, WP, 2012)
"Current drugs for the treatment of seizure disorders, although effective in many patients, still suffer from a number of failures and are not effective in some forms of resistant epilepsies."1.36Novel KCNQ2/Q3 agonists as potential therapeutics for epilepsy and neuropathic pain. ( Amato, GS; Burns, JF; Eargle, CW; Fritch, PC; Harrison, W; Jones, L; McNaughton-Smith, G; Roeloffs, R; Wickenden, AD, 2010)
" GBP plasma concentrations in the neonates declined with an estimated half-life of 14 h."1.33Pharmacokinetics of gabapentin during delivery, in the neonatal period, and lactation: does a fetal accumulation occur during pregnancy? ( Ohman, I; Tomson, T; Vitols, S, 2005)
"The influence of age and administered daily dosage on the plasma concentrations of gabapentin (GBP) at steady state was evaluated in a group of 41 children and young adults (aged 3-30 years) receiving long-term adjunctive treatment with GBP for the management of refractory partial-onset seizures."1.32Plasma gabapentin concentrations in children with epilepsy: influence of age, relationship with dosage, and preliminary observations on correlation with clinical response. ( Bonanni, P; Bonomi, I; Ferrari, AR; Gatti, G; Guerrini, R; Perucca, E, 2003)
"Gabapentin is a clinically effective anticonvulsant with an unclear mechanism of action."1.32Gabapentin actions on Kir3 currents and N-type Ca2+ channels via GABAB receptors in hippocampal pyramidal cells. ( Bertrand, S; Lacaille, JC; Morin, F; Nagy, F; Nouel, D, 2003)
"ent/ent mice develop ataxia by postnatal day 13-15, followed by paroxysmal dyskinesia a few days later."1.32entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse. ( Becker, CM; Becker, K; Boison, D; Brill, J; Gouder, N; Hofmann, F; Klocke, R; Klugbauer, N; Paul, D, 2004)
"Electroconvulsions were produced by means of an alternating current (ear-clip electrodes, 0."1.31Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis. ( Borowicz, KK; Czuczwar, SJ; Luszczki, J; Swiader, M, 2002)
"Gabapentin (GBP) is a novel antiepileptic drug (AED), currently used as add-on therapy in patients with partial seizures."1.31Gabapentin-induced modulation of interictal epileptiform activity related to different vigilance levels. ( Bassetti, MA; Marciani, MG; Mattia, D; Placidi, F; Romigi, A; Spanedda, F, 2000)
"Epilepsy is a common condition in people with learning disabilities with many patients continuing to suffer from seizures despite antiepileptic drug (AED) treatment."1.30A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. ( Bhaumik, S; Branford, D; Duggirala, C; Ismail, IA, 1997)
"Lamotrigine was the only drug which antagonized tonic convulsions in the MES test (ED50 = 36 mumol/kg)."1.30Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin. ( Dalby, NO; Nielsen, EB, 1997)
"Gabapentin is a new antiepileptic drug."1.30[Gabapentin--a new antiepileptic agent]. ( Johannessen, SI; Nakken, KO; Rytter, E, 1998)
" However, GBP concentrations were much lower after rectal administration; therefore, we concluded that the aqueous solution was poorly absorbed rectally."1.30Failure of absorption of gabapentin after rectal administration. ( Birnbaum, AK; Caruso, KJ; Cloyd, JC; Jones Saete, C; Kriel, RL; Ricker, BJ, 1997)
"Length of seizure disorder, seizure frequency at initiation, the number of previously used failed drugs and the total number of drugs previously used were all significantly lower in the seizure-free group."1.30The outcome of prescribing novel anticonvulsants in an outpatient setting: factors affecting response to medication. ( Kerr, MP; Thijs, RD, 1998)
"In 1993, 27% of patients were being treated for epilepsy and in 1995/6, 30."1.30The management of epilepsy in a hospital for people with a learning disability. ( Carvill, S; Cassidy, G; Clarke, D, 1999)
"Gabapentin is a new AED not appreciably metabolized by the liver in humans."1.29Gabapentin treatment of seizures in acute intermittent porphyria. ( Tatum, WO; Zachariah, SB, 1995)
"Gabapentin is a gamma-aminobutyric acid (GABA) analog which passes the blood-brain barrier."1.29[New medical treatment of epilepsy]. ( Loiseau, P, 1996)
"Gabapentin is a novel antiepileptic drug that has recently been introduced in Canada."1.29Gabapentin. ( Bruni, J, 1996)
"Gabapentin is a novel anti-epileptic drug which enhances GABA (gamma-aminobutyric acid) turnover in certain brain regions, including substantia nigra."1.29The anticonvulsant gabapentin decreases firing rates of substantia nigra pars reticulata neurons. ( Bloms-Funke, P; Löscher, W, 1996)

Research

Studies (261)

TimeframeStudies, this research(%)All Research%
pre-19902 (0.77)18.7374
1990's122 (46.74)18.2507
2000's82 (31.42)29.6817
2010's39 (14.94)24.3611
2020's16 (6.13)2.80

