gabapentin has been researched along with Anxiety in 34 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the effectiveness of preoperative administration of gabapentin in reduction of acute postoperative pain, morphine consumption and preoperative anxiety and sedation in obese patients undergoing laparoscopic sleeve gastrectomy." | 9.30 | The Effect of Gabapentin on Postoperative Pain, Morphine Sparing Effect and Preoperative Anxiety in Patients Going for Sleeve Gastrectomy Surgical Procedure. ( Aqil, M; Bamehriz, FY; Dammas, FA; Fadin, A; Khan, MU; Khokhar, RS, 2019) |
| "undergoing ophthalmic surgery as well as opioid consumption between groups." | 9.27 | Gabapentine 300 mg vs. 450 mg as anesthetic premedication for reactive hypertension, anxiety and analgesia ( Arguelles-Uribe, GD; Carrillo-Torres, O; Corral-Urdapilleta, NP; Guzmán-Sánchez, JA; Rascón-Martínez, DM; Soto-Palma, G; Velázquez-Loeza, J, 2018) |
| "Gabapentin is increasingly being used for the treatment of postoperative pain and a variety of psychiatric diseases, including chronic anxiety disorders." | 9.17 | Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: a blinded randomized placebo-controlled trial. ( Clarke, H; Katz, J; Katznelson, R; Kirkham, KR; Ko, R; Ma, M; Mitsakakis, N; Orser, BA; Snyman, A, 2013) |
| "Gabapentin is used for the treatment of hot flashes and neuropathic pain in breast cancer survivors, and is commonly used off-label for the treatment of anxiety." | 9.16 | A randomized, controlled, double-blinded clinical trial of gabapentin 300 versus 900 mg versus placebo for anxiety symptoms in breast cancer survivors. ( Amos, E; Heckler, C; Jacobs, A; Kirshner, JJ; Lavigne, JE; Lord, R; Mathews, JL; Morrow, GR; Mustian, K; Palesh, O, 2012) |
| "Gabapentin is an anti-epileptic drug which is also used for the treatment of postoperative pain and a variety of psychiatric diseases including chronic anxiety disorders." | 9.14 | Gabapentin does not reduce preoperative anxiety when given prior to total hip arthroplasty. ( Clarke, H; Gollish, J; Katz, J; Kay, J; Mitsakakis, N; Orser, BA, 2010) |
| "The effects of gabapentin, 400 mg and 800 mg, on anxiety induced by simulated public speaking (SPS) were investigated." | 9.10 | Effects of gabapentin on anxiety induced by simulated public speaking. ( Barichello, T; Busnello, JV; de-Paris, F; Izquierdo, I; Kapczinski, F; Quevedo, J; Sant'Anna, MK; Vianna, MR, 2003) |
| " Gabapentin is a relatively new anticonvulsant being investigated for potential use in the treatment of bipolar disorder (BD), anxiety disorders, behavioral dyscontrol, and substance use disorders." | 8.80 | Gabapentin: a review of published experience in the treatment of bipolar disorder and other psychiatric conditions. ( Letterman, L; Markowitz, JS, 1999) |
| " Pregabalin is currently recommended by NICE for the treatment of anxiety." | 8.02 | Should gabapentinoids be prescribed long-term for anxiety and other mental health conditions? ( Horowitz, MA; Kelleher, M; Taylor, D, 2021) |
| " The anticonvulsant gabapentin, which is widely used as an analgesic agent, also reduces anxiety." | 7.77 | The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity. ( Coelho, AM; Cryan, JF; Dinan, TG; Fitzgerald, P; Lee, K; O' Mahony, SM; Winchester, W, 2011) |
