Page last updated: 2024-10-27

gabapentin and Acute Liver Injury, Drug-Induced

gabapentin has been researched along with Acute Liver Injury, Drug-Induced in 13 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Research Excerpts

ExcerptRelevanceReference
"Gabapentin is an anticonvulsant medication used as an adjuvant in the treatment of neuropathic pain; few cases have been reported in which it causes acute liver injury."1.62[Hepatotoxicity probably associated with gabapentin]. ( Contreras-Mota, M; Rosales-Cortés, V, 2021)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (38.46)29.6817
2010's6 (46.15)24.3611
2020's2 (15.38)2.80

Authors

AuthorsStudies
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Ekins, S1
Williams, AJ1
Xu, JJ1
Liu, Z1
Shi, Q1
Ding, D1
Kelly, R1
Fang, H1
Tong, W2
Warner, DJ1
Chen, H1
Cantin, LD1
Kenna, JG1
Stahl, S1
Walker, CL1
Noeske, T1
Chen, M1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Chalasani, N1
Bonkovsky, HL1
Stine, JG1
Gu, J1
Barnhart, H1
Jacobsen, E1
Björnsson, E1
Fontana, RJ1
Kleiner, DE1
Hoofnagle, JH1
Contreras-Mota, M1
Rosales-Cortés, V1
Crespo Pérez, L1
Moreira Vicente, V1
Cano Ruiz, A1
Gobernado Serrano, JM1
Cobo Ibañez, N1
Milicua Salamero, JM1
Hauben, M1
Bureau, C1
Poirson, H1
Péron, JM1
Vinel, JP1
Himmerich, H1
Nickel, T1
Dalal, MA1
Müller, MB1
Lasso-de-la-Vega, MC1
Zapater, P1
Such, J1
Pérez-Mateo, M1
Horga, JF1

Reviews

2 reviews available for gabapentin and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
[Anticonvulsant hypersensitivity syndrome: an entity to be remembered].
    Gastroenterologia y hepatologia, 2009, Volume: 32, Issue:10

    Topics: Adolescent; Amines; Anemia, Hemolytic; Anticonvulsants; Astrocytoma; Brain Neoplasms; Carbamazepine;

2009

Other Studies

11 other studies available for gabapentin and Acute Liver Injury, Drug-Induced

ArticleYear
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
Clinical characteristics of antiepileptic-induced liver injury in patients from the DILIN prospective study.
    Journal of hepatology, 2022, Volume: 76, Issue:4

    Topics: Adult; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Chemical and Drug Ind

2022
[Hepatotoxicity probably associated with gabapentin].
    Revista medica del Instituto Mexicano del Seguro Social, 2021, Jun-14, Volume: 59, Issue:2

    Topics: Amines; Analgesics; Chemical and Drug Induced Liver Injury; Cyclohexanecarboxylic Acids; Gabapentin;

2021
Gabapentin and pregabalin: hepatic and haematological toxicity.
    Prescrire international, 2014, Volume: 23, Issue:154

    Topics: Amines; Analgesics; Chemical and Drug Induced Liver Injury; Cyclohexanecarboxylic Acids; France; Gab

2014
Re: Lasso-de-la-Vega et al. gabapentin as a probable cause of hepatotoxicity and eosinophilia.
    The American journal of gastroenterology, 2002, Volume: 97, Issue:8

    Topics: Acetates; Amines; Analgesics; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Ciprofl

2002
[Gabapentine-induced acute hepatitis].
    Gastroenterologie clinique et biologique, 2003, Volume: 27, Issue:12

    Topics: Acetates; Acute Disease; Amines; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cyclohexan

2003
[Gabapentin treatment in a female patient with panic disorder and adverse effects under carbamazepine during benzodiazepine withdrawal].
    Psychiatrische Praxis, 2007, Volume: 34, Issue:2

    Topics: Aged; Alprazolam; Amines; Antimanic Agents; Benzodiazepines; Carbamazepine; Chemical and Drug Induce

2007
Gabapentin-associated hepatotoxicity.
    The American journal of gastroenterology, 2001, Volume: 96, Issue:12

    Topics: Acetates; Amines; Analgesics; Chemical and Drug Induced Liver Injury; Cyclohexanecarboxylic Acids; G

2001