Authors

AuthorsStudies
Fritch, PC1
McNaughton-Smith, G1
Amato, GS1
Burns, JF1
Eargle, CW1
Roeloffs, R1
Harrison, W1
Jones, L1
Wickenden, AD1
McComsey, DF1
Smith-Swintosky, VL1
Parker, MH1
Brenneman, DE1
Malatynska, E1
White, HS1
Klein, BD1
Wilcox, KS1
Milewski, ME1
Herb, M1
Finley, MF1
Liu, Y1
Lubin, ML1
Qin, N1
Reitz, AB1
Maryanoff, BE1
Terman, SW1
Youngerman, BE1
Choi, H1
Burke, JF1
Panda, SP1
Dhurandhar, Y1
Agrawal, M1
Gremke, N1
Printz, M1
Möller, L1
Ehrenberg, C1
Kostev, K2
Kalder, M1
Tomson, T3
Battino, D1
Bromley, R1
Kochen, S2
Meador, KJ2
Pennell, PB1
Thomas, SV1
Hessenberger, M1
Haddad, S1
Obermair, GJ1
Kośmider, K1
Kamieniak, M1
Czuczwar, SJ3
Miziak, B1
Abraham, DS1
Nguyen, TPP1
Blank, LJ2
Thibault, D1
Gray, SL1
Hennessy, S1
Leonard, CE1
Weintraub, D1
Willis, AW1
Agarwal, P1
Kwon, CS1
Jetté, N1
Zhao, K1
Bai, X1
Wang, X1
Cao, Y1
Zhang, L1
Li, W1
Wang, S1
Lopez, MR1
VanCott, AC1
Amuan, ME1
Panahi, S1
Henion, A1
Pugh, MJ2
Ziganshina, LE1
Abakumova, T1
Hoyle, CHV1
Lawal, OD1
Hume, AL1
Wen, X1
Lattanzi, S1
Trinka, E1
Del Giovane, C1
Nardone, R1
Silvestrini, M1
Brigo, F1
Klein, P1
Friedman, A1
Hameed, MQ1
Kaminski, RM1
Bar-Klein, G1
Klitgaard, H1
Koepp, M1
Jozwiak, S1
Prince, DA1
Rotenberg, A1
Twyman, R1
Vezzani, A1
Wong, M1
Löscher, W2
Noguchi, Y1
Takaoka, M1
Hayashi, T1
Tachi, T1
Teramachi, H1
Soldovieri, MV1
Freri, E1
Ambrosino, P1
Rivolta, I1
Mosca, I1
Binda, A1
Murano, C1
Ragona, F1
Canafoglia, L1
Vannicola, C1
Solazzi, R1
Granata, T1
Castellotti, B1
Messina, G1
Gellera, C1
Labalme, A1
Lesca, G1
DiFrancesco, JC1
Taglialatela, M1
Furugen, A1
Jacob, L1
Hamer, HM1
Nevitt, SJ2
Sudell, M2
Weston, J2
Tudur Smith, C2
Marson, AG6
Conway, JM1
Eberly, LE1
Collins, JF2
Macias, FM1
Ramsay, RE6
Leppik, IE3
Birnbaum, AK2
Kanda, J1
Izumo, N1
Kobayashi, Y1
Onodera, K1
Shimakura, T1
Yamamoto, N1
Takahashi, HE1
Wakabayashi, H1
Brandt, C1
May, TW1
Süße, M1
Hamann, L1
Flöel, A1
von Podewils, F1
Tutka, P1
Mróz, K1
Mróz, T1
Buszewicz, G1
Aebisher, D1
Bartusik-Aebisher, D1
Kołodziejczyk, P1
Łuszczki, JJ1
Miyake, Z1
Ishii, K1
Tamaoka, A1
Larsen Burns, M1
Kinge, E1
Stokke Opdal, M1
Johannessen, SI6
Johannessen Landmark, C2
Ayala-Guerrero, F1
Mexicano, G1
Gutiérrez-Chávez, CA1
Lazo, LA1
Mateos, EL1
Laghari, AA1
Ahmed, SI1
Qadeer, N1
Shamim, MS1
Martinez, GM1
Olabisi, J1
Ruekert, L1
Hasan, S1
Daugaard, CA1
Sun, Y1
Dreier, JW1
Christensen, J1
Di Fabio, R1
D'Agostino, C1
Baldi, G1
Pierelli, F1
Rapinesi, C1
Del Casale, A1
Serata, D1
Kotzalidis, GD1
Scatena, P1
Muzi, A1
Lazanio, S1
Savoja, V1
Carbonetti, P1
Fensore, C1
Ferracuti, S1
Angeletti, G1
Tatarelli, R1
Girardi, P1
Dambach, H1
Hinkerohe, D1
Prochnow, N1
Stienen, MN1
Moinfar, Z1
Haase, CG1
Hufnagel, A1
Faustmann, PM1
Ito, S2
Oguni, H1
Ohtsuka, Y1
Andresen, L1
Hampton, D1
Taylor-Weiner, A1
Morel, L1
Yang, Y1
Maguire, J1
Dulla, CG1
Mohammed, AS1
Ewais, MM1
Tawfik, MK1
Essawy, SS1
Beiske, G1
Baftiu, A1
Burns, ML1
Vanya, M1
Devosa, I1
Szok, D1
Bártfai, G1
Lai, EC1
Hsieh, CY1
Su, CC1
Yang, YK1
Huang, CW1
Lin, SJ1
Setoguchi, S1
Maguire, MJ1
Hemming, K1
Hutton, JL2
Striano, P1
Striano, S1
Peltola, J1
Peltola, M1
Auvinen, A1
Raitanen, J1
Fallah, M1
Keränen, T1
Carpay, JA1
Aalbers, K1
Graveland, GA1
Engelsman, M1
Gijsen, VM1
de Wildt, SN1
Rouvel-Tallec, A1
Pellock, JM7
Blake, MG1
Boccia, MM2
Carcaboso, AM1
Chiappetta, DA1
Höcht, C1
Krawczyk, MC1
Sosnik, A1
Baratti, CM2
Cavanna, AE1
Ali, F1
Rickards, HE1
McCorry, D1
Arif, H1
Buchsbaum, R1
Pierro, J1
Whalen, M1
Sims, J1
Resor, SR1
Bazil, CW2
Hirsch, LJ1
Bujoreanu, IS1
Ibeziako, P1
DeMaso, DR1
Lucey, BP1
Noetzel, MJ1
Duntley, SP1
Bittner, S1
Höhn, K1
Göbel, K1
Kleinschnitz, C1
Wiendl, H1
Meuth, SG1
Akamatsu, N1
Kaufman, KR1
Struck, PJ1
Wu, B1
Wong, S1
Mills, JK1
Ruslan, NE1
Lewis, TG1
Mughal, K1
Ali, I1
Ugar, A1
Wassmer, E1
Siddiqua, A1
Gupta, R1
Mordekar, SR1
Sharma, R1
Sasidharan, L1
Whitehouse, WP1
Delattre, M1
Savic, RM1
Miller, R1
Karlsson, MO1
Lavielle, M1
Tupal, S1
Faingold, CL1
Terada, K1
Inoue, Y1
Arvio, M1
Sipilä, I1
Jones, OT1
Borowicz, KK1
Swiader, M1
Luszczki, J1
Wilton, LV1
Shakir, S1
Brodie, MJ4
Chadwick, DW7
Anhut, H1
Otte, A1
Messmer, SL1
Maton, S2
Sauermann, W1
Murray, G2
Garofalo, EA1
Vega-Hernández, A1
Felix, R1
Sancho-Rieger, J1
Guéguen, A1
Guy, C1
Cartry, O1
Bouchou, K1
Gouilloud, S1
Cathébras, P1
Zachariae, CO1
Sirven, JI1
Berry, DJ1
Beran, RG1
Plunkeft, MJ1
Clarke, LA1
Hung, WT1
Gatti, G1
Ferrari, AR1
Guerrini, R1
Bonanni, P1
Bonomi, I1
Perucca, E4
Bergin, AM1
Connolly, M1
Montouris, G2
McLean, MJ5
Gidal, BE2
Btaiche, IF1
Woster, PS1
Bertrand, S1
Nouel, D1
Morin, F1
Nagy, F1
Lacaille, JC1
Huber, B1
Tomka-Hoffmeister, M1
Brill, J1
Klocke, R1
Paul, D1
Boison, D1
Gouder, N1
Klugbauer, N1
Hofmann, F1
Becker, CM1
Becker, K1
Cramer, J1
Knoefel, J1
Charbonneau, A1
Mandell, A1
Kazis, L1
Berlowitz, D1
Wu, SP1
Shyu, MK1
Liou, HH1
Gau, CS1
Lin, CJ1
French, JA2
Kanner, AM1
Bautista, J1
Abou-Khalil, B1
Browne, T1
Harden, CL2
Theodore, WH1
Bazil, C1
Stern, J1
Schachter, SC1
Bergen, D2
Hirtz, D1
Montouris, GD1
Nespeca, M1
Gidal, B1
Marks, WJ1
Turk, WR1
Fischer, JH2
Bourgeois, B1
Wilner, A1
Faught, RE2
Sachdeo, RC1
Beydoun, A1
Glauser, TA1
Knörle, R1
Feuerstein, TJ2
Schulze-Bonhage, A1
Marshall, L1
Doyle, KM1
Kirby, BP1
Murphy, D1
Shaw, GG1
Rowan, AJ1
Pryor, F1
Boardman, KD1
Uthman, BM1
Spitz, M1
Frederick, T1
Towne, A1
Carter, GS1
Marks, W1
Felicetta, J1
Tomyanovich, ML1
Selai, CE2
Trimble, MR3
Price, MJ1
Remak, E1
Harrison, PK1
Sheridan, RD1
Green, AC1
Tattersall, JE1
Ohman, I1
Vitols, S1
Sander, JW6
Govendir, M1
Perkins, M1
Malik, R1
Freiman, TM1
Surges, R1
Kukolja, J1
Heinemeyer, J1
Klar, M1
van Velthoven, V1
Zentner, J1
Fife, TD1
Blum, D1
Fisher, RS2
Bialer, M1
Stefan, H3
Rajna, P1
Szíjártó, E1
Matsuura, M1
Sajatovic, M1
Ramsay, E1
Nanry, K1
Thompson, T1
Calabresi, P1
Galletti, F1
Rossi, C1
Sarchielli, P1
Cupini, LM1
Oommen, J1
Kraus, AC1
Yoshino, A1
Davies, A1
Hendrich, J1
Van Minh, AT1
Wratten, J1
Douglas, L1
Dolphin, AC1
Savica, R1
Beghi, E2
Mazzaglia, G1
Innocenti, F1
Brignoli, O1
Cricelli, C1
Caputi, AP1
Musolino, R1
Spina, E1
Trifirò, G1
Appleton, R3
Baker, GA1
Doughty, J1
Eaton, B1
Gamble, C1
Jacoby, A1
Shackley, P1
Smith, DF1
Tudur-Smith, C1
Vanoli, A1
Williamson, PR1
Macleod, S1
Appleton, RE2
Baillieux, H1
Verslegers, W1
Paquier, P1
De Deyn, PP1
Mariën, P1
Hwang, H1
Kim, KJ1
Despland, PA3
Macdonald, RL2
Kelly, KM3
Kilpatrick, C1
Kupecz, D1
Goa, KL1
Sorkin, EM1
Murdoch, LA1
Pimentel, J1
Pinto, F1
Tatum, WO1
Zachariah, SB1
Betts, T1
O'Neill, BA1
Bloom, DS1
Leach, JP1
Devinsky, O1
Vazquez, B1
Luciano, D1
Andrews, CO1
Chadwick, D3
Patsalos, PN2
Sivenius, J1
Ylinen, A1
Kälviäinen, R1
Riekkinen, PJ1
Buchanan, N1
Laxer, KD1
Parks, BR1
Dostrow, VG1
Noble, SL1
Byers, VL1
Graves, NM1
Skolnick, AA1
Manack, L1
Slater, JD1
Okamoto, Y1
Ota, K1
Galdames, D1
Aguilera, L1
Fauré, E1
Lee, EK1
Vassella, F2
Krämer, G1
Wieser, HG1
Lee, DO1
Steingard, RJ1
Cesena, M1
Helmers, SL1
Riviello, JJ1
Mikati, MA1
Vossler, DG2
Reynolds, NC1
Legido, A1
Iivanainen, M1
Gaily, E1
Loiseau, P1
Davies, JA1
Dimond, KR1
Pande, AC1
Lamoreaux, L2
Pierce, MW1
McDonnell, GV1
Morrow, JI1
Bourgeois, BF3
Reeves, AL1
So, EL1
Sharbrough, FW1
Krahn, LE1
Hauck, A1
Bhaumik, S2
Hussein, G1
Troupin, AS1
Morton, LD2
Jackson, D1
Duthie, T1
Kadir, ZA2
Gram, L1
Meldrum, BS1
Mattson, RH3
Marson, T1
Kadir, Z1
Bruni, J1
Herranz, JL2
Grippo, J1
Bloms-Funke, P1
Morris, HH1
Wilson, EA1
Shorvon, S1
Bannister, SM1
Padró, L1
Arbizu, T1
Rovira, R1
Gil-Nagel, A1
Gapany, S1
Blesi, K1
Villanueva, N1
Branford, D1
Duggirala, C1
Ismail, IA1
Chapman, DP1
Giles, WH1
Chudnow, RS1
Dewey, RB1
Lawson, CR1
Wyler, AR1
Dalby, NO1
Nielsen, EB1
Barron, TF1
Hunt, SL1
Holmes, GL2
Pedley, TA1
Nakken, KO1
Rytter, E1
Petroff, OA2
Rothman, DL2
Kriel, RL1
Cloyd, JC1
Ricker, BJ1
Jones Saete, C1
Caruso, KJ1
Benetello, P1
Furlanut, M1
Fortunato, M1
Baraldo, M1
Pea, F1
Tognon, A1
Testa, G1
Bryans, JS1
Davies, N1
Gee, NS1
Dissanayake, VU1
Ratcliffe, GS1
Horwell, DC1
Kneen, CO1
Morrell, AI1
Oles, RJ1
O'Toole, JC1
Perkins, GM1
Singh, L1
Suman-Chauhan, N1
O'Neill, JA1
Lücke, A1
Musshoff, U1
Köhling, R1
Osterfeld, M1
Mayer, T2
Wolf, P2
Schütte, W2
Speckmann, EJ1
DeCerce, J1
Bockbrader, HN2
Gonzalez, J1
Kruger, S1
Pitterle, ME1
Rutecki, P1
Podell, M1
Ferrier, IN1
Mortimore, C1
Trimble, M1
Emmers, E1
Thijs, RD1
Kerr, MP1
Zadra, M1
Grandi, R1
Erli, LC1
Mirabile, D1
Brambilla, A1
Feely, M1
Wilner, AN1
Elger, CE2
Langan, Y1
Duncan, JS1
Carvill, S1
Clarke, D1
Cassidy, G1
Cramer, JA1
Fisher, R1
Ben-Menachem, E1
French, J1
Morrell, MJ1
Willmore, LJ1
Privitera, MD1
Magnus-Miller, L1
Bernstein, P1
Rose-Legatt, A1
Bernatik, J1
Knorr, J1
Wong, IC3
Fenwick, PB1
Mawer, GE2
Fernández, G1
Morris, GL1
Korn-Merker, E1
Borusiak, P1
Boenigk, HE1
Datta, PK1
Crawford, PM1
Acosta, GB1
Usiskin, SI1
Nicolson, R1
Lenane, M1
Rapoport, JL1
Placidi, F2
Diomedi, M1
Scalise, A1
Marciani, MG2
Romigi, A2
Gigli, GL1
Asconapé, J1
Diedrich, A1
DellaBadia, J1
Hyder, F1
Vajda, FJ1
Mattia, D1
Bassetti, MA1
Spanedda, F1
Foletti, GB1
Lhatoo, SD1
Polizzi, G1
Yoon, Y1
Jagoda, A1
Fichtner, K1
Alexander, J1
Garofalo, E2
Crawford, P2
Brown, S1
Kerr, M1
Aldenkamp, AP1
Goldberg, JF1
Burdick, KE1
Bassilios, N1
Launay-Vacher, V1
Khoury, N1
Rondeau, E1
Deray, G1
Sraer, JD1
Ouellet, D1
Wesche, DL1
Shapiro, DY1
Annegers, JF1
Hurley, SC1
Salinsky, MC1
Binder, LM1
Oken, BS1
Storzbach, D1
Aron, CR1
Dodrill, CB1
Sussman, N1
Grant, AC1
Oh, H1
Foot, M1
Wallace, J1
Kondo, T1
Fromm, GH1
Schmidt, B1
Porter, RJ1
Ghadiali, E1
Lane, R1
Blumhardt, L1