| "The GABA amides of the antidepressants nortriptyline and fluoxetine, 1 and 2, were compared to their respective parent compounds in rodent models of pain." | 7.75 | Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. ( Aharoni, A; Geffen, Y; Gil-Ad, I; Halbfinger, E; Nisemblat, Y; Nudelman, A; Rephaeli, A; Tarasenko, I; Tarasenko, N; Weizman, A, 2009) |
| "The purpose of this article was to report a case of chorea that developed in an elderly man being treated with gabapentin for severe anxiety." | 7.75 | Chorea associated with gabapentin use in an elderly man. ( Attupurath, R; Aziz, R; Muralee, S; Tampi, RR; Wollman, D, 2009) |
| "Gabapentin has antihyperalgesic and potential anxiolytic effects." | 6.77 | Effects of a single 1200-mg preoperative dose of gabapentin on anxiety and memory. ( Adam, F; Bordenave, L; Chauvin, M; Sessler, DI, 2012) |
| "Gabapentin has antihyperalgesic and anxiolytic properties." | 6.71 | Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery. ( Adam, F; Chauvin, M; Guignard, B; Ménigaux, C; Sessler, DI, 2005) |
| "Gabapentin is a commonly prescribed antiepileptic agent for seizures, which is also used for pain and addiction management." | 5.91 | Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition. ( Ali, G; Alkahramaan, YMSA; Arif, M; Gohar, A; Khan, MS; Rashid, U; Rauf, K; Sewell, RDE, 2023) |
| "Diazepam demonstrated a statistically significant, sustained reduction in anxiety levels compared with placebo ( p = ." | 5.69 | Efficacy and Safety of Anxiolytics in Mohs Micrographic Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial. ( Guo, D; Kossintseva, I; Zloty, DM, 2023) |
| "Gabapentin was used to provide an anxiolytic effect on drug-free days." | 5.38 | Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats. ( Açikmeşe, B; Enginar, N; Hatipoğlu, I; Haznedar, S, 2012) |
| "In both neuropathic pain models, rats exhibited mechanical hypersensitivity, whereas a significant increase in anxiety-like behaviour was observed only in CCI rats (time spent in open arms decreased significantly from 99+/-15." | 5.35 | Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. ( Arndt, K; Ceci, A; Doods, H; Roeska, K; Treede, RD, 2008) |
| "Neuropathic pain is commonly associated with affective disorders such as anxiety and depression." | 5.35 | Anxiety-like behaviour is attenuated by gabapentin, morphine and diazepam in a rodent model of HIV anti-retroviral-associated neuropathic pain. ( Blackbeard, J; Pheby, T; Rice, AS; Segerdahl, AR; Wallace, VC, 2008) |
| "To determine the effectiveness of preoperative administration of gabapentin in reduction of acute postoperative pain, morphine consumption and preoperative anxiety and sedation in obese patients undergoing laparoscopic sleeve gastrectomy." | 5.30 | The Effect of Gabapentin on Postoperative Pain, Morphine Sparing Effect and Preoperative Anxiety in Patients Going for Sleeve Gastrectomy Surgical Procedure. ( Aqil, M; Bamehriz, FY; Dammas, FA; Fadin, A; Khan, MU; Khokhar, RS, 2019) |
