Page last updated: 2024-10-27

gabapentin and Aggression

gabapentin has been researched along with Aggression in 19 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.

Research Excerpts

ExcerptRelevanceReference
"To provide a qualitative, systematic update and review of the pharmacology, pharmacokinetics, efficacy in mood disorders, adverse effects, and costs of lamotrigine."8.81Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002)
"The possible role of GABA in human aggression was evaluated by administering gabapentin to subjects with and without a history of conduct disorder and comparing the effects on laboratory measures of aggression and escape."7.72Acute effects of gabapentin on laboratory measures of aggressive and escape responses of adult parolees with and without a history of conduct disorder. ( Cherek, DR; Lane, SD; Pietras, CJ; Tcheremissine, OV, 2004)
"In a 24-patient case series from retrospective chart review, the authors examined the use of gabapentin for the treatment of aggressive and agitated behaviors in nursing home patients with a DSM-IV diagnosis of dementia."7.70A retrospective chart review of gabapentin for the treatment of aggressive and agitated behavior in patients with dementias. ( Hawkins, JW; Peyser, CE; Sheikh, JI; Tinklenberg, JR; Yesavage, JA, 2000)
"Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults."7.69Gabapentin associated with aggressive behavior in pediatric patients with seizures. ( Lo, W; Nahata, MC; Tallian, KB; Tsao, CY, 1996)
"Following PRISMA guidelines, we systematically reviewed evidence for gabapentin and pregabalin against BPSD symptoms of agitation or aggression in any dementia, using six databases (Pubmed, CINHL, PsychINFO, HealthStar, Embase, and Web of Science)."5.01Gabapentin and pregabalin to treat aggressivity in dementia: a systematic review and illustrative case report. ( Abdool, PS; Asmer, S; Bolea-Alamanac, BM; Davies, SJC; Supasitthumrong, T; Woo, VL, 2019)
"To review and summarize the currently available data on the use of anticonvulsant mood stabilizers (carbamazepine, valproic acid, gabapentin, lamotrigine, topiramate) in the treatment of behavioral and psychological symptoms of dementia (BPSD); to determine whether these medications can be recommended for routine clinical use."4.84Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review. ( Konovalov, S; Muralee, S; Tampi, RR, 2008)
"To provide a qualitative, systematic update and review of the pharmacology, pharmacokinetics, efficacy in mood disorders, adverse effects, and costs of lamotrigine."4.81Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002)
"The possible role of GABA in human aggression was evaluated by administering gabapentin to subjects with and without a history of conduct disorder and comparing the effects on laboratory measures of aggression and escape."3.72Acute effects of gabapentin on laboratory measures of aggressive and escape responses of adult parolees with and without a history of conduct disorder. ( Cherek, DR; Lane, SD; Pietras, CJ; Tcheremissine, OV, 2004)