Clinical Trials (9)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Retrospective Study to Evaluate Retention Rate of Topiramate With That of Levetiracetam and Oxcarbazepine in a Long-term Epilepsy Treatment[NCT02098941]2,500 participants (Anticipated)Observational2014-03-31Recruiting
A Multicentre, Double-blind, Randomized, Phase IV Clinical Trial Comparing the Safety, Tolerability and Efficacy of Levetiracetam Versus Lamotrigine and Carbamazepine in the Oral Antiepileptic Therapy of Newly Diagnosed Elderly Patients With Focal Epileps[NCT00438451]Phase 4361 participants (Actual)Interventional2007-01-31Completed
Efficacy, Tolerability and Adherence of the Modified Atkins Diet on Drug-resistant Epilepsy in Adults Patients[NCT03183076]14 participants (Actual)Interventional2015-09-01Completed
The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822]550 participants (Anticipated)Observational2022-02-18Recruiting
Open Labeled, Non-randomized, Study of Efficacy and Safety of Gralise in Fibromyalgia Patients.[NCT02052414]34 participants (Actual)Interventional2012-07-31Completed
The Effect of Gabapentin on Prefrontal GABA Concentration and Emotional Processing in Healthy Humans[NCT00094510]30 participants (Actual)Observational2004-10-14Completed
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776]Phase 254 participants (Actual)Interventional2017-08-07Completed
The Efficacy of Gabapentine and Splint Therapy in Bruxers: a Randomized Clinical Trial[NCT01255878]20 participants (Actual)Interventional2010-03-31Completed
An Open Prospective Randomised Long-Term Effectiveness Study, Comparing Best Medical Practice With or Without Adjunctive VNS Therapy in Patients 16 Years and Older With Pharmaco-resistant Partial Epilepsy[NCT00522418]Phase 4122 participants (Actual)Interventional2006-02-28Terminated (stopped due to Insufficient enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

58-week Retention Rate Measured by the Number of Drop Outs Due to Adverse Events or Seizures From Day 1 of Treatment

(NCT00438451)
Timeframe: 58 weeks

Interventionproportion of participants (Mean)
Levetiracetam0.61
Carbamazepine0.46
Lamotrigine0.56

Percentage of Patients Remaining Seizure Free at Week 58 (Visit 6)

Percentage of patients experiencing no seizures until week 58 (Visit 6) and did not discontinue the study until week 58. (NCT00438451)
Timeframe: week 58

Interventionpercentage of participants (Number)
Levetiracetam43
Carbamazepine33
Lamotrigine38

Percentage of Patients Remaining Seizure-free at Week 30 (Visit 4)

Percentage of patients experiencing no seizures until week 30 (Visit 4) and did not discontinue the study until week 30. (NCT00438451)
Timeframe: Week 30

Interventionpercentage of participants (Number)
Levetiracetam48
Carbamazepine39
Lamotrigine49

Proportion of Seizure-free Days During the Maintenance Phase for Subjects Who Enter the Maintenance Phase

(NCT00438451)
Timeframe: 52 weeks

Interventionproportion of seizure-free days (Number)
Levetiracetam0.99
Carbamazepine0.99
Lamotrigine0.99

Results of Cognitive Testing (EpiTrack© by UCB) - Score at V6

EPITrack-Score shows the performance of attention and executive functions. Higher values indicate a better performance. The results of EPITrack Score ranges between 7 and 45. (NCT00438451)
Timeframe: week 58

Interventionunits on a scale (Mean)
Levetiracetam26.0
Carbamazepine26.0
Lamotrigine25.4

The Absolute Seizure Frequency During the Maintenance Phase (Weeks 7 - 58)

"Seizure frequency was assessed by investigators in the CRF at the Visits V3, V4, V5 and V6.~The absolute seizure frequency during the maintenance phase was defined as the sum of those entries." (NCT00438451)
Timeframe: over 52 weeks

Interventionnumber of seizures (Number)
Levetiracetam168
Carbamazepine131
Lamotrigine130

The Time (in Days) to First Break-through Seizure (From Day 1 of Treatment)

(NCT00438451)
Timeframe: over the whole duration of 58 weeks

Interventiondays (Median)
LevetiracetamNA
CarbamazepineNA
LamotrigineNA

Time to Drop Out

number of days between randomization and premature discontinuation of the study (NCT00438451)
Timeframe: 58 weeks

Interventiondays (Median)
LevetiracetamNA
Carbamazepine265
LamotrigineNA

Portland Neurotoxicity Scale (PNS) at V6

"The PNS is a 15-item scale. Each item can be scored from 1 to 9. There are a total score (includes all items, range:15 to 135) and two subscores: The cognitive toxicity subscore (10 items: Energy Level, Memory, Interest, Concentration, Forgetfulness, Sleepliness, Moodiness, Alertness, Attention Span, Motivation, range:10 to 90) and the somatomoto subscore (5 items: Vision, Walking, Coordination, Tremor, Speech, range:5-45). The score is calculated by taking the mean of all non-missing values times the number of items.~Lower values indicate better quality of life." (NCT00438451)
Timeframe: at week 58

,,
Interventionunits on a scale (Mean)
Cognitive toxicity subscoreSomatomotor subscoreTotal Score
Carbamazepine27.311.438.7
Lamotrigine23.710.834.5
Levetiracetam22.210.532.7

QOLIE-31 (Quality Of Life In Epilepsy) Results at V6

The QOLIE-31 is a 31 item score that measures the quality of life in epilepsy (each item with a range of 0 to 100). There are 7 sub-scores seizure worry (items 11,21,22,23,25), overall quality of life (items 1,14), emotional well-being (items 3,4,5,7,9), energy/fatigue (items 2,6,8,10), cognitive functioning (items 12,15,16,17,18,26), medication effects (items 24,29,30) and social functioning (13,19,20,27,28). These scores were combined to a total score by Total score = seizure worry*0.08 + overall quality of life*0.14 + emotional well-being*0.15 + energy/fatigue*0.12 + cognitive functioning*0.27 + medication effects*0.03 + social functioning*0.21 For all scores, higher values indicate better quality of life. Each score has a possible range from 0 to 100. (NCT00438451)
Timeframe: 58 weeks, final visit

,,
Interventionunits on a scale (Mean)
Seizure worryOverall quality of lifeEmotional well-beingEnergy/fatigueCognitive functioningMedication effectsSocial functioningTotal ScoreHealth Scale
Carbamazepine75.465.069.854.568.970.676.368.965.7
Lamotrigine75.067.167.459.868.072.676.769.167.5
Levetiracetam85.167.272.060.875.177.681.173.969.5

Results of Cognitive Testing (EpiTrack© by UCB) - Categories at V6

"Evaluation of current testing at V6:~≥29 score points: Inconspicuous; 26 to 28 score points: Borderline;~≤25 score points: Impaired" (NCT00438451)
Timeframe: 58 weeks

,,
Interventionparticipants (Number)
Without pathological findingsBorderlineImpaired
Carbamazepine341733
Lamotrigine311539
Levetiracetam381036

Results of Cognitive Testing (EpiTrack© by UCB) - Changes to Baseline (V0) at Week 58 (V6)

"Evaluation of Changes~Changes in the EpiTrack® Score were categorized as follows:~≥5 score points: Improved;~-3 to 4 score points: Unchanged;~≤-4 score points: Worsened" (NCT00438451)
Timeframe: week 58

,,
Interventionparticipants (Number)
ImprovedUnchangedWorsened
Carbamazepine16568
Lamotrigine155313
Levetiracetam15616

Fibromyalgia Impact Questionnaire (FIQ)

The Fibromyalgia Impact Questionnaire (FIQ) is an instrument designed to quantitate the overall impact of fibromyalgia over many dimensions (e.g. function, pain level, fatigue, sleep disturbance, psychological distress etc.). It is scored from 0 to 100 with the latter number being the worst case. The average score for patients seen in tertiary care settings is about 50. The FIQ is widely used to assess change in fibromyalgia status. (NCT02052414)
Timeframe: 15 weeks.

Interventionunits on a scale (Mean)
FIQ BaselineFIQ Week 4FIQ Week 8FIQ Week 12FIQ Week 15
Gralise (Gabapentin ER)71.0441.8240.7939.2761.86

Medical Outcome Study (MOS) Sleep Questionnaires

"Medical Outcomes Study (MOS) sleep questionnaires to assess how Fibromyalgia impacts patients' sleep in various areas.~Specifically, Data reported below measured number of hours subjects spent per night sleeping. MOS sleep questionnaires were assessed at each follow up visits. (visits 1, 2, 3, 4, and 5)." (NCT02052414)
Timeframe: 15 weeks

InterventionHours (Mean)
Sleep Quantity BaselineSleep Quantity week 4Sleep quantity week 8Sleep quantity week 12Sleep quantity week 15
Gralise (Gabapentin ER)5.867.176.817.046.23

Numeric Pain Rating System (NPRS)

Fibromyalgia pain experienced by study subjects will be captured using NPRS at baseline visit, at each follow visits that are scheduled to occur every 4 weeks over 12 weeks of treatment period, and at the end of treatment visit that will occur 3 weeks after treatment period (12 weeks treatment period + 3 weeks = 15 weeks). Any difference in NPRS scores between baseline and any subsequent visits will indicate the magnitude of pain relief as reflected in digital scale of 0-10 (0=no pain, 10=worst pain imaginable). (NCT02052414)
Timeframe: 15 weeks

Interventionunits on a scale (Mean)
NPRS Baseline (Visit 1)NPRS on Week 4 (Visit 2)NPRS on week 8 (Visit 3)NPRS on Week 12 (Visit 4)NPRS on week 15 (Visit 5)
Gralise (Gabapentin ER)7.294.723.953.836.94

Patient Global Impression of Change (PGIC)

Patient Global impression of Change (PGIC) is an outcome commonly used measure of the efficacy of treatments. PGIC is a 7 point scale that requires the subjects to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention. and rated as: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse. (NCT02052414)
Timeframe: 15 Weeks.

Interventionunits on a scale (Mean)
PGIC After 4 weeksPGIC After 8 weeksPGIC After 12 weeksPGIC After 15 weeks
Gralise (Gabapentin ER)4.965.405.374.44

Self Reported Side Effects.

Side / adverse effects were assessed at each follow up visits and resulted are as follows. (NCT02052414)
Timeframe: 15 Weeks

Interventionparticipants (Number)
Extremity SwellingWeight GainDrowsyDizzyIrritabilityDry EyesPainMood ChangesDifficulty ConcentratingDry MouthSuspected Drug interactionAcute DeleriumAdhesionNone
Gralise (Gabapentin ER)228332122111112

Prefrontal GABA+ Concentrations

Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine3.90
Gabapentin3.93
Placebo Oral Tablet3.73

Prefrontal Glx Concentrations

Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine21.59
Gabapentin21.69
Placebo Oral Tablet22.25

Change From Baseline in Adverse Event Profile (AEP) Score

Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Mean change from baseline AEP Score at 12 months

InterventionUnits on a scale (Mean)
VNS Therapy-6.0
Best Medical Practice-3.2

Change From Baseline in Center for Epidemiologic Studies Depression Scale (CES-D) Score

The Center for Epidemiologic Studies Depression Scale (CES-D) includes 20 items comprising six scales reflecting major dimensions of depression: depressed mood, feelings of guilt and worthlessness, feelings of helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance. Possible range of scores is 0 to 60, higher scores indicate more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline CES-D Score at 12 months

InterventionUnits on a Scale (Mean)
VNS Therapy-2.2
Best Medical Practice0.5

Change From Baseline in Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) Score

The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a 6-item questionnaire validated to screen for depression in people with epilepsy. Scores range from 6 to 24, with higher scores indicating more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline NDDI-E Score at 12 months

InterventionUnits on a Scale (Mean)
VNS Therapy-1.0
Best Medical Practice-0.2

Changes in Anti-epileptic Drugs (AEDs)

Change from baseline in number of AED medications by visit (NCT00522418)
Timeframe: Change from baseline in number of AEDs at 12 months

InterventionNumber of AEDs Taken (Median)
VNS Therapy0
Best Medical Practice0

Mean Change From Beginning of Intervention Clinical Global Impression-Improvement Scale (CGI-I) Score at 12 Months

