g(m2)-ganglioside and Colorectal-Neoplasms

g(m2)-ganglioside has been researched along with Colorectal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for g(m2)-ganglioside and Colorectal-Neoplasms

Article	Year
Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1. International journal of oncology, 2000, Volume: 16, Issue:2 Natural killer (NK) and T cells express a superfamily of proteins with structural features of C-type lectins. Recombinantly prepared soluble form of rat NKR-P1 (CD161) recognized carbohydrate GalNac and GlcNac moieties. Ganglioside GM2 and heparin related-IS oligosaccharides representing the high affinity ligands for this receptor, increased the sensitivity of targets for killing by the rat effectors isolated from blood and spleen in vitro. Based on these results, we investigated in vivo the possible therapeutic effect of GM2 and IS carried by liposomes during induced rat colorectal carcinogenesis. The reduction of cancer incidence versus the controls (50% vs 88.88%), approached the 5-fluorouracil treatment (41.66%). Topics: Animals; Antigens, Surface; Antimetabolites, Antineoplastic; Azoxymethane; Carcinogens; Colorectal Neoplasms; Drug Carriers; Drug Screening Assays, Antitumor; Escherichia coli; Fluorouracil; G(M2) Ganglioside; Lectins, C-Type; Liposomes; Male; NK Cell Lectin-Like Receptor Subfamily B; Oligosaccharides; Rats; Rats, Sprague-Dawley	2000

Article

Year

Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1.

International journal of oncology, 2000, Volume: 16, Issue:2

Natural killer (NK) and T cells express a superfamily of proteins with structural features of C-type lectins. Recombinantly prepared soluble form of rat NKR-P1 (CD161) recognized carbohydrate GalNac and GlcNac moieties. Ganglioside GM2 and heparin related-IS oligosaccharides representing the high affinity ligands for this receptor, increased the sensitivity of targets for killing by the rat effectors isolated from blood and spleen in vitro. Based on these results, we investigated in vivo the possible therapeutic effect of GM2 and IS carried by liposomes during induced rat colorectal carcinogenesis. The reduction of cancer incidence versus the controls (50% vs 88.88%), approached the 5-fluorouracil treatment (41.66%).

Topics: Animals; Antigens, Surface; Antimetabolites, Antineoplastic; Azoxymethane; Carcinogens; Colorectal Neoplasms; Drug Carriers; Drug Screening Assays, Antitumor; Escherichia coli; Fluorouracil; G(M2) Ganglioside; Lectins, C-Type; Liposomes; Male; NK Cell Lectin-Like Receptor Subfamily B; Oligosaccharides; Rats; Rats, Sprague-Dawley

2000