"In a 24-patient case series from retrospective chart review, the authors examined the use of gabapentin for the treatment of aggressive and agitated behaviors in nursing home patients with a DSM-IV diagnosis of dementia."3.70A retrospective chart review of gabapentin for the treatment of aggressive and agitated behavior in patients with dementias. ( Hawkins, JW; Peyser, CE; Sheikh, JI; Tinklenberg, JR; Yesavage, JA, 2000)
"Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults."3.69Gabapentin associated with aggressive behavior in pediatric patients with seizures. ( Lo, W; Nahata, MC; Tallian, KB; Tsao, CY, 1996)
" Results of the study indicate that 1) Early SIS could be considered as an animal model of psychosocial stress to investigate the psychiatric comorbidities in seizure disorders, 2) Chronic administration of low dose GBP prevented the shaping of behavioral abnormalities in adulthood, 3) Chronic administration of low dose GBP produced no negative behavioral effects in socially conditioned mice suggesting the safety of the drug, 4) Gabapentin at low doses may be considered as an agent for management of epilepsy in individuals with psychiatric comorbidities."1.46Protective effects of gabapentin against the seizure susceptibility and comorbid behavioral abnormalities in the early socially isolated mice. ( Amini-Khoei, H; Amiri, S; Ghazi-Khansari, M; Haj-Mirzaian, A; Mohsenzadeh, A; Olson, CO; Rahimi-Balaei, M; Rastegar, M; Razmi, A; Shirzadian, A; Zarrindast, MR, 2017)
"Early treatment of epilepsy is warranted to avoid possible severe consequences."1.39Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle. ( Angeletti, G; Carbonetti, P; Del Casale, A; Fensore, C; Ferracuti, S; Girardi, P; Kotzalidis, GD; Lazanio, S; Muzi, A; Rapinesi, C; Savoja, V; Scatena, P; Serata, D; Tatarelli, R, 2013)
" Chronic administration of the synthetic gonadotropin (luteinising hormone) releasing hormone analogue, goserelin, reduces testosterone activity."1.33Gonadotrophin-releasing hormone agonist treatment of aggression in Alzheimer's disease: a case report. ( Raskind, MA; Rosin, RA, 2005)
" Optimal dosing remains unclear."1.31Gabapentin for treatment of behavioral and psychological symptoms of dementia. ( Miller, LJ, 2001)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (21.05)18.2507
2000's9 (47.37)29.6817
2010's5 (26.32)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Kruszka, M1
Graff, E1
Medam, T1
Masson, S1
Supasitthumrong, T1
Bolea-Alamanac, BM1
Asmer, S1
Woo, VL1
Abdool, PS1
Davies, SJC1
Calder, CD1
Cooney, C1
Murphy, S1
Tessema, H1
Freyne, A1
Rapinesi, C1
Del Casale, A1
Serata, D1
Kotzalidis, GD1
Scatena, P1
Muzi, A1
Lazanio, S1
Savoja, V1
Carbonetti, P1
Fensore, C1
Ferracuti, S1
Angeletti, G1
Tatarelli, R1
Girardi, P1
Amiri, S1
Haj-Mirzaian, A1
Amini-Khoei, H1
Razmi, A1
Shirzadian, A1
Rahimi-Balaei, M1
Olson, CO1
Mohsenzadeh, A1
Rastegar, M1
Zarrindast, MR1
Ghazi-Khansari, M1
Cherek, DR1
Tcheremissine, OV1
Lane, SD1
Pietras, CJ1
Rosin, RA1
Raskind, MA1
Konovalov, S1
Muralee, S1
Tampi, RR1
Demily, C1
Franck, N1
Wolf, SM1
Shinnar, S1
Kang, H1
Gil, KB1
Moshé, SL1
Lee, DO1
Steingard, RJ1
Cesena, M1
Helmers, SL1
Riviello, JJ1
Mikati, MA1
Tallian, KB1
Nahata, MC1
Lo, W1
Tsao, CY1
Low, RA1
Brandes, M1
Hawkins, JW1
Tinklenberg, JR1
Sheikh, JI1
Peyser, CE1
Yesavage, JA1
Miller, LJ1
Pinninti, NR1
Mahajan, DS1
Hurley, SC1
Biancosino, B1
Facchi, A1
Marmai, L1
Grassi, L1