The Clinical Global Impression scale (CGI-I) is a 7 point scale that requires the clinician to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention Scores range from 1-7: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse. (NCT00522418)
Timeframe: Mean change from baseline CGI-I Score at 12 months

InterventionUnits on a Scale (Mean)
VNS Therapy-0.8
Best Medical Practice-0.3

Mean Percent Change in Seizure Frequency

Percent change in total seizuires per week from baseline at 12 months (NCT00522418)
Timeframe: Mean percent change from baseline in seizure frequency at 12 months

InterventionPercent Change (Mean)
VNS Therapy-19.1
Best Medical Practice-1.0

Overall Quality of Life in Epilepsy-89 (QOLIE-89) Score in Patients With Baseline & at Least One Post-baseline QOLIE Assessment

QOLIE-89 contains 17 multi-item measures of overall quality of life, emotional well-being, role limitations due to emotional problems, social support, social isolation, energy/fatigue, worry about seizure, medication effects, health discouragement, work/driving/social function, attention/concentration, language, memory, physical function, pain, role limitations due to physical problems, and health perceptions. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. (NCT00522418)
Timeframe: Mean change from baseline QOLIE-89 Overall Score at 12 months

Interventionunits on a scale (Mean)
VNS Therapy5.5
Best Medical Practice1.2

Response Rate

Response Rate is defined as the percent of participants who are responders. A Responder is defined as participants with a reduction of at least 50% or 75% in seizure frequency from baseline to the seizure count evaluation period. (NCT00522418)
Timeframe: Number of Responders at 12 Months

Interventionparticipants (Number)
VNS Therapy10
Best Medical Practice7

Change From Baseline in QOLIE-89 Measures: Subgroup Analysis of Population With Baseline Adverse Event Profile Score < 40

QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months

Interventionunits on a scale (Least Squares Mean)
VNS TherapyBest Medical Practice
Baseline Adverse Event Profile Score < 403.30.5

Change From Baseline in QOLIE-89 Measures: Subgroup Analysis of Population With Baseline Adverse Event Profile Score >= 40

QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months

InterventionUnits on a Scale (Least Squares Mean)
VNS TherapyBest Medical Practice
Baseline Adverse Event Profile Score >= 403.30.7

Reviews

113 reviews available for gabapentin and Aura

ArticleYear
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches.
    Mitochondrion, 2022, Volume: 66

    Topics: Anticonvulsants; Carbamazepine; Dementia; Epilepsy; Felbamate; Gabapentin; Humans; Inflammasomes; La

2022
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force
    Epileptic disorders : international epilepsy journal with videotape, 2022, 12-01, Volume: 24, Issue:6

    Topics: Breast Feeding; Cannabidiol; Carbamazepine; Child; Clobazam; Clonazepam; Epilepsy; Ethosuximide; Eve

2022
Second Generation of Antiepileptic Drugs and Oxidative Stress.
    International journal of molecular sciences, 2023, Feb-15, Volume: 24, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Diazepam; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; Hum

2023
Gabapentin monotherapy for epilepsy: A review.
    The International journal of risk & safety in medicine, 2023, Volume: 34, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Drug Resistant Epilepsy; Epilepsies, Partial; Epilepsy; Gabapentin;

2023
Antiepileptic drug monotherapy for epilepsy in the elderly: A systematic review and network meta-analysis.
    Epilepsia, 2019, Volume: 60, Issue:11

    Topics: Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Gabapentin; Humans; Levetiracetam; Male; Net

2019
Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?
    Epilepsia, 2020, Volume: 61, Issue:3

    Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Atorvastatin; Brain Injuries, Traumatic; Cef

2020
[Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2020, Volume: 140, Issue:10

    Topics: Anticonvulsants; Benzodiazepines; Biological Transport; Breast Feeding; Cell Line; Epilepsy; Female;

2020
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
    The Cochrane database of systematic reviews, 2017, 06-29, Volume: 6

    Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti

2017
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
    The Cochrane database of systematic reviews, 2017, 12-15, Volume: 12

    Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti

2017
Extended-release drug formulations for the treatment of epilepsy.
    Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:8

    Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Delayed-Action Preparations; Dr

2018
Choice of therapeutic anti-seizure medication in patients with brain tumour.
    JPMA. The Journal of the Pakistan Medical Association, 2019, Volume: 69, Issue:3

    Topics: Anticonvulsants; Brain Neoplasms; Drug Therapy, Combination; Epilepsy; Gabapentin; Glioma; Humans; L

2019
[Treatment of pediatric epilepsy].
    Nihon rinsho. Japanese journal of clinical medicine, 2014, Volume: 72, Issue:5

    Topics: Adolescent; Amines; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic A

2014
[New antiepileptic drugs: characteristics and clinical applications].
    Nihon rinsho. Japanese journal of clinical medicine, 2014, Volume: 72, Issue:5

    Topics: Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dioxolanes; Drug App

2014
[Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
    Orvosi hetilap, 2016, Apr-10, Volume: 157, Issue:15

    Topics: Adult; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epileps

2016
Reporting and analysis of open-label extension studies of anti-epileptic drugs.
    Epilepsy research, 2008, Volume: 81, Issue:1

    Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Databases, Factual; Drug Resistance; Epilepsy;

2008
Gabapentin: a Ca2+ channel alpha 2-delta ligand far beyond epilepsy therapy.
    Drugs of today (Barcelona, Spain : 1998), 2008, Volume: 44, Issue:5

    Topics: Amines; Animals; Anticonvulsants; Calcium Channels, L-Type; Clinical Trials as Topic; Cognition; Cyc

2008
New pharmacotherapies for pediatric seizures.
    Pediatric annals, 2004, Volume: 33, Issue:6

    Topics: Adolescent; Amines; Animals; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecar

2004
Behavioral and cognitive effects of anti-epileptic drugs.
    Discovery medicine, 2010, Volume: 9, Issue:45

    Topics: Amines; Anticonvulsants; Antidepressive Agents; Behavior; Cognition; Cognition Disorders; Cyclohexan

2010
Psychiatric concerns in pediatric epilepsy.
    Child and adolescent psychiatric clinics of North America, 2010, Volume: 19, Issue:2

    Topics: Adolescent; Amines; Anxiety Disorders; Bipolar Disorder; Child; Child, Preschool; Cyclohexanecarboxy

2010
[Pregabalin and gabapentin in multiple sclerosis: clinical experiences and therapeutic implications].
    Der Nervenarzt, 2011, Volume: 82, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Antineoplastic Agents; Carbamazepine; Cohor

2011
Ca2+ channels and epilepsy.
    European journal of pharmacology, 2002, Jul-05, Volume: 447, Issue:2-3

    Topics: Acetates; Amines; Calcium Channels; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobu

2002
[Characteristics and indications of gabapentin].
    Revista de neurologia, 2002, Volume: 35 Suppl 1

    Topics: Acetates; Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Child; Child, Prescho

2002
Antiepileptic drug therapy for adults: when to initiate and how to choose.
    Mayo Clinic proceedings, 2002, Volume: 77, Issue:12

    Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Felb

2002
New antiepileptic drug therapies.
    Neurologic clinics, 2002, Volume: 20, Issue:4

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Dioxolanes; Ep

2002
Gabapentin dosing in the treatment of epilepsy.
    Clinical therapeutics, 2003, Volume: 25, Issue:5

    Topics: Acetates; Adult; Amines; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Cyclohe

2003
Gabapentin and lamotrigine: novel antiepileptic drugs.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1995, Jan-01, Volume: 52, Issue:1

    Topics: Acetates; Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Epilepsy;

1995
The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come?
    Epileptic disorders : international epilepsy journal with videotape, 2003, Volume: 5 Suppl 1

    Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interac

2003
Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epileps
    Neurology, 2004, Apr-27, Volume: 62, Issue:8

    Topics: Acetates; Acute Disease; Adolescent; Adult; Amines; Anticonvulsants; Carbamazepine; Child; Controlle

2004
New antiepileptic drugs that are second generation to existing antiepileptic drugs.
    Expert opinion on investigational drugs, 2006, Volume: 15, Issue:6

    Topics: Amines; Animals; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Drug

2006
Novel anticonvulsant drugs.
    Pharmacology & therapeutics, 2007, Volume: 113, Issue:1

    Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Ga

2007
Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed?
    Clinical pharmacokinetics, 2006, Volume: 45, Issue:11

    Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Monitor

2006
[Newer antiepileptic drugs].
    No to shinkei = Brain and nerve, 2007, Volume: 59, Issue:2

    Topics: Amines; Animals; Anti-Anxiety Agents; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Cycl

2007
Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia.
    International journal of geriatric psychiatry, 2007, Volume: 22, Issue:10

    Topics: Aged; Aged, 80 and over; Amines; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine;

2007
Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms.
    Trends in pharmacological sciences, 2007, Volume: 28, Issue:4

    Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma

2007
[Epilepsy in the elderly].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2007, Volume: 27, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Amines; Anticonvulsants; Cerebrovascular Disorders; Comorbidity; Cyc

2007
Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels.
    Trends in pharmacological sciences, 2007, Volume: 28, Issue:5

    Topics: Amines; Animals; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cerebellar Ataxia; Cyclo

2007
The new antiepileptic drugs.
    Archives of disease in childhood. Education and practice edition, 2007, Volume: 92, Issue:6

    Topics: Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsies,

2007
[Current viewpoints in the treatment of epilepsies: role of new antiepileptics?].
    Praxis, 1995, Sep-19, Volume: 84, Issue:38

    Topics: 4-Aminobutyrate Transaminase; Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxyli

1995
Mechanisms of action of currently prescribed and newly developed antiepileptic drugs.
    Epilepsia, 1994, Volume: 35 Suppl 4

    Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Drugs, Investigational; Epi

1994
Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy.
    Drugs, 1993, Volume: 46, Issue:3

    Topics: Acetates; Amines; Animals; Anticonvulsants; Biological Availability; Clinical Trials as Topic; Cyclo

1993
[New antiepileptic medications].
    Acta medica portuguesa, 1995, Volume: 8, Issue:1

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin;

1995
Adjunctive therapy in epilepsy: a cost-effectiveness comparison of alternative treatment options.
    Seizure, 1995, Volume: 4, Issue:1

    Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam

1995
New antiepileptic drugs--an explosion of activity.
    Seizure, 1995, Volume: 4, Issue:1

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Approval; Drug Interactions; Dr

1995
New antiepileptic drugs for children: felbamate, gabapentin, lamotrigine, and vigabatrin.
    Journal of child neurology, 1994, Volume: 9 Suppl 1

    Topics: Acetates; Adult; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Approval; Epileps

1994
Gabapentin: a new agent for the management of epilepsy.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:10

    Topics: Acetates; Adult; Age Factors; Amines; Anticonvulsants; Controlled Clinical Trials as Topic; Cyclohex

1994
Gabapentin.
    Lancet (London, England), 1994, Jan-08, Volume: 343, Issue:8889

    Topics: Acetates; Adult; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; E

1994
Newer antiepileptic drugs. Towards an improved risk-benefit ratio.
    Drug safety, 1994, Volume: 11, Issue:1

    Topics: Acetamides; Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dioxolane

1994
New anti-epileptic drugs in the 1990s.
    Journal of paediatrics and child health, 1994, Volume: 30, Issue:4

    Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam

1994
Guidelines for treating epilepsy in the age of felbamate, vigabatrin, lamotrigine, and gabapentin.
    The Western journal of medicine, 1994, Volume: 161, Issue:3

