gabapentin and Anesthesia studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

Excerpt	Relevance	Reference
" After standard premedication, 25 patients in each group received propofol, fentanyl, and local anesthesia at the operative site."	9.11	The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. ( Karamanlioğlu, B; Memiş, D; Pamukçu, Z; Turan, A; Yağiz, R; Yavuz, E, 2004)
"Further study of gabapentin and postoperative pain is needed employing rigorous and robust methodology and diversity of the sample selections."	6.82	Opioid-Sparing Anesthesia: Gabapentin and Postoperative Pain. ( Ladich, EM; Moore, CB; Spence, DL; Zhou, KQ, 2022)
"There are no sufficient evidences for the sedative effect of gabapentin during anesthesia, especially intravenous sedation (IVS)."	5.27	Effectiveness of preanesthetic administration of gabapentin on sedative action during intravenous sedation with propofol. ( Hirokawa, J; Hosokawa, R; Ito, S; Oshima, Y; Yokoyama, T, 2018)
"Patients undergoing craniotomy received either placebo (group D) or gabapentin (600 mg) (group GD) premedication orally, 2 hours before induction of anesthesia."	5.17	The effect of gabapentin premedication on postoperative nausea, vomiting, and pain in patients on preoperative dexamethasone undergoing craniotomy for intracranial tumors. ( Misra, S; Parthasarathi, G; Vilanilam, GC, 2013)
" After standard premedication, 25 patients in each group received propofol, fentanyl, and local anesthesia at the operative site."	5.11	The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. ( Karamanlioğlu, B; Memiş, D; Pamukçu, Z; Turan, A; Yağiz, R; Yavuz, E, 2004)
"Further study of gabapentin and postoperative pain is needed employing rigorous and robust methodology and diversity of the sample selections."	2.82	Opioid-Sparing Anesthesia: Gabapentin and Postoperative Pain. ( Ladich, EM; Moore, CB; Spence, DL; Zhou, KQ, 2022)
"Gabapentin was administered IV (4 mg/kg) or orally (10 mg/kg) in a crossover randomized design."	1.36	Pharmacokinetics of gabapentin in cats. ( Ilkiw, JE; Pypendop, BH; Siao, KT, 2010)

Research

Studies (15)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (26.67)	29.6817
2010's	9 (60.00)	24.3611
2020's	2 (13.33)	2.80

Authors	Studies
Ladich, EM	1
Zhou, KQ	1
Spence, DL	1
Moore, CB	1
Zetlaoui, PJ	1
Pesche, L	1
Benhamou, D	1
Martinez, V	1
Carles, M	1
Marret, E	1
Beloeil, H	1
Hosokawa, R	1
Ito, S	1
Hirokawa, J	1
Oshima, Y	1
Yokoyama, T	1
Hopkins, SC	1
Zhao, FY	1
Bowen, CA	1
Fang, X	1
Wei, H	1
Heffernan, ML	1
Spear, KL	1
Spanswick, DC	1
Varney, MA	1
Large, TH	1
Misra, S	1
Parthasarathi, G	1
Vilanilam, GC	1
Chamaraux-Tran, TN	1
Levy, F	1
Zappaterra, M	1
Goetz, J	1
Goichot, B	1
Steib, A	1
Rashiq, S	1
Dick, BD	1
Crociolli, GC	1
Cassu, RN	1
Barbero, RC	1
Rocha, TL	1
Gomes, DR	1
Nicácio, GM	1
Hoffmann, U	1
Dileköz, E	1
Kudo, C	1
Ayata, C	1
Siao, KT	1
Pypendop, BH	1
Ilkiw, JE	1
Freye, E	1
Levy, JV	1
Partecke, L	1
Turan, A	2
Memiş, D	2
Karamanlioğlu, B	2
Yağiz, R	1
Pamukçu, Z	1
Yavuz, E	1
Seker, S	1
Türe, M	1
Chizh, BA	1
Scheede, M	1
Schlütz, H	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]	Phase 4	77 participants (Actual)	Interventional	2018-05-15	Completed
A Prospective Randomized Double Blind Trial to Assess the Effect of a Single Preoperative Dose of Gabapentin on Postoperative Opioid Consumption in Patients Undergoing Rhinoplasty[NCT03498261]	Phase 1	50 participants (Actual)	Interventional	2018-01-30	Active, not recruiting
Efficacy of Preoperative Administration of Gabapentin in Managing Intraoperative and Postoperative Pain From Third Molar Extractions.[NCT04860141]	Phase 4	98 participants (Anticipated)	Interventional	2021-06-16	Recruiting
Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187]		8 participants (Actual)	Interventional	2009-11-30	Terminated (stopped due to PI left institution)
Effect of Preoperative Pregabalin on Propofol Induction Dose[NCT01158859]	Phase 4	50 participants (Anticipated)	Interventional	2010-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Intervention	score on 10-point scale (Mean)
Standard of Care	2.26
Postoperative Gabapentin Regimen	2.46

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 3: How Well Are You Sleeping?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	3.84
Postoperative Gabapentin Regimen	3.54