| "undergoing ophthalmic surgery as well as opioid consumption between groups." | 5.27 | Gabapentine 300 mg vs. 450 mg as anesthetic premedication for reactive hypertension, anxiety and analgesia ( Arguelles-Uribe, GD; Carrillo-Torres, O; Corral-Urdapilleta, NP; Guzmán-Sánchez, JA; Rascón-Martínez, DM; Soto-Palma, G; Velázquez-Loeza, J, 2018) |
| "Gabapentin is increasingly being used for the treatment of postoperative pain and a variety of psychiatric diseases, including chronic anxiety disorders." | 5.17 | Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: a blinded randomized placebo-controlled trial. ( Clarke, H; Katz, J; Katznelson, R; Kirkham, KR; Ko, R; Ma, M; Mitsakakis, N; Orser, BA; Snyman, A, 2013) |
| "Gabapentin is used for the treatment of hot flashes and neuropathic pain in breast cancer survivors, and is commonly used off-label for the treatment of anxiety." | 5.16 | A randomized, controlled, double-blinded clinical trial of gabapentin 300 versus 900 mg versus placebo for anxiety symptoms in breast cancer survivors. ( Amos, E; Heckler, C; Jacobs, A; Kirshner, JJ; Lavigne, JE; Lord, R; Mathews, JL; Morrow, GR; Mustian, K; Palesh, O, 2012) |
| "Gabapentin is an anti-epileptic drug which is also used for the treatment of postoperative pain and a variety of psychiatric diseases including chronic anxiety disorders." | 5.14 | Gabapentin does not reduce preoperative anxiety when given prior to total hip arthroplasty. ( Clarke, H; Gollish, J; Katz, J; Kay, J; Mitsakakis, N; Orser, BA, 2010) |
| "Gabapentin reduces anxiety in psychiatric patients." | 5.14 | Gabapentin premedication: assessment of preoperative anxiolysis and postoperative patient satisfaction. ( Bernard, JC; Debaene, B; Foucan, L; Frasca, D; Lebrun, T; Sandefo, I; Tirault, M; Van Elstraete, AC, 2010) |
| "The effects of gabapentin, 400 mg and 800 mg, on anxiety induced by simulated public speaking (SPS) were investigated." | 5.10 | Effects of gabapentin on anxiety induced by simulated public speaking. ( Barichello, T; Busnello, JV; de-Paris, F; Izquierdo, I; Kapczinski, F; Quevedo, J; Sant'Anna, MK; Vianna, MR, 2003) |
| " Gabapentin is a relatively new anticonvulsant being investigated for potential use in the treatment of bipolar disorder (BD), anxiety disorders, behavioral dyscontrol, and substance use disorders." | 4.80 | Gabapentin: a review of published experience in the treatment of bipolar disorder and other psychiatric conditions. ( Letterman, L; Markowitz, JS, 1999) |
| " Pregabalin is currently recommended by NICE for the treatment of anxiety." | 4.02 | Should gabapentinoids be prescribed long-term for anxiety and other mental health conditions? ( Horowitz, MA; Kelleher, M; Taylor, D, 2021) |
| " The anticonvulsant gabapentin, which is widely used as an analgesic agent, also reduces anxiety." | 3.77 | The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity. ( Coelho, AM; Cryan, JF; Dinan, TG; Fitzgerald, P; Lee, K; O' Mahony, SM; Winchester, W, 2011) |
| "The purpose of this article was to report a case of chorea that developed in an elderly man being treated with gabapentin for severe anxiety." | 3.75 | Chorea associated with gabapentin use in an elderly man. ( Attupurath, R; Aziz, R; Muralee, S; Tampi, RR; Wollman, D, 2009) |
