Page last updated: 2024-10-27

gabapentin and Acute Brain Injuries

gabapentin has been researched along with Acute Brain Injuries in 13 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Research Excerpts

ExcerptRelevanceReference
"Gabapentin treatment significantly improved the behavioral scores, decreased levels of phosphorylated IκB-α and cleaved caspase3, apoptosis rate, and serum IL-6 level in ICH rats."5.72Gabapentin Alleviates Brain Injury in Intracerebral Hemorrhage Through Suppressing Neuroinflammation and Apoptosis. ( Guo, L; Li, X; Nan, C; Sun, Z; Wang, B; Yang, L; Yu, N; Zhao, Z, 2022)
"Acquired brain injury can cause eye movement disorders which may include: strabismus, gaze deficits and nystagmus, causing visual symptoms of double, blurred or 'juddery' vision and reading difficulties."2.58Interventions for eye movement disorders due to acquired brain injury. ( Dodridge, CS; Evans, JR; Garcia-Finana, M; Hanna, K; Howard, C; Jarvis, KA; Maan, T; MacDiarmid, SL; Noonan, CP; North, L; Rodgers, H; Rowe, FJ, 2018)
"Gabapentin treatment significantly improved the behavioral scores, decreased levels of phosphorylated IκB-α and cleaved caspase3, apoptosis rate, and serum IL-6 level in ICH rats."1.72Gabapentin Alleviates Brain Injury in Intracerebral Hemorrhage Through Suppressing Neuroinflammation and Apoptosis. ( Guo, L; Li, X; Nan, C; Sun, Z; Wang, B; Yang, L; Yu, N; Zhao, Z, 2022)
"Macroglossia has been reported in patients undergoing posterior fossa neurosurgical procedures and is thought to be as a result of venous engorgement from intubation or mechanical positioning during these prolonged procedures."1.40Macroglossia associated with brainstem injury. ( Ardelt, A; Cueva, W; Frank, J; Goldenberg, F; Iwuchukwu, I; Reshi, R, 2014)
"Early treatment of epilepsy is warranted to avoid possible severe consequences."1.39Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle. ( Angeletti, G; Carbonetti, P; Del Casale, A; Fensore, C; Ferracuti, S; Girardi, P; Kotzalidis, GD; Lazanio, S; Muzi, A; Rapinesi, C; Savoja, V; Scatena, P; Serata, D; Tatarelli, R, 2013)
"Intracranial stab wounds are low-velocity, penetrating injuries to the brain and fatality and outcome significantly depend on route, depth and location of cranial penetration."1.39Self-inflicted trans-oral intracranial stab wound. ( Han, ZA; Kim, JH; Kim, SW, 2013)
"Gabapentin (GBP) is an anticonvulsant that acts at the α2δ-1 submit of the L-type calcium channel."1.38Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma. ( Barres, BA; Graber, KD; Jin, S; Li, H; McDonald, W; Prince, DA, 2012)
"Paroxysmal autonomic instability with dystonia, an under-recognized and poorly understood phenomenon of episodic central dysautonomia is associated with various cerebral insults."1.34Paroxysmal autonomic instability with dystonia. ( Lim, CC; Srinivasan, S; Thirugnanam, U, 2007)
"The severe burning pain, deep pressure-like pain, and deep mechanical allodynia, which presented over the contralateral side to the TBI, were successfully relieved with motor cortex stimulation (MCS)."1.33Motor cortex stimulation for central pain following a traumatic brain injury. ( Choi, ES; Hong, JT; Lee, SW; Son, BC; Sung, JH, 2006)
"Nonconvulsive seizures (NCSs) after traumatic and ischemic brain injury are often refractory to antiepileptic drug therapy and are associated with a decline in patient outcome."1.32Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia. ( Hartings, JA; Lu, XM; Moreton, JE; Tortella, FC; Williams, AJ, 2004)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's4 (30.77)29.6817
2010's7 (53.85)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Li, X1
Wang, B1
Yu, N1
Yang, L1
Nan, C1
Sun, Z1
Guo, L1
Zhao, Z1
Rowe, FJ1
Hanna, K1
Evans, JR1
Noonan, CP1
Garcia-Finana, M1
Dodridge, CS1
Howard, C1
Jarvis, KA1
MacDiarmid, SL1
Maan, T1
North, L1
Rodgers, H1
Yamada, H1
Kikuchi, R1
Katayama, J1
Nakamura, A1
Miyazaki, H1
Belozertsev, IuA1
Zapol'skaia, IuA1
Belozertsev, FIu1
Iuntsev, SV1
Rapinesi, C1
Del Casale, A1
Serata, D1
Kotzalidis, GD1
Scatena, P1
Muzi, A1
Lazanio, S1
Savoja, V1
Carbonetti, P1
Fensore, C1
Ferracuti, S1
Angeletti, G1
Tatarelli, R1
Girardi, P1
Kim, SW1
Kim, JH1
Han, ZA1
Iwuchukwu, I1
Ardelt, A1
Cueva, W1
Reshi, R1
Goldenberg, F1
Frank, J1
Li, H1
Graber, KD1
Jin, S1
McDonald, W1
Barres, BA1
Prince, DA1
Williams, AJ1
Tortella, FC1
Lu, XM1
Moreton, JE1
Hartings, JA1
Son, BC1
Lee, SW1
Choi, ES1
Sung, JH1
Hong, JT1
Baguley, IJ1
Heriseanu, RE1
Gurka, JA1
Nordenbo, A1
Cameron, ID1
Srinivasan, S1
Lim, CC1
Thirugnanam, U1
Childers, MK1
Holland, D1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Examining the Effect of Eye Gaze Technology on Children With Cortical Visual Impairment and Its Impact on Occupational Performance[NCT06067607]10 participants (Anticipated)Interventional2023-02-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for gabapentin and Acute Brain Injuries