    Topics: Acetates; Adult; Amines; Animals; Anticonvulsants; Child; Clinical Protocols; Controlled Clinical Tr

1994
Phenobarbitone to gabapentin: a guide to 82 years of anti-epileptic drug pharmacokinetic interactions.
    Seizure, 1994, Volume: 3, Issue:3

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Gabapen

1994
Clinical pharmacokinetics of gabapentin.
    Neurology, 1994, Volume: 44, Issue:6 Suppl 5

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Gabapen

1994
Clinical efficacy and safety of gabapentin.
    Neurology, 1994, Volume: 44, Issue:6 Suppl 5

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Ep

1994
Drug therapy for epilepsy.
    American family physician, 1994, Sep-01, Volume: 50, Issue:3

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Decision Trees; Epilepsy; Felbamate;

1994
Antiepileptic drugs in development: prospects for the near future.
    Epilepsia, 1994, Volume: 35 Suppl 4

    Topics: Acetates; Adult; Amines; Aminocaproates; Animals; Anticonvulsants; Clinical Trials as Topic; Cyclohe

1994
Advances in pharmacotherapy: recent developments in the treatment of epilepsy.
    Journal of clinical pharmacy and therapeutics, 1993, Volume: 18, Issue:4

    Topics: Acetates; Amines; Aminocaproates; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Aci

1993
Antiepileptic drugs in clinical development.
    Epilepsy research. Supplement, 1993, Volume: 10

    Topics: Acetates; Amines; Aminocaproates; Anticonvulsants; Brain; Clinical Trials as Topic; Cyclohexanecarbo

1993
[Diagnosis and therapy of epilepsy and myoclonus].
    Nihon rinsho. Japanese journal of clinical medicine, 1993, Volume: 51, Issue:11

    Topics: Acetates; Amines; Cerebral Cortex; Cyclohexanecarboxylic Acids; Electrophysiology; Epilepsy; Gabapen

1993
Advances in the pharmacotherapy of epilepsy.
    Epilepsia, 1993, Volume: 34 Suppl 5

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Gabapentin; gam

1993
[Refractory epilepsy in adults and the new antiepileptic drugs: the role of gabapentin].
    Revista medica de Chile, 1995, Volume: 123, Issue:4

    Topics: Acetates; Amines; Anticonvulsants; Chile; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dru

1995
Pharmacokinetic profile of topiramate in comparison with other new antiepileptic drugs.
    Epilepsia, 1996, Volume: 37 Suppl 2

    Topics: Acetates; Amines; Anticonvulsants; Biological Availability; Carbamazepine; Clinical Trials as Topic;

1996
Utilization of new antiepileptic drugs in children.
    Epilepsia, 1996, Volume: 37 Suppl 1

    Topics: Acetates; Adolescent; Adult; Age Factors; Amines; Anticonvulsants; Carbamazepine; Child; Child, Pres

1996
[Advances in the diagnostic and treatment of infantile epilepsy].
    Revista de neurologia, 1996, Volume: 24, Issue:130

    Topics: Acetates; Amines; Anticonvulsants; Brain; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Elec

1996
[Current anti-epilepsy drugs].
    Duodecim; laaketieteellinen aikakauskirja, 1995, Volume: 111, Issue:8

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Therapy, Combina

1995
Mechanisms of action of antiepileptic drugs.
    Seizure, 1995, Volume: 4, Issue:4

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; GABA Antagonists; Gabapent

1995
Antiepileptic drug mechanisms of action.
    Epilepsia, 1995, Volume: 36 Suppl 2

    Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Calciu

1995
Gabapentin.
    Epilepsia, 1995, Volume: 36 Suppl 2

    Topics: Acetates; Adult; Amines; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Cyclohexanecarbo

1995
Important pharmacokinetic properties of antiepileptic drugs.
    Epilepsia, 1995, Volume: 36 Suppl 5

    Topics: Acetates; Amines; Anticonvulsants; Biological Availability; Biopharmaceutics; Carbamazepine; Cyclohe

1995
Diagnosis and treatment of epilepsy in children and adolescents.
    Drugs, 1996, Volume: 51, Issue:3

    Topics: Acetates; Adolescent; Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic Acids;

1996
New antiepileptic drugs: a systematic review of their efficacy and tolerability.
    BMJ (Clinical research ed.), 1996, Nov-09, Volume: 313, Issue:7066

    Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Child; Cross-Over Studies; Cyclohexaneca

1996
Pharmacokinetics of new antiepileptic drugs.
    Epilepsia, 1996, Volume: 37 Suppl 6

    Topics: Acetates; Amines; Anticonvulsants; Biological Availability; Carbamazepine; Cyclohexanecarboxylic Aci

1996
Update on the mechanism of action of antiepileptic drugs.
    Epilepsia, 1996, Volume: 37 Suppl 6

    Topics: 4-Aminobutyrate Transaminase; Acetamides; Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecar

1996
The role of the old and the new antiepileptic drugs in special populations: mental and multiple handicaps.
    Epilepsia, 1996, Volume: 37 Suppl 6

    Topics: Acetates; Amines; Anticonvulsants; Cerebral Palsy; Cyclohexanecarboxylic Acids; Disabled Persons; Dr

1996
Clinical administration of new antiepileptic drugs: an overview of safety and efficacy.
    Epilepsia, 1996, Volume: 37 Suppl 6

    Topics: Acetates; Amines; Anticonvulsants; Confidence Intervals; Cyclohexanecarboxylic Acids; Drug Interacti

1996
[Advantages and disadvantages of new antiepileptic drugs].
    Revista de neurologia, 1996, Volume: 24, Issue:135

    Topics: Acetates; Adrenocorticotropic Hormone; Amines; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids;

1996
[Treatment of the epilepsy: new drugs].
    Revista de neurologia, 1996, Volume: 24, Issue:135

    Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamaz

1996
The new antiepileptic drugs.
    Archives of disease in childhood, 1996, Volume: 75, Issue:3

    Topics: Abnormalities, Drug-Induced; Acetates; Adolescent; Adult; Amines; Anticonvulsants; Child; Child, Pre

1996
New antiepileptic drugs.
    Current opinion in pediatrics, 1996, Volume: 8, Issue:6

    Topics: Acetates; Adult; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; F

1996
New antiepileptic drugs.
    Bailliere's clinical neurology, 1996, Volume: 5, Issue:4

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate;

1996
Pharmacokinetics and interaction profile of topiramate: review and comparison with other newer antiepileptic drugs.
    Epilepsia, 1997, Volume: 38 Suppl 1

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Monitoring;

1997
Overview of the safety of newer antiepileptic drugs.
    Epilepsia, 1997, Volume: 38 Suppl 1

    Topics: Acetates; Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Inter

1997
[New antiepileptic drugs].
    Revista de neurologia, 1997, Volume: 25, Issue:138

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Gabapentin; gam

1997
Pharmacologic and dietary therapies in epilepsy: conventional treatments and recent advances.
    Southern medical journal, 1997, Volume: 90, Issue:5

    Topics: Acetates; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epil

1997
Recent advancements in epilepsy.
    Surgical neurology, 1997, Volume: 48, Issue:2

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabap

1997
A review of the newer antiepileptic drugs and the ketogenic diet.
    Clinical pediatrics, 1997, Volume: 36, Issue:9

    Topics: Acetates; Age Factors; Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic Acids

1997
Gabapentin for treatment of epilepsy in children.
    Seminars in pediatric neurology, 1997, Volume: 4, Issue:3

    Topics: Acetates; Adolescent; Adult; Amines; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Cycl

1997
Overview of lamotrigine and the new antiepileptic drugs: the challenge.
    Journal of child neurology, 1997, Volume: 12 Suppl 1

    Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy;

1997
Advances in the medical treatment of epilepsy.
    Annual review of medicine, 1998, Volume: 49

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diazepam; Drug Approv

1998
Measuring human brain GABA in vivo: effects of GABA-transaminase inhibition with vigabatrin.
    Molecular neurobiology, 1998, Volume: 16, Issue:1

    Topics: 4-Aminobutyrate Transaminase; Acetates; Amines; Anticonvulsants; Brain; Brain Chemistry; Cyclohexane

1998
Monotherapy clinical trials of new antiepileptic drugs: design, indications, and controversies.
    Epilepsia, 1997, Volume: 38 Suppl 9

    Topics: Acetates; Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Bli

1997
The new antiepileptic drugs: a systematic review of their efficacy and tolerability.
    Epilepsia, 1997, Volume: 38, Issue:8

    Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug

1997
New antiepileptic drugs.
    Archives of neurology, 1998, Volume: 55, Issue:9

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Approval; Epilep

1998
Antiepileptic drug therapy.
    Clinical techniques in small animal practice, 1998, Volume: 13, Issue:3

    Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Cyclohexanecarboxylic Acid

1998
Gabapentin. Antiepileptic mechanism of action.
    Neuropsychobiology, 1998, Volume: 38, Issue:3

    Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Calcium Channels; Cyclohexanecarboxyl

1998
Lamotrigine and gabapentin. Alternative in the treatment of bipolar disorder.
    Neuropsychobiology, 1998, Volume: 38, Issue:3

    Topics: Acetates; Amines; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Clinic

1998
Fortnightly review: drug treatment of epilepsy.
    BMJ (Clinical research ed.), 1999, Jan-09, Volume: 318, Issue:7176

    Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Clobazam; Clo

1999
New medication options for patients with epilepsy.
    Medicine and health, Rhode Island, 1998, Volume: 81, Issue:12

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabap

1998
New antiepileptic drugs: comparison of key clinical trials.
    Epilepsia, 1999, Volume: 40, Issue:5

    Topics: Acetates; Amines; Anticonvulsants; Controlled Clinical Trials as Topic; Cyclohexanecarboxylic Acids;

1999
Options after the first antiepileptic drug has failed.
    Epilepsia, 1999, Volume: 40 Suppl 6

    Topics: Acetates; Amines; Anticonvulsants; Attitude to Health; Carbamazepine; Clinical Trials as Topic; Cycl

1999
Monostars: an aid to choosing an antiepileptic drug as monotherapy.
    Epilepsia, 1999, Volume: 40 Suppl 6

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Administration S

1999
Use of new antiepileptic drugs in the treatment of childhood epilepsy.
    Epilepsia, 1999, Volume: 40 Suppl 6

    Topics: Acetates; Adult; Age Factors; Amines; Anticonvulsants; Child; Clinical Trials as Topic; Cyclohexanec

1999
Gabapentin in the management of convulsive disorders.
    Epilepsia, 1999, Volume: 40 Suppl 6

    Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Clinical Trials as Topic; Cyclohexane

1999
Gabapentin.
    Epilepsia, 1999, Volume: 40 Suppl 5

    Topics: Acetates; Amines; Anticonvulsants; Controlled Clinical Trials as Topic; Cyclohexanecarboxylic Acids;

1999
Managing pediatric epilepsy syndromes with new antiepileptic drugs.
    Pediatrics, 1999, Volume: 104, Issue:5 Pt 1

    Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose

1999
The clinical pharmacokinetics of the new antiepileptic drugs.
    Epilepsia, 1999, Volume: 40 Suppl 9

    Topics: Acetates; Amines; Anticonvulsants; Biological Availability; Cyclohexanecarboxylic Acids; Dose-Respon

1999
[GABA-ergic system and antiepileptic drugs].
    Neurologia i neurochirurgia polska, 2000, Volume: 34 Suppl 1