| "The GABA amides of the antidepressants nortriptyline and fluoxetine, 1 and 2, were compared to their respective parent compounds in rodent models of pain." | 3.75 | Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. ( Aharoni, A; Geffen, Y; Gil-Ad, I; Halbfinger, E; Nisemblat, Y; Nudelman, A; Rephaeli, A; Tarasenko, I; Tarasenko, N; Weizman, A, 2009) |
| "Gabapentin has antihyperalgesic and potential anxiolytic effects." | 2.77 | Effects of a single 1200-mg preoperative dose of gabapentin on anxiety and memory. ( Adam, F; Bordenave, L; Chauvin, M; Sessler, DI, 2012) |
| "Gabapentin has antihyperalgesic and anxiolytic properties." | 2.71 | Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery. ( Adam, F; Chauvin, M; Guignard, B; Ménigaux, C; Sessler, DI, 2005) |
| "Gabapentin was originally designed as an anti-convulsant gamma-aminobutyric acid (GABA) mimetic capable of crossing the blood-brain barrier." | 2.42 | Cellular and molecular action of the putative GABA-mimetic, gabapentin. ( Chung, FZ; Gonzalez, MI; Lee, K; Maneuf, YP; Pinnock, RD; Sutton, KS, 2003) |
| "Gabapentin is a commonly prescribed antiepileptic agent for seizures, which is also used for pain and addiction management." | 1.91 | Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition. ( Ali, G; Alkahramaan, YMSA; Arif, M; Gohar, A; Khan, MS; Rashid, U; Rauf, K; Sewell, RDE, 2023) |
| "Musculoskeletal pain is a widespread complex regional pain syndrome associated with altered emotional and cognitive functioning along with heightened physical disability that has become a global health concern." | 1.62 | Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin. ( Bhatti, R; Garg, S; Kaur, A; Kaur, H; Singh, L; Singh, N, 2021) |
| " Results of the study indicate that 1) Early SIS could be considered as an animal model of psychosocial stress to investigate the psychiatric comorbidities in seizure disorders, 2) Chronic administration of low dose GBP prevented the shaping of behavioral abnormalities in adulthood, 3) Chronic administration of low dose GBP produced no negative behavioral effects in socially conditioned mice suggesting the safety of the drug, 4) Gabapentin at low doses may be considered as an agent for management of epilepsy in individuals with psychiatric comorbidities." | 1.46 | Protective effects of gabapentin against the seizure susceptibility and comorbid behavioral abnormalities in the early socially isolated mice. ( Amini-Khoei, H; Amiri, S; Ghazi-Khansari, M; Haj-Mirzaian, A; Mohsenzadeh, A; Olson, CO; Rahimi-Balaei, M; Rastegar, M; Razmi, A; Shirzadian, A; Zarrindast, MR, 2017) |
| "Gabapentin was used to provide an anxiolytic effect on drug-free days." | 1.38 | Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats. ( Açikmeşe, B; Enginar, N; Hatipoğlu, I; Haznedar, S, 2012) |
| "Neuropathic pain is commonly associated with affective disorders such as anxiety and depression." | 1.35 | Anxiety-like behaviour is attenuated by gabapentin, morphine and diazepam in a rodent model of HIV anti-retroviral-associated neuropathic pain. ( Blackbeard, J; Pheby, T; Rice, AS; Segerdahl, AR; Wallace, VC, 2008) |
