Page last updated: 2024-10-27

gabapentin and Ataxia

gabapentin has been researched along with Ataxia in 13 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.

Research Excerpts

ExcerptRelevanceReference
"The objective of this study was to compare the efficacy and tolerability of gabapentin and amitriptyline monotherapy in painful diabetic neuropathy."9.09Gabapentin vs. amitriptyline in painful diabetic neuropathy: an open-label pilot study. ( Buffa, C; Chiroli, S; Dallocchio, C; Mazzarello, P, 2000)
"The aim of this study was to report relief of optokinetic-triggered vertigo (OKTV) with low-dose gabapentin in three patients with periodic vestibulocerebellar ataxia [episodic ataxia type 4 (EA4); OMIM 606552]."8.02Gabapentin Relieves Vertigo of Periodic Vestibulocerebellar Ataxia: 3 Cases and Possible Mechanism. ( Coin, JT; Vance, JM, 2021)
"No causal treatment of ataxias is available at the moment, and so symptomatic and disease-modifying therapies are regarded as a reliable possibility for this complex group of movement disorders."5.35Gabapentin treatment improves motor coordination in a mice model of progressive ataxia. ( Calzà, L; D'Intino, G; Ferraro, L; Giardino, L; Gusciglio, M; Massella, A; Sivilia, S, 2009)
"The objective of this study was to compare the efficacy and tolerability of gabapentin and amitriptyline monotherapy in painful diabetic neuropathy."5.09Gabapentin vs. amitriptyline in painful diabetic neuropathy: an open-label pilot study. ( Buffa, C; Chiroli, S; Dallocchio, C; Mazzarello, P, 2000)
"The aim of this study was to report relief of optokinetic-triggered vertigo (OKTV) with low-dose gabapentin in three patients with periodic vestibulocerebellar ataxia [episodic ataxia type 4 (EA4); OMIM 606552]."4.02Gabapentin Relieves Vertigo of Periodic Vestibulocerebellar Ataxia: 3 Cases and Possible Mechanism. ( Coin, JT; Vance, JM, 2021)
"Thirty patients were enrolled: 10 on gabapentin, 10 on lamotrigine and 10 on carbamazepine monotherapy for epilepsy."3.73Measuring the effects of antiepileptic medications on balance in older people. ( Blum, D; Fife, TD; Fisher, RS, 2006)
"No causal treatment of ataxias is available at the moment, and so symptomatic and disease-modifying therapies are regarded as a reliable possibility for this complex group of movement disorders."1.35Gabapentin treatment improves motor coordination in a mice model of progressive ataxia. ( Calzà, L; D'Intino, G; Ferraro, L; Giardino, L; Gusciglio, M; Massella, A; Sivilia, S, 2009)
"In contrast, analgesia, sedation and catalepsy were not observed in this dose range, but were apparent at 100 mg/kg."1.33Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. ( Boulet, JM; Chaffer, SM; Elsemore, DA; Gottshall, SL; Harrison, JE; Koetzner, L; Lee, G; Mark, L; Miller, W; Pearson, MS; Rabadi, L; Rotshteyn, Y; Shan, S; Tafesse, L; Toth, M; Turchin, PI; Valenzano, KJ; Whiteside, GT, 2005)
"ent/ent mice develop ataxia by postnatal day 13-15, followed by paroxysmal dyskinesia a few days later."1.32entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse. ( Becker, CM; Becker, K; Boison, D; Brill, J; Gouder, N; Hofmann, F; Klocke, R; Klugbauer, N; Paul, D, 2004)
"Disappearance of the myokymia and improvement in the ataxia were attained with the use of the GABAergic drugs gabapentin and tiagabine."1.31[Adult GM2 gangliosidosis: improvement of ataxia with GABAergic drugs]. ( Benavente Aguilar, I; Gazulla Abío, J, 2002)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's7 (53.85)29.6817
2010's1 (7.69)24.3611
2020's4 (30.77)2.80

