g(m1)-ganglioside and Waldenstrom-Macroglobulinemia

An association between motor neuron disease and Waldenström disease is rarely reported in the literature. The association with peripheral neuropathy and IgM monoclonal gammapathy is well known.. In our patient, the malignant monoclonal gammapathy had an unusual antigen pattern. This patient was MAG (myelin-associated glycoprotein) negative but showed a very positive serology for GM1 ganglioside and SGPG (3-sulfated glycuronly paragloboside).. This is the fifth such case to be reported associated a malignant dyglobulinemia with an MAG-negative IgM gammapathy. It is the first case with positive serology for both the GM1 ganglioside and SGPG.

Topics: Aged; G(M1) Ganglioside; Humans; Middle Aged; Motor Neuron Disease; Myelin-Associated Glycoprotein; Serologic Tests; Waldenstrom Macroglobulinemia