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 4: How Bad is Your Nausea?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	5.73
Postoperative Gabapentin Regimen	6.38

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	0.36
Postoperative Gabapentin Regimen	0.17

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Days Taking Opioids

Intervention	score on a 10-point scale (Mean)
Standard of Care	7.83
Postoperative Gabapentin Regimen	8.48

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Opioid Consumption

Intervention	days (Mean)
Standard of Care	14.8
Postoperative Gabapentin Regimen	18.7

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Article	Year
Opioid-Sparing Anesthesia: Gabapentin and Postoperative Pain. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2022, Volume: 37, Issue:6 Topics: Analgesics; Analgesics, Opioid; Anesthesia; Gabapentin; Humans; Pain, Postoperative	2022
Post-surgical pain syndromes: a review for the non-pain specialist. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2014, Volume: 61, Issue:2 Topics: Age Factors; Amines; Analgesics; Anesthesia; Anesthetics; Anesthetics, Local; Animals; Chronic Pain;	2014

Article	Year
Effectiveness of preanesthetic administration of gabapentin on sedative action during intravenous sedation with propofol. Journal of anesthesia, 2018, Volume: 32, Issue:6 Topics: Adult; Anesthesia; Conscious Sedation; Female; Gabapentin; Humans; Hypnotics and Sedatives; Male; Pr	2018
The effect of gabapentin premedication on postoperative nausea, vomiting, and pain in patients on preoperative dexamethasone undergoing craniotomy for intracranial tumors. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:4 Topics: Adult; Amines; Anesthesia; Anti-Inflammatory Agents; Brain Neoplasms; Craniotomy; Cyclohexanecarboxy	2013
Use of gabapentin for attenuation of symptoms following rapid opiate detoxification (ROD)--correlation with neurophysiological parameters--. Neurophysiologie clinique = Clinical neurophysiology, 2004, Volume: 34, Issue:2 Topics: Acetates; Adult; Amines; Anesthesia; Anesthetics, Intravenous; Cyclohexanecarboxylic Acids; Electric	2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesthesia and analgesia, 2004, Volume: 99, Issue:2 Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;	2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesthesia and analgesia, 2004, Volume: 99, Issue:2 Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;	2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesthesia and analgesia, 2004, Volume: 99, Issue:2 Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;	2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesthesia and analgesia, 2004, Volume: 99, Issue:2 Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;	2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesthesia and analgesia, 2004, Volume: 99, Issue:2 Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;	2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesthesia and analgesia, 2004, Volume: 99, Issue:2 Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;	2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesthesia and analgesia, 2004, Volume: 99, Issue:2 Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;	2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesthesia and analgesia, 2004, Volume: 99, Issue:2 Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;	2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesthesia and analgesia, 2004, Volume: 99, Issue:2 Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;	2004
Gabapentin reduces cardiovascular responses to laryngoscopy and tracheal intubation. European journal of anaesthesiology, 2006, Volume: 23, Issue:8 Topics: Administration, Oral; Adult; Amines; Anesthesia; Blood Pressure; Cardiovascular Surgical Procedures;	2006

Article	Year
Do we still need gabapentinoids in anaesthesia? Anaesthesia, critical care & pain medicine, 2021, Volume: 40, Issue:4 Topics: Anesthesia; Gabapentin; Humans; Pregabalin	2021
Perioperative use of gabapentinoids in France. Mismatch between clinical practice and scientific evidence. Anaesthesia, critical care & pain medicine, 2018, Volume: 37, Issue:1 Topics: Anesthesia; Drug Prescriptions; Drug Utilization; Evidence-Based Medicine; Excitatory Amino Acid Ant	2018
Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:3 Topics: Amines; Analgesics; Anesthesia; Animals; Behavior, Animal; Constriction, Pathologic; Cyclohexanecarb	2013
Cardiac surgery and C1-inhibitor deficiency. Journal of cardiothoracic and vascular anesthesia, 2014, Volume: 28, Issue:6 Topics: Aged, 80 and over; Amines; Analgesics; Anesthesia; Angioedemas, Hereditary; Antifibrinolytic Agents;	2014
Gabapentin as an adjuvant for postoperative pain management in dogs undergoing mastectomy. The Journal of veterinary medical science, 2015, Volume: 77, Issue:8 Topics: Adjuvants, Anesthesia; Amines; Analgesics; Analgesics, Opioid; Anesthesia; Animals; Cyclohexanecarbo	2015
Gabapentin suppresses cortical spreading depression susceptibility. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, Volume: 30, Issue:9 Topics: Amines; Anesthesia; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Cortical Spreading	2010
Pharmacokinetics of gabapentin in cats. American journal of veterinary research, 2010, Volume: 71, Issue:7 Topics: Administration, Oral; Amines; Anesthesia; Animals; Anticonvulsants; Cats; Cyclohexanecarboxylic Acid	2010
Antinociception and (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid antagonism by gabapentin in the rat spinal cord in vivo. Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:2 Topics: Acetates; Amines; Analgesics; Anesthesia; Animals; Bicuculline; Cyclohexanecarboxylic Acids; Dose-Re	2000

gabapentin and Anesthesia