Page last updated: 2024-10-27

gabapentin and Anesthesia

gabapentin has been researched along with Anesthesia in 15 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
" After standard premedication, 25 patients in each group received propofol, fentanyl, and local anesthesia at the operative site."9.11The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. ( Karamanlioğlu, B; Memiş, D; Pamukçu, Z; Turan, A; Yağiz, R; Yavuz, E, 2004)
"Further study of gabapentin and postoperative pain is needed employing rigorous and robust methodology and diversity of the sample selections."6.82Opioid-Sparing Anesthesia: Gabapentin and Postoperative Pain. ( Ladich, EM; Moore, CB; Spence, DL; Zhou, KQ, 2022)
"There are no sufficient evidences for the sedative effect of gabapentin during anesthesia, especially intravenous sedation (IVS)."5.27Effectiveness of preanesthetic administration of gabapentin on sedative action during intravenous sedation with propofol. ( Hirokawa, J; Hosokawa, R; Ito, S; Oshima, Y; Yokoyama, T, 2018)
"Patients undergoing craniotomy received either placebo (group D) or gabapentin (600 mg) (group GD) premedication orally, 2 hours before induction of anesthesia."5.17The effect of gabapentin premedication on postoperative nausea, vomiting, and pain in patients on preoperative dexamethasone undergoing craniotomy for intracranial tumors. ( Misra, S; Parthasarathi, G; Vilanilam, GC, 2013)
" After standard premedication, 25 patients in each group received propofol, fentanyl, and local anesthesia at the operative site."5.11The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. ( Karamanlioğlu, B; Memiş, D; Pamukçu, Z; Turan, A; Yağiz, R; Yavuz, E, 2004)
"Further study of gabapentin and postoperative pain is needed employing rigorous and robust methodology and diversity of the sample selections."2.82Opioid-Sparing Anesthesia: Gabapentin and Postoperative Pain. ( Ladich, EM; Moore, CB; Spence, DL; Zhou, KQ, 2022)
"Gabapentin was administered IV (4 mg/kg) or orally (10 mg/kg) in a crossover randomized design."1.36Pharmacokinetics of gabapentin in cats. ( Ilkiw, JE; Pypendop, BH; Siao, KT, 2010)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (26.67)29.6817
2010's9 (60.00)24.3611
2020's2 (13.33)2.80

Authors

AuthorsStudies
Ladich, EM1
Zhou, KQ1
Spence, DL1
Moore, CB1
Zetlaoui, PJ1
Pesche, L1
Benhamou, D1
Martinez, V1
Carles, M1
Marret, E1
Beloeil, H1
Hosokawa, R1
Ito, S1
Hirokawa, J1
Oshima, Y1
Yokoyama, T1
Hopkins, SC1
Zhao, FY1
Bowen, CA1
Fang, X1
Wei, H1
Heffernan, ML1
Spear, KL1
Spanswick, DC1
Varney, MA1
Large, TH1
Misra, S1
Parthasarathi, G1
Vilanilam, GC1
Chamaraux-Tran, TN1
Levy, F1
Zappaterra, M1
Goetz, J1
Goichot, B1
Steib, A1
Rashiq, S1
Dick, BD1
Crociolli, GC1
Cassu, RN1
Barbero, RC1
Rocha, TL1
Gomes, DR1
Nicácio, GM1
Hoffmann, U1
Dileköz, E1
Kudo, C1
Ayata, C1
Siao, KT1
Pypendop, BH1
Ilkiw, JE1
Freye, E1
Levy, JV1
Partecke, L1
Turan, A2
Memiş, D2
Karamanlioğlu, B2
Yağiz, R1
Pamukçu, Z1
Yavuz, E1
Seker, S1
Türe, M1
Chizh, BA1
Scheede, M1
Schlütz, H1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]Phase 477 participants (Actual)Interventional2018-05-15Completed
A Prospective Randomized Double Blind Trial to Assess the Effect of a Single Preoperative Dose of Gabapentin on Postoperative Opioid Consumption in Patients Undergoing Rhinoplasty[NCT03498261]Phase 150 participants (Actual)Interventional2018-01-30Active, not recruiting
Efficacy of Preoperative Administration of Gabapentin in Managing Intraoperative and Postoperative Pain From Third Molar Extractions.[NCT04860141]Phase 498 participants (Anticipated)Interventional2021-06-16Recruiting
Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187]8 participants (Actual)Interventional2009-11-30Terminated (stopped due to PI left institution)
Effect of Preoperative Pregabalin on Propofol Induction Dose[NCT01158859]Phase 450 participants (Anticipated)Interventional2010-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

Interventionscore on 10-point scale (Mean)
Standard of Care2.26
Postoperative Gabapentin Regimen2.46

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care3.84
Postoperative Gabapentin Regimen3.54

"VAS Score 3: How Well Are You Sleeping?"