| "In both neuropathic pain models, rats exhibited mechanical hypersensitivity, whereas a significant increase in anxiety-like behaviour was observed only in CCI rats (time spent in open arms decreased significantly from 99+/-15." | 1.35 | Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. ( Arndt, K; Ceci, A; Doods, H; Roeska, K; Treede, RD, 2008) |
| "In contrast, analgesia, sedation and catalepsy were not observed in this dose range, but were apparent at 100 mg/kg." | 1.33 | Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. ( Boulet, JM; Chaffer, SM; Elsemore, DA; Gottshall, SL; Harrison, JE; Koetzner, L; Lee, G; Mark, L; Miller, W; Pearson, MS; Rabadi, L; Rotshteyn, Y; Shan, S; Tafesse, L; Toth, M; Turchin, PI; Valenzano, KJ; Whiteside, GT, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.94) | 18.2507 |
| 2000's | 10 (29.41) | 29.6817 |
| 2010's | 15 (44.12) | 24.3611 |
| 2020's | 8 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Rephaeli, A | 1 |
| Gil-Ad, I | 1 |
| Aharoni, A | 1 |
| Tarasenko, I | 1 |
| Tarasenko, N | 1 |
| Geffen, Y | 1 |
| Halbfinger, E | 1 |
| Nisemblat, Y | 1 |
| Weizman, A | 1 |
| Nudelman, A | 1 |
| Erickson, A | 1 |
| Harbin, K | 1 |
| MacPherson, J | 1 |
| Rundle, K | 1 |
| Overall, KL | 1 |
| Hong, JSW | 1 |
| Atkinson, LZ | 1 |
| Al-Juffali, N | 1 |
| Awad, A | 1 |
| Geddes, JR | 1 |
| Tunbridge, EM | 1 |
| Harrison, PJ | 1 |
| Cipriani, A | 1 |
| Mocanu, V | 1 |
| Wood, E | 1 |
| Barela, M | 1 |
| Wong, A | 1 |
| Chamberlain, R | 1 |
| Gohar, A | 1 |
| Ali, G | 1 |
| Rashid, U | 1 |
| Rauf, K | 1 |
| Arif, M | 1 |
| Khan, MS | 1 |
| Alkahramaan, YMSA | 1 |
| Sewell, RDE | 1 |
| Guo, D | 1 |
| Zloty, DM | 1 |
| Kossintseva, I | 1 |
| Kaur, A | 1 |
| Singh, L | 1 |
| Garg, S | 1 |
| Kaur, H | 1 |
| Singh, N | 1 |
| Bhatti, R | 1 |
| Horowitz, MA | 1 |
| Kelleher, M | 1 |
| Taylor, D | 1 |
| van Haaften, KA | 1 |
| Forsythe, LRE | 1 |
| Stelow, EA | 1 |
| Bain, MJ | 1 |
| Rascón-Martínez, DM | 1 |
| Guzmán-Sánchez, JA | 1 |
| Corral-Urdapilleta, NP | 1 |
| Arguelles-Uribe, GD | 1 |
| Velázquez-Loeza, J | 1 |
| Soto-Palma, G | 1 |
| Carrillo-Torres, O | 1 |
| Till, SR | 1 |
| As-Sanie, S | 1 |
| Schrepf, A | 1 |
| Khan, MU | 1 |
| Bamehriz, FY | 1 |
| Aqil, M | 1 |
| Dammas, FA | 1 |
| Fadin, A | 1 |
| Khokhar, RS | 1 |
| Zhang, MM | 1 |
| Liu, SB | 1 |
| Chen, T | 1 |
| Koga, K | 1 |
| Zhang, T | 1 |
| Li, YQ | 1 |
| Zhuo, M | 1 |
| Mehta, S | 1 |
| McIntyre, A | 1 |
| Dijkers, M | 1 |
| Loh, E | 1 |
| Teasell, RW | 1 |
| Kilic, FS | 1 |
| Ismailoglu, S | 1 |
| Kaygisiz, B | 1 |
| Oner, S | 1 |
| Amiri, S | 1 |
| Haj-Mirzaian, A | 1 |
| Amini-Khoei, H | 1 |
| Razmi, A | 1 |
| Shirzadian, A | 1 |
| Rahimi-Balaei, M | 1 |
| Olson, CO | 1 |
| Mohsenzadeh, A | 1 |
| Rastegar, M | 1 |
| Zarrindast, MR | 1 |
| Ghazi-Khansari, M | 1 |
| Roeska, K | 1 |
| Doods, H | 1 |
| Arndt, K | 1 |
| Treede, RD | 1 |
| Ceci, A | 1 |
| Wallace, VC | 1 |
| Segerdahl, AR | 1 |
| Blackbeard, J | 1 |
| Pheby, T | 1 |
| Rice, AS | 1 |
| Attupurath, R | 1 |
| Aziz, R | 1 |
| Wollman, D | 1 |
| Muralee, S | 1 |
| Tampi, RR | 1 |
| Clarke, H | 2 |
| Kay, J | 1 |
| Orser, BA | 2 |
| Gollish, J | 1 |
| Mitsakakis, N | 2 |
| Katz, J | 2 |
| Tirault, M | 1 |
| Foucan, L | 1 |
| Debaene, B | 1 |
| Frasca, D | 1 |
| Lebrun, T | 1 |
| Bernard, JC | 1 |