    Topics: Acetates; Amines; Anticonvulsants; Binding, Competitive; Calcium Channels; Chloride Channels; Cycloh

2000
New antiepileptic drugs.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2000, Volume: 7, Issue:2

    Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interac

2000
[Current data on gabapentin].
    Revista de neurologia, 2000, Volume: 30 Suppl 1

    Topics: Acetates; Adult; Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Drug

2000
Therapeutic safety monitoring: what to look for and when to look for it.
    Epilepsia, 2000, Volume: 41 Suppl 8

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Monitoring; Epil

2000
New antiepileptic drugs and preparations.
    Emergency medicine clinics of North America, 2000, Volume: 18, Issue:4

    Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids;

2000
Cognitive side effects of anticonvulsants.
    The Journal of clinical psychiatry, 2001, Volume: 62 Suppl 14

    Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cognition Disorders; Cyclohexane

2001
Lamotrigine update and its use in mood disorders.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:5

    Topics: Acetates; Aggression; Amines; Antidepressive Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids;

2002
Background and rationale for use of anticonvulsants in psychiatry.
    Cleveland Clinic journal of medicine, 1998, Volume: 65 Suppl 1

    Topics: Acetates; Amines; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Cycloh

1998
Gabapentin.
    Epilepsy research. Supplement, 1991, Volume: 3

    Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Drugs, Investigational; Ele

1991

Trials

23 trials available for gabapentin and Aura

ArticleYear
Analysis of exposure-response of CI-945 in patients with epilepsy: application of novel mixed hidden Markov modeling methodology.
    Journal of pharmacokinetics and pharmacodynamics, 2012, Volume: 39, Issue:3

    Topics: Adolescent; Adult; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Dose-Response Relati

2012
Gabapentin versus lamotrigine monotherapy: a double-blind comparison in newly diagnosed epilepsy.
    Epilepsia, 2002, Volume: 43, Issue:9

    Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Asthenia; Clinical Protocols; Cyclohexan

2002
The absorption of gabapentin following high dose escalation.
    Seizure, 2003, Volume: 12, Issue:1

    Topics: Absorption; Acetates; Amines; Anticonvulsants; Biological Availability; Cyclohexanecarboxylic Acids;

2003
New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine.
    Neurology, 2005, Jun-14, Volume: 64, Issue:11

    Topics: Aged; Aging; Amines; Anticonvulsants; Carbamazepine; Cerebral Infarction; Cyclohexanecarboxylic Acid

2005
[Efficacy, safety and effect on the quality of life of gabapentin in adult epilepsy--results of a prospective open-label quasi naturalistic Hungarian multicenter study (phase human-IV)].
    Ideggyogyaszati szemle, 2006, Sep-20, Volume: 59, Issue:9-10

    Topics: Adult; Aged; Ambulatory Care Facilities; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epile

2006
A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial.
    Health technology assessment (Winchester, England), 2007, Volume: 11, Issue:37

    Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructo

2007
Long-term study with gabapentin in patients with drug-resistant epileptic seizures.
    Archives of neurology, 1994, Volume: 51, Issue:10

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Double-Blind Method; Epilepsy

1994
Effect of gabapentin (Neurontin) [corrected] on mood and well-being in patients with epilepsy.
    Progress in neuro-psychopharmacology & biological psychiatry, 1996, Volume: 20, Issue:3

    Topics: Acetates; Adult; Affect; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Female; Gab

1996
Oral gabapentin disposition in patients with epilepsy after a high-protein meal.
    Epilepsia, 1997, Volume: 38, Issue:10

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dietary Proteins; Epilepsy; F

1997
Gabapentin bioavailability: effect of dose and frequency of administration in adult patients with epilepsy.
    Epilepsy research, 1998, Volume: 31, Issue:2

    Topics: Acetates; Adult; Amines; Anticonvulsants; Biological Availability; Cyclohexanecarboxylic Acids; Epil

1998
Effects of gabapentin on cognition and quality of life in patients with epilepsy.
    Seizure, 1998, Volume: 7, Issue:5

    Topics: Acetates; Adult; Affect; Aged; Amines; Anticonvulsants; Cognition; Cyclohexanecarboxylic Acids; Epil

1998
Adjunctive therapy in epilepsy with new antiepileptic drugs: is it of any value?
    Seizure, 1998, Volume: 7, Issue:5

    Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Clobazam; Cyclohexanecarbox

1998
Gabapentin add-on treatment: how many patients become seizure-free? An open-label multicenter study.
    Acta neurologica Scandinavica, 1999, Volume: 99, Issue:1

    Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; F

1999
An audit of the perceived efficacy and tolerability of gabapentin therapy in an out-patient cohort with chronic epilepsy.
    European neurology, 1999, Volume: 41, Issue:2

    Topics: Acetates; Adult; Ambulatory Care; Amines; Anticonvulsants; Chronic Disease; Cohort Studies; Cyclohex

1999
Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study.
    Epilepsia, 1999, Volume: 40, Issue:7

    Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Asthenia; Carbamazepine; Cycl

1999
[Visual field defects due to antiepileptic drugs].
    Der Nervenarzt, 1999, Volume: 70, Issue:6

    Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dr

1999
Gabapentin in childhood epilepsy: a prospective evaluation of efficacy and safety.
    Epilepsy research, 2000, Volume: 38, Issue:1

    Topics: Acetates; Adolescent; Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic Acids;

2000
Effect of anticonvulsants on nocturnal sleep in epilepsy.
    Neurology, 2000, Volume: 54, Issue:5 Suppl 1

    Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Circadian Rhythm; Cyclohexanecarboxylic Aci

2000
Gabapentin as add-on therapy in children with refractory partial seizures: a 24-week, multicentre, open-label study.
    Developmental medicine and child neurology, 2001, Volume: 43, Issue:4

    Topics: Acetates; Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Double-Blin

2001
A randomized open-label study of gabapentin and lamotrigine in adults with learning disability and resistant epilepsy.
    Seizure, 2001, Volume: 10, Issue:2

    Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Administrati

2001
Population pharmacokinetics of gabapentin in infants and children.
    Epilepsy research, 2001, Volume: 47, Issue:3

    Topics: Acetates; Adolescent; Amines; Anticonvulsants; Body Weight; Child; Child, Preschool; Creatinine; Cyc

2001
Effects of gabapentin and carbamazepine on the EEG and cognition in healthy volunteers.
    Epilepsia, 2002, Volume: 43, Issue:5

    Topics: Acetates; Adolescent; Adult; Alpha Rhythm; Amines; Anticonvulsants; Brain; Carbamazepine; Cognition;

2002
Gabapentin as an antiepileptic drug in man.
    Journal of neurology, neurosurgery, and psychiatry, 1987, Volume: 50, Issue:6

    Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxyli

1987

Other Studies

125 other studies available for gabapentin and Aura

ArticleYear
Novel KCNQ2/Q3 agonists as potential therapeutics for epilepsy and neuropathic pain.
    Journal of medicinal chemistry, 2010, Jan-28, Volume: 53, Issue:2

    Topics: Adamantane; Animals; Azides; Epilepsy; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Mice; Neura

2010
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).
    Journal of medicinal chemistry, 2013, Nov-27, Volume: 56, Issue:22

    Topics: Absorption; Amides; Animals; Anticonvulsants; Dioxanes; Dogs; Drug Evaluation, Preclinical; Drug Res

2013
Antiseizure medication treatment pathways for US Medicare beneficiaries with newly treated epilepsy.
    Epilepsia, 2022, Volume: 63, Issue:6

    Topics: Aged; Anticonvulsants; Epilepsy; Gabapentin; Humans; Lacosamide; Lamotrigine; Levetiracetam; Medicar

2022
Association between anti-seizure medication and the risk of lower urinary tract infection in patients with epilepsy.
    Epilepsy & behavior : E&B, 2022, Volume: 135

    Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Carbamazepine; Epilepsy; Female; Gabapentin; Humans;

2022
Pathophysiological Roles of Auxiliary Calcium Channel α
    Handbook of experimental pharmacology, 2023, Volume: 279

    Topics: Calcium; Calcium Channels; Epilepsy; Gabapentin; Humans; Neurons; Protein Subunits; Synapses

2023
Channeling of New Neuropsychiatric Drugs-Impact on Safety and Effectiveness Studies.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2023, Volume: 20, Issue:2

    Topics: Adult; Cross-Sectional Studies; Diabetic Neuropathies; Epilepsy; Gabapentin; Humans; Levetiracetam;

2023
Association of first anti-seizure medication choice with injuries in older adults with newly diagnosed epilepsy.
    Seizure, 2023, Volume: 109

    Topics: Aged; Anticonvulsants; Brain Injuries, Traumatic; Epilepsy; Gabapentin; Humans; Reinjuries; Retrospe

2023
Insight on the hub gene associated signatures and potential therapeutic agents in epilepsy and glioma.
    Brain research bulletin, 2023, Volume: 199

    Topics: Area Under Curve; Cell Communication; Epilepsy; Gabapentin; Glioma; Humans

2023
Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy.
    Military medicine, 2023, 11-03, Volume: 188, Issue:11-12

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Levetiracetam

2023
Utilization of Antiseizure Medications in Women of Childbearing Age With Epilepsy and Nonepilepsy Indications: A Retrospective Cohort Study.
    Neurology, 2023, 09-05, Volume: 101, Issue:10

    Topics: Anticonvulsants; Clonazepam; Diazepam; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Lorazepam;

2023
Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database.
    Epilepsia, 2020, Volume: 61, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Clobazam; Clonazepam; Databases, Factual; Drug Therapy, Combination;

2020
Gabapentin treatment in a patient with KCNQ2 developmental epileptic encephalopathy.
    Pharmacological research, 2020, Volume: 160

    Topics: Age of Onset; Animals; Anticonvulsants; Carbamates; Cells, Cultured; Child; CHO Cells; Cricetinae; C

2020
Persistence with antiepileptic drugs in epilepsy patients treated in neurological practices in Germany.
    Epilepsy & behavior : E&B, 2017, Volume: 73

    Topics: Adult; Age Factors; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Female; Ga

2017
Factors in Variability of Serial Gabapentin Concentrations in Elderly Patients with Epilepsy.
    Pharmacotherapy, 2017, Volume: 37, Issue:10

    Topics: Aged; Amines; Anticonvulsants; Biological Availability; Biological Variation, Individual; Cyclohexan

2017
Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats.
    Biological & pharmaceutical bulletin, 2017, Volume: 40, Issue:11

    Topics: Administration, Oral; Amines; Animals; Anticonvulsants; Bone Density; Bone Remodeling; Bone Resorpti

2017
Nonlesional late-onset epilepsy: Semiology, EEG, cerebrospinal fluid, and seizure outcome characteristics.
    Epilepsy & behavior : E&B, 2019, Volume: 91

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Electroencephalography; Epilepsy; Femal

2019
Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice.
    Psychoneuroendocrinology, 2019, Volume: 101

    Topics: Androgens; Androsterone; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease

2019
Hypothyroidism induced by phenytoin and gabapentin: A Case Report.
    Medicine, 2018, Volume: 97, Issue:43

    Topics: Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobutyric

2018
Therapeutic drug monitoring of gabapentin in various indications.
    Acta neurologica Scandinavica, 2019, Volume: 139, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; Drug Monitorin