Reviews

3 reviews available for gabapentin and Aggression

ArticleYear
Gabapentin and pregabalin to treat aggressivity in dementia: a systematic review and illustrative case report.
    British journal of clinical pharmacology, 2019, Volume: 85, Issue:4

    Topics: Aged; Aggression; Alzheimer Disease; Calcium Channel Blockers; Dose-Response Relationship, Drug; Gab

2019
Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review.
    International psychogeriatrics, 2008, Volume: 20, Issue:2

    Topics: Aggression; Amines; Anticonvulsants; Carbamazepine; Cognition Disorders; Cyclohexanecarboxylic Acids

2008
Lamotrigine update and its use in mood disorders.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:5

    Topics: Acetates; Aggression; Amines; Antidepressive Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids;

2002

Trials

2 trials available for gabapentin and Aggression

ArticleYear
Clinical evaluation of the effects of a single oral dose of gabapentin on fear-based aggressive behaviors in cats during veterinary examinations.
    Journal of the American Veterinary Medical Association, 2021, 11-01, Volume: 259, Issue:11

    Topics: Aggression; Analgesics; Animals; Cats; Double-Blind Method; Fear; Gabapentin; Physical Examination

2021
Gabapentin toxicity in children manifesting as behavioral changes.
    Epilepsia, 1995, Volume: 36, Issue:12

    Topics: Acetates; Affect; Aggression; Amines; Anticonvulsants; Behavior; Child; Cyclohexanecarboxylic Acids;

1995

Other Studies

14 other studies available for gabapentin and Aggression

ArticleYear
Animal Behavior Case of the Month.
    Journal of the American Veterinary Medical Association, 2019, Jan-15, Volume: 254, Issue:2

    Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior Therapy; Behavior, Animal; Dogs; Environment; Fea

2019
Use of low-dose gabapentin for aggressive behavior in vascular and Mixed Vascular/Alzheimer Dementia.
    The Journal of neuropsychiatry and clinical neurosciences, 2013,Spring, Volume: 25, Issue:2

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Amines; Cyclohexanecarboxylic Acids; Dementi

2013
Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle.
    Brain injury, 2013, Volume: 27, Issue:7-8

    Topics: Accidents, Traffic; Aggression; Amines; Anterior Temporal Lobectomy; Anticonvulsants; Brain Injuries

2013
Protective effects of gabapentin against the seizure susceptibility and comorbid behavioral abnormalities in the early socially isolated mice.
    European journal of pharmacology, 2017, Feb-15, Volume: 797

    Topics: Aggression; Amines; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Comorbidity; Cyclohexanecar

2017
Acute effects of gabapentin on laboratory measures of aggressive and escape responses of adult parolees with and without a history of conduct disorder.
    Psychopharmacology, 2004, Volume: 171, Issue:4

    Topics: Acetates; Adult; Aggression; Amines; Conduct Disorder; Cyclohexanecarboxylic Acids; Escape Reaction;

2004
Gonadotrophin-releasing hormone agonist treatment of aggression in Alzheimer's disease: a case report.
    International psychogeriatrics, 2005, Volume: 17, Issue:2

    Topics: Aged; Aggression; Alzheimer Disease; Amines; Antipsychotic Agents; Benzodiazepines; Cyclohexanecarbo

2005
Gabapentin for ultra resistant schizophrenia with aggressive behavior.
    Schizophrenia research, 2008, Volume: 100, Issue:1-3

    Topics: Adult; Aggression; Amines; Anticonvulsants; Antipsychotic Agents; Cyclohexanecarboxylic Acids; Drug

2008
Behavioral side effects of gabapentin in children.
    Epilepsia, 1996, Volume: 37, Issue:1

    Topics: Acetates; Aggression; Akathisia, Drug-Induced; Amines; Anticonvulsants; Attention Deficit Disorder w

1996
Gabapentin associated with aggressive behavior in pediatric patients with seizures.
    Epilepsia, 1996, Volume: 37, Issue:5

    Topics: Acetates; Adolescent; Age Factors; Aggression; Amines; Anticonvulsants; Child; Child Behavior Disord

1996
Gabapentin for the management of agitation.
    Journal of clinical psychopharmacology, 1999, Volume: 19, Issue:5

    Topics: Acetates; Aggression; Amines; Cyclohexanecarboxylic Acids; GABA Agonists; Gabapentin; gamma-Aminobut

1999
A retrospective chart review of gabapentin for the treatment of aggressive and agitated behavior in patients with dementias.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2000,Summer, Volume: 8, Issue:3

    Topics: Acetates; Aged; Aged, 80 and over; Aggression; Amines; Antimanic Agents; California; Cyclohexanecarb

2000
Gabapentin for treatment of behavioral and psychological symptoms of dementia.
    The Annals of pharmacotherapy, 2001, Volume: 35, Issue:4

    Topics: Acetates; Aggression; Amines; Behavior; Cyclohexanecarboxylic Acids; Dementia, Vascular; Excitatory

2001
Gabapentin-associated aggression.
    The Journal of neuropsychiatry and clinical neurosciences, 2001,Summer, Volume: 13, Issue:3

    Topics: Acetates; Adult; Aggression; Amines; Antimanic Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids

2001
Gabapentin treatment of impulsive-aggressive behaviour.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2002, Volume: 47, Issue:5

    Topics: Acetates; Adult; Aggression; Amines; Antimanic Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids

2002