| Sandefo, I | 1 |
| Van Elstraete, AC | 1 |
| O' Mahony, SM | 1 |
| Coelho, AM | 1 |
| Fitzgerald, P | 1 |
| Lee, K | 2 |
| Winchester, W | 1 |
| Dinan, TG | 1 |
| Cryan, JF | 1 |
| Açikmeşe, B | 1 |
| Haznedar, S | 1 |
| Hatipoğlu, I | 1 |
| Enginar, N | 1 |
| Adam, F | 2 |
| Bordenave, L | 1 |
| Sessler, DI | 2 |
| Chauvin, M | 2 |
| Lavigne, JE | 1 |
| Heckler, C | 1 |
| Mathews, JL | 1 |
| Palesh, O | 1 |
| Kirshner, JJ | 1 |
| Lord, R | 1 |
| Jacobs, A | 1 |
| Amos, E | 1 |
| Morrow, GR | 1 |
| Mustian, K | 1 |
| Kirkham, KR | 1 |
| Katznelson, R | 1 |
| Ko, R | 1 |
| Snyman, A | 1 |
| Ma, M | 1 |
| Maneuf, YP | 1 |
| Gonzalez, MI | 1 |
| Sutton, KS | 1 |
| Chung, FZ | 1 |
| Pinnock, RD | 1 |
| de-Paris, F | 1 |
| Sant'Anna, MK | 1 |
| Vianna, MR | 1 |
| Barichello, T | 1 |
| Busnello, JV | 1 |
| Kapczinski, F | 1 |
| Quevedo, J | 1 |
| Izquierdo, I | 1 |
| Valenzano, KJ | 1 |
| Tafesse, L | 1 |
| Lee, G | 1 |
| Harrison, JE | 1 |
| Boulet, JM | 1 |
| Gottshall, SL | 1 |
| Mark, L | 1 |
| Pearson, MS | 1 |
| Miller, W | 1 |
| Shan, S | 1 |
| Rabadi, L | 1 |
| Rotshteyn, Y | 1 |
| Chaffer, SM | 1 |
| Turchin, PI | 1 |
| Elsemore, DA | 1 |
| Toth, M | 1 |
| Koetzner, L | 1 |
| Whiteside, GT | 1 |
| Ménigaux, C | 1 |
| Guignard, B | 1 |
| Rejas, J | 1 |
| Ribera, MV | 1 |
| Ruiz, M | 1 |
| Masrramón, X | 1 |
| Letterman, L | 1 |
| Markowitz, JS | 1 |
| Weizman, R | 1 |
| Paz, L | 1 |
| Peter, Y | 1 |
| Toren, P | 1 |
| Pick, CG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Preoperative Anxiety Level to Postoperative Pain and Analgesic Consumption in Patients Who Had Laparoscopic Sleeve Gastrectomy[NCT04432558] | 42 participants (Actual) | Observational [Patient Registry] | 2017-04-12 | Completed | |||
| Effect of Preoperative Pregabalin on Propofol Induction Dose[NCT01158859] | Phase 4 | 50 participants (Anticipated) | Interventional | 2010-04-30 | Completed | ||
| Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187] | 8 participants (Actual) | Interventional | 2009-11-30 | Terminated (stopped due to PI left institution) | |||
| Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903] | Phase 4 | 77 participants (Actual) | Interventional | 2018-05-15 | Completed | ||
| Analgetic and Anxiolytic Effect of Preoperative Pregabalin in Patients Undergoing Surgery of the Vertebral Columna[NCT00353704] | Phase 4 | 50 participants (Actual) | Interventional | 2005-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)
| Intervention | score on 10-point scale (Mean) |
|---|---|
| Standard of Care | 2.26 |
| Postoperative Gabapentin Regimen | 2.46 |
Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 3.84 |
| Postoperative Gabapentin Regimen | 3.54 |
Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 5.73 |
| Postoperative Gabapentin Regimen | 6.38 |
Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 0.36 |
| Postoperative Gabapentin Regimen | 0.17 |
Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 7.83 |
| Postoperative Gabapentin Regimen | 8.48 |
Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | days (Mean) |
|---|---|
| Standard of Care | 14.8 |
| Postoperative Gabapentin Regimen | 18.7 |
Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).