ArticleYear
Interventions for eye movement disorders due to acquired brain injury.
    The Cochrane database of systematic reviews, 2018, 03-05, Volume: 3

    Topics: 4-Aminopyridine; Abducens Nerve Diseases; Amifampridine; Amines; Baclofen; Botulinum Toxins; Brain I

2018

Other Studies

12 other studies available for gabapentin and Acute Brain Injuries

ArticleYear
Gabapentin Alleviates Brain Injury in Intracerebral Hemorrhage Through Suppressing Neuroinflammation and Apoptosis.
    Neurochemical research, 2022, Volume: 47, Issue:10

    Topics: Animals; Apoptosis; Brain; Brain Injuries; Cerebral Hemorrhage; Gabapentin; Hemin; Inflammation; Int

2022
Paroxysmal Sympathetic Hyperactivity after Surgery for Cerebral Hemorrhagic Arteriovenous Malformation: A Case Report.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2018, Volume: 27, Issue:10

    Topics: Adolescent; Adrenergic beta-Antagonists; Amines; Autonomic Nervous System Diseases; Brain Injuries;

2018
[Comparison of neuroprotective effects of anticonvulsant drugs in brain injury therapy].
    Eksperimental'naia i klinicheskaia farmakologiia, 2012, Volume: 75, Issue:12

    Topics: Amines; Animals; Animals, Outbred Strains; Anticonvulsants; Brain; Brain Injuries; Brain Ischemia; C

2012
Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle.
    Brain injury, 2013, Volume: 27, Issue:7-8

    Topics: Accidents, Traffic; Aggression; Amines; Anterior Temporal Lobectomy; Anticonvulsants; Brain Injuries

2013
Self-inflicted trans-oral intracranial stab wound.
    Brain injury, 2013, Volume: 27, Issue:10

    Topics: Amines; Analgesics; Antidepressive Agents; Brain Injuries; Cerebellum; Citalopram; Cyclohexanecarbox

2013
Macroglossia associated with brainstem injury.
    Neurocritical care, 2014, Volume: 20, Issue:1

    Topics: Adolescent; Adrenergic beta-Antagonists; Aged; Amines; Anti-Inflammatory Agents; Brain Injuries; Bra

2014
Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma.
    Neurobiology of disease, 2012, Volume: 48, Issue:3

    Topics: Amines; Animals; Anticonvulsants; Blotting, Western; Brain Injuries; Cyclohexanecarboxylic Acids; Di

2012
Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:1

    Topics: Amines; Animals; Anticonvulsants; Brain Infarction; Brain Injuries; Brain Ischemia; Cyclohexanecarbo

2004
Motor cortex stimulation for central pain following a traumatic brain injury.
    Pain, 2006, Volume: 123, Issue:1-2

    Topics: Accidental Falls; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Aphasia, Broca; Brain Inju

2006
Gabapentin in the management of dysautonomia following severe traumatic brain injury: a case series.
    Journal of neurology, neurosurgery, and psychiatry, 2007, Volume: 78, Issue:5

    Topics: Adolescent; Adult; Amines; Anticonvulsants; Autonomic Nervous System Diseases; Brain Injuries; Cyclo

2007
Paroxysmal autonomic instability with dystonia.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2007, Volume: 17, Issue:6

    Topics: Adult; Amines; Autonomic Nervous System Diseases; Benzodiazepines; Brain Injuries; Cyclohexanecarbox

2007
Psychomotor agitation following gabapentin use in brain injury.
    Brain injury, 1997, Volume: 11, Issue:7

    Topics: Acetates; Adult; Akathisia, Drug-Induced; Amines; Analgesics; Brain Injuries; Cyclohexanecarboxylic

1997