2019
Effect of gabapentin on sleep patterns disturbed by epilepsy.
    Epilepsy & behavior : E&B, 2019, Volume: 92

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electrooculography; Epilepsy; Gabapentin

2019
A Call for Caution in Prescribing Gabapentin to Individuals With Concurrent Polysubstance Abuse: A Case Report.
    Journal of psychiatric practice, 2019, Volume: 25, Issue:4

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Gabapentin; Humans; Substance-Related Disorders

2019
Use of antiepileptic drugs in women of fertile age.
    Danish medical journal, 2019, Volume: 66, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Denmark; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Leve

2019
Delirium after gabapentin withdrawal. Case report.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2013, Volume: 40, Issue:1

    Topics: Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Delirium; Electroencephalography; Epilep

2013
Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle.
    Brain injury, 2013, Volume: 27, Issue:7-8

    Topics: Accidents, Traffic; Aggression; Amines; Anterior Temporal Lobectomy; Anticonvulsants; Brain Injuries

2013
Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation.
    Epilepsia, 2014, Volume: 55, Issue:1

    Topics: Amines; Animals; Anticonvulsants; Astrocytes; Blotting, Western; Carbamazepine; Cells, Cultured; Coc

2014
Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation.
    Neurobiology of disease, 2014, Volume: 71

    Topics: Age Factors; Amines; Animals; Animals, Newborn; Anticonvulsants; Calcium Channels; Cyclohexanecarbox

2014
Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats.
    Pharmacology, 2014, Volume: 94, Issue:1-2

    Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Epilepsy; Female; Gabapentin;

2014
Experience from therapeutic drug monitoring and gender aspects of gabapentin and pregabalin in clinical practice.
    Seizure, 2015, Volume: 28

    Topics: Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug;

2015
Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study.
    Medicine, 2016, Volume: 95, Issue:35

    Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilep

2016
Retention rates of new antiepileptic drugs in localization-related epilepsy: a single-center study.
    Acta neurologica Scandinavica, 2009, Volume: 119, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Ac

2009
Retention of new AEDs in institutionalized intellectually disabled patients with epilepsy.
    Seizure, 2009, Volume: 18, Issue:2

    Topics: Adolescent; Adult; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Utilization Rev

2009
Probability of rash related to gabapentin therapy in a child.
    The Annals of pharmacotherapy, 2009, Volume: 43, Issue:2

    Topics: Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Epilepsy; Exanthema; Gabapentin; gamma-

2009
[New antiepileptic drugs].
    La Revue de medecine interne, 2009, Volume: 30, Issue:4

    Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy;

2009
Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice.
    Epilepsy & behavior : E&B, 2010, Volume: 17, Issue:2

    Topics: Amines; Animals; Anticonvulsants; Cognition Disorders; Cyclohexanecarboxylic Acids; Disease Models,

2010
Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy.
    Archives of neurology, 2010, Volume: 67, Issue:4

    Topics: Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Response Rela

2010
Paroxysmal arousals and myoclonic movements associated with interictal epileptiform discharges in NREM and REM sleep.
    Clinical neurology and neurosurgery, 2011, Volume: 113, Issue:5

    Topics: Adolescent; Amines; Antiparkinson Agents; Arousal; Chromosome Disorders; Chromosome Inversion; Chrom

2011
[Clinical characteristics and treatment for new onset epilepsy in the elderly].
    Rinsho shinkeigaku = Clinical neurology, 2010, Volume: 50, Issue:11

    Topics: Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diagnostic Imaging; Elect

2010
Off-label gabapentin masking ictal triphasic waves: case analysis of neuropsychiatric and electrographic correlates.
    Epilepsy & behavior : E&B, 2011, Volume: 22, Issue:3

    Topics: Administration, Oral; Aged; Amines; Anticonvulsants; Brain Waves; Cyclohexanecarboxylic Acids; Elect

2011
Retention rate of Gabapentin in children with intractable epilepsies at 1 year.
    Seizure, 2012, Volume: 21, Issue:1

    Topics: Adolescent; Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Epilepsy;

2012
The amygdala to periaqueductal gray pathway: plastic changes induced by audiogenic kindling and reversal by gabapentin.
    Brain research, 2012, Sep-26, Volume: 1475

    Topics: Acoustic Stimulation; Action Potentials; Amines; Amygdala; Animals; Cyclohexanecarboxylic Acids; Ele

2012
[Clinical application of newer anti-epileptic drugs].
    Rinsho shinkeigaku = Clinical neurology, 2012, Volume: 52, Issue:11

    Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructose; Gabapentin; gamma-

2012
[Psychomotor slowness of a mentally retarded woman].
    Duodecim; laaketieteellinen aikakauskirja, 2001, Volume: 117, Issue:11

    Topics: Acetates; Adult; Amines; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Clobazam; Cyclohexan

2001
Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis.
    Epilepsia, 2002, Volume: 43, Issue:9

    Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease M

2002
A postmarketing surveillance study of gabapentin as add-on therapy for 3,100 patients in England.
    Epilepsia, 2002, Volume: 43, Issue:9

    Topics: Acetates; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 an

2002
Down-regulation of N-type voltage-activated Ca2+ channels by gabapentin.
    Cellular and molecular neurobiology, 2002, Volume: 22, Issue:2

    Topics: Acetates; Action Potentials; Amines; Amino Acid Transport System L; Animals; Anticonvulsants; Brain;

2002
[Edematous syndrome and alithiasic cholecystitis induced by gabapentin].
    Presse medicale (Paris, France : 1983), 2002, Oct-12, Volume: 31, Issue:33

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cholecystitis; Cyclohexanecarboxylic Acids; Edema; Epileps

2002
Gabapentin-induced bullous pemphigoid.
    Acta dermato-venereologica, 2002, Volume: 82, Issue:5

    Topics: Acetates; Amines; Anticonvulsants; Azathioprine; Cyclohexanecarboxylic Acids; Drug Therapy, Combinat

2002
Plasma gabapentin concentrations in children with epilepsy: influence of age, relationship with dosage, and preliminary observations on correlation with clinical response.
    Therapeutic drug monitoring, 2003, Volume: 25, Issue:1

    Topics: Acetates; Adolescent; Adult; Age Factors; Amines; Analysis of Variance; Child; Child, Preschool; Cyc

2003
Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry.
    Epilepsy & behavior : E&B, 2003, Volume: 4, Issue:3

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Female; Gabapentin;

2003
Gabapentin actions on Kir3 currents and N-type Ca2+ channels via GABAB receptors in hippocampal pyramidal cells.
    Synapse (New York, N.Y.), 2003, Volume: 50, Issue:2

    Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Baclofen; Barium; Calcium Channel Blo

2003
Limited efficacy of gabapentin in severe therapy-resistant epilepsies of learning-disabled patients.
    Seizure, 2003, Volume: 12, Issue:8

    Topics: Acetates; Amines; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans

2003
entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse.
    The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8

    Topics: Acetates; Alleles; Amines; Animals; Ataxia; Base Sequence; Blotting, Southern; Blotting, Western; Ca

2004
Potentially inappropriate antiepileptic drugs for elderly patients with epilepsy.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:3

    Topics: Acetates; Aged; Amines; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Epilepsy; Female; Ga

2004
Interaction between anticonvulsants and human placental carnitine transporter.
    Epilepsia, 2004, Volume: 45, Issue:3

    Topics: Acetates; Amines; Aminoisobutyric Acids; Anticonvulsants; Carnitine; Carrier Proteins; Culture Techn

2004
Determination of gabapentin-lactam in serum of patients under gabapentin therapy.
    Arzneimittel-Forschung, 2004, Volume: 54, Issue:3

    Topics: Acetates; Adult; Amines; Anticonvulsants; Aza Compounds; Chromatography, Ion Exchange; Cyclohexaneca

2004
Out with the old and in with the new...epilepsy drugs.
    The Lancet. Neurology, 2004, Volume: 3, Issue:5

    Topics: Acetates; Amines; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Drug Therapy; Epilepsy; Gab

2004
Effect of L-type calcium channel antagonists on spermine-induced CNS excitation in vivo.
    Neuroscience letters, 2005, Jun-03, Volume: 380, Issue:3

    Topics: Amines; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Central Nervous System; Convuls

2005
Antiepileptic drugs for the elderly: using the old to focus on the new.
    Neurology, 2005, Jun-14, Volume: 64, Issue:11

    Topics: Age Factors; Aged; Aged, 80 and over; Amines; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy;

2005
Evaluation of health status in epilepsy using the EQ-5D questionnaire: a prospective, observational, 6-month study of adjunctive therapy with anti-epileptic drugs.
    Current medical research and opinion, 2005, Volume: 21, Issue:5

    Topics: Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructose; Gabapentin;

2005
Effects of anticonvulsants on soman-induced epileptiform activity in the guinea-pig in vitro hippocampus.
    European journal of pharmacology, 2005, Aug-22, Volume: 518, Issue:2-3

    Topics: Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Chlormethiazole; Clozapine; Cyclohexane

2005
Pharmacokinetics of gabapentin during delivery, in the neonatal period, and lactation: does a fetal accumulation occur during pregnancy?
    Epilepsia, 2005, Volume: 46, Issue:10

    Topics: Amines; Anticonvulsants; Breast Feeding; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fetal Blood;

2005
New antiepileptic drugs in practice--how do they perform in the real world?
    Acta neurologica Scandinavica. Supplementum, 2005, Volume: 181

    Topics: Amines; Anticonvulsants; Controlled Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Epilepsy;

2005
Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent.
    Australian veterinary journal, 2005, Volume: 83, Issue:10

    Topics: Amines; Animals; Anticonvulsants; Bromides; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Dog

2005
K(+)-evoked [(3)H]-norepinephrine release in human brain slices from epileptic and non-epileptic patients is differentially modulated by gabapentin and pinacidil.
    Neuroscience research, 2006, Volume: 55, Issue:2

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Amines; Anticonvulsants; Brimonidine Tartrate; Calcium Chann

2006
Measuring the effects of antiepileptic medications on balance in older people.
    Epilepsy research, 2006, Volume: 70, Issue:2-3

    Topics: Aged; Amines; Anticonvulsants; Ataxia; Carbamazepine; Cyclohexanecarboxylic Acids; Dizziness; Epilep

2006
Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold.
    Neuroscience letters, 2007, May-07, Volume: 417, Issue:3

    Topics: Amines; Animals; Anticonvulsants; Brain; Brain Chemistry; Cerebral Cortex; Convulsants; Cyclohexanec

2007
Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005.
    European journal of neurology, 2007, Volume: 14, Issue:12

    Topics: Adolescent; Adult; Age Distribution; Aged; Amines; Anticonvulsants; Carbamazepine; Catchment Area, H

2007
Cerebellar cognitive affective syndrome associated with topiramate.
    Clinical neurology and neurosurgery, 2008, Volume: 110, Issue:5

    Topics: Amines; Anticonvulsants; Carbamazepine; Cerebellar Diseases; Cerebellum; Cognition Disorders; Cycloh

2008
New antiepileptic drugs in pediatric epilepsy.
    Brain & development, 2008, Volume: 30, Issue:9

    Topics: Amines; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Epilep

2008
The role of newer anticonvulsants in the management of epilepsy.
    Australian and New Zealand journal of medicine, 1995, Volume: 25, Issue:2

    Topics: Acetates; Amines; Anticonvulsants; Australia; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gam

1995
New drugs for the treatment of epilepsy.
    The Nurse practitioner, 1995, Volume: 20, Issue:5

    Topics: Acetates; Amines; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Gabape