| Intervention | morphine equivalents (Mean) |
|---|---|
| Standard of Care | 287.0 |
| Postoperative Gabapentin Regimen | 281.1 |
The visual analogue scale (VAS) was used for registration of the pain intensity at rest. The score ranges from 0-100, where 0 means no pain and 100 means maximal pain. Higher values represent a worse outcome. (NCT00353704)
Timeframe: 120 minutes after surgery
| Intervention | Units on a scale (Mean) |
|---|---|
| Pregabalin | 11.7 |
| Placebo | 22.5 |
"Patients were equipped with a morphine PCA (patient controlled analgesia) for 24 hours after surgery. So they could administrate morphine intravenously by pressing a button. The sum of morphine was registered as cumulated opioid consumption (milligram)" (NCT00353704)
Timeframe: 240 minutes
| Intervention | mg (Mean) |
|---|---|
| Pregabalin | 7.3 |
| Placebo | 16.0 |
8 reviews available for gabapentin and Anxiety
| Article | Year |
|---|---|
A review of pre-appointment medications to reduce fear and anxiety in dogs and cats at veterinary visits.
Topics: Animals; Anxiety; Cat Diseases; Cats; Dog Diseases; Dogs; Fear; Gabapentin | 2021 |
Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale.
Topics: Amines; Anxiety; Bipolar Disorder; Calcium Channels; Cyclohexanecarboxylic Acids; Gabapentin; gamma- | 2022 |
Alcohol use disorder with comorbid anxiety disorder: a case report and focused literature review.
Topics: Alcoholism; Anxiety; Anxiety Disorders; Comorbidity; Gabapentin; Humans; Male; Middle Aged; Randomiz | 2022 |
Concussion and Psychological Effects: A Review of Recent Literature.
Topics: Anxiety; Athletic Injuries; Brain Concussion; Gabapentin; Humans; Risk Factors; Sports | 2023 |
Psychology of Chronic Pelvic Pain: Prevalence, Neurobiological Vulnerabilities, and Treatment.
Topics: Antidepressive Agents, Tricyclic; Anxiety; Catastrophization; Chronic Pain; Cognitive Behavioral The | 2019 |
Gabapentinoids are effective in decreasing neuropathic pain and other secondary outcomes after spinal cord injury: a meta-analysis.
Topics: Amines; Analgesics; Anxiety; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Depression; Gaba | 2014 |
Cellular and molecular action of the putative GABA-mimetic, gabapentin.
Topics: Acetates; Amines; Analgesics; Animals; Anticonvulsants; Anxiety; Brain; Cyclohexanecarboxylic Acids; | 2003 |
Gabapentin: a review of published experience in the treatment of bipolar disorder and other psychiatric conditions.
Topics: Acetates; Amines; Anticonvulsants; Anxiety; Bipolar Disorder; Cyclohexanecarboxylic Acids; Gabapenti | 1999 |
12 trials available for gabapentin and Anxiety
| Article | Year |
|---|---|
Efficacy and Safety of Anxiolytics in Mohs Micrographic Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial.
Topics: Alprazolam; Anti-Anxiety Agents; Anxiety; Diazepam; Double-Blind Method; Gabapentin; Humans; Lorazep | 2023 |
Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination.
Topics: Amines; Animal Welfare; Animals; Anxiety; Behavior, Animal; Cats; Cross-Over Studies; Cyclohexanecar | 2017 |
Gabapentine 300 mg vs. 450 mg as anesthetic premedication for reactive hypertension, anxiety and analgesia
Topics: Amines; Analgesia; Analgesics; Anti-Anxiety Agents; Anxiety; Cyclohexanecarboxylic Acids; Double-Bli | 2018 |
The Effect of Gabapentin on Postoperative Pain, Morphine Sparing Effect and Preoperative Anxiety in Patients Going for Sleeve Gastrectomy Surgical Procedure.
Topics: Adolescent; Adult; Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Anxiety; Double-Blind Method | 2019 |
Gabapentin does not reduce preoperative anxiety when given prior to total hip arthroplasty.
Topics: Aged; Amines; Anti-Anxiety Agents; Anxiety; Arthroplasty, Replacement, Hip; Cyclohexanecarboxylic Ac | 2010 |
Gabapentin premedication: assessment of preoperative anxiolysis and postoperative patient satisfaction.
