g(m1)-ganglioside and Wallerian-Degeneration

g(m1)-ganglioside has been researched along with Wallerian-Degeneration* in 2 studies

Other Studies

2 other study(ies) available for g(m1)-ganglioside and Wallerian-Degeneration

Article	Year
Acute motor axonal neuropathy rabbit model: immune attack on nerve root axons. Annals of neurology, 2003, Volume: 54, Issue:3 Macrophages in the periaxonal space and surrounding intact myelin sheath are the most prominent pathological feature of acute motor axonal neuropathy (AMAN). We describe this characteristic in nerve roots from paralyzed rabbits immunized with bovine brain ganglioside or GM1. IgG was deposited on nerve root axons. Distal nerve conduction was preserved, and late F wave components were absent during the acute phase. Initial lesions were located mainly on nerve root axons, as in human AMAN. This study thus provides supportive evidence that the rabbits constitute a model of AMAN. Topics: Action Potentials; Animals; Axons; Electrophysiology; G(M1) Ganglioside; Immunoglobulin G; Immunohistochemistry; Macrophages; Microscopy, Electron; Models, Animal; Motor Neurons; Neural Conduction; Peripheral Nervous System Diseases; Rabbits; Sciatic Nerve; Spinal Nerve Roots; Wallerian Degeneration	2003
Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside. Annals of neurology, 2001, Volume: 49, Issue:6 Some humans develop the axonal form of Guillain-Barré syndrome after receiving bovine brain ganglioside. On sensitization with the ganglioside mixture, all of a group of rabbits injected developed high anti-GM1 IgG antibody titers, flaccid limb weakness of acute onset, and a monophasic illness course. Pathological findings for the peripheral nerves showed predominant Wallerian-like degeneration, with neither lymphocytic infiltration nor demyelination. IgG was deposited on the axons of the anterior roots, and GM1 was proved to be present on the axons of peripheral nerves. Sensitization with purified GM1 also induced axonal neuropathy, indicating that GM1 was the immunogen in the mixture. A model of human axonal Guillain-Barré syndrome has been established that uses inoculation with a bovine brain ganglioside mixture or isolated GM1. This model may help to clarify the molecular pathogenesis of the syndrome and to develop new treatments for it. Topics: Animals; Antibodies; Antibody Specificity; Autoantibodies; Axons; Cattle; Chemotaxis, Leukocyte; Disease Models, Animal; G(M1) Ganglioside; Guillain-Barre Syndrome; Immunization; Immunoglobulin G; Immunoglobulin M; Immunohistochemistry; Male; Muscle Weakness; Peripheral Nerves; Rabbits; Wallerian Degeneration	2001

Article

Year

Acute motor axonal neuropathy rabbit model: immune attack on nerve root axons.

Annals of neurology, 2003, Volume: 54, Issue:3

Macrophages in the periaxonal space and surrounding intact myelin sheath are the most prominent pathological feature of acute motor axonal neuropathy (AMAN). We describe this characteristic in nerve roots from paralyzed rabbits immunized with bovine brain ganglioside or GM1. IgG was deposited on nerve root axons. Distal nerve conduction was preserved, and late F wave components were absent during the acute phase. Initial lesions were located mainly on nerve root axons, as in human AMAN. This study thus provides supportive evidence that the rabbits constitute a model of AMAN.

Topics: Action Potentials; Animals; Axons; Electrophysiology; G(M1) Ganglioside; Immunoglobulin G; Immunohistochemistry; Macrophages; Microscopy, Electron; Models, Animal; Motor Neurons; Neural Conduction; Peripheral Nervous System Diseases; Rabbits; Sciatic Nerve; Spinal Nerve Roots; Wallerian Degeneration

2003

Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside.

Annals of neurology, 2001, Volume: 49, Issue:6

Some humans develop the axonal form of Guillain-Barré syndrome after receiving bovine brain ganglioside. On sensitization with the ganglioside mixture, all of a group of rabbits injected developed high anti-GM1 IgG antibody titers, flaccid limb weakness of acute onset, and a monophasic illness course. Pathological findings for the peripheral nerves showed predominant Wallerian-like degeneration, with neither lymphocytic infiltration nor demyelination. IgG was deposited on the axons of the anterior roots, and GM1 was proved to be present on the axons of peripheral nerves. Sensitization with purified GM1 also induced axonal neuropathy, indicating that GM1 was the immunogen in the mixture. A model of human axonal Guillain-Barré syndrome has been established that uses inoculation with a bovine brain ganglioside mixture or isolated GM1. This model may help to clarify the molecular pathogenesis of the syndrome and to develop new treatments for it.

Topics: Animals; Antibodies; Antibody Specificity; Autoantibodies; Axons; Cattle; Chemotaxis, Leukocyte; Disease Models, Animal; G(M1) Ganglioside; Guillain-Barre Syndrome; Immunization; Immunoglobulin G; Immunoglobulin M; Immunohistochemistry; Male; Muscle Weakness; Peripheral Nerves; Rabbits; Wallerian Degeneration

2001