Authors

AuthorsStudies
Kharasch, ED1
Clark, JD1
Kheterpal, S1
Coin, JT2
Vance, JM2
Gazulla, J1
Androsova, G1
Krause, R1
Borghei, M1
Wassenaar, M1
Auce, P1
Avbersek, A1
Becker, F1
Berghuis, B1
Campbell, E1
Coppola, A1
Francis, B1
Wolking, S1
Cavalleri, GL1
Craig, J1
Delanty, N1
Koeleman, BPC1
Kunz, WS1
Lerche, H1
Marson, AG1
Sander, JW1
Sills, GJ1
Striano, P1
Zara, F1
Sisodiya, SM1
Depondt, C1
Massella, A1
Gusciglio, M1
D'Intino, G1
Sivilia, S1
Ferraro, L1
Calzà, L1
Giardino, L1
Brill, J1
Klocke, R1
Paul, D1
Boison, D1
Gouder, N1
Klugbauer, N1
Hofmann, F1
Becker, CM1
Becker, K1
Spira, PJ1
Beran, RG1
Valenzano, KJ1
Tafesse, L1
Lee, G1
Harrison, JE1
Boulet, JM1
Gottshall, SL1
Mark, L1
Pearson, MS1
Miller, W1
Shan, S1
Rabadi, L1
Rotshteyn, Y1
Chaffer, SM1
Turchin, PI1
Elsemore, DA1
Toth, M1
Koetzner, L1
Whiteside, GT1
Fife, TD1
Blum, D1
Fisher, RS1
Watson, WP1
Robinson, E1
Little, HJ1
Dallocchio, C1
Buffa, C1
Mazzarello, P1
Chiroli, S1
Gazulla Abío, J1
Benavente Aguilar, I1

Trials

2 trials available for gabapentin and Ataxia

ArticleYear
Gabapentin in the prophylaxis of chronic daily headache: a randomized, placebo-controlled study.
    Neurology, 2003, Dec-23, Volume: 61, Issue:12

    Topics: Acetates; Adolescent; Adult; Aged; Amines; Analgesics; Anticonvulsants; Ataxia; Chronic Disease; Cro

2003
Gabapentin vs. amitriptyline in painful diabetic neuropathy: an open-label pilot study.
    Journal of pain and symptom management, 2000, Volume: 20, Issue:4

    Topics: Acetates; Aged; Aged, 80 and over; Amines; Amitriptyline; Analgesics; Ataxia; Cyclohexanecarboxylic

2000

Other Studies

11 other studies available for gabapentin and Ataxia

ArticleYear
Perioperative Gabapentinoids: Deflating the Bubble.
    Anesthesiology, 2020, Volume: 133, Issue:2

    Topics: Analgesics; Ataxia; Dizziness; Gabapentin; Humans; Pain, Postoperative; Pregabalin; Preoperative Car

2020
Gabapentin Relieves Vertigo of Periodic Vestibulocerebellar Ataxia: 3 Cases and Possible Mechanism.
    Movement disorders : official journal of the Movement Disorder Society, 2021, Volume: 36, Issue:5

    Topics: Ataxia; Gabapentin; Humans; Nystagmus, Pathologic; Vertigo

2021
Gabapentin Relieves Vertigo of Periodic Vestibulocerebellar Ataxia: 3 Cases and Possible Mechanism.
    Movement disorders : official journal of the Movement Disorder Society, 2021, Volume: 36, Issue:8

    Topics: Ataxia; Gabapentin; Humans; Vertigo

2021
Reply to: Gabapentin Relieves Vertigo of Periodic Vestibulocerebellar Ataxia: 3 Cases and Possible Mechanism.
    Movement disorders : official journal of the Movement Disorder Society, 2021, Volume: 36, Issue:8

    Topics: Ataxia; Gabapentin; Humans; Vertigo

2021
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
    Epilepsia, 2017, Volume: 58, Issue:10

    Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Ataxia; Benzodiazepines; Carbamazepine; Clobazam;

2017
Gabapentin treatment improves motor coordination in a mice model of progressive ataxia.
    Brain research, 2009, Dec-08, Volume: 1301

    Topics: Age Factors; Amines; Analysis of Variance; Animals; Ataxia; Atrophy; Cell Count; Cerebellum; Chromat

2009
entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse.
    The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8

    Topics: Acetates; Alleles; Amines; Animals; Ataxia; Base Sequence; Blotting, Southern; Blotting, Western; Ca

2004
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
    Neuropharmacology, 2005, Volume: 48, Issue:5

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Ataxia; Behavior, Ani

2005
Measuring the effects of antiepileptic medications on balance in older people.
    Epilepsy research, 2006, Volume: 70, Issue:2-3

    Topics: Aged; Amines; Anticonvulsants; Ataxia; Carbamazepine; Cyclohexanecarboxylic Acids; Dizziness; Epilep

2006
The novel anticonvulsant, gabapentin, protects against both convulsant and anxiogenic aspects of the ethanol withdrawal syndrome.
    Neuropharmacology, 1997, Volume: 36, Issue:10

    Topics: Acetates; Amines; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Cyclohexanecarboxylic Acids; E

1997
[Adult GM2 gangliosidosis: improvement of ataxia with GABAergic drugs].
    Neurologia (Barcelona, Spain), 2002, Volume: 17, Issue:3

    Topics: Acetates; Adult; Amines; Ataxia; beta-N-Acetylhexosaminidases; Cerebellum; Cyclohexanecarboxylic Aci

2002