Topics: Adult; Amines; Anti-Anxiety Agents; Anxiety; Cyclohexanecarboxylic Acids; Double-Blind Method; Femal | 2010 |
Effects of a single 1200-mg preoperative dose of gabapentin on anxiety and memory.
Topics: Adult; Aged; Amines; Analgesics; Anesthesia, General; Anti-Anxiety Agents; Anxiety; Cyclohexanecarbo | 2012 |
A randomized, controlled, double-blinded clinical trial of gabapentin 300 versus 900 mg versus placebo for anxiety symptoms in breast cancer survivors.
Topics: Amines; Anti-Anxiety Agents; Anxiety; Breast Neoplasms; Cyclohexanecarboxylic Acids; Female; Gabapen | 2012 |
Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: a blinded randomized placebo-controlled trial.
Topics: Adult; Amines; Analysis of Variance; Anti-Anxiety Agents; Anxiety; Catastrophization; Cyclohexanecar | 2013 |
Effects of gabapentin on anxiety induced by simulated public speaking.
Topics: Acetates; Adolescent; Adult; Amines; Anti-Anxiety Agents; Anxiety; Blood Pressure; Cyclohexanecarbox | 2003 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery.
Topics: Adult; Amines; Anterior Cruciate Ligament; Anxiety; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2005 |
Psychometric properties of the MOS (Medical Outcomes Study) Sleep Scale in patients with neuropathic pain.
Topics: Adult; Aged; Amines; Analgesics; Anxiety; Cyclohexanecarboxylic Acids; Depression; Disability Evalua | 2007 |
14 other studies available for gabapentin and Anxiety
| Article | Year |
|---|---|
Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity.
Topics: Analgesics; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Fluoxetine; Formaldehyde; gam | 2009 |
Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Ascorbic Acid; Behavior, Animal; Cogni | 2023 |
Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin.
Topics: Analgesics; Animals; Anxiety; Brain Chemistry; Cognition Disorders; Cytokines; Drug Evaluation, Prec | 2021 |
Should gabapentinoids be prescribed long-term for anxiety and other mental health conditions?
Topics: Anxiety; England; Gabapentin; Humans; Mental Health; Pregabalin | 2021 |
Effects of NB001 and gabapentin on irritable bowel syndrome-induced behavioral anxiety and spontaneous pain.
Topics: Adenosine Triphosphate; Amines; Animals; Anxiety; Behavior, Animal; Cyclohexanecarboxylic Acids; Gab | 2014 |
Effects of single and combined gabapentin use in elevated plus maze and forced swimming tests.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Anxiety; Cyclohexanecarboxylic Acids; Depression; D | 2014 |
Protective effects of gabapentin against the seizure susceptibility and comorbid behavioral abnormalities in the early socially isolated mice.
Topics: Aggression; Amines; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Comorbidity; Cyclohexanecar | 2017 |
Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin.
Topics: Amines; Analgesics; Animals; Anxiety; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapenti | 2008 |
Anxiety-like behaviour is attenuated by gabapentin, morphine and diazepam in a rodent model of HIV anti-retroviral-associated neuropathic pain.
Topics: Amines; Analgesics; Animal Diseases; Animals; Anxiety; Behavior, Animal; Cyclohexanecarboxylic Acids | 2008 |
Chorea associated with gabapentin use in an elderly man.
Topics: Aged; Amines; Analgesics; Anti-Dyskinesia Agents; Anxiety; Chorea; Cognition Disorders; Cyclohexanec | 2009 |
The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity.
Topics: Amines; Animals; Anxiety; Comorbidity; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; | 2011 |
Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats.
Topics: Amines; Animals; Anti-Anxiety Agents; Anxiety; Cyclohexanecarboxylic Acids; Diazepam; Disease Models | 2012 |
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Ataxia; Behavior, Ani | 2005 |
Behavioral effects of agents active at the gamma-aminobutyric acid receptor complex in the staircase paradigm.
Topics: Acetates; Adjuvants, Immunologic; Amines; Animals; Anti-Anxiety Agents; Anxiety; Azabicyclo Compound | 2001 |