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care5.73
Postoperative Gabapentin Regimen6.38

"VAS Score 4: How Bad is Your Nausea?"

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care0.36
Postoperative Gabapentin Regimen0.17

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care7.83
Postoperative Gabapentin Regimen8.48

Days Taking Opioids

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventiondays (Mean)
Standard of Care14.8
Postoperative Gabapentin Regimen18.7

Opioid Consumption

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Interventionmorphine equivalents (Mean)
Standard of Care287.0
Postoperative Gabapentin Regimen281.1

Reviews

2 reviews available for gabapentin and Anesthesia

ArticleYear
Opioid-Sparing Anesthesia: Gabapentin and Postoperative Pain.
    Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2022, Volume: 37, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Anesthesia; Gabapentin; Humans; Pain, Postoperative

2022
Post-surgical pain syndromes: a review for the non-pain specialist.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2014, Volume: 61, Issue:2

    Topics: Age Factors; Amines; Analgesics; Anesthesia; Anesthetics; Anesthetics, Local; Animals; Chronic Pain;

2014

Trials

5 trials available for gabapentin and Anesthesia

ArticleYear
Effectiveness of preanesthetic administration of gabapentin on sedative action during intravenous sedation with propofol.
    Journal of anesthesia, 2018, Volume: 32, Issue:6

    Topics: Adult; Anesthesia; Conscious Sedation; Female; Gabapentin; Humans; Hypnotics and Sedatives; Male; Pr

2018
The effect of gabapentin premedication on postoperative nausea, vomiting, and pain in patients on preoperative dexamethasone undergoing craniotomy for intracranial tumors.
    Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:4

    Topics: Adult; Amines; Anesthesia; Anti-Inflammatory Agents; Brain Neoplasms; Craniotomy; Cyclohexanecarboxy

2013
Use of gabapentin for attenuation of symptoms following rapid opiate detoxification (ROD)--correlation with neurophysiological parameters--.
    Neurophysiologie clinique = Clinical neurophysiology, 2004, Volume: 34, Issue:2

    Topics: Acetates; Adult; Amines; Anesthesia; Anesthetics, Intravenous; Cyclohexanecarboxylic Acids; Electric

2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;

2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;

2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;

2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;

2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;

2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;

2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;

2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;

2004
The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Acetates; Adult; Amines; Analgesics; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous;

2004
Gabapentin reduces cardiovascular responses to laryngoscopy and tracheal intubation.
    European journal of anaesthesiology, 2006, Volume: 23, Issue:8

    Topics: Administration, Oral; Adult; Amines; Anesthesia; Blood Pressure; Cardiovascular Surgical Procedures;

2006

Other Studies

8 other studies available for gabapentin and Anesthesia

ArticleYear
Do we still need gabapentinoids in anaesthesia?
    Anaesthesia, critical care & pain medicine, 2021, Volume: 40, Issue:4

    Topics: Anesthesia; Gabapentin; Humans; Pregabalin

2021
Perioperative use of gabapentinoids in France. Mismatch between clinical practice and scientific evidence.
    Anaesthesia, critical care & pain medicine, 2018, Volume: 37, Issue:1

    Topics: Anesthesia; Drug Prescriptions; Drug Utilization; Evidence-Based Medicine; Excitatory Amino Acid Ant

2018
Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:3

    Topics: Amines; Analgesics; Anesthesia; Animals; Behavior, Animal; Constriction, Pathologic; Cyclohexanecarb

2013
Cardiac surgery and C1-inhibitor deficiency.
    Journal of cardiothoracic and vascular anesthesia, 2014, Volume: 28, Issue:6

    Topics: Aged, 80 and over; Amines; Analgesics; Anesthesia; Angioedemas, Hereditary; Antifibrinolytic Agents;

2014
Gabapentin as an adjuvant for postoperative pain management in dogs undergoing mastectomy.
    The Journal of veterinary medical science, 2015, Volume: 77, Issue:8

    Topics: Adjuvants, Anesthesia; Amines; Analgesics; Analgesics, Opioid; Anesthesia; Animals; Cyclohexanecarbo

2015
Gabapentin suppresses cortical spreading depression susceptibility.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, Volume: 30, Issue:9

    Topics: Amines; Anesthesia; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Cortical Spreading

2010
Pharmacokinetics of gabapentin in cats.
    American journal of veterinary research, 2010, Volume: 71, Issue:7

    Topics: Administration, Oral; Amines; Anesthesia; Animals; Anticonvulsants; Cats; Cyclohexanecarboxylic Acid

2010
Antinociception and (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid antagonism by gabapentin in the rat spinal cord in vivo.
    Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:2

    Topics: Acetates; Amines; Analgesics; Anesthesia; Animals; Bicuculline; Cyclohexanecarboxylic Acids; Dose-Re

2000