1995
Gabapentin (NEURONTIN)--a novel anticonvulsant.
    Axone (Dartmouth, N.S.), 1994, Volume: 16, Issue:2

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobut

1994
Gabapentin treatment of seizures in acute intermittent porphyria.
    Neurology, 1995, Volume: 45, Issue:6

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-A

1995
Neurontin--1 year on. London October 1994.
    Seizure, 1995, Volume: 4, Issue:1

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Approval; Epilepsy; Gabapentin;

1995
FDA approved new drug bulletin. Gabapentin (neurontin).
    RN, 1994, Volume: 57, Issue:7

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy;

1994
Novel antiepileptic drugs: nursing implications.
    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 1993, Volume: 25, Issue:6

    Topics: Acetates; Amines; Aminocaproates; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Approval; Drug

1993
Science reporters hear wide range of recent data at 12th annual conference.
    JAMA, 1993, Nov-24, Volume: 270, Issue:20

    Topics: Acetates; Aged; AIDS Vaccines; American Medical Association; Amines; Animals; Anticonvulsants; beta-

1993
New antiepileptic medications.
    The Western journal of medicine, 1995, Volume: 163, Issue:5

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Dr

1995
Costing of antiepileptic drugs.
    Lancet (London, England), 1996, Jan-27, Volume: 347, Issue:8996

    Topics: Acetates; Amines; Anticonvulsants; Argentina; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Costs

1996
[Gabapentin--a new add-on antiepileptic drug].
    Praxis, 1996, Jan-23, Volume: 85, Issue:4

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobut

1996
[Current role of novel antiepileptics in the treatment of epilepsies].
    Praxis, 1996, Jan-23, Volume: 85, Issue:4

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Resistance; Epil

1996
[Recommendations on clinical epilepsy treatment using gabapentin].
    Praxis, 1996, Jan-23, Volume: 85, Issue:4

    Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Child; Contraindications; Cyclohexanecarboxyli

1996
Behavioral side effects of gabapentin in children.
    Epilepsia, 1996, Volume: 37, Issue:1

    Topics: Acetates; Aggression; Akathisia, Drug-Induced; Amines; Anticonvulsants; Attention Deficit Disorder w

1996
Exacerbation of seizures in Lennox-Gastaut syndrome by gabapentin.
    Neurology, 1996, Volume: 46, Issue:3

    Topics: Acetates; Adolescent; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; ga

1996
Epilepsy in porphyria.
    Neurology, 1996, Volume: 46, Issue:5

    Topics: 5-Aminolevulinate Synthetase; Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids;

1996
[New medical treatment of epilepsy].
    Presse medicale (Paris, France : 1983), 1996, Mar-23, Volume: 25, Issue:10

    Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Costs; Epile

1996
An audit of the new antiepileptic drugs in clinical neurological practice.
    Seizure, 1996, Volume: 5, Issue:2

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Female; Gabapentin;

1996
Movement disorders associated with the use of gabapentin.
    Epilepsia, 1996, Volume: 37, Issue:10

    Topics: Acetates; Adult; Amines; Anticonvulsants; Benzodiazepines; Cyclohexanecarboxylic Acids; Dyskinesia,

1996
Hypomania induced by gabapentin.
    The British journal of psychiatry : the journal of mental science, 1995, Volume: 167, Issue:4

    Topics: Acetates; Affect; Amines; Anticonvulsants; Bipolar Disorder; Cyclohexanecarboxylic Acids; Electroenc

1995
Gabapentin interaction with felbamate.
    Neurology, 1996, Volume: 47, Issue:4

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy;

1996
If comparisons can be odious, so can assumptions.
    Seizure, 1996, Volume: 5, Issue:3

    Topics: Acetates; Amines; Anticonvulsants; Cost-Benefit Analysis; Cyclohexanecarboxylic Acids; Epilepsy; Gab

1996
Gabapentin.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1996, Volume: 23, Issue:4 Suppl 2

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobut

1996
The anticonvulsant gabapentin decreases firing rates of substantia nigra pars reticulata neurons.
    European journal of pharmacology, 1996, Dec-05, Volume: 316, Issue:2-3

    Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Female; Gabapenti

1996
New treatment options for epilepsy.
    Cleveland Clinic journal of medicine, 1997, Volume: 64, Issue:3

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabap

1997
New antiepileptic drugs: case studies.
    Seminars in pediatric neurology, 1997, Volume: 4, Issue:1

    Topics: Acetates; Amines; Anticonvulsants; Child, Preschool; Cyclohexanecarboxylic Acids; Drug Resistance; E

1997
Incontinence during treatment with gabapentin.
    Neurology, 1997, Volume: 48, Issue:5

    Topics: Acetates; Adult; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Epilepsy; Fecal Incont

1997
A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities.
    Seizure, 1997, Volume: 6, Issue:2

    Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Comorbidity; Cyclohexanecarboxylic Acids; Dose-Respo

1997
[Gabapentine--advances in the management of epilepsy].
    Der Nervenarzt, 1994, Volume: 65, Issue:11 Suppl

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobut

1994
[Gabapentin--a new anti-epileptic agent].
    Der Nervenarzt, 1994, Volume: 65, Issue:6 Suppl

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobut

1994
Choreoathetosis as a side effect of gabapentin therapy in severely neurologically impaired patients.
    Archives of neurology, 1997, Volume: 54, Issue:7

    Topics: Acetates; Adult; Amines; Anticonvulsants; Athetosis; Chorea; Cyclohexanecarboxylic Acids; Epilepsy;

1997
Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin.
    Epilepsy research, 1997, Volume: 28, Issue:1

    Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dos

1997
[GabapentinE++--improved treatment possibility for epilepsy].
    Der Nervenarzt, 1994, Volume: 65, Issue:9 Suppl Ga

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobut

1994
[Gabapentin--a new antiepileptic agent].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1998, Feb-28, Volume: 118, Issue:6

    Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic

1998
Failure of absorption of gabapentin after rectal administration.
    Epilepsia, 1997, Volume: 38, Issue:11

    Topics: Acetates; Administration, Oral; Administration, Rectal; Adolescent; Amines; Anticonvulsants; Biologi

1997
Identification of novel ligands for the gabapentin binding site on the alpha2delta subunit of a calcium channel and their evaluation as anticonvulsant agents.
    Journal of medicinal chemistry, 1998, May-21, Volume: 41, Issue:11

    Topics: Acetates; Amines; Animals; Anticonvulsants; Binding Sites; Calcium Channels; Cyclohexanecarboxylic A

1998
Gabapentin potentiation of the antiepileptic efficacy of vigabatrin in an in vitro model of epilepsy.
    British journal of pharmacology, 1998, Volume: 124, Issue:2

    Topics: 4-Aminobutyrate Transaminase; Acetates; Amines; Animals; Anticonvulsants; Bicuculline; Cyclohexaneca

1998
The outcome of prescribing novel anticonvulsants in an outpatient setting: factors affecting response to medication.
    Seizure, 1998, Volume: 7, Issue:5

    Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Chi-Square Distribution; Cycl

1998
Treatment of seizures in acute intermittent porphyria: safety and efficacy of gabapentin.
    Seizure, 1998, Volume: 7, Issue:5

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Female; Gabapentin;

1998
The management of epilepsy in a hospital for people with a learning disability.
    Seizure, 1999, Volume: 8, Issue:3

    Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Uti

1999
The long-term use of gabapentin, lamotrigine, and vigabatrin in patients with chronic epilepsy.
    Epilepsia, 1999, Volume: 40, Issue:10

    Topics: Acetates; Ambulatory Care; Amines; Anticonvulsants; Chronic Disease; Clinical Trials as Topic; Cyclo

1999
Refractory epilepsy: treatment with new antiepileptic drugs.
    Seizure, 2000, Volume: 9, Issue:1

    Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Resist

2000
Gabapentin, an antiepileptic drug, improves memory storage in mice.
    Neuroscience letters, 2000, Feb-04, Volume: 279, Issue:3

    Topics: Acetates; Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin

2000
Gabapentin prophylaxis of clozapine-induced seizures.
    The American journal of psychiatry, 2000, Volume: 157, Issue:3

    Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Antipsychotic Agents; Clozapine; Cyclohexaneca

2000
Myoclonus associated with the use of gabapentin.
    Epilepsia, 2000, Volume: 41, Issue:4

    Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Rel

2000
Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy patients.
    Epilepsia, 2000, Volume: 41, Issue:6

    Topics: Acetates; Adult; Amines; Anticonvulsants; Brain Chemistry; Carnosine; Cyclohexanecarboxylic Acids; D

2000
Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy patients.
    Epilepsia, 2000, Volume: 41, Issue:6

    Topics: Acetates; Adult; Amines; Anticonvulsants; Brain Chemistry; Carnosine; Cyclohexanecarboxylic Acids; D

2000
Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy patients.
    Epilepsia, 2000, Volume: 41, Issue:6

    Topics: Acetates; Adult; Amines; Anticonvulsants; Brain Chemistry; Carnosine; Cyclohexanecarboxylic Acids; D

2000
Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy patients.
    Epilepsia, 2000, Volume: 41, Issue:6

    Topics: Acetates; Adult; Amines; Anticonvulsants; Brain Chemistry; Carnosine; Cyclohexanecarboxylic Acids; D

2000
Gabapentin-induced modulation of interictal epileptiform activity related to different vigilance levels.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2000, Volume: 111, Issue:9

    Topics: Acetates; Adult; Amines; Arousal; Cyclohexanecarboxylic Acids; Electroencephalography; Epilepsy; Fem

2000
[Clinical utilization of new anti-epileptic agents].
    Revue medicale de la Suisse romande, 2000, Volume: 120, Issue:9

    Topics: Acetates; Amines; Anemia, Aplastic; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dru

2000
Long-term retention rates of lamotrigine, gabapentin, and topiramate in chronic epilepsy.
    Epilepsia, 2000, Volume: 41, Issue:12

    Topics: Acetates; Adolescent; Adult; Age of Onset; Aged; Amines; Anticonvulsants; Chronic Disease; Cyclohexa

2000
Adverse event monitoring in lamotrigine patients: a pharmacoepidemiologic study in the United Kingdom.
    Epilepsia, 2001, Volume: 42, Issue:2

    Topics: Acetates; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Amines; Anticonvulsants;

2001
Effects of antiepileptic drugs on cognition.
    Epilepsia, 2001, Volume: 42 Suppl 1

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Cyclohexanecarboxy

2001
Gabapentin neurotoxicity in a chronic haemodialysis patient.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:10

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Epilepsy, Absence;

2001
Pregnancy registries in epilepsy.
    Epilepsia, 2001, Volume: 42, Issue:11

    Topics: Abnormalities, Drug-Induced; Acetates; Amines; Anticonvulsants; Australia; Cross-Cultural Comparison

2001
Gabapentin-induced anorgasmia in women.
    The American journal of psychiatry, 2002, Volume: 159, Issue:7

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, D

2002
Comparison of gabapentin with other antiepileptic and GABAergic drugs.
    Epilepsy research, 1991, Volume: 8, Issue:3

    Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Carbamazepine; Cats; Cyclohexanecarbo

1991
Mechanisms of action of new antiepileptic drugs.
    Epilepsia, 1989, Volume: 30 Suppl 1

    Topics: Acetamides; Acetates; Amines; Aminocaproates; Aminopyridines; Anti-Anxiety Agents; Anticonvulsants;

1989